KR20190117579A - 화농성 한선염의 치료 - Google Patents
화농성 한선염의 치료 Download PDFInfo
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- KR20190117579A KR20190117579A KR1020197025797A KR20197025797A KR20190117579A KR 20190117579 A KR20190117579 A KR 20190117579A KR 1020197025797 A KR1020197025797 A KR 1020197025797A KR 20197025797 A KR20197025797 A KR 20197025797A KR 20190117579 A KR20190117579 A KR 20190117579A
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- mabp1
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Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/245—IL-1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
- C07K16/1271—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Micrococcaceae (F), e.g. Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dermatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762459841P | 2017-02-16 | 2017-02-16 | |
| US62/459,841 | 2017-02-16 | ||
| PCT/IB2018/000209 WO2018150265A1 (en) | 2017-02-16 | 2018-02-16 | Treatment of hidradenitis suppurativa |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190117579A true KR20190117579A (ko) | 2019-10-16 |
Family
ID=63170129
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197025797A Ceased KR20190117579A (ko) | 2017-02-16 | 2018-02-16 | 화농성 한선염의 치료 |
Country Status (12)
| Country | Link |
|---|---|
| US (5) | US11225517B2 (enExample) |
| EP (1) | EP3582813A4 (enExample) |
| JP (2) | JP7145162B2 (enExample) |
| KR (1) | KR20190117579A (enExample) |
| CN (1) | CN110382001A (enExample) |
| AU (1) | AU2018220862A1 (enExample) |
| CA (1) | CA3053231A1 (enExample) |
| IL (1) | IL268569A (enExample) |
| MX (1) | MX2019009798A (enExample) |
| PH (1) | PH12019501900A1 (enExample) |
| SG (1) | SG11201907159SA (enExample) |
| WO (1) | WO2018150265A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20130098279A (ko) | 2010-06-18 | 2013-09-04 | 엑스바이오테크, 인크. | 관절염 치료 |
| KR20210128021A (ko) | 2010-08-23 | 2021-10-25 | 얀센 바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| EP3558363A1 (en) | 2016-12-21 | 2019-10-30 | Amgen Inc. | Anti-tnf alpha antibody formulations |
| US10975146B2 (en) | 2018-06-29 | 2021-04-13 | Cedars-Sinai Medical Center | Interleukin-1 inhibition for combination treatment of pancreatic cancer |
| TWI737000B (zh) * | 2018-10-22 | 2021-08-21 | 美商美國禮來大藥廠 | 用於治療化膿性汗腺炎之泛-ｅｌｒ＋ｃｘｃ趨化介素抗體 |
| JP2022523530A (ja) * | 2019-02-28 | 2022-04-25 | ヤンセン バイオテツク，インコーポレーテツド | 化膿性汗腺炎の治療のための抗ＩＬ－α抗体 |
| US20230235042A1 (en) * | 2020-04-16 | 2023-07-27 | Janssen Biotech, Inc. | Treatment of hidradenitis suppurativa |
| KR20240162125A (ko) * | 2022-03-17 | 2024-11-14 | 화이자 인코포레이티드 | 한선염 치료를 위한 방법, 투여 레지멘, 및 조성물 |
Family Cites Families (81)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH652145A5 (de) | 1982-01-22 | 1985-10-31 | Sandoz Ag | Verfahren zur in vitro-herstellung von hybridomen welche humane monoklonale antikoerper erzeugen. |
| US5672347A (en) | 1984-07-05 | 1997-09-30 | Genentech, Inc. | Tumor necrosis factor antagonists and their use |
| US5168062A (en) | 1985-01-30 | 1992-12-01 | University Of Iowa Research Foundation | Transfer vectors and microorganisms containing human cytomegalovirus immediate-early promoter-regulatory DNA sequence |
| US4965198A (en) | 1985-12-24 | 1990-10-23 | Konica Corporation | Monoclonal antibody and method of manufacturing hybridoma producing the same |
| DE3631229A1 (de) | 1986-09-13 | 1988-03-24 | Basf Ag | Monoklonale antikoerper gegen humanen tumornekrosefaktor (tnf) und deren verwendung |
