KR20220139838A - Natural Ingredient-Based Men's Cleaner - Google Patents

Abstract

The present invention relates to a male cleanser based on natural ingredients. Specifically, the male cleanser of the present invention has antibacterial and antifungal properties and excellent deodorizing effect by including a fig enzyme and a zinc mixture. In addition, the present invention maximizes antibacterial and antifungal effects by increasing percutaneous absorption, and is made of natural ingredients to minimize skin irritation.

Description

Natural Ingredient-Based Men's Cleaner

The present invention relates to a male cleanser based on natural raw materials. Specifically, the male cleanser of the present invention is characterized in that it has antibacterial and antifungal properties and excellent deodorizing effect by including a fig enzyme and a zinc mixture.

Recently, due to the global COVID-19 pandemic, interest in hygiene products and cleaning products has surged, and related markets and sales are rapidly growing.

Various local cleansing products such as feminine washes and vaginal cleansers have been released due to the body structure of the reproductive system, which is prone to bad odors, and factors to prevent gynecological diseases. A representative disease that such topical cleaning products are trying to prevent is Candida vaginitis. Candida vulvovaginitis, one of the gynecological diseases, is so common that about 75% of women experience it at least once in their lifetime, and about 45% of women experience it at least twice a year. It is always under the influence of body secretions, and the female genitals are susceptible to bacterial and fungal diseases due to the characteristic of the mucosal structure without an epidermis. Paying attention to this point, the feminine cleanser not only prevents infectious diseases with its disinfecting, sterilizing and cleaning effects, but also provides auxiliary functions such as deodorization, pH control, moisturizing, non-viscosity, and strengthening immunity. Products with various raw materials and functions are on the market.

However, in the case of men, due to the relatively easy-to-clean genital structure and lack of interest, there are not many types of male cleanser, and its functionality is limited in its deodorizing effect and refreshing feeling.

On the other hand, the cosmetics market, which was considered exclusively for women, has gradually expanded to target men, forming a total market size of 144 trillion won, and is expected to continue increasing at a growth rate of 15.9% until 2026.

Due to this situation, the domestic men's cleanser market is also growing rapidly, and numerous men's cleanser is being launched. However, there is still no product that stimulates the purchase necessity of consumers, so products with more diverse functions are required.

Korean Patent Registration No. 10-1979827 relates to a male cleanser composition and a method for manufacturing the same. The present invention discloses a method for producing a male cleanser cosmetic composition comprising a maca extract and a detergent as main components and forming an emulsion phase including a disinfectant, a pH adjuster, a moisturizing component, and the like.

Korean Patent No. 10-2385414 relates to a cosmetic composition for men's cleanliness comprising extracts of maca and purslane as active ingredients and a method for manufacturing the same. The present invention is characterized in that it contains maca and purslane hot water extract as active ingredients and has antibacterial and whitening effects.

However, looking at existing inventions and commercial products, the existing male cleanser acts only on the outer surface of the skin, and there is no male cleanser that acts on the inside of the skin or the urethra. Therefore, it can be said that existing men's cleanser products are no different from general soaps in terms of performance and pharmacology compared to the advertised bars.

An object of the present invention for solving the above-mentioned problems is to provide a male cleanser with enhanced antibacterial and antifungal effects by increasing the transdermal absorption rate and allowing penetration into the male genitals and urethra.

Another object of the present invention is to provide a male cleanser having an excellent effect of removing odors.

Another object of the present invention is to provide an eco-friendly vegan male cleanser made using vegetable raw materials.

In order to solve the above object, the present invention provides an eco-friendly vegan male cleanser comprising a fig fig enzyme and a zinc mixture.

Specifically, the present invention uses fig enzyme extract 0.1 to 3 parts by weight, echinacea extract 0.1 to 2 parts by weight, zinc pyrithione 0.05 to 0.5 parts by weight, sodium polynaphthalenesulfonate 0.5 to 5 parts by weight as active ingredients, and surfactant It provides an eco-friendly vegan male cleanser containing a fig enzyme and zinc mixture, including 10 to 30 parts by weight, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of an acidity regulator, and the remaining parts by weight of purified water.

