KR102518446B1 - Natural Ingredient-Based Men's Cleaner - Google Patents

Abstract

The present invention relates to a male cleanser based on natural ingredients. Specifically, the male cleanser of the present invention is characterized in that it has antibacterial and antifungal properties and excellent deodorizing effect by including a mixture of fig enzyme and zinc.
In addition, the present invention is characterized in that the antibacterial and antifungal effect is maximized by increasing the percutaneous absorption rate, and skin irritation is minimized by making it from natural raw materials.

Description

Natural Ingredient-Based Men's Cleaner}

The present invention relates to a male cleanser based on natural ingredients. Specifically, the male cleanser of the present invention is characterized in that it has antibacterial and antifungal properties and excellent deodorizing effect by including a mixture of fig enzyme and zinc.

Recently, while going through the worldwide COVID-19 pandemic, interest in sanitary products and cleaning products has increased rapidly, and related markets and sales are rapidly growing.

Various local cleaning products such as female cleansers and vaginal cleansers have been released due to the body structure of the reproductive system, which is prone to odor, and factors to prevent gynecological diseases. A typical disease to be prevented by such topical cleansing products is Candida vaginitis. Candida vulvovaginitis, one of the gynecological diseases, is a common disease that about 75% of women experience at least once in their lifetime, and about 45% of women experience it at least twice a year. It is always under the influence of body secretions, and due to the mucosal structure without epidermis, the female genital organs are susceptible to bacterial and fungal diseases. Feminine cleanser pays attention to this point and not only prevents infectious diseases with disinfection and sterilization effects and cleaning effects, but also provides auxiliary functions such as deodorization, pH control, moisturizing, non-viscous, and immunity enhancement, so a lot of research and development has been done. Products with various raw materials and functions are being released.

However, in the case of men, due to the relatively easy-to-clean genital structure and lack of interest, there are not many types of men's cleansers, and their functionality is limited to deodorizing effect and refreshing feeling.

On the one hand, the cosmetics market, which was considered exclusively for women, has gradually expanded to target men, forming a total market size of 144 trillion won, and is expected to continue to grow at a growth rate of 15.9% by 2026.

Due to this situation, the domestic men's cleanser market is also making rapid progress, and numerous men's cleansers are being released. However, since there is still no product that stimulates consumers' need to purchase, products with more diverse functions are in demand.

Republic of Korea Patent Registration No. 10-1979827 is an invention related to a male cleanser composition and a manufacturing method thereof. The present invention discloses a method for producing a male cleanser cosmetic composition comprising a maca extract and a detergent as main components and including a disinfectant, a pH adjuster, and a moisturizing ingredient to form an emulsion phase.

Korean Patent Registration No. 10-2385414 relates to a cosmetic composition for male cleansing containing maca and purslane extracts as active ingredients and a manufacturing method thereof. The present invention is characterized in that it contains maca and purslane hot water extracts as active ingredients and has antibacterial and whitening effects.

However, even when looking at existing inventions or commercial products, existing male cleansers only act on the surface of the outer skin, and there are no male cleansers that act on the inside of the skin or the urethra. Therefore, it can be said that existing male cleanser products are no different from general soaps in terms of performance and pharmacology compared to advertised products.

One object of the present invention for solving the above problems is to provide a male cleanser with enhanced antibacterial and antifungal effects by increasing percutaneous absorption and being able to penetrate the male organ and the urethra.

In addition, one object of the present invention is to provide a male cleanser having an excellent odor removal effect.

Another object of the present invention is to provide an eco-friendly vegan male cleanser made using vegetable raw materials.

In order to solve the above object, the present invention provides an eco-friendly vegan male cleanser containing a fig enzyme and a zinc mixture.