| DK590387A (da) | 1986-11-13 | 1988-05-14 | Otsuka Pharma Co Ltd | Antistoffer mod interleukin-1 |
| US5034316A (en) | 1987-03-30 | 1991-07-23 | The Regents Of The University Of California | In vitro human monoclonal IgG rheumatoid factor autoantibody |
| US4968607A (en) | 1987-11-25 | 1990-11-06 | Immunex Corporation | Interleukin-1 receptors |
| FR2640146B1 (fr) | 1988-12-08 | 1993-12-24 | Commissariat A Energie Atomique | Anticorps monoclonaux anti-interleukines 1(alpha) et 1(beta), leur procede de production et applications desdits anticorps a la detection des interleukines 1(alpha) et 1(beta) et en therapeutique |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5407431A (en) | 1989-07-11 | 1995-04-18 | Med-Design Inc. | Intravenous catheter insertion device with retractable needle |
| US7192584B2 (en) | 1991-03-18 | 2007-03-20 | Centocor, Inc. | Methods of treating psoriasis with anti-TNF antibodies |
| GB9122820D0 (en) | 1991-10-28 | 1991-12-11 | Wellcome Found | Stabilised antibodies |
| ES2140469T3 (es) | 1992-10-14 | 2000-03-01 | Nycomed Imaging As | Composiciones y metodos terapeuticos y de diagnostico por obtencion de imagenes. |
| DE122009000074I1 (de) | 1993-03-05 | 2011-12-01 | Bayer Healthcare Ag | Humane monoklonale anti-TNF alpha Antikorper. |
| EP0659766A1 (en) | 1993-11-23 | 1995-06-28 | Schering-Plough | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| US5959085A (en) | 1993-11-23 | 1999-09-28 | Schering Corporation | Human monoclonal antibodies against human cytokines and methods of making and using such antibodies |
| GB9405021D0 (en) | 1994-03-15 | 1994-04-27 | Unilever Plc | Skin treatment composition |
| GB9509620D0 (en) | 1995-05-12 | 1995-07-05 | Nat Blood Authority | Transepithelial transport of molecular species |
| WO1997002479A2 (en) | 1995-06-30 | 1997-01-23 | Yale University | Human monoclonal anti-tumor antibodies |
| US6090382A (en) | 1996-02-09 | 2000-07-18 | Basf Aktiengesellschaft | Human antibodies that bind human TNFα |
| SE9802402D0 (sv) | 1998-07-03 | 1998-07-03 | Karolinska Innovations Ab | Method of diagnosing cardiovascular disease and early atherosclerosis |
| US20030040617A9 (en) | 1999-03-12 | 2003-02-27 | Rosen Craig A. | Nucleic acids, proteins and antibodies |
| DE19943790C2 (de) | 1999-09-13 | 2001-11-15 | Ericsson Telefon Ab L M | Verfahren und Vorrichtung zur Bestimmung eines Synchronisationsfehlers in einem Netzwerkknoten |
| US6380129B1 (en) | 1999-11-02 | 2002-04-30 | Richard J. Kraemer | Enhanced materials for treatment of contamination |
| US6811788B2 (en) | 2000-01-19 | 2004-11-02 | Baofa Yu | Combinations and methods for treating neoplasms |
| US20030232054A1 (en) | 2000-01-25 | 2003-12-18 | Tang Y. Tom | Novel nucleic acids and polypeptides |
| US20020131954A1 (en) | 2000-05-02 | 2002-09-19 | Tobinick Edward L. | Interleukin antagonists for the treatment of neurological, retinal and muscular disorders |
| AU2007202323C1 (en) | 2000-06-29 | 2012-04-12 | Abbvie Inc. | Dual specificity antibodies and methods of making and using |
| CA2426384A1 (en) | 2000-10-19 | 2003-04-17 | Kyowa Hakko Kogyo Co., Ltd. | Antibody inhibiting vplf activity |
| US20030026806A1 (en) | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| US7348003B2 (en) | 2001-05-25 | 2008-03-25 | Human Genome Sciences, Inc. | Methods of treating cancer using antibodies that immunospecifically bind to TRAIL receptors |
