KR20200020712A - 2-플루오로아크릴레이트의 제조방법 - Google Patents

2-플루오로아크릴레이트의 제조방법 Download PDF

Info

Publication number
KR20200020712A
KR20200020712A KR1020197037267A KR20197037267A KR20200020712A KR 20200020712 A KR20200020712 A KR 20200020712A KR 1020197037267 A KR1020197037267 A KR 1020197037267A KR 20197037267 A KR20197037267 A KR 20197037267A KR 20200020712 A KR20200020712 A KR 20200020712A
Authority
KR
South Korea
Prior art keywords
formula
acid
cyclopropane compound
chloride
fluoroacrolein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197037267A
Other languages
English (en)
Korean (ko)
Inventor
쿤룬 추
웬보 왕
첸지에 유
보타오 리
슝동 리안
공용 리
Original Assignee
린하이 티안유 파마슈티컬 컴퍼니 리미티드
상하이 치순 파마슈티컬 테크놀로지 컴퍼니 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 린하이 티안유 파마슈티컬 컴퍼니 리미티드, 상하이 치순 파마슈티컬 테크놀로지 컴퍼니 리미티드 filed Critical 린하이 티안유 파마슈티컬 컴퍼니 리미티드
Publication of KR20200020712A publication Critical patent/KR20200020712A/ko
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/01—Preparation of ethers
    • C07C41/18—Preparation of ethers by reactions not forming ether-oxygen bonds
    • C07C41/30—Preparation of ethers by reactions not forming ether-oxygen bonds by increasing the number of carbon atoms, e.g. by oligomerisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/39—Preparation of carboxylic acid esters by oxidation of groups which are precursors for the acid moiety of the ester
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C41/00—Preparation of ethers; Preparation of compounds having groups, groups or groups
    • C07C41/48—Preparation of compounds having groups
    • C07C41/50—Preparation of compounds having groups by reactions producing groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/51—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition
    • C07C45/511—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups
    • C07C45/515—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by pyrolysis, rearrangement or decomposition involving transformation of singly bound oxygen functional groups to >C = O groups the singly bound functional group being an acetalised, ketalised hemi-acetalised, or hemi-ketalised hydroxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C07C51/16—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation
    • C07C51/285—Preparation of carboxylic acids or their salts, halides or anhydrides by oxidation with peroxy-compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/14—Preparation of carboxylic acid esters from carboxylic acid halides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
KR1020197037267A 2017-06-28 2018-01-11 2-플루오로아크릴레이트의 제조방법 Ceased KR20200020712A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710505701.4 2017-06-28
CN201710505701.4A CN107417524B (zh) 2017-06-28 2017-06-28 一种2-氟丙烯酸酯的制备方法
PCT/CN2018/072199 WO2019000910A1 (zh) 2017-06-28 2018-01-11 一种2-氟丙烯酸酯的制备方法

Publications (1)

Publication Number Publication Date
KR20200020712A true KR20200020712A (ko) 2020-02-26

Family

ID=60426724

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197037267A Ceased KR20200020712A (ko) 2017-06-28 2018-01-11 2-플루오로아크릴레이트의 제조방법

Country Status (8)

Country Link
US (1) US10844000B2 (enExample)
EP (1) EP3647304B1 (enExample)
JP (1) JP6880249B2 (enExample)
KR (1) KR20200020712A (enExample)
CN (1) CN107417524B (enExample)
ES (1) ES2901485T3 (enExample)
PT (1) PT3647304T (enExample)
WO (1) WO2019000910A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107417524B (zh) 2017-06-28 2019-09-24 临海天宇药业有限公司 一种2-氟丙烯酸酯的制备方法
CN115427383B (zh) * 2020-03-27 2025-08-26 维福(国际)有限公司 2-氟丙烯酸甲酯的合成
CN115956065A (zh) * 2020-08-19 2023-04-11 大金工业株式会社 含卤素（甲基）丙烯酸酯的精制方法
CN114940647B (zh) * 2022-06-06 2023-05-26 龙岩学院 一种双溶剂合成氟乙酸乙酯的方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2744929A (en) * 1952-09-26 1956-05-08 Shell Dev Production of unsaturated carboxylic acids
JPS59222430A (ja) * 1983-05-31 1984-12-14 Shionogi & Co Ltd フルオロシクロプロパン誘導体
US4570018A (en) * 1983-05-31 1986-02-11 Shionogi & Co., Ltd. Fluorocyclopropanes
WO1985003931A1 (fr) 1984-03-02 1985-09-12 Institut National De Recherche Chimique Appliquee Dihalogeno-2,3-fluoro-2-propanals, leur procede d'obtention et leurs applications a l'obtention d'halogenures et d'esters de dihalogeno-2,3-fluoro-2-propanoyles et de fluoracrylates d'alkyle ou d'aryle
JP5521640B2 (ja) * 2009-05-19 2014-06-18 セントラル硝子株式会社 ２−フルオロアクリル酸エステルの製造方法
CN102432465B (zh) 2011-11-18 2014-02-12 太仓市运通化工厂 一种制备甲基丙烯酸甲酯的方法
CN105130798A (zh) * 2015-08-27 2015-12-09 朱虹 一种f-丙烯酸及其衍生物的新合成方法
CN107417524B (zh) 2017-06-28 2019-09-24 临海天宇药业有限公司 一种2-氟丙烯酸酯的制备方法

