KR20200084028A - 영장류 망막 색소 상피 세포-특이적 프로모터 - Google Patents

영장류 망막 색소 상피 세포-특이적 프로모터 Download PDF

Info

Publication number
KR20200084028A
KR20200084028A KR1020207016484A KR20207016484A KR20200084028A KR 20200084028 A KR20200084028 A KR 20200084028A KR 1020207016484 A KR1020207016484 A KR 1020207016484A KR 20207016484 A KR20207016484 A KR 20207016484A KR 20200084028 A KR20200084028 A KR 20200084028A
Authority
KR
South Korea
Prior art keywords
nucleic acid
acid molecule
sequence
acid sequence
isolated nucleic
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020207016484A
Other languages
English (en)
Korean (ko)
Inventor
요제피네 위트너
야체크 크롤
보톤트 로스카
Original Assignee
프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 filed Critical 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치
Publication of KR20200084028A publication Critical patent/KR20200084028A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86Viral vectors
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027New or modified breeds of vertebrates
    • A01K67/0275Genetically modified vertebrates, e.g. transgenic
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/177Receptors; Cell surface antigens; Cell surface determinants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • A61K48/005Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy characterised by an aspect of the 'active' part of the composition delivered, i.e. the nucleic acid delivered
    • A61K48/0058Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01KANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00Animals characterised by purpose
    • A01K2267/03Animal model, e.g. for test or diseases
    • A01K2267/0393Animal model comprising a reporter system for screening tests
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2750/00MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
    • C12N2750/00011Details
    • C12N2750/14011Parvoviridae
    • C12N2750/14111Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/008Vector systems having a special element relevant for transcription cell type or tissue specific enhancer/promoter combination
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00Vector systems having a special element relevant for transcription
    • C12N2830/15Vector systems having a special element relevant for transcription chimeric enhancer/promoter combination

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Veterinary Medicine (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Environmental Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biophysics (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Animal Husbandry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Toxicology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020207016484A 2017-11-15 2018-11-15 영장류 망막 색소 상피 세포-특이적 프로모터 Ceased KR20200084028A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17201828.5 2017-11-15
EP17201828 2017-11-15
PCT/IB2018/059015 WO2019097454A1 (en) 2017-11-15 2018-11-15 Primate retinal pigment epithelium cell-specific promoter

Publications (1)

Publication Number Publication Date
KR20200084028A true KR20200084028A (ko) 2020-07-09

Family

ID=60331462

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207016484A Ceased KR20200084028A (ko) 2017-11-15 2018-11-15 영장류 망막 색소 상피 세포-특이적 프로모터

Country Status (14)

Country Link
US (1) US11739349B2 (enExample)
EP (1) EP3709798B1 (enExample)
JP (2) JP7348176B2 (enExample)
KR (1) KR20200084028A (enExample)
CN (1) CN111726985B (enExample)
AU (1) AU2018369975B2 (enExample)
BR (1) BR112020009579A2 (enExample)
CA (1) CA3082080A1 (enExample)
CR (1) CR20200210A (enExample)
IL (1) IL274460A (enExample)
MX (1) MX2020005033A (enExample)
PH (1) PH12020550757A1 (enExample)
SG (1) SG11202004205YA (enExample)
WO (1) WO2019097454A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010011467A (es) 2008-04-18 2011-02-15 Novartis Forschungsstiftung Novedosas herramientas y metodos terapeuticos para tratar la ceguera.
EP3289090B1 (en) 2015-04-30 2019-06-26 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in müller cells
US10857241B2 (en) 2015-09-15 2020-12-08 Friedrich Miescher Institute For Biomedical Research Therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
CN108474001B (zh) 2015-12-03 2022-04-08 弗里德里克·米谢尔生物医学研究所 SynP160,用于基因在视杆光感受器中特异性表达的启动子
WO2017093936A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
ES2761328T3 (es) 2015-12-03 2020-05-19 Friedrich Miescher Institute For Biomedical Res SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón
KR20190077471A (ko) 2016-11-02 2019-07-03 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198
CN110392582A (zh) 2017-02-08 2019-10-29 弗里德里克·米谢尔生物医学研究所 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88
SG11202004205YA (en) 2017-11-15 2020-06-29 Friedrich Miescher Institute For Biomedical Res Primate retinal pigment epithelium cell-specific promoter
AU2018376259A1 (en) 2017-11-30 2020-06-11 Friedrich Miescher Institute For Biomedical Research SynPIII, a promoter for the specific expression of genes in retinal pigment epithelium
BR112020010775A2 (pt) * 2017-11-30 2020-11-24 Friedrich Miescher Institute For Biomedical Research synp61, promotor específico à célula de epitélio de pigmento retiniano de primata
CN114045264B (zh) * 2021-11-16 2024-05-14 珠海中科先进技术研究院有限公司 一种获取驱动元件的方法
AU2023323390A1 (en) * 2022-08-11 2025-02-13 Institute Of Molecular And Clinical Ophthalmology Basel (Iob) Human cone photoreceptor optogenetic constructs