| AU2002343609B2 (en) | 2001-11-16 | 2008-12-11 | Als Therapy Development Foundation, Inc. | Treatment of neurodegenerative disorders through the modulation of the polyamine pathway |
| KR101033196B1 (ko) | 2002-02-14 | 2011-05-09 | 이뮤노메딕스, 인코오포레이티드 | 항-ｃｄ20 항체 및 그 융합 단백질 및 이들의 이용방법 |
| US7438910B2 (en) | 2002-09-06 | 2008-10-21 | Amgen Inc. | Therapeutic human anti-IL1-R1 monoclonal antibody |
| JP4450644B2 (ja) | 2003-03-03 | 2010-04-14 | 日本化薬株式会社 | Ａｍｆ類を有効成分とする医薬製剤 |
| US20040224893A1 (en) | 2003-05-06 | 2004-11-11 | Li-Hsien Wang | Methods of using IL-1 antagonists to treat neointimal hyperplasia |
| KR100493102B1 (ko) | 2003-06-30 | 2005-06-02 | 삼성전자주식회사 | 서브 하우징 스토퍼를 구비하는 휴대용 단말기의 힌지 장치 |
| HN2004000285A (es) | 2003-08-04 | 2006-04-27 | Pfizer Prod Inc | ANTICUERPOS DIRIGIDOS A c-MET |
| US7799327B2 (en) | 2003-12-24 | 2010-09-21 | Henry John Smith | Autoantibodies utilized as carrier agents for pharmaceutical compounds used in cancer treatment |
| US7105183B2 (en) | 2004-02-03 | 2006-09-12 | The Regents Of The University Of California | Chlorite in the treatment of neurodegenerative disease |
| US8957056B2 (en) | 2004-05-25 | 2015-02-17 | Sloan-Kettering Instiute For Cancer Research | Migrastatin analogs in the treatment of cancer |
| JP5022216B2 (ja) * | 2004-06-04 | 2012-09-12 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | 自己炎症性疾患を処置するためのｉｌ−１アンタゴニストを使用する方法 |
| US20050276807A1 (en) | 2004-06-15 | 2005-12-15 | Advanced Biotherapy, Inc. | Treatment of acne |
| US7718674B2 (en) | 2004-09-27 | 2010-05-18 | Bridge Pharma, Inc. | Methods of relieving neuropathic pain with the S-isomer of 2-{2[N-(2-indanyl)-N-phenylamino]ethyl}piperidine |
| KR101281501B1 (ko) | 2004-12-09 | 2013-07-15 | 얀센 바이오테크 인코포레이티드 | 항인테그린 면역 컨쥬게이트, 방법 및 용도 |
| ES2346691T3 (es) | 2005-08-02 | 2010-10-19 | Xbiotech, Inc | Diagnostico, tratamiento y prevencion de trastornos vasculares usando autoanticuerpos il-1alfa. |
| US20090215992A1 (en) | 2005-08-19 | 2009-08-27 | Chengbin Wu | Dual variable domain immunoglobulin and uses thereof |
| US7612181B2 (en) | 2005-08-19 | 2009-11-03 | Abbott Laboratories | Dual variable domain immunoglobulin and uses thereof |
| JP5312028B2 (ja) | 2005-09-28 | 2013-10-09 | サイトス バイオテクノロジー アーゲー | インターロイキン−１コンジュゲート及びその使用 |
| BRPI0709977A2 (pt) | 2006-04-14 | 2011-08-02 | Novartis Ag | uso de anticorpos de il-1 para o tratamento de distúrbios oftálmicos |
| US20090191149A1 (en) | 2006-05-15 | 2009-07-30 | Xbiotech Inc. | IL-1alpha IMMUNIZATION INDUCES AUTOANTIBODIES PROTECTIVE AGAINST ATHEROSCLEROSIS |
| US20110008282A1 (en) | 2006-05-15 | 2011-01-13 | Xbiotech, Inc. | IL-1alpha immunization induces autoantibodies protective against atherosclerosis |
| SI2109623T1 (sl) | 2006-05-22 | 2012-05-31 | Xbiotech Inc | Zdravljenje raka z anti il protitelesi |
| US8524865B2 (en) | 2006-05-30 | 2013-09-03 | Genentech, Inc. | Antibodies and immunoconjugates and uses therefor |
| FR2902659A1 (fr) | 2006-06-23 | 2007-12-28 | Pierre Fabre Medicament Sa | Ester de dha et son utilisation dans le traitement et la prevention des maladies cardiovasculaires |
| US8324350B2 (en) | 2006-12-29 | 2012-12-04 | Abbott Laboratories | Dual-specific IL-1α/IL-1β antibodies |
| EP3632444A3 (en) | 2008-04-15 | 2020-08-26 | SARcode Bioscience Inc. | Topical lfa-1 antagonists for use in localized treatment of immune related disorders |
| JP5670318B2 (ja) * | 2008-05-30 | 2015-02-18 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | インターロイキン１α抗体及び有用な方法 |
