KR20220167282A - 핵산 올리고머를 포함하는 조성물 - Google Patents

핵산 올리고머를 포함하는 조성물 Download PDF

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Publication number
KR20220167282A
KR20220167282A KR1020227035338A KR20227035338A KR20220167282A KR 20220167282 A KR20220167282 A KR 20220167282A KR 1020227035338 A KR1020227035338 A KR 1020227035338A KR 20227035338 A KR20227035338 A KR 20227035338A KR 20220167282 A KR20220167282 A KR 20220167282A
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KR
South Korea
Prior art keywords
group
nucleic acid
hydrogen atom
chch
methionine
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Pending
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KR1020227035338A
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English (en)
Korean (ko)
Inventor
유야 모리야마
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스미또모 가가꾸 가부시끼가이샤
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Publication of KR20220167282A publication Critical patent/KR20220167282A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • C12N15/1006—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers
    • C12N15/101—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor by means of a solid support carrier, e.g. particles, polymers by chromatography, e.g. electrophoresis, ion-exchange, reverse phase
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020227035338A 2020-04-14 2021-03-31 핵산 올리고머를 포함하는 조성물 Pending KR20220167282A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2020072234 2020-04-14
JPJP-P-2020-072234 2020-04-14
PCT/JP2021/014017 WO2021210409A1 (ja) 2020-04-14 2021-03-31 核酸オリゴマーを含む組成物

Publications (1)

Publication Number Publication Date
KR20220167282A true KR20220167282A (ko) 2022-12-20

Family

ID=78084944

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227035338A Pending KR20220167282A (ko) 2020-04-14 2021-03-31 핵산 올리고머를 포함하는 조성물

Country Status (6)

Country Link
US (1) US20230192755A1 (https=)
EP (1) EP4137501A4 (https=)
JP (1) JP7699581B2 (https=)
KR (1) KR20220167282A (https=)
CN (1) CN115397831B (https=)
WO (1) WO2021210409A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4368627A4 (en) * 2021-07-06 2025-10-08 Sumitomo Chemical Co COMPOSITION CONTAINING A NUCLEIC ACID OLIGOMER
US12509485B2 (en) * 2022-03-23 2025-12-30 Sumitomo Chemical Company, Limited Method for producing nucleic acid oligomer

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068377A1 (en) 2015-10-23 2017-04-27 Silence Therapeutics (London) Ltd Modified guide rnas, methods and uses

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3687808A (en) 1969-08-14 1972-08-29 Univ Leland Stanford Junior Synthetic polynucleotides
JPH07170981A (ja) * 1993-12-17 1995-07-11 Res Dev Corp Of Japan オリゴヌクレオチドの製造法
JP4476386B2 (ja) 1999-08-03 2010-06-09 長谷川香料株式会社 環状ジスルフィド類の製法
US6586586B1 (en) * 2000-01-31 2003-07-01 Isis Pharmaceuticals, Inc. Purification of oligonucleotides
US20030096770A1 (en) * 2001-07-11 2003-05-22 Krotz Achim H. Enhancement of the stability of oligonucleotides comprising phosphorothioate linkages by addition of water-soluble antioxidants
JP4580870B2 (ja) * 2003-09-02 2010-11-17 株式会社キラルジェン リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
AU2005275801B2 (en) 2004-08-26 2012-05-10 Nippon Shinyaku Co., Ltd. Phosphoramidite compound and method for producing oligo-RNA
JP5317836B2 (ja) 2009-06-12 2013-10-16 住友精化株式会社 アルキルスルフィド化合物の製造方法
MX370398B (es) 2011-08-25 2019-12-11 Bonac Corp Compuesto de glicosido, metodo para producir tioeter, eter, metodo para producir eter, metodo para producir un compuesto de glicosido, metodo para producir acido nucleico.
TW201734026A (zh) * 2015-12-28 2017-10-01 昭和電工股份有限公司 分離分析法
LT3576753T (lt) * 2017-02-03 2024-07-25 Laboratoires Kôl Sterili emulsija, apimanti stabilų fosforotioato oligonukleotidą
KR102670605B1 (ko) 2018-04-24 2024-05-29 스미또모 가가꾸 가부시끼가이샤 아미다이트 화합물 및 그 화합물을 사용한 폴리뉴클레오티드의 제조 방법
JP7431498B2 (ja) 2018-11-02 2024-02-15 株式会社東海理化電機製作所 電子機器、およびフレキシブルプリント基板
EP3950698A4 (en) * 2019-03-28 2023-01-25 Ajinomoto Co., Inc. METHOD OF PREPARING AN OLIGONUCLEOTIDE WITH PHOSPHOROTHIOATE SITE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017068377A1 (en) 2015-10-23 2017-04-27 Silence Therapeutics (London) Ltd Modified guide rnas, methods and uses

Also Published As

Publication number Publication date
EP4137501A4 (en) 2024-05-22
JP7699581B2 (ja) 2025-06-27
CN115397831B (zh) 2026-02-24
US20230192755A1 (en) 2023-06-22
WO2021210409A1 (ja) 2021-10-21
EP4137501A1 (en) 2023-02-22
JPWO2021210409A1 (https=) 2021-10-21
CN115397831A (zh) 2022-11-25

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