Family Cites Families (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6582908B2 (en) 1990-12-06 2003-06-24 Affymetrix, Inc. Oligonucleotides
US5474796A (en) 1991-09-04 1995-12-12 Protogene Laboratories, Inc. Method and apparatus for conducting an array of chemical reactions on a support surface
US20020052332A1 (en) 2000-04-11 2002-05-02 The Board Of Regents, University Of Texas System Methods of inhibiting retinal pigment epithelial cell degeneration, stable cell lines, and uses
US20040208847A1 (en) * 2003-03-28 2004-10-21 Fabienne Rolling Method and vectors for selectively transducing retinal pigment epithelium cells
EP2438815A3 (en) 2004-01-23 2012-10-03 Advanced Cell Technology, Inc. Improved modalities for the treatment of degenerative diseases of the retina
US7309487B2 (en) 2004-02-09 2007-12-18 George Inana Methods and compositions for detecting and treating retinal diseases
EP1891976A1 (en) 2006-08-23 2008-02-27 Novartis Forschungsstiftung, Zweigniederlassung Friedrich Miescher Institute for Biomedical Research Use of light sensitive genes
MX2010011467A (es) 2008-04-18 2011-02-15 Novartis Forschungsstiftung Novedosas herramientas y metodos terapeuticos para tratar la ceguera.
WO2009134681A2 (en) * 2008-04-30 2009-11-05 The Trustees Of The University Of Pennsylvania Aav7 viral vectors for targeted delivery of rpe cells
CN101747425B (zh) 2008-12-16 2012-03-28 清华大学 与视网膜光反应相关的蛋白及其编码基因与应用
US20120172419A1 (en) * 2009-09-15 2012-07-05 Medical College Of Wisconsin Research Foundation Inc. Reagents and methods for modulating cone photoreceptor activity
MX362513B (es) 2010-03-23 2019-01-22 Intrexon Corp Vectores que expresan de manera condicional proteinas terapeuticas, celulas hospedadoras que comprenden vectores, y usos de los mismos.
GB2498325B (en) * 2010-10-15 2018-05-02 Eos Neuroscience Inc Engineered human GRM6 enhancer sequence for use in eye therapies
US9579399B2 (en) 2012-08-27 2017-02-28 Friedrich Miescher Institute For Biomedical Research Retinal OFF circuit-specific promoter
EP3104895A1 (en) 2014-02-10 2016-12-21 Friedrich Miescher Institute for Biomedical Research Aii retinal amacrine cell-specific promoter
WO2015121793A1 (en) 2014-02-11 2015-08-20 Friedrich Miescher Institute For Biomedical Research Müller cell-specific promoter
LT3137497T (lt) * 2014-05-02 2021-07-26 Genzyme Corporation Aav vektoriai, skirti tinklainės ir cns genų terapijai
EP3289090B1 (en) 2015-04-30 2019-06-26 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in müller cells
US10857241B2 (en) 2015-09-15 2020-12-08 Friedrich Miescher Institute For Biomedical Research Therapeutical tools and methods for treating blindness by targeting photoreceptors
EP3362101B1 (en) 2015-10-14 2021-05-19 Friedrich Miescher Institute for Biomedical Research Promoter for the specific expression of genes in retinal endothelial cells
WO2017093936A1 (en) 2015-12-03 2017-06-08 Friedrich Miescher Institute For Biomedical Research Synp162, a promoter for the specific expression of genes in rod photoreceptors
CN108474001B (zh) 2015-12-03 2022-04-08 弗里德里克·米谢尔生物医学研究所 SynP160,用于基因在视杆光感受器中特异性表达的启动子
US10995344B2 (en) 2015-12-03 2021-05-04 Friedrich Miescher Institute For Biomedical Research SYNP159, a promoter for the specific expression of genes in rod photoreceptors
