KR20240007393A - Eco-friendly cleaning composition for reducing male genital odor - Google Patents

Abstract

The present invention relates to an eco-friendly detergent composition for reducing male genital odor. The eco-friendly detergent composition of the present invention contains 0.1 to 3 parts by weight of fig enzyme extract, 0.05 to 0.5 parts by weight of zinc pyrithione, 10 to 30 parts by weight of surfactant, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of acidity regulator, and Includes the remaining parts by weight of purified water. The present invention provides a vegan men's cleanser with enhanced antibacterial and antifungal effects by increasing the transdermal absorption rate, and also contains natural plant extracts to reduce skin irritation and reduce bad odor, which helps improve genital hygiene and increases satisfaction with sexual life. .

Description

Eco-friendly cleaning composition for reducing male genital odor}

The present invention relates to an eco-friendly detergent composition. More specifically, it relates to an eco-friendly detergent composition for reducing male genital odor that has antibacterial and antifungal properties and has excellent deodorizing effects.

Recently, due to the global COVID-19 pandemic, interest in hygiene products and cleaning products has increased rapidly, and the related market and sales volume are growing rapidly.

A variety of topical cleansing products, such as feminine cleansers and vaginal cleansers, have been released due to women's reproductive system structure that is prone to bad odors and factors aimed at preventing gynecological diseases. The representative disease that such topical cleaning products are intended to prevent is candida vaginitis. Candida vulvovaginitis, one of the gynecological diseases, is a common disease that about 75% of women experience at least once in their lives, and about 45% of women experience it at least twice a year. The female genitals are always under the influence of body secretions, and due to the nature of the mucous membrane structure without epidermis, the female genitals are susceptible to bacterial and fungal diseases. Paying attention to this, feminine washes not only prevent infectious diseases through disinfection, sterilization, and cleansing effects, but also provide auxiliary functions such as deodorization, pH control, moisturizing, non-viscosity, and strengthening immunity, and much research and development has been conducted. Products with various raw materials and functions are being released.

However, in the case of men, due to the relatively easy-to-clean genital structure and lack of interest, the field of men's cleansers is limited in that there are not many types and their functionality is limited to a deodorizing effect and a refreshing feeling.

On the one hand, the cosmetics market, which was considered exclusively for women, has gradually expanded to include male targets, currently forming a total market size of 144 trillion won, and is expected to continue to increase at a growth rate of 15.9% until 2026.

Due to this situation, the domestic men's cleanser market is also growing rapidly, and numerous men's cleanser products are being released. However, because there are still no products that stimulate consumers' need to purchase, products with more diverse functionality are required.

Republic of Korea Patent No. 10-1979827 is an invention relating to a male cleanser composition and its manufacturing method. The invention discloses a method for producing a men's cleanser cosmetic composition that forms an emulsion phase using maca extract and detergent as main ingredients and including a disinfectant, pH adjuster, and moisturizing ingredient.

Republic of Korea Patent No. 10-2385414 is an invention relating to a cosmetic composition for men's cleanliness containing extracts of maca and purslane as active ingredients and a method of manufacturing the same. The invention contains maca and purslane thermal water extracts as active ingredients and is characterized by having antibacterial and whitening effects.

However, even if we look at existing inventions or commercial products, existing male cleansers only act on the outer surface of the skin, and there are no male cleansers that act on the inner skin or urethra. Therefore, compared to what is advertised, existing male cleanser products are no different from regular soap in terms of performance and pharmacology.

One purpose of the present invention to solve the above-described problems is to provide a men's cleanser with enhanced antibacterial and antifungal effects by increasing the transdermal absorption rate and allowing it to penetrate the inside of the male genitalia and urethra.

Another object of the present invention is to provide a men's cleanser with excellent odor removal effect.

Another object of the present invention is to provide an eco-friendly detergent composition made using vegetable raw materials.

In order to solve the above-mentioned object, the present invention provides an eco-friendly detergent composition for reducing male genital odor.

