CA3142271A1 - Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof - Google Patents

Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof Download PDF

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Publication number
CA3142271A1
CA3142271A1 CA3142271A CA3142271A CA3142271A1 CA 3142271 A1 CA3142271 A1 CA 3142271A1 CA 3142271 A CA3142271 A CA 3142271A CA 3142271 A CA3142271 A CA 3142271A CA 3142271 A1 CA3142271 A1 CA 3142271A1
Authority
CA
Canada
Prior art keywords
salt
crystalline salt
hygroscopic crystalline
acid
crystalline
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3142271A
Other languages
English (en)
French (fr)
Inventor
Robert Sullivan
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yissum Research Development Co of Hebrew University of Jerusalem
Original Assignee
BioTheryX Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BioTheryX Inc filed Critical BioTheryX Inc
Publication of CA3142271A1 publication Critical patent/CA3142271A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3142271A 2019-06-03 2020-06-02 Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof Pending CA3142271A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962856605P 2019-06-03 2019-06-03
US62/856,605 2019-06-03
PCT/US2020/035654 WO2020247345A1 (en) 2019-06-03 2020-06-02 Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof

Publications (1)

Publication Number Publication Date
CA3142271A1 true CA3142271A1 (en) 2020-12-10

Family

ID=71787173

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3142271A Pending CA3142271A1 (en) 2019-06-03 2020-06-02 Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof

Country Status (13)

Country Link
US (1) US12428399B2 (https=)
EP (1) EP3976600A1 (https=)
JP (1) JP2022535850A (https=)
KR (1) KR20220041050A (https=)
CN (1) CN114423752B (https=)
AU (1) AU2020288163B2 (https=)
BR (1) BR112021024330A2 (https=)
CA (1) CA3142271A1 (https=)
IL (1) IL288547B2 (https=)
MX (1) MX2021014842A (https=)
SG (1) SG11202113211PA (https=)
TW (1) TWI866977B (https=)
WO (1) WO2020247345A1 (https=)

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* Cited by examiner, † Cited by third party
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US20230047732A1 (en) * 2020-01-13 2023-02-16 Biotheryx, Inc. Pyrazolylpyrimidines and use thereof
WO2022204220A1 (en) * 2021-03-24 2022-09-29 Biotheryx, Inc. Pyrazolylpyrimidines for treating malignant solid tumor
US20230053307A1 (en) * 2021-07-19 2023-02-16 Buddhist Tzu Chi Medical Foundation Method for preventing or treating skin disorders and conditions
WO2025199440A1 (en) * 2024-03-21 2025-09-25 Edgewood Oncology Methods of treating liposarcoma using a pyrazole compound

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Also Published As

Publication number Publication date
TW202110827A (zh) 2021-03-16
SG11202113211PA (en) 2021-12-30
MX2021014842A (es) 2022-02-21
EP3976600A1 (en) 2022-04-06
IL288547A (en) 2022-02-01
JP2022535850A (ja) 2022-08-10
IL288547B2 (en) 2025-10-01
KR20220041050A (ko) 2022-03-31
TWI866977B (zh) 2024-12-21
US12428399B2 (en) 2025-09-30
US20220332702A1 (en) 2022-10-20
BR112021024330A2 (pt) 2022-01-11
WO2020247345A1 (en) 2020-12-10
IL288547B1 (en) 2025-06-01
CN114423752B (zh) 2025-06-24
AU2020288163A1 (en) 2022-01-06
CN114423752A (zh) 2022-04-29
AU2020288163B2 (en) 2026-03-26

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