ES2761328T3 (es) 2015-12-03 2020-05-19 Friedrich Miescher Institute For Biomedical Res SynP161, un promotor para la expresión específica de genes en fotorreceptores de bastón
KR102312253B1 (ko) 2015-12-04 2021-10-15 쏘흐본느 유니베흐시테 프로모터 및 이의 용도
CN107287238B (zh) 2016-04-11 2020-10-16 厦门继景生物技术有限责任公司 一种基因载体及其用于治疗雷柏氏先天性黑矇2型疾病的基因治疗药物
EP3458476A1 (en) 2016-05-17 2019-03-27 Friedrich Miescher Institute for Biomedical Research Novel therapeutic tools and methods for treating blindness
KR20190077471A (ko) 2016-11-02 2019-07-03 프리드리히 미셔 인스티튜트 포 바이오메디칼 리서치 방향 선택적인 망막 신경절 세포에서의 유전자의 특이적 발현을 위한 프로모터, synp198
US20190376082A1 (en) 2016-12-01 2019-12-12 Friedrich Miescher Institute For Biomedical Research Synp107, a promoter for the specific expression of genes in interneurons
CN110072558A (zh) 2016-12-01 2019-07-30 弗里德里克·米谢尔生物医学研究所 用于使基因在中间神经元中特异性表达的启动子SynPI
CN110392582A (zh) 2017-02-08 2019-10-29 弗里德里克·米谢尔生物医学研究所 用于使基因在视网膜神经节细胞中特异性表达的启动子SynP88
SG11202004205YA (en) 2017-11-15 2020-06-29 Friedrich Miescher Institute For Biomedical Res Primate retinal pigment epithelium cell-specific promoter
BR112020010775A2 (pt) 2017-11-30 2020-11-24 Friedrich Miescher Institute For Biomedical Research synp61, promotor específico à célula de epitélio de pigmento retiniano de primata
AU2018376259A1 (en) 2017-11-30 2020-06-11 Friedrich Miescher Institute For Biomedical Research SynPIII, a promoter for the specific expression of genes in retinal pigment epithelium
WO2020084539A1 (en) 2018-10-25 2020-04-30 Friedrich Miescher Institute For Biomedical Research Synp57 (proa14), a promoter for the specific expression of genes in photoreceptors
EP3870709A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp27 (prob12), a promoter for the specific expression of genes in protoplasmic astrocytes
CN112912111A (zh) 2018-10-25 2021-06-04 弗里德里克·米谢尔生物医学研究所 用于视网膜神经节细胞中特异表达基因的启动子SynP17(ProB1)
JP2022512784A (ja) 2018-10-25 2022-02-07 フリードリッヒ ミーシェー インスティトゥート フォー バイオメディカル リサーチ 網膜神経節細胞中の遺伝子の特異的発現のためのプロモーターSynP78(ProA27)
US20210353773A1 (en) 2018-10-25 2021-11-18 Friedrich Miescher Institute For Biomedical Research Synp194 (prob15), a promoter for the specific expression of genes in retinal ganglion cells
EP3870242A1 (en) 2018-10-25 2021-09-01 Friedrich Miescher Institute for Biomedical Research Synp151 (proc29), a promoter for the specific expression of genes in retinal ganglion cells
EP3914300A1 (en) 2019-01-24 2021-12-01 Friedrich Miescher Institute for Biomedical Research Synp66 (proa21), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152623A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp5 (proa9), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152624A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp35 (proc8), a promoter for the specific expression of genes in retinal ganglion cells
WO2020152626A1 (en) 2019-01-24 2020-07-30 Friedrich Miescher Institute For Biomedical Research Synp166 (proa36), a promoter for the specific expression of genes in photoreceptors
JP2022520875A (ja) 2019-02-25 2022-04-01 ノバルティス アーゲー Biettiクリスタリン網膜症を治療するための組成物及び方法
EP3931334A1 (en) 2019-02-25 2022-01-05 Novartis AG Compositions and methods to treat bietti crystalline dystrophy