Specifically, the present invention uses 0.1 to 3 parts by weight of fig enzyme extract, 0.1 to 2 parts by weight of Echinacea extract, 0.05 to 0.5 parts by weight of zinc pyrithione, and 0.5 to 5 parts by weight of sodium polynaphthalenesulfonate as active ingredients, and a surfactant Provides an eco-friendly vegan male cleanser containing fig enzyme and zinc mixture containing 10 to 30 parts by weight, vegetable oil 5 to 10 parts by weight, acidity regulator 0.1 to 3 parts by weight and the remaining parts by weight purified water.

The fig ( Ficus carica ) is a plant of the genus Ficus, and is native to Asia Minor, and has a record of being planted in Egypt about 4,000 years ago, and is known as the world's oldest fruit tree. Figs are horticulturally classified into four types, Capri, Smyrna, Botan, and San Pedro, depending on the type of flower and the need for pollination. It is known that the excellent varieties that are being developed have already been cultivated in Europe. The leaves of the fig tree are alternate and broadly egg-shaped. From spring to summer, pocket-like inflorescences develop in the leaf axils, and there are many small flowers in them. The fruit is a dark purple lichen, which ripens in autumn and is used for food. Since ancient times, figs have been highly valued in the Bible and Donguibogam as a folk medicine. Efficacy has been recorded as being good for blood pressure strengthening, stomachache, nourishment, constipation, hepatitis, cancer, women's diseases, and vitality recovery. Its efficacy is described in the herbal medicine (name) as "making the function of the bone intestine smooth, stopping diarrhea and healing sore throat." In Jinnam Boncho (name), "It is called Myeongmok-gwa, so it is good to wash it frequently with the milk of the skin of the fruit. Efficacy is described. General efficacy includes action as a gastrointestinal medicine, treatment of diarrhea or hemorrhoids, sore throat, anti-inflammatory action, small action, digestion promotion, etc., and is also used for anthelmintic medicine and jaundice. In animal experiments, there is a report that the milk contained in the fruits of the Miseongyeol was effective against breast cancer, leukemia, and impure sarcoma. Figs are resistant to diseases and pests, and young shoots grow cleanly. It is a natural health food that grows in nature without pesticides and without pollution.

It has been reported in several studies that the flesh, leaf, and sap extract of the fig has antibacterial and antifungal effects. According to reports by Khaleel Ibrahim Rashid, 2014., Amirah Nadiah Ali, 2018., and Shahzada Nadeem Abbas, 2019., it was confirmed that fig extracts show strong antibacterial and antifungal effects against various bacteria and fungi. The present invention paid attention to the antibacterial and antifungal effects of these figs and came to invent an eco-friendly vegan male cleanser.

The fig enzyme extract of the present invention can be obtained by extracting fig fruits with hot water and an organic solvent. Specifically, after collecting and pulverizing fig fruits, 1 to 50 times the amount of solvent may be added and extracted by immersion, compression, or pulverization at room temperature for 12 hours to 3 months. The extraction solvent may be fractionated and extracted using at least one solvent selected from the group consisting of purified water, lower alcohol having 1 to 4 carbon atoms, dichloromethane, chloroform, and ethyl acetate. Preferably, fractional extraction may be performed using methanol, ethanol or ethyl acetate as a solvent.

The Echinacea Angustifolia is a wild plant of the Asteraceae family that lives in the Great Plains of North America and has been widely used as a traditional herbal medicine for enhancing immune function against diseases caused by colds or other viral infections for centuries. Recently, Echinacea extract has been applied as a cosmetic raw material for skin protection. The Echinacea extract is known to have antioxidant, immune enhancing, reactive oxygen species scavenging, and melanin inhibitory effects.

The zinc pyrithione is a substance having a chemical formula of C ₁₀ H ₁₀ N ₂ O ₂ S ₂ Zn (CAS No. 13463-41-7) and is used as a preservative because of its antibacterial and antifungal properties. ( Malassezia ) Due to its effect of inhibiting the proliferation of dandruff and hair loss treatment has been used as a component of hair wash.