Specifically, the present invention contains 0.1 to 3 parts by weight of fig enzyme extract, 0.1 to 2 parts by weight of Echinacea extract, 0.05 to 0.5 parts by weight of zinc pyrithione, and 0.5 to 5 parts by weight of sodium polynaphthalenesulfonate as active ingredients, and a surfactant. Provides an eco-friendly detergent composition for reducing male genital odor, comprising 10 to 30 parts by weight, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of an acidity regulator, and the remaining parts by weight of purified water.

The fig ( Ficus carica ) is a plant of the fig tree and is native to Asia Minor. There is a record of it being planted in Egypt about 4,000 years ago, making it known as the oldest fruit tree in the world. Figs are horticulturally classified into four types, Capri, Smyrna, Common, and San Pedro, depending on the type of flower and the need for pollination. This differentiation process has already been in cultivation since BC (4-7 BC) and is cultivated today. It is known that superior varieties are already being cultivated in Europe. Fig tree leaves are alternate and broadly egg-shaped. From spring to summer, sac-like inflorescences develop in the leaf axils, and many small flowers grow inside them. The male flowers are located at the top and the female flowers are located at the bottom, making them difficult to see. The fruit is a dark purple silver berry that ripens in the fall and is used as food. The leaves contain protein and rubber, and their juice is used as a remedy for roundworms and neuralgia. Figs have been a folk medicine since ancient times and have been highly prized in the Bible and Donguibogam. It is said to be good for strengthening blood pressure, health, nourishment, constipation, hepatitis, cancer, gynecological diseases, and restoring vitality. In the herbal medicine, its efficacy is described as "promotes smooth functioning of the bone intestine, stops diarrhea, and relieves sore throat." Jinnamboncho (myeong) says, “It is also called Myeongmokgwa, so it is good to wash it frequently with the milky juice of the fruit skin. The taste emulsifies the throat, opens the encephalothorax, and enters the liver to improve the flow of blood vessels and clear the eyes.” Efficacy is described. General effects include acting as a gastrointestinal medicine, treating diarrhea or hemorrhoids, sore throat, anti-inflammatory effect, small intestine effect, promoting digestion, etc. In addition, it is used for anthelmintic medicine and jaundice. In animal experiments, it was reported that the milk contained in the fruit of immature fever was effective in treating breast cancer, leukemia, and Imper's sarcoma. Figs are resistant to pests and diseases, their young shoots grow cleanly, and they are a natural health food that grows in nature without pesticides and without pollution.

Several studies have reported that the pulp, leaves, and sap extracts of the fig have antibacterial and antifungal effects. According to reports such as Khaleel Ibrahim Rashid, 2014., Amirah Nadiah Ali, 2018., and Shahzada Nadeem Abbas, 2019., it was confirmed that fig extract shows strong antibacterial and antifungal effects against various bacteria and fungi. The present invention focused on the antibacterial and antifungal effects of figs and developed an eco-friendly detergent composition.

The fig enzyme extract of the present invention can be obtained by extracting fig fruits with hot water and organic solvents. Specifically, after collecting and pulverizing fig fruits, 1 to 50 times the amount of solvent can be added and extracted by immersion, compression, or pulverization at room temperature for 12 hours to 3 months. The extraction solvent may be used for fractional extraction using any one or more solvents selected from the group consisting of purified water, lower alcohols having 1 to 4 carbon atoms, dichloromethane, chloroform, and ethyl acetate. Preferably, fractional extraction can be performed using methanol, ethanol, or ethyl acetate as a solvent.

Echinacea ( Echinacea Angustifolia ) is a wild plant of the Asteraceae family that lives in the Great Plains of North America and has been widely used for centuries as a traditional plant medicine to improve immune function against diseases caused by colds or other viral infections. Recently, Echinacea extract has been applied as a cosmetic raw material for skin protection. The Echinacea extract is known to have antioxidant, immune-enhancing, reactive oxygen species scavenging, and melanin-inhibiting effects.

