KR20190128619A - 의약에서 사용하기 위한 술폭시알킬 오르가노니트로 및 관련 화합물 및 제약 조성물 - Google Patents
의약에서 사용하기 위한 술폭시알킬 오르가노니트로 및 관련 화합물 및 제약 조성물 Download PDFInfo
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- KR20190128619A KR20190128619A KR1020197013789A KR20197013789A KR20190128619A KR 20190128619 A KR20190128619 A KR 20190128619A KR 1020197013789 A KR1020197013789 A KR 1020197013789A KR 20197013789 A KR20197013789 A KR 20197013789A KR 20190128619 A KR20190128619 A KR 20190128619A
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- GBABOYUKABKIAF-GHYRFKGUSA-N vinorelbine Chemical compound C1N(CC=2C3=CC=CC=C3NC=22)CC(CC)=C[C@H]1C[C@]2(C(=O)OC)C1=CC([C@]23[C@H]([C@]([C@H](OC(C)=O)[C@]4(CC)C=CCN([C@H]34)CC2)(O)C(=O)OC)N2C)=C2C=C1OC GBABOYUKABKIAF-GHYRFKGUSA-N 0.000 description 1
- 229960002066 vinorelbine Drugs 0.000 description 1
- 201000005102 vulva cancer Diseases 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
- C07C317/50—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0215—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing natural amino acids, forming a peptide bond via their side chain functional group, e.g. epsilon-Lys, gamma-Glu
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/04—Systems containing only non-condensed rings with a four-membered ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
- C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Psychology (AREA)
- Communicable Diseases (AREA)
- Immunology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662408182P | 2016-10-14 | 2016-10-14 | |
| US62/408,182 | 2016-10-14 | ||
| PCT/US2017/056454 WO2018071741A1 (en) | 2016-10-14 | 2017-10-13 | Sulfoxyalkyl organonitro and related compounds and pharmaceutical compositions for use in medicine |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190128619A true KR20190128619A (ko) | 2019-11-18 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197013789A Withdrawn KR20190128619A (ko) | 2016-10-14 | 2017-10-13 | 의약에서 사용하기 위한 술폭시알킬 오르가노니트로 및 관련 화합물 및 제약 조성물 |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11008287B2 (enExample) |
| EP (1) | EP3526195A4 (enExample) |
| JP (1) | JP7332469B2 (enExample) |
| KR (1) | KR20190128619A (enExample) |
| CN (1) | CN110352190A (enExample) |
| AU (2) | AU2017342436C1 (enExample) |
| BR (1) | BR112019007453A2 (enExample) |
| CA (1) | CA3040479A1 (enExample) |
| EA (1) | EA201990949A1 (enExample) |
| IL (1) | IL265970B (enExample) |
| MX (1) | MX2019004280A (enExample) |
| SG (1) | SG11201903312VA (enExample) |
| WO (1) | WO2018071741A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US7507842B2 (en) | 2005-08-12 | 2009-03-24 | Radiorx, Inc. | Cyclic nitro compounds, pharmaceutical compositions thereof and uses thereof |
| US20140308260A1 (en) | 2011-10-07 | 2014-10-16 | Radiorx, Inc. | Methods and compositions comprising a nitrite-reductase promoter for treatment of medical disorders and preservation of blood products |
| US10342778B1 (en) | 2015-10-20 | 2019-07-09 | Epicentrx, Inc. | Treatment of brain metastases using organonitro compound combination therapy |
| US9987270B1 (en) | 2015-10-29 | 2018-06-05 | Epicentrix, Inc. | Treatment of gliomas using organonitro compound combination therapy |