The zinc pyrithione has a solubility in water as low as 15 ppm, and may show a suspension phenomenon in cosmetics or external preparations. In order to alleviate this suspension phenomenon, the vegan male cleanser of the present invention may form a zinc pyrithione complex by further including 0.1 to 5 parts by weight of sodium polynaphthalenesulfonate and / or cellulose gum as an emulsion stabilizer relative to the total weight.

The vegan male cleanser of the present invention may include a surfactant. The surfactant may be, for example, a mixture of one or more of lauryl betaine, sodium cocoyl isethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate, but is not limited thereto. The surfactant may include 10 to 30 parts by weight based on the total weight.

In one embodiment, the vegan male cleanser of the present invention may include a vegetable oil. The vegetable oil may be at least one selected from the group consisting of tea tree leaf oil, evening primrose oil, hemp seed oil, pine nut branch oil, and pine nut leaf oil.

In one embodiment, the vegan male cleanser of the present invention may include an acidity regulator. The acidity regulator may be an organic acid such as coconut acid or citric acid.

In one embodiment, the vegan male cleanser of the present invention may include arginine. The arginine is a type of amino acid, and is widely used in cosmetics because it has a moisturizing effect of holding moisture in the skin and a unique fragrance. It is also used as an acidity regulator in cosmetics because of its strong alkalinity.

In addition, the vegan male cleanser of the present invention may include a liposomal structure. The liposome generally surrounds a polar substance or high molecular substance that is difficult to penetrate the cell membrane of the skin with a lipid membrane of a component similar to a biological membrane to help permeate the cell membrane and promote absorption of active ingredients into the body.

In order to form the liposome, the present invention further contains 1 to 8 parts by weight of lecithin, 1 to 5 parts by weight of caprylyl glycol, 1 to 5 parts by weight of caprylic/capric triglyceride, and 3 to 10 parts by weight of glycerin. can include Lecithin is a class of phospholipids having amniotic properties, and is widely contained in animals and plants, and can be easily obtained from soybeans, eggs, milk, and seed oil. The material to be supported may be supported in the liposome structure by mixing the material to be supported with lecithin, a surfactant, and an oil component and using a conventional high-pressure emulsification device.

On the other hand, the vegan male cleanser of the present invention has a growth inhibitory effect on Staphylococcus aureus , Escherichia coli and Candida albicans .

Candida is a fungus that normally resides in the skin, oral cavity, digestive tract, genital area, etc. of the human body and is generally not harmful. However, when the body's immune ability is temporarily weakened, it overproliferates in the mucous membrane and moist areas of the skin, causing candidiasis such as thrush, inflammation of the oropharynx or esophagus, vulvitis, vaginitis, and paronychia. In particular, 70% of vulvitis and vaginitis in women are caused by bacterial inflammation such as candidiasis, and symptoms such as itching, stinging, vaginal pain, pain during sexual intercourse, and white lumpy vaginal discharge appear. If the male genitals are also infected, glans itching, rashes, blisters, foul odor, painful urination and, rarely, urethritis may occur. In addition, smegma increases between the foreskin and glans of uncircumcised men and causes an odor.

In the examples of the present invention, it was confirmed that candidiasis, which causes candidiasis, and Escherichia coli and Staphylococcus aureus, which can cause various dermatitis and allergic reactions, can be effectively inhibited.

The vegan male cleanser of the present invention does not use animal raw materials, and is environmentally friendly by using plant-derived raw materials and plant extracts, and can satisfy the needs of vegans.

The vegan male cleanser of the present invention can be applied as a cosmetic or external composition for skin diseases and deodorization caused by human epithelial flora, such as a dandruff-inhibiting scalp improver, a foot cleaner for athlete's foot symptom relief, an armpit underarm remover, etc. It is not limited to this.

According to the present invention, by providing a vegan male cleanser with enhanced antibacterial and antifungal effects by increasing percutaneous absorption, there is an effect of helping to improve genital hygiene.

In addition, it contains natural antibiotics to reduce skin irritation and reduce odor, thereby increasing satisfaction in sexual life.