In the present invention, the zinc mixture may include zinc pyrithione. Zinc pyrithione is a substance with the chemical formula C ₁₀ H ₁₀ N ₂ O ₂ S ₂ Zn (CAS No. 13463-41-7) and has antibacterial and antifungal properties and is used as a preservative, especially against the dandruff fungus Malassezia ( Due to its effect in suppressing the growth of Malassezia , it has been used as an ingredient in hair cleansers for the treatment of dandruff and hair loss.

The zinc pyrithione has a solubility in water as low as 15ppm, so it may show suspension in cosmetics or external preparations. In order to alleviate this suspension phenomenon, the vegan men's cleanser of the present invention may further include 0.1 to 5 parts by weight of sodium polynaphthalenesulfonate and/or cellulose gum as an emulsion stabilizer based on the total weight to form a zinc pyrithione complex.

The vegan male wash of the present invention may include a surfactant. For example, the surfactant may be a mixture of one or more of lauryl betaine, sodium cocoyl isethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate, but is not limited thereto. The surfactant may contain 10 to 30 parts by weight relative to the total weight.

In one embodiment, the vegan men's cleanser of the present invention may include vegetable oil. The vegetable oil may be any one or more selected from the group consisting of tea tree leaf oil, evening primrose oil, hemp seed oil, pine pine branch oil, and pine pine leaf oil.

In one embodiment, the vegan male wash of the present invention may include an acidity regulator. The acidity regulator may be an organic acid such as coconut acid or citric acid.

In one embodiment, the vegan men's wash of the present invention may include arginine. The arginine is a type of amino acid and is widely used in cosmetics because it has a moisturizing effect that retains moisture in the skin and a unique scent. It also has strong alkaline properties, so it is also used as an acidity regulator in cosmetics.

Additionally, the vegan men's wash of the present invention may include a liposome structure. The liposome generally surrounds polar substances or polymer substances that are difficult to penetrate the cell membrane of the skin with a lipid membrane made of components similar to biological membranes, thereby helping the penetration of the cell membrane and promoting the absorption of active ingredients into the body.

In order to form the liposome, the present invention further adds 1 to 8 parts by weight of lecithin, 1 to 5 parts by weight of caprylyl glycol, 1 to 5 parts by weight of caprylic/capric triglyceride, and 3 to 10 parts by weight of glycerin. It can be included. Lecithin is a type of amniotic phospholipid and is widely found in animals and plants, and can be easily obtained from soybeans, eggs, milk, and seed oil. The supported material can be mixed into a liposome structure by mixing the supported material with lecithin, surfactant, and oil components and using a method using a typical high-pressure emulsification device.

Meanwhile, the vegan men's cleanser of the present invention has a growth inhibitory effect on Staphylococcus aureus , Escherichia coli , and Candida albicans .

The Candida bacteria are fungi that normally reside on the skin, oral cavity, digestive tract, genital area, etc. of the human body and are generally not harmful. However, if the body's immune system is temporarily weakened, it can overproliferate in moist areas of the mucous membrane and skin, causing candidiasis such as thrush, inflammation of the oropharynx or esophagus, vulvovaginitis, vaginitis, and paronychia. In particular, 70% of vulvovaginitis and vaginitis in women are caused by bacterial inflammation such as candidiasis, and symptoms include vulvar itching, stinging, vaginal pain, pain during intercourse, and white lumpy vaginal discharge. If the male genitals are also infected, itching of the glans penis, rash, blisters, foul odor, painful urination, and rarely urethritis may occur. Additionally, smegma increases between the foreskin and glans of uncircumcised men, causing a foul odor.

In the examples of the present invention, it was confirmed that Candida, which causes candidiasis, and Escherichia coli and Staphylococcus aureus, which can cause various dermatitis and allergic reactions, can be effectively suppressed.

The vegan men's cleanser of the present invention does not use animal raw materials, but uses plant-derived raw materials and plant extracts, so it is environmentally friendly and can meet the needs of vegans.