The fig ( Ficus carica ) is a plant of the genus of figs, native to Asia Minor, and planted in Egypt about 4,000 years ago, so it is known as the world's oldest fruit tree. Figs are classified into four horticulturally, Capri, Smyrna, Common, and San Pedro, depending on the type of flower and the need for pollination. It is known that the high-quality varieties that are being developed have already been cultivated in Europe. The fig leaves are alternate and broad egg-shaped. From spring to summer, a pouch-like inflorescence develops in the leaf axil, and many small flowers hang in it. The fruit is a dark purple sagebrush that ripens in autumn and is used for food. The leaves contain protein and rubber, and the milk is used as a remedy for roundworms or as a medicine for neuralgia. Figs have been highly valued in the Bible and Donguibogam as a folk medicine since ancient times. It has been documented to be effective in strengthening blood pressure, health, nourishment, constipation, hepatitis, cancer, gynecological diseases, and recovery of vitality. Its efficacy is described in "Bonchogangmok (Myeong)", "It smoothes the action of the bone, stops diarrhea, and relieves sore throat." In Jinnam Boncho (Myeong), "It is called Myongmokgwa, so it is good to wash it frequently with the milk of the rind, and the taste is to soften the throat, so it opens the brain and chest, enters the liver, improves the flow of blood vessels and clears the eyes." Efficacy is described. Its general efficacy is as a gastrointestinal drug, treatment of diarrhea or hemorrhoids, sore throat, anti-inflammatory action, vital action, and digestion promotion. In animal experiments, there is a report that the milk contained in the fruit of mild fever was effective against carcinogenesis, leukemia, and impurs' sarcoma. Figs are a natural health food that is resistant to pests and diseases, young shoots grow clean, and grows in nature without pesticides and pollution.

It has been reported in several studies that the fig flesh, leaves, and sap extracts have antibacterial and antifungal effects. According to reports by Khaleel Ibrahim Rashid, 2014., Amirah Nadiah Ali, 2018., and Shahzada Nadeem Abbas, 2019. et al., fig extract showed strong antibacterial and antifungal effects against several bacteria and fungi. The present invention has led to the invention of an eco-friendly vegan male cleanser by paying attention to the antibacterial and antifungal effects of these figs.

The fig enzyme extract of the present invention can be obtained by extracting fig fruits with hot water and an organic solvent. Specifically, fig fruits can be collected and pulverized, followed by addition of 1 to 50 times the amount of solvent and extraction at room temperature for 12 hours to 3 months by immersion, compression or pulverization. The extraction solvent may be fractionally extracted using any one or more solvents selected from the group consisting of purified water, lower alcohols having 1 to 4 carbon atoms, dichloromethane, chloroform, and ethyl acetate. Preferably, fractional extraction may be performed using methanol, ethanol or ethyl acetate as a solvent.

The Echinacea ( Echinacea Angustifolia ) is a wild plant of the Asteraceae that inhabits the great plains of North America, and has been widely used as a traditional herbal medicine for enhancing immune function against diseases caused by colds or other viral infections for centuries. Recently, echinacea extract has been applied as a cosmetic raw material for skin protection. The echinacea extract is known to have antioxidant, immune enhancement, reactive oxygen species scavenging, and melanin suppression effects.

The zinc pyrithione is a material having a chemical formula of C ₁₀ H ₁₀ N ₂ O ₂ S ₂ Zn (CAS No. 13463-41-7) and has antibacterial and antifungal properties and is used as a preservative, especially Malassezia, a dandruff bacteria. ( Malassezia ) has been used as a component of a hair cleanser for the treatment of dandruff and hair loss due to the effect of inhibiting the proliferation.

