KR20210131373A - 오르토폭스바이러스 주요 조직적합성 복합체(mhc) 클래스 i-유사 단백질(omcp) 및 종양-특이 결합 파트너를 사용한 이중특이적 융합 단백질 - Google Patents

오르토폭스바이러스 주요 조직적합성 복합체(mhc) 클래스 i-유사 단백질(omcp) 및 종양-특이 결합 파트너를 사용한 이중특이적 융합 단백질 Download PDF

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KR20210131373A
KR20210131373A KR1020217029846A KR20217029846A KR20210131373A KR 20210131373 A KR20210131373 A KR 20210131373A KR 1020217029846 A KR1020217029846 A KR 1020217029846A KR 20217029846 A KR20217029846 A KR 20217029846A KR 20210131373 A KR20210131373 A KR 20210131373A
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알렉산더 사샤 크루프닉
에릭 리드 래지어
사라 하인
대니얼 마빈 왓킨스
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커리어 테라퓨틱스, 인코포레이티드.
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3069—Reproductive system, e.g. ovaria, uterus, testes, prostate
    • A—HUMAN NECESSITIES
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    • C07K2317/622—Single chain antibody (scFv)
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KR1020217029846A 2019-02-18 2020-02-18 오르토폭스바이러스 주요 조직적합성 복합체(mhc) 클래스 i-유사 단백질(omcp) 및 종양-특이 결합 파트너를 사용한 이중특이적 융합 단백질 Ceased KR20210131373A (ko)

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US201962807190P 2019-02-18 2019-02-18
US62/807,190 2019-02-18
PCT/US2020/018680 WO2020172189A1 (en) 2019-02-18 2020-02-18 BISPECIFIC FUSION PROTEIN USING ORTHOPOXVIRUS MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) CLASS l-LIKE PROTEIN (OMCP) AND TUMOR-SPECIFIC BINDING PARTNER

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KR20210131373A true KR20210131373A (ko) 2021-11-02

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KR1020217029846A Ceased KR20210131373A (ko) 2019-02-18 2020-02-18 오르토폭스바이러스 주요 조직적합성 복합체(mhc) 클래스 i-유사 단백질(omcp) 및 종양-특이 결합 파트너를 사용한 이중특이적 융합 단백질

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US (2) US20230002450A1 (https=)
EP (1) EP3927722A4 (https=)
JP (1) JP2022520978A (https=)
KR (1) KR20210131373A (https=)
CN (1) CN114072416A (https=)
AU (1) AU2020226493B2 (https=)
CA (1) CA3130582A1 (https=)
GB (1) GB2596001B (https=)
IL (1) IL285668A (https=)
SG (1) SG11202108878VA (https=)
WO (1) WO2020172189A1 (https=)

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CN108261426B (zh) * 2017-01-04 2019-04-05 杭州康万达医药科技有限公司 药物组合物及其在治疗肿瘤和/或癌症的药物中的应用
AU2018219887B2 (en) 2017-02-08 2024-08-15 Dragonfly Therapeutics, LLC Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
BR112020015994A2 (pt) 2018-02-08 2020-12-15 Dragonfly Therapeutics, Inc. Terapia de combinação do câncer que envolve proteínas de ligação multiespecíficas que ativam células natural killer
CA3237846A1 (en) 2018-02-08 2019-08-15 Dragonfly Therapeutics, Inc. Antibody variable domains targeting the nkg2d receptor
WO2019164930A1 (en) 2018-02-20 2019-08-29 Dragonfly Therapeutics, Inc. Multi-specific binding proteins that bind cd33, nkg2d, and cd16, and methods of use
KR20210018275A (ko) * 2018-05-07 2021-02-17 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양-연관 항원에 결합하는 단백질
KR102835308B1 (ko) 2018-08-08 2025-07-21 드래곤플라이 쎄라퓨틱스, 인크. Nkg2d, cd16 및 종양 관련 항원에 결합하는 단백질
EA202091888A1 (ru) 2018-08-08 2020-10-23 Драгонфлай Терапьютикс, Инк. Вариабельные домены антител, нацеленные на рецептор nkg2d
EP3833392A4 (en) 2018-08-08 2022-05-18 Dragonfly Therapeutics, Inc. MULTISPECIFIC BINDING PROTEINS FOR BINDING CD33, NKG2D AND CD16 AND METHODS OF USE
JP7512394B2 (ja) 2020-05-06 2024-07-08 ドラゴンフライ セラピューティクス， インコーポレイテッド Ｎｋｇ２ｄ、ｃｄ１６及びｃｌｅｃ１２ａに結合するタンパク質
EP4301774A4 (en) 2021-03-03 2025-08-13 Dragonfly Therapeutics Inc METHODS OF TREATING CANCER USING MULTI-SPECIFIC BINDING PROTEINS THAT BIND TO NKG2D, CD16, AND A TUMOR-ASSOCIATED ANTIGEN
WO2022258691A1 (en) 2021-06-09 2022-12-15 Innate Pharma Multispecific proteins binding to nkg2d, a cytokine receptor, a tumour antigen and cd16a