Also Published As

Publication number Publication date
JP7348176B2 (ja) 2023-09-20
CN111726985B (zh) 2022-06-10
US11739349B2 (en) 2023-08-29
MX2020005033A (es) 2020-10-28
AU2018369975B2 (en) 2022-05-19
RU2020119176A (ru) 2021-12-16
JP2023075139A (ja) 2023-05-30
EP3709798A1 (en) 2020-09-23
PH12020550757A1 (en) 2021-05-10
IL274460A (en) 2020-06-30
JP2021502813A (ja) 2021-02-04
EP3709798B1 (en) 2024-04-17
US20210054408A1 (en) 2021-02-25
CN111726985A (zh) 2020-09-29
AU2018369975A1 (en) 2020-05-28
SG11202004205YA (en) 2020-06-29
BR112020009579A2 (pt) 2020-10-13
CR20200210A (es) 2020-09-23
CA3082080A1 (en) 2019-05-23
RU2020119176A3 (enExample) 2022-01-26
WO2019097454A1 (en) 2019-05-23

Similar Documents

Publication Publication Date Title
KR20200084028A (ko) 영장류 망막 색소 상피 세포-특이적 프로모터
AU2018376544B2 (en) SynP61, a primate retinal pigment epithelium cell-specific promoter
RU2766353C2 (ru) Synp198, промотор для специфической экспрессии генов в ганглионарных клетках сетчатки, избирательных в отношении направления
US9999685B2 (en) AII retinal amacrine cell-specific promoter
EP3105334B1 (en) Müller cell-specific promoter
EP3383438B1 (en) Synp159, a promoter for the specific expression of genes in rod photoreceptors
EP3289090B1 (en) Promoter for the specific expression of genes in müller cells
KR20200091432A (ko) 망막 색소 상피에서의 유전자의 특이적 발현을 위한 프로모터 SynPIII
EP3579884A1 (en) Synp88, a promoter for the specific expression of genes in retinal ganglion cells
KR20180084136A (ko) 간상 광수용체에서의 유전자의 특이적 발현을 위한 프로모터 SynP161
EP3914721A1 (en) Synp35 (proc8), a promoter for the specific expression of genes in retinal ganglion cells
WO2017093934A1 (en) Synp160, a promoter for the specific expression of genes in rod photoreceptors
WO2014033095A1 (en) Retinal off circuit-specific promoter
WO2017093936A1 (en) Synp162, a promoter for the specific expression of genes in rod photoreceptors
EP3007730A1 (en) Retinal on bipolar cells-specific artificial promoter
RU2773940C2 (ru) Промотор, специфический в отношении клеток пигментного эпителия сетчатки приматов

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20200609

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20211027

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20240422

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20240708

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D