The zinc pyrithione has a low solubility in water of 15 ppm, which may cause suspension in cosmetics or external preparations. In order to alleviate this suspension phenomenon, the vegan male cleanser of the present invention may further include 0.1 to 5 parts by weight of sodium polynaphthalene sulfonate and/or cellulose gum as an emulsion stabilizer, based on the total weight, to form a zinc pyrithione complex.

The vegan male cleanser of the present invention may contain a surfactant. The surfactant may be, for example, a mixture of any one or more of lauryl betaine, sodium cocoyl ethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate, but is not limited thereto. The surfactant may include 10 to 30 parts by weight based on the total weight.

In one embodiment, the vegan male cleanser of the present invention may include vegetable oil. The vegetable oil may be any one or more selected from the group consisting of tea tree leaf oil, evening primrose oil, hemp seed oil, pine needle branch oil, and pine needle leaf oil.

In one embodiment, the vegan male cleanser of the present invention may include an acidity control agent. The acidity regulator may be an organic acid such as coconut acid or citric acid.

In one embodiment, the vegan male cleanser of the present invention may include arginine. Arginine is a kind of amino acid and is widely used in cosmetics because it has a moisturizing effect that holds moisture in the skin and a unique scent. In addition, it has strong basic properties and is used as an acidity regulator in cosmetics.

In addition, the vegan male cleanser of the present invention may include a liposome construct. The liposome generally surrounds a polar or high molecular material, which is difficult to penetrate the cell membrane of the skin, with a lipid membrane of a component similar to a biological membrane, thereby helping the penetration of the cell membrane and promoting absorption of the active ingredient into the body.

In order to form the liposome, the present invention further comprises 1 to 8 parts by weight of lecithin, 1 to 5 parts by weight of caprylyl glycol, 1 to 5 parts by weight of caprylic/capric triglyceride, and 3 to 10 parts by weight of glycerin. may include Lecithin is a class of phospholipids having amniotic properties and is widely contained in animals and plants, and can be easily obtained from soybeans, eggs, milk, and seed oil. By mixing the material to be supported with lecithin, a surfactant, and an oil component, the material to be supported can be supported as a liposome structure using a method using a conventional high-pressure emulsifier.

On the other hand, the vegan male cleanser of the present invention has a growth inhibitory effect against Staphylococcus aureus , Escherichia coli and Candida albicans .

The Candida bacteria normally reside in the skin, oral cavity, digestive tract, genitals, etc. of the human body and are generally not harmful fungi. However, if the immune capacity of the body is temporarily weakened, it overgrowth in the moist areas of the mucous membrane and skin, causing candidiasis such as thrush, inflammation of the oropharynx or esophagus, vulvitis, vaginitis, and paronychia. In particular, 70% of vulvitis and vaginitis in women are caused by bacterial inflammation such as candidiasis, and symptoms such as itching, stinging, vaginal pain, pain during sexual intercourse and white lumpy vaginal discharge appear. If the male genitals are also infected, it may present with itching of the glans, rash, blisters, odor, pain during urination and, rarely, urethritis. Also, in uncircumcised men, smegma increases between the foreskin and the glans and causes odor.

In the examples of the present invention, it was confirmed that Candida, which causes candidiasis, and Escherichia coli and Staphylococcus aureus, which can cause various dermatitis and allergic reactions, can be effectively inhibited.

The vegan male cleanser of the present invention does not use animal raw materials, is eco-friendly by using plant-derived raw materials and plant extracts, and can satisfy the needs of veganists.

The vegan male cleanser of the present invention can be applied as a cosmetic or topical composition for skin diseases and deodorants caused by the human epithelial flora, such as a dandruff-inhibiting scalp improvement agent, a foot cleaner for alleviating athlete's foot symptoms, and an armpit cancer remover, but is not limited thereto.

According to the present invention, by providing a vegan male cleanser with enhanced antibacterial and antifungal effects by increasing transdermal absorption, there is an effect of helping to improve genital hygiene.

