MX2021014842A - Sales cristalinas no higroscopicas de un compuesto de pirazol y composiciones farmaceuticas y uso de las mismas. - Google Patents

Sales cristalinas no higroscopicas de un compuesto de pirazol y composiciones farmaceuticas y uso de las mismas.

Info

Publication number
MX2021014842A
MX2021014842A MX2021014842A MX2021014842A MX2021014842A MX 2021014842 A MX2021014842 A MX 2021014842A MX 2021014842 A MX2021014842 A MX 2021014842A MX 2021014842 A MX2021014842 A MX 2021014842A MX 2021014842 A MX2021014842 A MX 2021014842A
Authority
MX
Mexico
Prior art keywords
pharmaceutical compositions
crystalline salts
pyrazole compound
hygroscopic crystalline
hygroscopic
Prior art date
Application number
MX2021014842A
Other languages
English (en)
Inventor
Robert Sullivan
Original Assignee
Biotheryx Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biotheryx Inc filed Critical Biotheryx Inc
Publication of MX2021014842A publication Critical patent/MX2021014842A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

En la presente se proporcionan sales cristalina higroscópicas de (1r, 4r)-N1-(5-cloro-4-(5-(ciclopropilmetil-metil-1H-pirazol-4-il) pirimidin-2-il)ciclohexano-1,4-diamina y composiciones farmacéuticas de las mismas. También se proporcionan métodos de su uso para tratar, prevenir o mejorar uno más síntomas de una enfermedad proliferativa.
MX2021014842A 2019-06-03 2020-06-02 Sales cristalinas no higroscopicas de un compuesto de pirazol y composiciones farmaceuticas y uso de las mismas. MX2021014842A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962856605P 2019-06-03 2019-06-03
PCT/US2020/035654 WO2020247345A1 (en) 2019-06-03 2020-06-02 Non-hygroscopic crystalline salts of a pyrazole compound, and pharmaceutical compositions and use thereof

Publications (1)

Publication Number Publication Date
MX2021014842A true MX2021014842A (es) 2022-02-21

Family

ID=71787173

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2021014842A MX2021014842A (es) 2019-06-03 2020-06-02 Sales cristalinas no higroscopicas de un compuesto de pirazol y composiciones farmaceuticas y uso de las mismas.

Country Status (13)

Country Link
US (1) US20220332702A1 (es)
EP (1) EP3976600A1 (es)
JP (1) JP2022535850A (es)
KR (1) KR20220041050A (es)
CN (1) CN114423752A (es)
AU (1) AU2020288163A1 (es)
BR (1) BR112021024330A2 (es)
CA (1) CA3142271A1 (es)
IL (1) IL288547A (es)
MX (1) MX2021014842A (es)
SG (1) SG11202113211PA (es)
TW (1) TW202110827A (es)
WO (1) WO2020247345A1 (es)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2021209057A1 (en) * 2020-01-13 2022-06-30 Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. Pyrazolylpyrimidines and use thereof
TW202304883A (zh) * 2021-03-24 2023-02-01 美商拜歐斯瑞克斯公司 用於治療惡性實體腫瘤之吡唑基嘧啶
US20230053307A1 (en) * 2021-07-19 2023-02-16 Buddhist Tzu Chi Medical Foundation Method for preventing or treating skin disorders and conditions

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Also Published As

Publication number Publication date
SG11202113211PA (en) 2021-12-30
JP2022535850A (ja) 2022-08-10
AU2020288163A1 (en) 2022-01-06
EP3976600A1 (en) 2022-04-06
TW202110827A (zh) 2021-03-16
US20220332702A1 (en) 2022-10-20
WO2020247345A1 (en) 2020-12-10
KR20220041050A (ko) 2022-03-31
CN114423752A (zh) 2022-04-29
BR112021024330A2 (pt) 2022-01-11
CA3142271A1 (en) 2020-12-10
IL288547A (en) 2022-02-01

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