| PL3402480T3 (pl) | 2016-01-11 | 2021-11-22 | Epicentrx, Inc. | Kompozycje i sposoby dożylnego podawania 2-bromo-1-(3,3-dinitroazetydyn-1-ylo)etanonu |
| MX2019004280A (es) | 2016-10-14 | 2019-09-18 | Epicentrx Inc | Organonitro-sulfoalquilo y compuestos relacionados y composiciones farmacéuticas para uso en medicina. |
| JP7377791B2 (ja) | 2017-07-07 | 2023-11-10 | エピセントアールエックス，インコーポレイテッド | 治療剤の非経口投与のための組成物 |
| US11510901B2 (en) | 2018-01-08 | 2022-11-29 | Epicentrx, Inc. | Methods and compositions utilizing RRx-001 combination therapy for radioprotection |
| US20240382451A1 (en) * | 2021-06-16 | 2024-11-21 | Epicentrx, Inc. | Organonitro and sulfoxyalkyl organonitro compounds for use in treating medical disorders |
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| PL3402480T3 (pl) | 2016-01-11 | 2021-11-22 | Epicentrx, Inc. | Kompozycje i sposoby dożylnego podawania 2-bromo-1-(3,3-dinitroazetydyn-1-ylo)etanonu |
| MX2019004280A (es) | 2016-10-14 | 2019-09-18 | Epicentrx Inc | Organonitro-sulfoalquilo y compuestos relacionados y composiciones farmacéuticas para uso en medicina. |
| JP7377791B2 (ja) | 2017-07-07 | 2023-11-10 | エピセントアールエックス，インコーポレイテッド | 治療剤の非経口投与のための組成物 |
-
2017
- 2017-10-13 MX MX2019004280A patent/MX2019004280A/es unknown
- 2017-10-13 EP EP17859688.8A patent/EP3526195A4/en not_active Withdrawn
- 2017-10-13 AU AU2017342436A patent/AU2017342436C1/en active Active
- 2017-10-13 US US16/341,538 patent/US11008287B2/en active Active
- 2017-10-13 KR KR1020197013789A patent/KR20190128619A/ko not_active Withdrawn
- 2017-10-13 EA EA201990949A patent/EA201990949A1/ru unknown
- 2017-10-13 WO PCT/US2017/056454 patent/WO2018071741A1/en not_active Ceased
- 2017-10-13 CN CN201780077202.8A patent/CN110352190A/zh active Pending
- 2017-10-13 JP JP2019519978A patent/JP7332469B2/ja active Active
- 2017-10-13 CA CA3040479A patent/CA3040479A1/en active Pending
- 2017-10-13 SG SG11201903312VA patent/SG11201903312VA/en unknown
- 2017-10-13 BR BR112019007453A patent/BR112019007453A2/pt not_active Application Discontinuation
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2019
- 2019-04-11 IL IL265970A patent/IL265970B/en unknown
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2022
- 2022-05-12 AU AU2022203169A patent/AU2022203169B2/en active Active
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| AU2017342436A1 (en) | 2019-05-02 |
| JP7332469B2 (ja) | 2023-08-23 |
| MX2019004280A (es) | 2019-09-18 |
| EP3526195A4 (en) | 2020-05-20 |
| US20200157047A1 (en) | 2020-05-21 |
| JP2019532067A (ja) | 2019-11-07 |
| BR112019007453A2 (pt) | 2019-07-16 |
| AU2017342436C1 (en) | 2022-11-03 |
| EP3526195A1 (en) | 2019-08-21 |
| SG11201903312VA (en) | 2019-05-30 |
| WO2018071741A8 (en) | 2019-05-31 |
| US11008287B2 (en) | 2021-05-18 |
| AU2017342436B2 (en) | 2022-05-19 |
| IL265970A (en) | 2019-06-30 |
| EA201990949A1 (ru) | 2019-10-31 |
| AU2022203169B2 (en) | 2024-04-18 |
| WO2018071741A1 (en) | 2018-04-19 |
| CN110352190A (zh) | 2019-10-18 |
| AU2022203169A1 (en) | 2022-06-02 |
| CA3040479A1 (en) | 2018-04-19 |
| IL265970B (en) | 2022-03-01 |
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