In addition, including natural antibiotics, it has the effect of reducing skin irritation and reducing odors, thereby increasing satisfaction with sex life.

In addition, there is an effect that can satisfy the needs of vegans because it does not use animal ingredients.

Hereinafter, embodiments of the present invention will be described in detail so that those of ordinary skill in the art can easily carry out the present invention. However, the present invention may be embodied in several different forms and is not limited to the embodiments described herein.

Preparation Example 1. Process of obtaining fig enzyme extract

After collecting and pulverizing fig fruits of the Bongraesi variety cultivated in Yeongam-gun, Jeollanam-do, 10 times the weight of ethanol solvent is added, extracted by immersion method at room temperature for 24 hours, and the extract is filtered by suction with a Buchner funnel. The mixture was removed using a reduced pressure concentrator at 50 ℃ to obtain a fig enzyme extract. The extraction and concentration processes were repeated three times.

Preparation Examples 2 to 5. Obtaining fig enzyme fraction

The fig enzyme extract obtained in Preparation Example 1 was extracted three times with a 5-fold weight of n-hexane solvent and then concentrated under reduced pressure to obtain a fig enzyme hexane fraction. Then, sequentially extracting the same with chloroform, ethyl acetate, and n-butanol solvent, the fig enzyme chloroform fraction (Preparation Example 3), the fig enzyme ethyl acetate fraction (Preparation Example 4) , a fig enzyme butanol fraction (Preparation Example 5) was obtained, respectively.

Preparation Example 6. Preparation of Echinacea Extract

Echinacea dry powder was obtained by dry-pulverizing the flowers, leaves, stems, and roots of Echinacea. The obtained dry echinacea powder was added with 20 times the weight of water, boiled for 4 hours, extracted with hot water, filtered, and the filtrate was freeze-dried to obtain a hot water extract. Thereafter, the hot water extract was immersed in 75% ethanol of 20 times the weight for 24 hours, and the leachate was concentrated under reduced pressure to prepare an echinacea extract.

<Example 1>

* Based on the total weight of the total composition, 2 parts by weight of the fig enzyme extract of Preparation Example 1, 1.5 parts by weight of the echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate, and the remaining parts by weight of purified water was mixed to prepare a composition.

<Examples 2 to 5>

The composition of Example 2 was obtained by preparing in the same manner except that the fig enzyme extract in the composition of Example 1 was replaced with the fig enzyme hexane fraction of Preparation Example 2. Similarly, the fig enzyme extract in the composition of Example 1 was replaced with the chloroform, ethyl acetate, butanol fractions of Preparation Examples 3 to 5, respectively, to prepare the compositions of Examples 3 to 5, respectively.

<Example 6>

2 parts by weight of the fig enzyme ethyl acetate fraction of Preparation Example 4 based on the total weight of the total composition, 1.5 parts by weight of the echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate, 6 parts by weight of lecithin parts, 3 parts by weight of caprylyl glycol, 3 parts by weight of caprylic/capric triglyceride, and 5 parts by weight of glycerin are mixed, and 5 parts by weight in a microfludizer under the conditions of a pressure of 1200 bar and a flow rate of 500 m/s. By passing twice, a stabilized liposome composition was prepared.

<Comparative Example 1>

A composition having the same composition ratio as in Example 6 was prepared, but the composition was prepared by simple mixing without using a high-pressure emulsifier.

<Example 7>

A cleaning composition was prepared by mixing 20 parts by weight of a surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity control agent, and the remaining parts by weight of purified water to the composition of Example 6.

As the surfactant, a mixture of lauryl betaine, sodium cocoyl cethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate in the same volume was used.

As the acidity control agent, a mixture of coconut acid and citric acid in the same weight was used. The acidity of the prepared cleaning composition was neutral at pH 7.4.