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US20040038339A1 (en) * 2000-03-24 2004-02-26 Peter Kufer Multifunctional polypeptides comprising a binding site to an epitope of the nkg2d receptor complex
US20110123440A1 (en) * 2005-03-29 2011-05-26 Genevieve Hansen Altered Antibody FC Regions and Uses Thereof
WO2007002905A1 (en) * 2005-06-29 2007-01-04 University Of Miami Antibody-immune cell ligand fusion protein for cancer therapy
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WO2016166139A1 (en) * 2015-04-14 2016-10-20 Eberhard Karls Universität Tübingen Bispecific fusion proteins for enhancing immune responses of lymphocytes against tumor cells
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HRP20240997T1 (hr) * 2015-08-04 2024-10-25 Xyphos Biosciences Inc. Varijabilni fragmenti antitijela koji se mogu umetnuti i modificirane α1-α2 domene nkg2d liganada, kao i neprirodni nkg2d ligandi koji se vežu za neprirodne nkg2d receptore
CN106467576B (zh) * 2015-08-18 2020-04-07 中国科学院微生物研究所 一种抗体融合蛋白及其制备方法与应用
AU2017213659B2 (en) * 2016-02-05 2024-04-18 Washington University Compositions and methods for targeted cytokine delivery
CN109310766A (zh) * 2016-02-26 2019-02-05 伊蒙纽斯私人有限公司 多特异性分子
JP2019523016A (ja) * 2016-06-24 2019-08-22 サイフォス、バイオサイエンシズ、インコーポレイテッドＸｙｐｈｏｓ Ｂｉｏｓｃｉｅｎｃｅｓ Ｉｎｃ． 抗体の挿入可能な可変フラグメントおよびｎｋｇ２ｄリガンドの改変型ａ１−ａ２ドメイン
AU2018219887B2 (en) * 2017-02-08 2024-08-15 Dragonfly Therapeutics, LLC Multi-specific binding proteins for activation of natural killer cells and therapeutic uses thereof to treat cancer
CN107226866A (zh) * 2017-07-05 2017-10-03 中国药科大学 一种抗cd24人源化抗体融合蛋白

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EP3927722A1 (en) 2021-12-29
EP3927722A4 (en) 2022-11-23
GB202112934D0 (en) 2021-10-27
AU2020226493A1 (en) 2021-10-14
CA3130582A1 (en) 2020-08-27
AU2020226493B2 (en) 2025-10-23
IL285668A (en) 2021-10-31
GB2596001A8 (en) 2022-08-24
US20260008822A1 (en) 2026-01-08
WO2020172189A1 (en) 2020-08-27
US20230002450A1 (en) 2023-01-05
SG11202108878VA (en) 2021-09-29
GB2596001A (en) 2021-12-15
GB2596001B (en) 2023-11-29
CN114072416A (zh) 2022-02-18
JP2022520978A (ja) 2022-04-04

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