In addition, it has the effect of meeting the demand of vegans by not using animal raw materials.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily implement the present invention. However, the present invention may be embodied in many different forms and is not limited to the embodiments described herein.

Preparation Example 1. Fig Enzyme Extract Obtaining Process

After collecting and crushing the fig fruit of the Bongnaesi variety cultivated in Yeongam-gun, Jeollanam-do, 10 times the weight of ethanol solvent was added and extracted by the immersion method at room temperature for 24 hours, and the extract was suction filtered with a Buchner funnel. were mixed to obtain a fig enzyme extract by removing ethanol using a vacuum concentrator at 50 °C. The extraction and concentration process was repeated three times.

Preparation Examples 2 to 5. Obtaining fig enzyme fractions

The fig enzyme extract obtained in Preparation Example 1 was extracted three times with a 5-fold weight n-hexane (hexane) solvent and then concentrated under reduced pressure to obtain a fig enzyme hexane fraction. Thereafter, the fig enzyme chloroform fraction (Preparation Example 3) and the fig enzyme ethyl acetate fraction (Preparation Example 4) were sequentially extracted in the same manner with chloroform, ethyl acetate, and n-butanol solvents , Fig enzyme butanol fraction (Preparation Example 5) was obtained, respectively.

Preparation Example 6. Preparation of Echinacea extract

Echinacea flowers, leaves, stems, and roots were dried and pulverized to obtain Echinacea dry powder. After adding 20 times the weight of water to the obtained dried Echinacea powder, it was boiled for 4 hours for hot water extraction, followed by filtration, and the filtrate was freeze-dried to obtain a hot water extract. Thereafter, the hot water extract was immersed in 20 times the weight of 75% ethanol for 24 hours, and the leachate was concentrated under reduced pressure to prepare an Echinacea extract.

<Example 1>

* Compared to the total weight of the total composition, 2 parts by weight of the fig enzyme extract of Preparation Example 1, 1.5 parts by weight of Echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate and the remaining parts by weight of purified water A composition was prepared by mixing.

<Examples 2 to 5>

The composition of Example 2 was obtained by preparing in the same manner, except that the fig enzyme extract in the composition of Example 1 was replaced with the hexane fraction of the fig enzyme of Preparation Example 2. Similarly, the compositions of Examples 3 to 5 were prepared by replacing the fig enzyme extract in the composition of Example 1 with the chloroform, ethyl acetate, and butanol fractions of Preparation Examples 3 to 5, respectively.

<Example 6>

2 parts by weight of the fig enzyme ethyl acetate fraction of Preparation Example 4, 1.5 parts by weight of Echinacea extract of Preparation Example 6, 0.3 parts by weight of zinc pyrithione, 3 parts by weight of sodium polynaphthalenesulfonate, 6 parts by weight of lecithin, relative to the total weight of the total composition Part, 3 parts by weight of caprylyl glycol, 3 parts by weight of caprylic/capric triglyceride, and 5 parts by weight of glycerin were mixed, and 5 parts were mixed in a high-pressure emulsifier (Microfludizer) under conditions of a pressure of 1200 bar and a flow rate of 500 m/s. By passage twice, a stabilized liposome composition was prepared.

<Comparative Example 1>

A composition having the same composition ratio as in Example 6 was prepared, but the composition was prepared by simple mixing without using a high-pressure emulsification device.

<Example 7>

A detergent composition was prepared by mixing the composition of Example 6 with 20 parts by weight of a surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity regulator, and the remaining parts by weight of purified water.

As the surfactant, a mixture of equal volumes of lauryl betaine, sodium cocoyl isethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate was used.

As the acidity regulator, a mixture of coconut acid and citric acid in the same weight was used. The acidity of the prepared detergent composition showed neutrality of pH 7.4.

<Example 8>

A cleaning composition was prepared by further adding 8 parts by weight of vegetable oil to the composition of Example 7. As the vegetable oil, a mixture of tea tree leaf oil, evening primrose oil, hemp seed oil, pine nut branch oil, and pine nut leaf oil in a weight ratio of 2:2:2:1:1 was used.