<Example 8>

A cleaning composition was prepared by further adding 8 parts by weight of vegetable oil to the composition of Example 7. The vegetable oil was a mixture of tea tree leaf oil, evening primrose oil, hemp seed oil, pine needle branch oil, and pine needle leaf oil in a weight ratio of 2:2:2:1:1.

<Comparative Example 2>

A cleaning composition was prepared by mixing 20 parts by weight of a surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity regulator, and the remaining parts by weight of purified water. The surfactant and the acidity regulator were prepared in the same configuration as in Example 7.

<Comparative Example 3>

8 parts by weight of vegetable oil was further added to the composition of Comparative Example 2 to prepare a cleaning composition. Vegetable oil was prepared in the same configuration as in Example 8.

Test Example 1. Evaluation of antibacterial ability

The antibacterial ability of the cleaning agent of the present invention was tested by the disc diffusion test. As test strains, Gram-positive bacteria, Staphylococcus aureus ) and Gram-negative bacteria, Escherichia coli ) were selected. Each strain was inoculated in LB liquid medium (Luria-Berani broth) and cultured at 37° C. for 24 hours, respectively. The cultured medium was prepared by measuring the absorbance and diluting it based on 0.5 McFarland standards.

Meanwhile, a solid medium was prepared by pouring Muller Hilton (MH) agar into a sterile Petri dish to a thickness of 4 mm and cooling it to solidify. 100 μl of the above-mentioned culture solution was spread evenly on MH solid medium. Thereafter, a paper disk was placed on the smeared MH medium, and 50 μl of the fig fractions of Examples 1 to 4 were adsorbed, and then incubated at 37° C. for 24 hours to measure the diameter of the zone of inhibition.

restraint diameter (mm) Staphylococcus aureus Escherichia coli Example 2 2 2 Example 3 12 10 Example 4 17 15 Example 5 5 4

As a result of the test, as shown in Table 1, the composition containing the fig ethyl acetate fraction of Example 4 formed an inhibition zone of 17 mm in the Staphylococcus aureus medium, and formed an inhibition zone of 15 mm in the E. coli medium, confirming that the antibacterial ability was the best. . Test Example 2. Evaluation of antifungal ability

The antibacterial ability of the cleaning agent of the present invention was tested by the disc diffusion test. As the test fungus, Candida albicans was selected. Candida was inoculated into Potato Dextrose Broth (PDB) and cultured at 30°C for 3 days. The cultured medium was prepared by measuring the absorbance and diluting it based on 0.5 McFarland standards.

Meanwhile, a solid medium was prepared by pouring Potato Dextrose Agar (PDA) to a thickness of 4 mm in a sterile Petri dish and cooling it to solidify. 100 μl of the above-mentioned culture solution was spread evenly on the PDA solid medium. Thereafter, a paper disk was placed on the spread PDA medium, and 50 μl of the fig fractions of Examples 1 to 4 was adsorbed, and then incubated at 30° C. for 48 hours to measure the diameter of the zone of inhibition.

Restraint diameter (mm) - Candida albicans Example 2 One Example 3 7 Example 4 12 Example 5 3

As a result of the test, as shown in Table 2, the composition including the fig ethyl acetate fraction of Example 4 formed an inhibition zone of 12 mm, confirming that the antifungal ability was the best. Test Example 3. Evaluation of percutaneous absorption capacity

For Example 4, Example 6, and Comparative Example 1, a skin permeation test was performed under a sink condition using a Franz diffusion cell (effective area: 0.64 cm2, volume of accommodation compartment: 5 ml). carried out. As the aqueous phase, phosphate buffered saline (PBS) of pH 7.4 was used.

The prepared epidermal layer (1.5 cm x 1.5 cm) of the human skin was placed on the receptor chamber with the stratum corneum facing up, and the donor chamber was covered and fixed with a clamp, and then the aqueous phase was transferred to Franz The diffusion cell was filled and maintained at 32±1°C. A permeation experiment was performed by attaching the prepared Examples 4, 6, and Comparative Example 1 to the donor site. At 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, and 24 hours after the permeation experiment, 5 ml of the aqueous phase was collected and analyzed, and supplemented with fresh phosphate buffered saline.