The vegan men's cleanser of the present invention can be applied as a cosmetic or external composition for deodorization and skin diseases caused by human epithelial flora, such as a scalp improver to inhibit dandruff, a foot wash for alleviating athlete's foot symptoms, and an armpit cancer remover, but is not limited thereto.

According to the present invention, a vegan men's cleanser with enhanced antibacterial and antifungal effects by increasing the transdermal absorption rate is provided, which has the effect of helping to improve genital hygiene.

In addition, it contains natural antibiotics, which has the effect of reducing skin irritation and bad odor, thereby increasing satisfaction with sexual life.

In addition, since it does not use animal raw materials, it has the effect of meeting the demand of vegans.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement it. However, the present invention may be implemented in many different forms and is not limited to the embodiments described herein.

Preparation Example 1. Process for obtaining fig enzyme extract

에서 감압농축기를 사용하여 에탄올을 제거하여 무화과 효소 추출물을 얻었다. 상기 추출 및 농축과정은 3회 반복 실시하였다.Fig fruits of the Bongraesi variety grown in Yeongam-gun, Jeollanam-do were collected and crushed, then 10 times the weight of ethanol solvent was added, extracted by immersion at room temperature for 24 hours, and suction filtered using a Buchner funnel to produce the extract. Mix 50

Ethanol was removed using a vacuum concentrator to obtain a fig enzyme extract. The extraction and concentration process was repeated three times.

Preparation Examples 2 to 5. Obtaining fig enzyme fraction

The fig enzyme extract obtained in Preparation Example 1 was extracted three times with 5 times the weight of n-hexane solvent and then concentrated under reduced pressure to obtain a fig enzyme hexane fraction. Afterwards, each fraction was obtained by sequentially extracting the same with chloroform, ethyl acetate, and n-butanol solvents.

Preparation Example 6. Preparation of Echinacea extract

Echinacea dried powder was obtained by drying and grinding the flowers, leaves, stems, and roots of Echinacea. The obtained dried Echinacea powder was added with 20 times the weight of water, boiled for 4 hours, extracted with hot water, filtered, and the filtrate was freeze-dried to obtain a hot water extract. Afterwards, the hot water extract was immersed in 20 times the weight of 75% ethanol for 24 hours and the leachate was concentrated under reduced pressure to prepare an Echinacea extract.

<Example 1>

Based on the total weight of the entire composition, 2 parts by weight of the fig enzyme extract of Preparation Example 1, 1.5 parts by weight of the Echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate, and the remaining parts by weight of purified water A composition was prepared by mixing.

<Examples 2 to 5>

The composition of Example 2 was obtained by preparing it in the same manner, except that the fig enzyme extract in the composition of Example 1 was replaced with the fig enzyme hexane fraction of Preparation Example 2. Similarly, the compositions of Examples 3 to 5 were prepared by replacing the fig enzyme extract in the composition of Example 1 with the chloroform, ethyl acetate, and butanol fractions of Preparation Examples 3 to 5, respectively.

<Example 6>

Based on the total weight of the entire composition, 2 parts by weight of the fig enzyme ethyl acetate fraction of Preparation Example 4, 1.5 parts by weight of the Echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate, and 6 parts by weight of lecithin. 3 parts by weight of caprylyl glycol, 3 parts by weight of caprylic/capric triglyceride, and 5 parts by weight of glycerin were mixed, and 5 parts by weight were placed in a high-pressure emulsifier (Microfludizer) under the conditions of a pressure of 1200 bar and a flow speed of 500 m/s. After passage, stabilized liposomes were obtained.

<Comparative Example 1>

A composition having the same composition ratio as in Example 6 was prepared by simple mixing without using a high-pressure emulsifier.

<Example 7>

A cleaning composition was prepared by mixing the composition of Example 6 with 20 parts by weight of surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity regulator, and the remaining parts by weight of purified water.

