KR20220041050A - 피라졸 화합물의 비흡습성 결정질 염, 및 이의 약제학적 조성물 및 용도 - Google Patents

피라졸 화합물의 비흡습성 결정질 염, 및 이의 약제학적 조성물 및 용도 Download PDF

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Publication number
KR20220041050A
KR20220041050A KR1020217042889A KR20217042889A KR20220041050A KR 20220041050 A KR20220041050 A KR 20220041050A KR 1020217042889 A KR1020217042889 A KR 1020217042889A KR 20217042889 A KR20217042889 A KR 20217042889A KR 20220041050 A KR20220041050 A KR 20220041050A
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South Korea
Prior art keywords
crystalline salt
hygroscopic crystalline
salt
acid
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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KR1020217042889A
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English (en)
Korean (ko)
Inventor
로버트 설리번
Original Assignee
바이오테릭스, 인코포레이티드
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Application filed by 바이오테릭스, 인코포레이티드 filed Critical 바이오테릭스, 인코포레이티드
Publication of KR20220041050A publication Critical patent/KR20220041050A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020217042889A 2019-06-03 2020-06-02 피라졸 화합물의 비흡습성 결정질 염, 및 이의 약제학적 조성물 및 용도 Pending KR20220041050A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962856605P 2019-06-03 2019-06-03
US62/856,605 2019-06-03
PCT/US2020/035654 WO2020247345A1 (en) 2019-06-03 2020-06-02 Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof

Publications (1)

Publication Number Publication Date
KR20220041050A true KR20220041050A (ko) 2022-03-31

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ID=71787173

Family Applications (1)

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KR1020217042889A Pending KR20220041050A (ko) 2019-06-03 2020-06-02 피라졸 화합물의 비흡습성 결정질 염, 및 이의 약제학적 조성물 및 용도

Country Status (13)

Country Link
US (1) US12428399B2 (https=)
EP (1) EP3976600A1 (https=)
JP (1) JP2022535850A (https=)
KR (1) KR20220041050A (https=)
CN (1) CN114423752B (https=)
AU (1) AU2020288163B2 (https=)
BR (1) BR112021024330A2 (https=)
CA (1) CA3142271A1 (https=)
IL (1) IL288547B2 (https=)
MX (1) MX2021014842A (https=)
SG (1) SG11202113211PA (https=)
TW (1) TWI866977B (https=)
WO (1) WO2020247345A1 (https=)

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* Cited by examiner, † Cited by third party
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US20230047732A1 (en) * 2020-01-13 2023-02-16 Biotheryx, Inc. Pyrazolylpyrimidines and use thereof
WO2022204220A1 (en) * 2021-03-24 2022-09-29 Biotheryx, Inc. Pyrazolylpyrimidines for treating malignant solid tumor
US20230053307A1 (en) * 2021-07-19 2023-02-16 Buddhist Tzu Chi Medical Foundation Method for preventing or treating skin disorders and conditions
WO2025199440A1 (en) * 2024-03-21 2025-09-25 Edgewood Oncology Methods of treating liposarcoma using a pyrazole compound

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Publication number Publication date
TW202110827A (zh) 2021-03-16
SG11202113211PA (en) 2021-12-30
MX2021014842A (es) 2022-02-21
EP3976600A1 (en) 2022-04-06
IL288547A (en) 2022-02-01
JP2022535850A (ja) 2022-08-10
IL288547B2 (en) 2025-10-01
TWI866977B (zh) 2024-12-21
US12428399B2 (en) 2025-09-30
CA3142271A1 (en) 2020-12-10
US20220332702A1 (en) 2022-10-20
BR112021024330A2 (pt) 2022-01-11
WO2020247345A1 (en) 2020-12-10
IL288547B1 (en) 2025-06-01
CN114423752B (zh) 2025-06-24
AU2020288163A1 (en) 2022-01-06
CN114423752A (zh) 2022-04-29
AU2020288163B2 (en) 2026-03-26

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