Artificial skin was purchased from Hans Biomed and stored at -20°C after purchase, and was washed and hydrated in phosphate buffered saline for 30 minutes before use.

The collected phosphate buffered saline was analyzed through high-performance liquid chromatography (HPLC), and the skin permeability was summarized in Table 3 below.

Example 4 Transmittance (%) Example 6 Transmittance (%) Comparative Example 1 Transmittance (%) 30 minutes 0.48 30 minutes 1.38 30 minutes 0.51 1 hours 0.75 1 hours 2.73 1 hours 0.84 2 hours 0.83 2 hours 3.78 2 hours 1.27 4 hours 1.12 4 hours 7.21 4 hours 1.64 6 hours 2.38 6 hours 10.76 6 hours 2.78 24 hours 4.15 24 hours 16.34 24 hours 4.47

Referring to Table 3, the composition in which only the active ingredient of Example 4 was mixed showed a result that the skin permeability was not high. On the other hand, even in the composition containing lecithin of Comparative Example 1, the skin permeability was not as high as in Example 4. On the other hand, the liposome-formed composition of Example 6 showed a significantly high skin permeability, confirming that the composition of Example 6 showed an excellent transdermal absorption effect. Test Example 4. Sensory evaluation

For 30 males in their 20s to 40s, the cleaning compositions of Examples 7 to 8 and Comparative Examples 2 to 3 were used once a day for 2 weeks, respectively, and sensory properties were evaluated. At this time, the cleaning agent was pumped once (2 mg) into the container provided, and the male Y zone was maintained for at least 3 minutes after washing, and then washed off, so that the ingredients of the cleaning agent could be sufficiently absorbed. The evaluation items were classified into irritation (the degree of tingling, erythema, or rash), deodorizing ability (satisfaction felt by you or your partner), dryness (degree of keratin), and feeling of use. 5 points, and 1 point for the most dissatisfaction was evaluated and summarized in Table 4 below.

pepper deodorant dryness feeling Example 7 4.5 3.7 3.2 4.1 Example 8 4.8 4.5 3.8 4.6 Comparative Example 2 1.8 2.3 2.4 2.4 Comparative Example 3 2.2 2.5 2.8 2.7

Referring to the results of Table 4, it can be confirmed that the cleaning composition of Example 8 has a high deodorization ability and a feeling of use while having less side effects such as irritation or dryness of the skin, thereby obtaining the highest overall satisfaction.

Claims (1)

Male Cleansing Composition by Total Weight
Fig enzyme extract 0.1-3 parts by weight, echinacea extract 0.1-2 parts by weight, zinc pyrithione 0.05-0.5 parts by weight, sodium polynaphthalenesulfonate 0.5-5 parts by weight as active ingredients,
In the male cleanser composition further comprising 10 to 30 parts by weight of a surfactant, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of an acidity regulator, and the remaining parts by weight of purified water,
The fig enzyme extract is an ethyl acetate fraction obtained by sequentially extracting fig fruits with ethanol, n-hexane and ethyl acetate,
The echinacea extract is obtained by hot water extraction of echinacea dry powder, followed by immersion in 75% ethanol for 24 hours, and concentrated under reduced pressure of the leachate obtained,
The surfactant is a mixture of any one or more of lauryl betaine, sodium cocoyl cethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate;
The vegetable oil is a mixture of tea tree leaf oil, evening primrose oil, hemp seed oil, pine needle branch oil, and pine needle leaf oil in a weight ratio of 2:2:2:1:1,
The acidity regulator is any one or more selected from the group consisting of coconut acid and citric acid,
The male cleanser composition has a growth inhibitory ability against Staphylococcus aureus , Escherichia coli and Candida albicans ,
The male cleanser composition, characterized in that the active ingredient forms liposomes to increase the transdermal absorption rate.