The surfactant used was a mixture of lauryl betaine, sodium cocoyl isethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate in equal volumes.

The acidity regulator used was a mixture of coconut acid and citric acid in equal weight. The acidity of the prepared cleaning composition was neutral at pH 7.4.

<Example 8>

A cleaning composition was prepared by adding 8 parts by weight of vegetable oil to the composition of Example 7. The vegetable oil used was a mixture of tea tree leaf oil, evening primrose oil, hemp seed oil, pine pine branch oil, and pine pine leaf oil in a weight ratio of 2:2:2:1:1.

<Comparative Example 2>

A cleaning composition was prepared by mixing 20 parts by weight of a surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity regulator, and the remaining parts by weight of purified water. The surfactant and acidity regulator were prepared in the same configuration as Example 7.

<Comparative Example 3>

A cleaning composition was prepared by adding 8 parts by weight of vegetable oil to the composition of Comparative Example 2. Vegetable oil was prepared in the same manner as Example 8 above.

Test Example 1. Antibacterial ability evaluation

The antibacterial ability of the cleaning agent of the present invention was tested using the disk diffusion test. Staphylococcus aureus , a gram-positive bacterium, and Escherichia coli, a gram-negative bacterium, were selected as test strains. Each strain was inoculated into LB liquid medium (Luria-Berani broth) and cultured at 37°C for 24 hours. The cultured medium was prepared by measuring the absorbance and diluting it to 0.5 McFarland standard.

Meanwhile, a solid medium was prepared by pouring Muller Hilton (MH) agar into a sterile Petri dish to a thickness of 4 mm and cooling and solidifying it. 100 ㎕ of the above-mentioned culture medium was evenly spread on MH solid medium. Afterwards, a paper disc was placed on the smeared MH medium, 50㎕ of the fig fractions of Examples 1 to 4 were adsorbed, and the culture was incubated at 37°C for 24 hours to measure the diameter of the zone of inhibition.

Suppressor diameter (mm) Staphylococcus aureus Escherichia coli Example 2 2 2 Example 3 12 10 Example 4 17 15 Example 5 5 4

As a result of the test, as shown in Table 1 above, the composition containing the fig ethyl acetate fraction of Example 4 formed an inhibition zone of 17 mm in the Staphylococcus aureus medium and an inhibition zone of 15 mm in the E. coli medium, confirming that it had the best antibacterial ability. .

Test Example 2. Evaluation of antifungal ability

The antibacterial ability of the cleaning agent of the present invention was tested using the disk diffusion test. Candida albicans was selected as the test fungus. Candida bacteria were inoculated into Potato Dextrose Broth (PDB) and cultured at 30°C for 3 days. The cultured medium was prepared by measuring the absorbance and diluting it to 0.5 McFarland standard.

Meanwhile, a solid medium was prepared by pouring Potato Dextrose Agar (PDA) into a sterile Petri dish to a thickness of 4 mm and cooling and solidifying it. 100 ㎕ of the above-mentioned culture medium was evenly spread on PDA solid medium. Afterwards, a paper disk was placed on the smeared PDA medium, 50㎕ of the fig fractions of Examples 1 to 4 were adsorbed, and the culture was incubated at 30°C for 48 hours to measure the diameter of the zone of inhibition.

Inhibitory zone diameter (mm) - Candida albicans Example 2 One Example 3 7 Example 4 12 Example 5 3

As a result of the test, as shown in Table 2 above, it was confirmed that the composition containing the fig ethyl acetate fraction of Example 4 had the best antifungal ability by forming an inhibition zone of 12 mm.

Test Example 3. Evaluation of transdermal absorption capacity

For Example 4, Example 6, and Comparative Example 1, a skin permeation test was conducted under sink conditions using a Franz diffusion cell (effective area: 0.64 cm2, volume of storage compartment: 5 ml). It was carried out. Phosphate buffered saline (PBS) at pH 7.4 was used as the aqueous phase.

