KR20190120238A - 발효에 의한 티라민의 제조를 위해 조작된 생합성 경로 - Google Patents

발효에 의한 티라민의 제조를 위해 조작된 생합성 경로 Download PDF

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KR20190120238A
KR20190120238A KR1020197025667A KR20197025667A KR20190120238A KR 20190120238 A KR20190120238 A KR 20190120238A KR 1020197025667 A KR1020197025667 A KR 1020197025667A KR 20197025667 A KR20197025667 A KR 20197025667A KR 20190120238 A KR20190120238 A KR 20190120238A
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마이클 에스 시디퀴
코크 스테판 데
알렉산더 시어러
프랭클린 루
캐라 트레이스웰
스티븐 에드가
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지머젠 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/001—Oxidoreductases (1.) acting on the CH-CH group of donors (1.3)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1085—Transferases (2.) transferring alkyl or aryl groups other than methyl groups (2.5)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • C—CHEMISTRY; METALLURGY
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/88—Lyases (4.)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01012—Prephenate dehydrogenase (1.3.1.12)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01002—Transaldolase (2.2.1.2)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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    • C12Y—ENZYMES
    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01071—Shikimate kinase (2.7.1.71)
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    • C12Y—ENZYMES
    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01025—Tyrosine decarboxylase (4.1.1.25)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99005—Chorismate mutase (5.4.99.5)

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  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
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  • Microbiology (AREA)
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  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
KR1020197025667A 2017-02-06 2018-02-06 발효에 의한 티라민의 제조를 위해 조작된 생합성 경로 Withdrawn KR20190120238A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762455428P 2017-02-06 2017-02-06
US62/455,428 2017-02-06
PCT/US2018/017127 WO2018203947A2 (en) 2017-02-06 2018-02-06 Engineered biosynthetic pathways for production of tyramine by fermentation

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KR20190120238A true KR20190120238A (ko) 2019-10-23

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KR1020197025667A Withdrawn KR20190120238A (ko) 2017-02-06 2018-02-06 발효에 의한 티라민의 제조를 위해 조작된 생합성 경로