| JP5976319B2 (ja) | 2008-09-12 | 2016-08-23 | エックスバイオテク, インコーポレイテッドXbiotech, Inc. | 病原性単球の標的化 |
| RU2517181C2 (ru) | 2008-10-16 | 2014-05-27 | Орто-Макнейл-Янссен Фармасьютикалз, Инк. | Производные индола и бензоморфолина в качестве модулятора метаботропных глутаматных рецепторов |
| BRPI1007371A2 (pt) | 2009-01-29 | 2018-03-27 | Abbott Lab | proteínas de ligação a il-1 |
| UY32949A (es) | 2009-10-15 | 2011-02-28 | Abbott Lab | Proteínas de unión a il-1 |
| RS57543B1 (sr) | 2010-06-03 | 2018-10-31 | Abbvie Biotechnology Ltd | Primene i kompozicije za lečenje hidradenitis suppurativa (hs) |
| KR20130098279A (ko) | 2010-06-18 | 2013-09-04 | 엑스바이오테크, 인크. | 관절염 치료 |
| KR20210128021A (ko) | 2010-08-23 | 2021-10-25 | 얀센 바이오테크 인코포레이티드 | 종양성 질병들에 대한 치료 |
| NZ607510A (en) | 2010-09-10 | 2014-10-31 | Apexigen Inc | Anti-il-1 beta antibodies and methods of use |
| KR101962483B1 (ko) * | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| US20120275996A1 (en) | 2010-12-21 | 2012-11-01 | Abbott Laboratories | IL-1 Binding Proteins |
| RU2013145283A (ru) * | 2011-03-14 | 2015-04-20 | Флого АпС | Новые антагонисты рецептора интерлейкина-1 |
| US9724409B2 (en) | 2011-04-01 | 2017-08-08 | Xbiotech, Inc. | Treatment of inflammatory skin disease |
| ES2697056T3 (es) | 2011-04-01 | 2019-01-21 | Xbiotech Inc | Tratamiento para patologías dermatológicas |
| US8790651B2 (en) * | 2011-07-21 | 2014-07-29 | Zoetis Llc | Interleukin-31 monoclonal antibody |
| CN103906536A (zh) | 2011-09-23 | 2014-07-02 | 埃克斯生物科技公司 | 恶病质治疗 |
| US20130195877A1 (en) | 2012-01-31 | 2013-08-01 | Xbiotech, Inc. | Treatment of cachexia by targeting interleukin-1 beta |
| US9545441B2 (en) | 2012-09-18 | 2017-01-17 | Xbiotech, Inc. | Treatment of diabetes |
| WO2014055544A1 (en) | 2012-10-04 | 2014-04-10 | Xbiotech, Inc. | Treating vascular disease and complications thereof |
| AU2013327498B2 (en) * | 2012-10-04 | 2018-06-28 | Janssen Biotech, Inc. | Treatment of psychiatric conditions |
| EP2975054A4 (en) * | 2013-03-12 | 2016-11-23 | Zenyaku Kogyo Kk | ANTIBODIES TO STAPHYLOKOKEN, METHOD FOR THE PRODUCTION THEREOF AND USE THEREOF |
| US20150024031A1 (en) | 2013-07-17 | 2015-01-22 | Baxter International Inc. | Methods And Compositions For Reducing Pain, Inflammation, And/Or Immunological Reactions Associated With Parenterally Administering A Primary Therapeutic Agent |
| EP3154584B1 (en) | 2014-06-03 | 2021-08-04 | XBiotech Inc. | Compositions and methods for treating and preventing staphylococcus aureus infections |
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- 2018-02-16 EP EP18753575.2A patent/EP3582813A4/en not_active Withdrawn
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| EP3582813A4 (en) | 2020-12-30 |
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| JP2022188083A (ja) | 2022-12-20 |
| US20220127353A1 (en) | 2022-04-28 |
| IL268569A (en) | 2019-09-26 |
| RU2019127384A (ru) | 2021-03-16 |
| CA3053231A1 (en) | 2018-08-23 |
| EP3582813A1 (en) | 2019-12-25 |
| US20210179704A1 (en) | 2021-06-17 |
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| US20180230211A1 (en) | 2018-08-16 |
| US11225517B2 (en) | 2022-01-18 |
| US20240025989A1 (en) | 2024-01-25 |
| JP7145162B2 (ja) | 2022-09-30 |
| SG11201907159SA (en) | 2019-09-27 |
| WO2018150265A1 (en) | 2018-08-23 |
| US20190389946A1 (en) | 2019-12-26 |
| RU2019127384A3 (enExample) | 2021-06-04 |
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