KR20200032454A - Cosmetic composition for skin sebum control comprising rx complex s - Google Patents

Abstract

The present invention relates to a cosmetic composition for sebum secretion control, comprising an RX complex S produced by combining iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid in an optimal ratio.

Description

Cosmetic composition for skin sebum control containing RX Complex S {COSMETIC COMPOSITION FOR SKIN SEBUM CONTROL COMPRISING RX COMPLEX S}

The present invention relates to a cosmetic composition for regulating skin sebum that contains iron oxide, zinc oxide, madecassoside, asiatic acid, and asiaticoside in a certain ratio to suppress sebum secretion and improve skin side effects (inflammatory reactions) due to sebum secretion. .

Human skin can be divided into three parts. There is a fat layer composed of the epidermis located outside and the dermis with structures such as sweat glands, hair follicles, sebaceous glands, and blood vessels below it, and fat cells located below. The keratinocytes of the epidermis are divided into a basal layer, a visible layer, a granular layer, and a stratum corneum from the inside depending on the differentiation stage. The border between the epidermis and the dermis is called the basal rod, and consists of the plasma membrane of the basal cells from the epidermis to the dermis and the transverse body, transparent plate, base plate, and fiber component. The dermis is called the papillary dermis directly below the epidermis, and the part that occupies most of the dermis to the subcutaneous substratum is called the reticular dermis.

Skin trouble is a phenomenon that occurs in the skin, and mainly occurs in the epidermis, and includes various phenomena such as pigmentation, acne, erythema, and clogging of pores. In particular, various troubles occur due to clogging of the pores. Typical symptoms include acne caused by acne bacteria in the pores and skin dullness due to excessive sebum secretion, all of which are caused by sebum hypersecretion in the pores.

Various cosmetic compositions have been developed in connection with sebum control.

For example, Korean Patent Registration No. 10-1749690 discloses a sebum management and pore improvement cosmetic composition containing pear scent.

In addition, Korean Patent No. 10-109636 discloses a makeup cosmetic composition containing a silica composite pigment, and contains a composite pigment coated with a surface of an inorganic pigment with silica to correct skin defects such as skin color problems, pores, and wrinkles. Disclosed are compositions that can.

Accordingly, an object of the present invention is to provide a cosmetic composition capable of controlling sebum hypersecretion occurring in the pores.

In particular, the present invention is to provide a cosmetic composition for regulating sebum secretion comprising RX complex S prepared by combining iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid in an optimal ratio.

The above object is achieved by a cosmetic composition for controlling sebum containing iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid as active ingredients.

Preferably, the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid may be contained in an amount of 1.0 to 30.0% by weight based on the total weight of the cosmetic composition.

Also, preferably, the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid may be contained in a weight ratio of 1 to 4: 1 to 4: 1: 1: 1.

Also preferably, the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid may be contained in a weight ratio of 3.5: 3.5: 1: 1: 1.

The cosmetic composition containing RX complex S according to the present invention exhibits excellent sebum control effect and inflammation suppression effect due to sebum secretion.

All technical terms used in the present invention, unless defined otherwise, have the following definitions and conform to the meaning as commonly understood by those skilled in the art in the relevant field of the present invention. In addition, although a preferred method or sample is described herein, similar or equivalent ones are included in the scope of the present invention.

The term “about” means 30, 25, 20, 15, 10, 9, 8, 7, 6, 5, for reference amount, level, value, number, frequency, percent, dimension, size, amount, weight or length It means a quantity, level, value, number, frequency, percentage, dimension, size, quantity, weight or length that varies by 4, 3, 2 or 1%. Throughout this specification, the terms “comprises” and “comprising”, unless the context requires otherwise, include the steps or components presented, or groups of steps or components, but any other steps or components, or It should be understood that it implies that the group of steps or components is not excluded.

Hereinafter, the present invention will be described in detail.

The present invention relates to a cosmetic composition comprising RX complex S made of iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid as one complex as an active ingredient.

In the present invention, 'RX complex S (S)' refers to a complex containing iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid. The cosmetic composition comprising the RX complex S according to the present invention is excellent in controlling the sebum and improving the side effects of skin due to sebum secretion, especially the inflammatory response.

Iron (II) oxide (FeO) used in the present invention is iron oxide in which one oxygen atom is bonded to an iron atom, and the chemical formula is FeO. It exists as a black powder at room temperature. The mineral of iron (II) oxide is mainly known as bustite. In the present invention, it was purchased and used by Sigma (New Jersey, United States of America).

Zinc oxide (ZnO) used in the present invention is a colorless crystalline powder that does not dissolve in water and is called zincation, zinc bag, or the like. It is a light white powder with melting points of 1,975 ° C (pressurized), 1,720 ° C (normal pressure), and specific gravity of 5.47 (non-crystalline) and 5.78 (crystalline). When heated to about 300 ℃, it turns yellow, but when cooled, it becomes the original color. It is an amphoteric oxide that is hardly soluble in water but soluble in dilute acids and concentrated alkalis. In the present invention, it was purchased and used by Sigma (New Jersey, United States of America).