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US (1) US11028416B2 (https=)
EP (1) EP3577220A2 (https=)
JP (1) JP2020513790A (https=)
KR (1) KR20190120238A (https=)
CN (1) CN110494560A (https=)
CA (1) CA3052635A1 (https=)
WO (1) WO2018203947A2 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
WO2016183023A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
WO2018203947A2 (en) 2017-02-06 2018-11-08 Zymergen Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
CA3087269A1 (en) 2018-01-10 2019-07-18 Brightseed, Inc. Method for modulating metabolism
EP3656857A1 (en) * 2018-11-21 2020-05-27 Danmarks Tekniske Universitet Utilization of phosphoketolase for production of aromatic amino acid derived products
CN113784758B (zh) 2019-03-08 2025-03-07 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
WO2020232027A1 (en) * 2019-05-13 2020-11-19 Zymergen Inc. Stabilization of amines with sulfur compounds
CA3158769A1 (en) * 2019-10-25 2021-04-29 Brightseed, Inc. Recombinant cell, extract, consumable product and method for production of bioactive plant metabolite
CN116368233A (zh) * 2020-08-20 2023-06-30 齐默尔根公司 通过发酵生产4-氨基苯乙胺的工程化生物合成途径
CN113174375B (zh) * 2021-04-23 2022-11-04 天津大学 Aro3蛋白突变体及其应用
WO2022245340A1 (en) * 2021-05-18 2022-11-24 Zymergen Inc. Engineered biosynthetic pathways for production of deoxyhydrochorismic acid by fermentation
CN113684165B (zh) * 2021-08-12 2023-07-25 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
EP4198123A1 (de) * 2021-12-17 2023-06-21 Covestro Deutschland AG Besonders geeignete 3-desoxyarabinoheptulosanat-7-phosphat-synthase zur fermentativen herstellung von ortho-aminobenzoesäure
CN116083387B (zh) * 2022-12-29 2025-09-02 华熙生物科技股份有限公司 酶、生产红景天苷的菌株及生产方法
CN116042553B (zh) * 2022-12-29 2025-08-26 浙江工业大学 甘油醛-3-磷酸脱氢酶突变体及在提高o-琥珀酰-l-高丝氨酸产量中的应用
CN117736960B (zh) * 2024-02-21 2024-05-07 滨州医学院 一种小白链霉菌基因工程菌及其应用
CN119144595B (zh) * 2024-11-13 2025-02-14 中国科学院微生物研究所 一种酪氨酸脱羧酶突变体及其在发酵合成3-氨基-1-丙醇中的应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3128411A1 (de) 1980-07-18 1983-09-15 Unisearch Ltd., 2033 Kensington, New South Wales Kulturstamm-mutante von esccherichia coli sowie verfahren zur herstellung von phenylalanin
EP0077196A3 (en) 1981-10-09 1984-06-06 Genex Corporation Aromatic amino acid-producing microorganisms
JPH07108228B2 (ja) 1990-10-15 1995-11-22 味の素株式会社 温度感受性プラスミド
DK0782621T3 (da) 1994-09-16 2006-07-03 Texas A & M Univ Sys Mikroorganismer samt fremgangsmåde til overproduktion af DAHP ved hjælp af klonet PPS-gen
US6210937B1 (en) 1997-04-22 2001-04-03 Bechtel Bwxt Idaho, Llc Development of genetically engineered bacteria for production of selected aromatic compounds
US6297055B1 (en) 1998-09-08 2001-10-02 E. I. Du Pont De Nemours And Company Amino acid decarboxylases
US6600077B1 (en) 1999-01-29 2003-07-29 Board Of Trustees Operating Michigan State University Biocatalytic synthesis of quinic acid and conversion to hydroquinone
WO2000073484A1 (en) 1999-05-28 2000-12-07 University Of North Texas Health Science Center At Fort Worth A global regulator used to enhance the synthesis of aromatic substances
US20050089974A1 (en) 2000-10-27 2005-04-28 Townsend Craig A. Fermentative production of d-hydroxyphenylglycine and d-phenylglycine
RU2229514C2 (ru) 2000-11-13 2004-05-27 Закрытое акционерное общество "Научно-исследовательский институт "Аджиномото-Генетика" 3-дезокси-d-арабиногептулозонат-7-фосфатсинтаза и фрагмент днк, кодирующий 3-дезокси-d-арабиногептулозонат-7-фосфатсинтазу из methylophilus methylotrophus
KR101148255B1 (ko) 2002-10-04 2012-08-08 다니스코 유에스 인크. 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법
US8206955B2 (en) 2003-10-21 2012-06-26 Cargill, Incorporated Production of monatin and monatin precursors
CN1280417C (zh) * 2004-11-01 2006-10-18 清华大学 一种人酪氨酸酶表达载体及其应用
WO2007118682A1 (en) * 2006-04-13 2007-10-25 Dsm Ip Assets B.V. Process for the preparation of enantiomeri cally enriched beta-amino alcohols starting from glycine and an aldehyde in the presence of a threonine aldolase and a decarboxylase
WO2007140339A2 (en) 2006-05-26 2007-12-06 Amyris Biotechnologies, Inc. Production of isoprenoids
US7700328B2 (en) 2006-06-07 2010-04-20 E.I. Du Pont De Nemours And Company Method for producing an L-tyrosine over-producing bacterial strain
US8975063B2 (en) 2006-10-19 2015-03-10 California Institute Of Technology Compositions and methods for producing benzylisoquinoline alkaloids
US20080102499A1 (en) 2006-10-27 2008-05-01 Lori Jean Templeton Method of enhancing L-tyrosine production in recombinant bacteria
US20100047887A1 (en) 2006-11-27 2010-02-25 Jihane Achkar Method for preparing hydroxytyrosol
WO2009046370A2 (en) 2007-10-04 2009-04-09 Bio Architecture Lab, Inc. Biofuel production
CN105368764B (zh) 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
US20110045563A1 (en) 2008-02-06 2011-02-24 The Regents Of The University Of California Short chain volatile isoprene hydrocarbon production using the mevalonic acid pathway in genetically engineered yeast and fungi
WO2009132220A2 (en) 2008-04-23 2009-10-29 Danisco Us Inc. Isoprene synthase variants for improved microbial production of isoprene
US7632995B2 (en) 2008-05-09 2009-12-15 Monsanto Technology Llc Plants and seeds of hybrid corn variety CH852179
MX318543B (es) 2008-07-02 2014-03-18 Danisco Us Inc Composiciones y metodos para producir isopreno libre de hidrocarburos de c5 bajo condicion de desacoplamiento y/o intervalos de operacion seguros.
DE102008040352A1 (de) 2008-07-11 2010-01-14 Evonik Degussa Gmbh Verfahren zur Herstellung von L-Tryptophan unter Verwendung von verbesserten Stämmen der Familie Enterobacteriaceae
US20100297749A1 (en) 2009-04-21 2010-11-25 Sapphire Energy, Inc. Methods and systems for biofuel production
US20120252054A1 (en) 2009-09-15 2012-10-04 Sapphire Energy Inc System for transformation of the chloroplast genome of scenedesmus sp. and dunaliella sp.
KR20180014240A (ko) 2009-10-23 2018-02-07 게노마티카 인코포레이티드 아닐린의 제조를 위한 미생물
WO2012135389A2 (en) 2011-03-28 2012-10-04 The Regents Of The University Of California Host cells and methods for oxidizing aromatic amino acids
ES2663445T3 (es) 2012-01-30 2018-04-12 Myriant Corporation Producción de ácido mucónico a partir de microorganismos modificados genéticamente
US9234203B2 (en) 2012-05-21 2016-01-12 Cathay Industrial Biotech Ltd. Stabilized recombinant expression plasmid vector in hafnia alvei and applications thereof
EP3241902B1 (en) 2012-05-25 2018-02-28 The Regents of The University of California Methods and compositions for rna-directed target dna modification and for rna-directed modulation of transcription
MX374090B (es) 2013-03-14 2025-03-05 Caribou Biosciences Inc Composiciones y métodos de ácidos nucleicos dirigidos al ácido nucleico.
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
WO2015192233A1 (en) 2014-06-19 2015-12-23 Epimeron Inc. Compositions and methods for making (s)-norcoclaurine and (s)-norlaudanosoline, and synthesis intermediates thereof
CN106795486B (zh) 2014-08-21 2021-06-08 公益财团法人地球环境产业技术研究机构 棒状细菌转化体及使用该转化体的有机化合物的制造方法
WO2016183023A1 (en) * 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
WO2018203947A2 (en) 2017-02-06 2018-11-08 Zymergen Inc. Engineered biosynthetic pathways for production of tyramine by fermentation

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EP3577220A2 (en) 2019-12-11
JP2020513790A (ja) 2020-05-21
CN110494560A (zh) 2019-11-22
US20190390236A1 (en) 2019-12-26
CA3052635A1 (en) 2018-11-08
WO2018203947A9 (en) 2020-05-07
US11028416B2 (en) 2021-06-08
WO2018203947A2 (en) 2018-11-08
WO2018203947A3 (en) 2019-01-17

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