The prepared epidermal layer of human skin (1.5 cm The diffusion cell was filled and maintained at 32±1°C. A permeation experiment was performed by attaching the prepared Examples 4, 6, and Comparative Example 1 to the donor site. At 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, and 24 hours after the permeation experiment, 5 ml of the aqueous phase was collected and analyzed, and supplemented with fresh phosphate-buffered saline solution.

에서 보관하였으며, 사용 시 인산 완충 식염수에 30분간 세척 및 수화시켜 사용하였다.Artificial skin was purchased and used from Hans Biomed, and after purchase, -20%

It was stored in , and when used, it was washed and hydrated in phosphate buffered saline for 30 minutes.

The collected phosphate-buffered saline solution was analyzed through high-performance liquid chromatography (HPLC), and the skin penetration rate is summarized in Table 3 below.

Example 4 Transmittance (%) Example 6 Transmittance (%) Comparative Example 1 Transmittance (%) 30 minutes 0.48 30 minutes 1.38 30 minutes 0.51 1 hours 0.75 1 hours 2.73 1 hours 0.84 2 hours 0.83 2 hours 3.78 2 hours 1.27 4 hours 1.12 4 hours 7.21 4 hours 1.64 6 hours 2.38 6 hours 10.76 6 hours 2.78 24 hours 4.15 24 hours 16.34 24 hours 4.47

Referring to Table 3, the composition containing only the active ingredients of Example 4 did not have a high skin permeability. Meanwhile, the skin permeability of the composition containing lecithin of Comparative Example 1 was not high, similar to Example 4. On the other hand, the liposome-formed composition of Example 6 showed a significantly higher skin permeability, confirming that the composition of Example 6 showed an excellent transdermal absorption effect.

Test Example 4. Sensory evaluation

Sensory properties were evaluated by having 30 men in their 20s to 40s use the cleaning compositions of Examples 7 to 8 and Comparative Examples 2 to 3 once a day for 2 weeks, respectively. At this time, instructions were given to pump the cleanser once (2 mg) into the provided container, clean the man's Y zone, hold it for at least 3 minutes, and then rinse it off so that the ingredients of the cleanser could be sufficiently absorbed. The evaluation items were categorized into irritation (stinging, erythema, or rash), deodorizing ability (satisfaction felt by the user or partner), dryness (degree of exfoliation), and feeling of use. A 5-point scale was used to determine the most satisfactory condition. The evaluation was given 5 points, and 1 point for the most dissatisfied, and is summarized in Table 4 below.

pepper Deodorizing ability dry feeling of use Example 7 4.5 3.7 3.2 4.1 Example 8 4.8 4.5 3.8 4.6 Comparative Example 2 1.8 2.3 2.4 2.4 Comparative Example 3 2.2 2.5 2.8 2.7

Referring to the results in Table 4 above, it can be seen that the cleaning composition of Example 8 achieved the highest overall satisfaction level by having a high deodorizing ability and feeling of use while having less side effects such as irritating or drying the skin.

Claims (3)

Compared to the total weight of eco-friendly detergent composition
The active ingredients include 0.1 to 3 parts by weight of fig enzyme extract, 0.1 to 2 parts by weight of Echinacea extract, 0.05 to 0.5 parts by weight of zinc pyrithione, and 0.5 to 5 parts by weight of sodium polynaphthalenesulfonate,
An eco-friendly detergent composition for reducing male genital odor, further comprising 10 to 30 parts by weight of a surfactant, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of an acidity regulator, and the remaining parts by weight of purified water. According to paragraph 1,
The fig enzyme extract is an eco-friendly detergent composition that is fractionated from fig fruits with one or more solvents selected from the group consisting of purified water, lower alcohols having 1 to 4 carbon atoms, dichloromethane, chloroform, and ethyl acetate. According to paragraph 1,
The eco-friendly detergent composition is an eco-friendly detergent composition that has the ability to inhibit the growth of Staphylococcus aureus , Escherichia coli, and Candida albicans .