Also Published As

Publication number Publication date
CN107417524A (zh) 2017-12-01
CN107417524B (zh) 2019-09-24
US10844000B2 (en) 2020-11-24
WO2019000910A1 (zh) 2019-01-03
ES2901485T3 (es) 2022-03-22
EP3647304A4 (en) 2021-03-17
EP3647304A1 (en) 2020-05-06
US20200123095A1 (en) 2020-04-23
JP6880249B2 (ja) 2021-06-02
PT3647304T (pt) 2021-12-27
EP3647304B1 (en) 2021-11-03
JP2020525447A (ja) 2020-08-27

Similar Documents

Publication Publication Date Title
KR20200020712A (ko) 2-플루오로아크릴레이트의 제조방법
JP5395908B2 (ja) ４−（１−ヒドロキシ−１−メチルエチル）−２−プロピルイミダゾール−５−カルボン酸エステルの製造方法
CN104379551A (zh) 3-二氟甲基-1-甲基-1h-吡唑-4-羧酸烷基酯及其类似物的制备方法
WO2019091179A1 (zh) 一种氟苯尼考中间体v的制备方法及利用该中间体v的氟苯尼考制备方法
EP2852583A1 (en) Sulfilimine and sulphoxide methods for producing festinavir
JP5309318B2 (ja) エステル、カルボン酸及びアミドの製造方法
CN104447328A (zh) 一种4,4-二氟乙酰乙酸烷基酯的制备方法
DE60015806T2 (de) Poly-3-cyclopropyl-3-hydroxypropionat und verfahren zu seiner herstellung und derivate daraus
TWI627162B (zh) Method for producing unsaturated acid ester or unsaturated acid
JP2838664B2 (ja) オキソ化合物の製造方法
JP2013067583A (ja) ３，３，３−トリフルオロプロパノール類の製造方法
JP2009161530A (ja) １，４−ビス（ブロモジフルオロメチル）テトラフルオロベンゼンおよびその製造方法
DE2842715A1 (de) 3-chlor-3-methyl-butan- bzw. 3-methyl- 2-buten-1,4-dial-bis-acetale, ein verfahren zur herstellung dieser verbindungen sowie deren verwendung
CN108178752A (zh) 一种联产制备3,3,3-三氟丙烯碳酸酯与3,3,3-三氟-1,2-丙二醇的方法
CN110467529B (zh) 一种酯的合成方法
JP4278938B2 (ja) トリフルオロメチル置換２−アルコキシアセトフェノン誘導体の製造方法
KR100515922B1 (ko) 디벤조티에핀 유도체의 개선된 제조방법
CN114539041A (zh) 一种氯氟醚菌唑中间体的制备方法
KR20240097112A (ko) 락틱산 유도체에 아세톡실화 반응을 적용한 화합물의 합성방법
US9580397B2 (en) Process and apparatus for producing divinylarene dioxide
JP2005047838A (ja) フルオロフェノール誘導体の製造方法
US7786330B2 (en) Process for producing 1,2-dialkoxy-3-fluorobenzene
JP3312414B2 (ja) ジエン酸ハライド類の製造方法
JP2024045205A (ja) ２－ヒドロキシ－２－（パーフルオロアルキル）マロン酸エステル誘導体の製造方法、並びに２－（トリメチルシリルオキシ）－２－（パーフルオロアルキル）マロン酸エステル誘導体及び５－ヒドロキシ－５－（パーフルオロアルキル）ピリミジン－２，４，６（１ｈ，３ｈ，５ｈ）－トリオンとそれらの製造方法
TW201309633A (zh) 製備２，２－二氟乙醇的方法

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20191217

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20201204

Comment text: Request for Examination of Application

A302 Request for accelerated examination
AMND Amendment
PA0302 Request for accelerated examination

Patent event date: 20201218

Patent event code: PA03022R01D

Comment text: Request for Accelerated Examination

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20210302

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20210705

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20210302

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

X091 Application refused [patent]
AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20210705

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20210415

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20201218

Comment text: Amendment to Specification, etc.

PX0601 Decision of rejection after re-examination

Comment text: Decision to Refuse Application

Patent event code: PX06014S01D

Patent event date: 20210823

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20210810

Comment text: Decision to Refuse Application

Patent event code: PX06011S01I

Patent event date: 20210705

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20210415

Comment text: Notification of reason for refusal

Patent event code: PX06013S01I

Patent event date: 20210302

Comment text: Amendment to Specification, etc.

Patent event code: PX06012R01I

Patent event date: 20201218

X601 Decision of rejection after re-examination