The madecassoside, asiaticoside, and asiatic acid used in the present invention can be obtained separately from the Centella extract, and a synthesized compound may be used. Centella asiatica (aka Centella asiatica ) is a plant known as tiger grass and has a very excellent healing effect.

In the present invention, Madecassoside, Asia Kikoside and Asiatic Acid were purchased from Sigma (New Jersey, United States of America) and used.

The RX complex S according to the present invention preferably contains iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid in a weight ratio of 1 to 4: 1 to 4: 1: 1: 1, more preferably May include a weight ratio of 3.5: 3.5: 1: 1: 1.

RX complex S according to the present invention is preferably included in 1.0 to 30.0% by weight relative to the total weight of the cosmetic composition. If the RX complex S is less than 1.0% by weight, the sebum control effect is insignificant, and when it exceeds 30.0% by weight, it is less economical compared to the effect, and may be irritating to the skin.

Ingredients included in the cosmetic composition of the present invention as an active ingredient may include ingredients commonly used in cosmetic compositions in addition to the active ingredient, for example, antioxidants, stabilizers, solubilizers, vitamins, pigments and flavors Adjuvants, and carriers.

The cosmetic composition of the present invention can be prepared in any formulation conventionally prepared in the art, for example, solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing , Oil, powder foundation, emulsion foundation, wax foundation, pack, massage cream and spray, but may be formulated, but is not limited thereto. More specifically, it can be prepared in the form of flexible lotion, nutrition lotion, nutrition cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.

When the formulation of the present invention is a paste, cream, or gel, animal oil, vegetable oil, wax, paraffin, starch, trakant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide, etc. may be used as a carrier component. You can.

When the formulation of the present invention is a solution or emulsion, a solvent, solubilizing agent or emulsifying agent is used as a carrier component, such as water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, 1 , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid ester.

When the formulation of the present invention is a suspension, liquid diluents such as water, ethanol or propylene glycol as carrier components, ethoxylated isostearyl alcohol, suspensions such as polyoxyethylene sorbitol esters and polyoxyethylene sorbitan esters, microcrystals Sex cellulose, aluminum metahydroxide, bentonite, agar or trakant, etc. can be used.

When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder can be used as a carrier component, and in the case of a spray, additionally chlorofluorohydrocarbon, propane / Propellant such as butane or dimethyl ether.

When the formulation of the present invention is a surfactant-containing cleansing, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives, methyltaurate, sarcosinate, fatty acid amide ether as carrier components Sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters and the like can be used.

When the cosmetic composition of the present invention is a soap, a surfactant-containing cleansing formulation, or a surfactant-free cleansing formulation, it may be wiped, peeled off, or washed with water after application to the skin. As a specific example, the soap is liquid soap, powdered soap, solid soap and oil soap, and the surfactant-containing cleansing formulation is a cleansing foam, cleansing water, a cleansing towel and a cleansing pack, and the surfactant-free cleansing formulation is a cleansing cream , Cleansing lotions, cleansing water and cleansing gels, but are not limited thereto.

Meanwhile, the cosmetic method of the present invention refers to all cosmetic methods using the cosmetic composition of the present invention. That is, all methods known in the art using the cosmetic composition belong to the cosmetic method of the present invention.

The cosmetic composition of the present invention may be used alone or in duplicate, or may be used in combination with other cosmetic compositions other than the present invention. In addition, the cosmetic composition according to the present invention may be used according to a conventional method of use, and the number of times of use may be varied according to a user's skin condition or taste.

Hereinafter, the present invention will be described in more detail through examples. These examples are only intended to illustrate the present invention more specifically, and it will be apparent to those skilled in the art that the scope of the present invention is not limited by these examples according to the gist of the present invention. .

Manufacturing example 1: RX Complex s  Produce

Iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid were mixed in a weight ratio shown in Table 1 below to prepare 10 g of RX complex S.

division compare
Preparation Example 1 compare
Preparation Example 2 compare
Preparation Example 3 compare
Preparation Example 4 compare
Preparation Example 5 Preparation Example 1 Preparation Example 2 Iron oxide 100 - - - - 20 35 Zinc oxide - 100 - - - 20 35 Madecassoside - - 100 - - 20 10 Asiaticoside - - - 100 - 20 10 Asiatic Acid - - - - 100 20 10

Example  And Comparative example

As a prescription of Examples and Comparative Examples, a cosmetic composition containing RX Complex S was prepared with the composition of Table 2 below.

