CN110494560A - 通过发酵产生酪胺的经改造的生物合成途径 - Google Patents

通过发酵产生酪胺的经改造的生物合成途径 Download PDF

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Publication number
CN110494560A
CN110494560A CN201880024534.4A CN201880024534A CN110494560A CN 110494560 A CN110494560 A CN 110494560A CN 201880024534 A CN201880024534 A CN 201880024534A CN 110494560 A CN110494560 A CN 110494560A
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M·S·西迪基
S·德科
A·希勒
F·卢
C·特雷西韦尔
S·埃德加
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Zymergen Inc
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    • C12P13/00—Preparation of nitrogen-containing organic compounds
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    • C12N9/1022—Transferases (2.) transferring aldehyde or ketonic groups (2.2)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/90—Isomerases (5.)
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    • C12Y103/00—Oxidoreductases acting on the CH-CH group of donors (1.3)
    • C12Y103/01—Oxidoreductases acting on the CH-CH group of donors (1.3) with NAD+ or NADP+ as acceptor (1.3.1)
    • C12Y103/01012—Prephenate dehydrogenase (1.3.1.12)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Y202/00—Transferases transferring aldehyde or ketonic groups (2.2)
    • C12Y202/01—Transketolases and transaldolases (2.2.1)
    • C12Y202/01002—Transaldolase (2.2.1.2)
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    • C12Y205/00—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5)
    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01054—3-Deoxy-7-phosphoheptulonate synthase (2.5.1.54)
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    • C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
    • C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
    • C12Y207/01071—Shikimate kinase (2.7.1.71)
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    • C12Y401/00—Carbon-carbon lyases (4.1)
    • C12Y401/01—Carboxy-lyases (4.1.1)
    • C12Y401/01025—Tyrosine decarboxylase (4.1.1.25)
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    • C12Y—ENZYMES
    • C12Y504/00—Intramolecular transferases (5.4)
    • C12Y504/99—Intramolecular transferases (5.4) transferring other groups (5.4.99)
    • C12Y504/99005—Chorismate mutase (5.4.99.5)

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
CN201880024534.4A 2017-02-06 2018-02-06 通过发酵产生酪胺的经改造的生物合成途径 Pending CN110494560A (zh)

Applications Claiming Priority (3)

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US201762455428P 2017-02-06 2017-02-06
US62/455,428 2017-02-06
PCT/US2018/017127 WO2018203947A2 (en) 2017-02-06 2018-02-06 Engineered biosynthetic pathways for production of tyramine by fermentation

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US (1) US11028416B2 (https=)
EP (1) EP3577220A2 (https=)
JP (1) JP2020513790A (https=)
KR (1) KR20190120238A (https=)
CN (1) CN110494560A (https=)
CA (1) CA3052635A1 (https=)
WO (1) WO2018203947A2 (https=)

Cited By (6)

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CN113174375A (zh) * 2021-04-23 2021-07-27 天津大学 Aro3蛋白突变体及其应用
CN113684165A (zh) * 2021-08-12 2021-11-23 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
CN116042553A (zh) * 2022-12-29 2023-05-02 浙江工业大学 甘油醛-3-磷酸脱氢酶突变体及在提高o-琥珀酰-l-高丝氨酸产量中的应用
CN116083387A (zh) * 2022-12-29 2023-05-09 北京华熙荣熙生物技术研究有限公司 酶、生产红景天苷的菌株及生产方法
CN118406626A (zh) * 2024-02-21 2024-07-30 滨州医学院 一种小白链霉菌基因工程菌及其应用
CN119144595A (zh) * 2024-11-13 2024-12-17 中国科学院微生物研究所 一种酪氨酸脱羧酶突变体及其在发酵合成3-氨基-1-丙醇中的应用

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WO2016183023A1 (en) 2015-05-08 2016-11-17 The Board Of Trustees Of The Leland Stanford Junior University Methods of producing epimerases and benzylisoquinoline alkaloids
WO2018203947A2 (en) 2017-02-06 2018-11-08 Zymergen Inc. Engineered biosynthetic pathways for production of tyramine by fermentation
CA3087269A1 (en) 2018-01-10 2019-07-18 Brightseed, Inc. Method for modulating metabolism
EP3656857A1 (en) * 2018-11-21 2020-05-27 Danmarks Tekniske Universitet Utilization of phosphoketolase for production of aromatic amino acid derived products
CN113784758B (zh) 2019-03-08 2025-03-07 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
WO2020232027A1 (en) * 2019-05-13 2020-11-19 Zymergen Inc. Stabilization of amines with sulfur compounds
CA3158769A1 (en) * 2019-10-25 2021-04-29 Brightseed, Inc. Recombinant cell, extract, consumable product and method for production of bioactive plant metabolite
CN116368233A (zh) * 2020-08-20 2023-06-30 齐默尔根公司 通过发酵生产4-氨基苯乙胺的工程化生物合成途径
WO2022245340A1 (en) * 2021-05-18 2022-11-24 Zymergen Inc. Engineered biosynthetic pathways for production of deoxyhydrochorismic acid by fermentation
EP4198123A1 (de) * 2021-12-17 2023-06-21 Covestro Deutschland AG Besonders geeignete 3-desoxyarabinoheptulosanat-7-phosphat-synthase zur fermentativen herstellung von ortho-aminobenzoesäure

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113174375A (zh) * 2021-04-23 2021-07-27 天津大学 Aro3蛋白突变体及其应用
CN113684165A (zh) * 2021-08-12 2021-11-23 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
CN113684165B (zh) * 2021-08-12 2023-07-25 江南大学 一种重组谷氨酸棒杆菌及其在生产l-谷氨酰胺中的应用
CN116042553A (zh) * 2022-12-29 2023-05-02 浙江工业大学 甘油醛-3-磷酸脱氢酶突变体及在提高o-琥珀酰-l-高丝氨酸产量中的应用
CN116083387A (zh) * 2022-12-29 2023-05-09 北京华熙荣熙生物技术研究有限公司 酶、生产红景天苷的菌株及生产方法
CN116042553B (zh) * 2022-12-29 2025-08-26 浙江工业大学 甘油醛-3-磷酸脱氢酶突变体及在提高o-琥珀酰-l-高丝氨酸产量中的应用
CN118406626A (zh) * 2024-02-21 2024-07-30 滨州医学院 一种小白链霉菌基因工程菌及其应用
CN119144595A (zh) * 2024-11-13 2024-12-17 中国科学院微生物研究所 一种酪氨酸脱羧酶突变体及其在发酵合成3-氨基-1-丙醇中的应用

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EP3577220A2 (en) 2019-12-11
JP2020513790A (ja) 2020-05-21
US20190390236A1 (en) 2019-12-26
CA3052635A1 (en) 2018-11-08
WO2018203947A9 (en) 2020-05-07
KR20190120238A (ko) 2019-10-23
US11028416B2 (en) 2021-06-08
WO2018203947A2 (en) 2018-11-08
WO2018203947A3 (en) 2019-01-17

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