<Comparative Example 2>

A detergent composition was prepared by mixing 20 parts by weight of a surfactant, 0.5 parts by weight of arginine, 0.4 parts by weight of an acidity regulator, and the remaining parts by weight of purified water. Surfactants and acidity regulators were prepared in the same configuration as in Example 7.

<Comparative Example 3>

A cleaning composition was prepared by further adding 8 parts by weight of vegetable oil to the composition of Comparative Example 2. Vegetable oil was prepared in the same configuration as in Example 8 above.

Test Example 1. Evaluation of antibacterial ability

The antibacterial ability of the cleaners of the present invention was tested by the disk diffusion assay. As test strains, Staphylococcus aureus , a gram-positive bacterium, and Escherichia coli , a gram-negative bacterium, were selected. Each strain was inoculated into LB liquid medium (Luria-Berani broth) and cultured at 37° C. for 24 hours. The culture medium was prepared by measuring the absorbance and diluting with 0.5 McFarland standards.

On the other hand, a solid medium was prepared by pouring Muller Hilton (MH) agar into a sterilized Petri dish to a thickness of 4 mm and cooling and solidifying. 100 μl of the aforementioned culture medium was spread evenly on MH solid medium. Thereafter, a paper disk was placed on the smeared MH medium, adsorbed with 50 μl of the fig fractions of Examples 1 to 4, and incubated at 37 ° C for 24 hours to measure the diameter of the zone of inhibition.

Restraint Diameter (mm) Staphylococcus aureus Escherichia coli Example 2 2 2 Example 3 12 10 Example 4 17 15 Example 5 5 4

As a result of the test, as shown in Table 1, the composition containing the fig ethyl acetate fraction of Example 4 formed an inhibition zone of 17 mm in the Staphylococcus aureus medium and a 15 mm inhibition zone in the E. coli medium, confirming that the antibacterial ability was the best. . Test Example 2. Evaluation of antifungal ability

The antibacterial ability of the cleaners of the present invention was tested by the disk diffusion assay. Candida albicans was selected as the test fungus. Candida was inoculated into Potato Dextrose Broth (PDB) and cultured at 30°C for 3 days. The culture medium was prepared by measuring the absorbance and diluting with 0.5 McFarland standards.

On the other hand, a solid medium was prepared by pouring Potato Dextrose Agar (PDA) into a sterile Petri dish to a thickness of 4 mm and cooling and solidifying. 100 μl of the aforementioned culture medium was spread evenly on the PDA solid medium. Thereafter, a paper disk was placed on the plated PDA medium, adsorbed with 50 μl of the fig fractions of Examples 1 to 4, and then incubated at 30 ° C for 48 hours to measure the diameter of the zone of inhibition.

Diameter of restraint zone (mm) - Candida albicans Example 2 One Example 3 7 Example 4 12 Example 5 3

As a result of the test, it was confirmed that the composition containing the fig ethyl acetate fraction of Example 4, as shown in Table 2, formed an inhibition zone of 12 mm and had the best antifungal ability. Test Example 3. Evaluation of transdermal absorption ability

For Example 4, Example 6, and Comparative Example 1, a skin permeation test was performed under sink conditions using a Franz diffusion cell (effective area: 0.64 cm 2 , volume of accommodation compartment: 5 ml). conducted. As the aqueous phase, pH 7.4 phosphate buffered saline (PBS) was used.

The prepared epidermal layer (1.5 cm x 1.5 cm) of human skin was placed on the receptor chamber with the stratum corneum on top, and the donor chamber was covered and clamped, and the receptor phase was placed in Franz The diffusion cell was filled and maintained at 32±1°C. Permeation experiments were conducted by attaching the prepared Example 4, Example 6, and Comparative Example 1 to the donor site. At 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, and 24 hours after the permeation experiment, 5 ml of the aqueous phase was collected and analyzed, and supplemented with fresh phosphate buffered saline.