(Unit:% by weight) ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Example 1 Example 2 Comparative Example 6 Comparative Production Example 1 5 - - - - - - - Comparative Production Example 2  - 5 - - - - - - Comparative Production Example 3 - - 5 - - - - - Comparative Production Example 4 - - - 5 - - - - Comparative Production Example 5 - - - - 5 - - - Preparation Example 1 - - - - - 5 - - Preparation Example 2 - - - - - - 5 glycerin 6 6 6 6 6 6 6 6 1,3-butylene glycol 3 3 3 3 3 3 3 3 PEG-1500 One One One One One One One One Allantoin 0.1 0.1 0.1 0.1 0.1 0.1 0.1 0.1 DL-panthenol 0.3 0.3 0.3 0.3 0.3 0.3 0.3 0.3 EDTA-2Na 0.02 0.02 0.02 0.02 0.02 0.02 0.02 0.02 Benzophenone-9 0.04 0.04 0.04 0.04 0.04 0.04 0.04 0.04 Sodium
Hyaluronate 5 5 5 5 5 5 5 5 ethanol 10 10 10 10 10 10 10 10 Octic dodeceth-16 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Polysorbate 20 0.2 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Preservative, fragrance, coloring a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount a very small amount Distilled water Balance Balance Balance Balance Balance Balance Balance Balance Sum 100 100 100 100 100 100 100 100

Experimental example  1: Sebum production inhibitory effect

The effects of inhibiting sebum production on the cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 to 6 were measured as follows. Whether or not the sebum secretion is positive and the sensitization effect was measured on the person with the oily skin having a lot of sebum secretion. For 30 women in their 20s and 40s who are suffering from excessive sebum secretion, clean the skin area of the face and then use the cosmetic composition for 60 days to determine the change in sebum secreted by SEBUMETER SM810 (C + K company) , Germany). Table 3 shows the number of people who had a positive response to sebaceous secretion effect (people with sebum control effect) and the rate of positive response after use compared to before use.

division Skin positive reaction (persons) Positive reaction rate (%) Comparative Example 1 13 43.3 Comparative Example 2 15 50.0 Comparative Example 3 12 40.0 Comparative Example 4 11 36.6 Comparative Example 5 10 33.3 Comparative Example 6 5 16.7 Example 1 22 73.3 Example 2 25 83.3

As shown in Table 3, it was confirmed that the sebum control effect in the formulation containing RX Complex S (Preparation Example 2) (Example 2) was the best. On the other hand, the sebum secretion value of the cosmetic composition of the present invention was measured according to the passage of time on the forehead and cheek, and the results are shown in Table 4.

division Sebum secretion in the forehead Sebum secretion in the ball Just before use 30 minutes later 1 hour later Just before use 30 minutes later 1 hour later Comparative Example 1 340 269 268 68 52 56 Comparative Example 2 339 285 288 66 53 53 Comparative Example 3 338 286 278 65 54 55 Comparative Example 4 339 266 256 68 53 53 Comparative Example 5 340 257 265 64 56 54 Comparative Example 6 340 300 312 69 66 64 Example 1 341 196 200 63 45 45 Example 2 341 180 186 70 40 38

As shown in Table 4, it was confirmed that the sebum control effect in the formulation containing RX Complex S (Preparation Example 2) (Example 2) was very excellent.

Experimental example  2: Skin pore shrinking effect

The effects of reducing skin pores on the cosmetic compositions of Examples 1 and 2 and Comparative Examples 1 to 6 were measured as follows. For each sample, 20 subjects in their 30s and 50s were selected, and all the cosmetic compositions were used twice daily for 3 weeks, and then the size of the pores before and after the experiment was measured using an image measuring device (C + K, Germany). The number of people with pore size changes was measured and is shown in Table 5 below (skin pore size reduction effect).

division People who have the effect of reducing skin pores Positive reaction rate (%) Comparative Example 1 10 50 Comparative Example 2 11 55 Comparative Example 3 11 55 Comparative Example 4 9 45 Comparative Example 5 8 40 Comparative Example 6 3 15 Example 1 17 85 Example 2 18 90

As shown in Table 5, it was confirmed that the pore size control effect in the formulation containing RX Complex S (Preparation Example 2) (Example 2) was very excellent. In addition, skin irritation could not be observed in the subjects using each product.

Experimental example  3: RX  complex S  Skin irritation test experiment of containing formulation

Whether the skin irritation occurred while using the formulations prepared in Examples 1 and 2 and Comparative Examples 1 to 6 in 20 healthy subjects in their 20s to 30s was evaluated by a subject questionnaire.

Irritation or not Before use after use Comparative Example 1 Irritation Irritation Comparative Example 2 Irritation Irritation Comparative Example 3 Irritation Irritation Comparative Example 4 Irritation Irritation Comparative Example 5 Irritation Irritation Comparative Example 6 Irritation Irritation Example 1 Irritation Irritation Example 2 Irritation Irritation

Since the specific parts of the present invention have been described in detail above, it is clear that for those skilled in the art, this specific technology is only a preferred embodiment, and the scope of the present invention is not limited thereto. Accordingly, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (4)

A cosmetic composition for regulating skin sebum containing iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid as active ingredients. The composition of claim 1, wherein the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid are contained in an amount of 10.0 to 90.0% by weight based on the total weight of the cosmetic composition. The cosmetic composition for controlling sebum according to claim 1, wherein the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid are contained in a weight ratio of 1 to 4: 1 to 4: 1: 1: 1. . The cosmetic composition for controlling sebum according to claim 1, wherein the iron oxide, zinc oxide, madecassoside, asiaticoside, and asiatic acid are contained in a weight ratio of 3.5: 3.5: 1: 1: 1.