KR20220034176A - 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 - Google Patents

치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 Download PDF

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Publication number
KR20220034176A
KR20220034176A KR1020227004179A KR20227004179A KR20220034176A KR 20220034176 A KR20220034176 A KR 20220034176A KR 1020227004179 A KR1020227004179 A KR 1020227004179A KR 20227004179 A KR20227004179 A KR 20227004179A KR 20220034176 A KR20220034176 A KR 20220034176A
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South Korea
Prior art keywords
seq
amino acid
acid sequence
antibody
ser
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Pending
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KR1020227004179A
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English (en)
Korean (ko)
Inventor
가츠 다카하시
마나부 스가이
요시히토 도키타
준이치 다카기
에미코 미하라
Original Assignee
고쿠리츠 다이가쿠 호진 교토 다이가쿠
고쿠리츠다이가쿠호징 후쿠이다이가쿠
고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸
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Application filed by 고쿠리츠 다이가쿠 호진 교토 다이가쿠, 고쿠리츠다이가쿠호징 후쿠이다이가쿠, 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 filed Critical 고쿠리츠 다이가쿠 호진 교토 다이가쿠
Publication of KR20220034176A publication Critical patent/KR20220034176A/ko
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/22—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Materials For Medical Uses (AREA)
KR1020227004179A 2019-07-12 2020-07-10 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체 Pending KR20220034176A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
JPJP-P-2019-130153 2019-07-12
JP2019130153 2019-07-12
JP2020080723 2020-04-30
JPJP-P-2020-080723 2020-04-30
PCT/JP2020/027127 WO2021010346A1 (ja) 2019-07-12 2020-07-10 歯の再生治療のためのｕｓａｇ－１を標的分子とした中和抗体

Publications (1)

Publication Number Publication Date
KR20220034176A true KR20220034176A (ko) 2022-03-17

Family

ID=74209883

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020227004179A Pending KR20220034176A (ko) 2019-07-12 2020-07-10 치아의 재생 치료를 위한 usag-1을 표적 분자로 한 중화 항체

Country Status (6)

Country Link
US (1) US20220259298A1 (https=)
EP (1) EP4000633A4 (https=)
JP (2) JP7572668B2 (https=)
KR (1) KR20220034176A (https=)
CN (2) CN114364694B (https=)
WO (1) WO2021010346A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4115889A4 (en) * 2020-02-21 2024-10-02 Kyoto University Medicine containing usag-1-targeting rna molecule for tooth regeneration therapy
EP4474394A4 (en) * 2022-02-03 2026-04-15 Univ Kyoto Neutralizing antibody targeting a molecule called USAG-1 for treating tooth regeneration
CN116425870A (zh) * 2023-05-24 2023-07-14 陕西师范大学 一种抗新型冠状病毒n蛋白单克隆抗体31a8及其产品和应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999000405A1 (en) * 1997-06-30 1999-01-07 Genetics Institute, Inc. Secreted proteins
US20040023356A1 (en) * 2002-06-14 2004-02-05 Robb Krumlauf Wise/Sost nucleic acid sequences and amino acid sequences
CN1618807A (zh) * 2003-11-21 2005-05-25 上海人类基因组研究中心 分泌蛋白及其编码序列和用途
CN1842540B (zh) * 2004-07-09 2012-07-04 中外制药株式会社 抗-磷脂酰肌醇蛋白聚糖3抗体
WO2009131553A2 (en) 2006-12-29 2009-10-29 Osteogenex Inc. Methods of altering bone growth by administration of sost or wise antagonist or agonist
TWI489993B (zh) 2007-10-12 2015-07-01 Novartis Ag 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法
CN101925611A (zh) * 2007-11-21 2010-12-22 安姆根有限公司 Wise结合剂和表位
GB0911060D0 (en) 2009-06-26 2009-08-12 Ge Healthcare Uk Ltd Methods for predicting the toxicity of a chemical
WO2011075636A2 (en) * 2009-12-18 2011-06-23 Amgen Inc. Wise binding agents and epitopes
KR102155531B1 (ko) * 2012-03-30 2020-09-15 도레이 카부시키가이샤 간암의 치료 및/또는 예방용 의약 조성물
WO2015120138A2 (en) * 2014-02-05 2015-08-13 Dana-Farber Cancer Institute, Inc. AGENTS THAT MODULATE RGMb-NEOGENIN-BMP SIGNALING AND METHODS OF USE THEREOF
KR102876923B1 (ko) * 2015-10-23 2025-10-28 화이자 인코포레이티드 항-il-2 항체 및 조성물 및 이의 용도
KR20190044070A (ko) * 2016-08-03 2019-04-29 넥스트큐어 인코포레이티드 Lair 신호 변환을 조정하기 위한 조성물 및 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Nakao, Nat Methods, 2007
Ohazama, J Denr Res, 2004

Also Published As

Publication number Publication date
JP7572668B2 (ja) 2024-10-24
CN114364694B (zh) 2024-05-10
CN114364694A (zh) 2022-04-15
EP4000633A4 (en) 2024-02-21
EP4000633A1 (en) 2022-05-25
JP2025004094A (ja) 2025-01-14
WO2021010346A1 (ja) 2021-01-21
US20220259298A1 (en) 2022-08-18
CN118307669A (zh) 2024-07-09
JP2021176829A (ja) 2021-11-11

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