Artificial skin was purchased and used from Hans Biomed, stored at -20 ° C after purchase, and washed and hydrated in phosphate buffered saline for 30 minutes before use.

The collected phosphate buffered saline was analyzed by high-performance liquid chromatography (HPLC), and the skin permeability was summarized in Table 3 below.

Example 4 Transmittance (%) Example 6 Transmittance (%) Comparative Example 1 Transmittance (%) 30 minutes 0.48 30 minutes 1.38 30 minutes 0.51 1 hours 0.75 1 hours 2.73 1 hours 0.84 2 hours 0.83 2 hours 3.78 2 hours 1.27 4 hours 1.12 4 hours 7.21 4 hours 1.64 6 hours 2.38 6 hours 10.76 6 hours 2.78 24 hours 4.15 24 hours 16.34 24 hours 4.47

Referring to Table 3, the composition in which only the active ingredients of Example 4 were mixed showed results in which skin permeability was not high. On the other hand, even in the composition containing lecithin of Comparative Example 1, skin permeability was not high, similar to Example 4. On the other hand, the liposome-formed composition of Example 6 showed a significantly high skin permeability, confirming that the composition of Example 6 exhibited an excellent percutaneous absorption effect. Test Example 4. Sensory evaluation

Thirty males in their 20s to 40s were allowed to use the detergent compositions of Examples 7 to 8 and Comparative Examples 2 to 3 once daily for 2 weeks, respectively, to evaluate the sensory properties. At this time, the cleaner was pumped (2 mg) once into the provided container, and the Y-zone of the male was maintained for at least 3 minutes after washing, and then rinsed so that the components of the cleaner could be sufficiently absorbed. The evaluation items were classified into irritation (severity of tingling, erythema, or rash), deodorization (satisfaction felt by oneself or a partner), dryness (degree of dead skin cells), and feeling of use. 5 points and 1 point for the most unsatisfactory evaluation were summarized in Table 4 below.

pepper Deodorization dryness feeling of use Example 7 4.5 3.7 3.2 4.1 Example 8 4.8 4.5 3.8 4.6 Comparative Example 2 1.8 2.3 2.4 2.4 Comparative Example 3 2.2 2.5 2.8 2.7

Referring to the results of Table 4, it can be seen that the detergent composition of Example 8 has the highest level of satisfaction overall with high deodorizing ability and feeling of use while reducing the side effects of irritating or drying the skin.

Claims (1)

Men's cleanser composition based on total weight
0.1 to 3 parts by weight of fig enzyme extract, 0.1 to 2 parts by weight of echinacea extract, 0.05 to 0.5 parts by weight of zinc pyrithione, and 0.5 to 5 parts by weight of sodium polynaphthalenesulfonate as active ingredients,
In the male cleanser composition further comprising 10 to 30 parts by weight of a surfactant, 5 to 10 parts by weight of vegetable oil, 0.1 to 3 parts by weight of an acidity regulator and the remaining parts by weight of purified water,
The fig enzyme extract is an ethyl acetate fraction obtained by sequentially extracting fig fruits with ethanol, n-hexane and ethyl acetate,
The Echinacea extract is obtained by extracting dried Echinacea powder with hot water and then soaking in 75% ethanol for 24 hours to concentrate the leachate under reduced pressure.
The surfactant is a mixture of one or more of lauryl betaine, sodium cocoyl isethionate, sodium cocoyl glutamate, decyl glucoside, and potassium cocoyl glycinate,
The vegetable oil is a mixture of tea tree leaf oil, evening primrose oil, hemp seed oil, pine nut branch oil, and pine nut leaf oil in a weight ratio of 2:2:2:1:1,
The acidity regulator is at least one selected from the group consisting of coconut acid and citric acid,
The male cleanser composition has a growth inhibitory ability against Staphylococcus aureus , Escherichia coli and Candida albicans ,
A male cleanser composition, characterized in that the active ingredient forms liposomes to increase percutaneous absorption.