KR20220146473A - 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 - Google Patents

알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 Download PDF

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KR20220146473A
KR20220146473A KR1020227029446A KR20227029446A KR20220146473A KR 20220146473 A KR20220146473 A KR 20220146473A KR 1020227029446 A KR1020227029446 A KR 1020227029446A KR 20227029446 A KR20227029446 A KR 20227029446A KR 20220146473 A KR20220146473 A KR 20220146473A
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South Korea
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alfelisib
compound
pharmaceutically acceptable
cancer
fluoropropyl
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Korean (ko)
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몬시프 보우아보울라
주옌 궈
스테판 포아리에
메이소운 쇼말리
팡시엔 쑨
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사노피
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020227029446A 2020-02-27 2021-02-26 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물 Withdrawn KR20220146473A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP20305190 2020-02-27
EP20305190.9 2020-02-27
PCT/EP2021/054815 WO2021170793A1 (en) 2020-02-27 2021-02-26 Combination comprising alpelisib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene-2-carboxylic acid

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KR20220146473A true KR20220146473A (ko) 2022-11-01

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KR1020227029446A Withdrawn KR20220146473A (ko) 2020-02-27 2021-02-26 알펠리십과 6-(2,4-디클로로페닐)-5-[4-[(3s)-1-(3-플루오로프로필)피롤리딘-3-일]옥시페닐]-8,9-디히드로-7h-벤조[7]아눌렌-2-카복실산을 포함하는 병용물

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US (1) US12427142B2 (https=)
EP (1) EP4110326B1 (https=)
JP (1) JP2023516951A (https=)
KR (1) KR20220146473A (https=)
CN (1) CN115209893B (https=)
AR (1) AR121589A1 (https=)
AU (1) AU2021227007A1 (https=)
BR (1) BR112022015972A2 (https=)
CA (1) CA3168936A1 (https=)
IL (1) IL295807A (https=)
MX (1) MX2022010539A (https=)
TW (1) TW202146007A (https=)
WO (1) WO2021170793A1 (https=)

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US20230089371A1 (en) 2023-03-23
CA3168936A1 (en) 2021-09-02
EP4110326A1 (en) 2023-01-04
WO2021170793A1 (en) 2021-09-02
CN115209893B (zh) 2024-08-30
US12427142B2 (en) 2025-09-30
BR112022015972A2 (pt) 2022-10-11
IL295807A (en) 2022-10-01
TW202146007A (zh) 2021-12-16
EP4110326B1 (en) 2024-01-31
CN115209893A (zh) 2022-10-18
MX2022010539A (es) 2022-09-21
JP2023516951A (ja) 2023-04-21
EP4110326C0 (en) 2024-01-31
AR121589A1 (es) 2022-06-22
AU2021227007A1 (en) 2022-10-20

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