KR20190076041A - Ror 감마 조정제 - Google Patents
Ror 감마 조정제 Download PDFInfo
- Publication number
- KR20190076041A KR20190076041A KR1020197016350A KR20197016350A KR20190076041A KR 20190076041 A KR20190076041 A KR 20190076041A KR 1020197016350 A KR1020197016350 A KR 1020197016350A KR 20197016350 A KR20197016350 A KR 20197016350A KR 20190076041 A KR20190076041 A KR 20190076041A
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- South Korea
- Prior art keywords
- substituted
- alkyl
- hydrogen
- phenyl
- independently
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 0 Nc1cccc(N)c1-c1ccc([C@](C*2)[C@](Cc3cccc4c3cccc4)C2C2=CCCC2)cc1 Chemical compound Nc1cccc(N)c1-c1ccc([C@](C*2)[C@](Cc3cccc4c3cccc4)C2C2=CCCC2)cc1 0.000 description 2
- KFOJBUYRYFISAX-UHFFFAOYSA-N C=C(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)cc(Br)c1F)(=O)=O Chemical compound C=C(c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)S(c(cc1)cc(Br)c1F)(=O)=O KFOJBUYRYFISAX-UHFFFAOYSA-N 0.000 description 1
- LTAVXAHRGINEMM-PGRDOPGGSA-N CC(C)(C)OC(N(C[C@H]([C@@]1(C)c2ccccc2)c(cc2)ccc2Br)C1=O)=O Chemical compound CC(C)(C)OC(N(C[C@H]([C@@]1(C)c2ccccc2)c(cc2)ccc2Br)C1=O)=O LTAVXAHRGINEMM-PGRDOPGGSA-N 0.000 description 1
- QLCHXHFFVBNWKF-MUAVYFROSA-N CC(N(CC1)CCN1C(N(C[C@H]1c2ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc3)c3F)cc2)C[C@H]1S(c(cc1)cc(Br)c1F)(=O)=O)=O)=O Chemical compound CC(N(CC1)CCN1C(N(C[C@H]1c2ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc3)c3F)cc2)C[C@H]1S(c(cc1)cc(Br)c1F)(=O)=O)=O)=O QLCHXHFFVBNWKF-MUAVYFROSA-N 0.000 description 1
- SEPUSTOWQJQTLO-QVWWMRLHSA-N CC(N(CC1)CCN1C(N(C[C@H]1c2ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc3)c3F)cc2)C[C@H]1S(c(cc1)cc(C2CC2)c1F)(=O)=O)=O)=O Chemical compound CC(N(CC1)CCN1C(N(C[C@H]1c2ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc3)c3F)cc2)C[C@H]1S(c(cc1)cc(C2CC2)c1F)(=O)=O)=O)=O SEPUSTOWQJQTLO-QVWWMRLHSA-N 0.000 description 1
- RORJOIXUJCZLMO-UHFFFAOYSA-N CCOC(C(C(CN)c(cc1)ccc1Br)c(cc1)ccc1F)=O Chemical compound CCOC(C(C(CN)c(cc1)ccc1Br)c(cc1)ccc1F)=O RORJOIXUJCZLMO-UHFFFAOYSA-N 0.000 description 1
- KDLMESCMNCRUPU-UHFFFAOYSA-N CCOC(C(C(C[N+]([O-])=O)c(cc1)ccc1Br)c(cc1)ccc1F)=O Chemical compound CCOC(C(C(C[N+]([O-])=O)c(cc1)ccc1Br)c(cc1)ccc1F)=O KDLMESCMNCRUPU-UHFFFAOYSA-N 0.000 description 1
- UHSNAOFRKKUVFA-NZQKXSOJSA-N CC[C@](CN(C1)C(OC(C)(C)C)=O)([C@@H]1c(cc1)ccc1Br)c1ccccc1 Chemical compound CC[C@](CN(C1)C(OC(C)(C)C)=O)([C@@H]1c(cc1)ccc1Br)c1ccccc1 UHSNAOFRKKUVFA-NZQKXSOJSA-N 0.000 description 1
- YRSGQLIINQKVHZ-WMZHIEFXSA-N C[C@](CNC1)([C@@H]1c(cc1)ccc1-c(c(F)ccc1)c1F)c(cc1)ccc1F Chemical compound C[C@](CNC1)([C@@H]1c(cc1)ccc1-c(c(F)ccc1)c1F)c(cc1)ccc1F YRSGQLIINQKVHZ-WMZHIEFXSA-N 0.000 description 1
- KVLGRJMEOCZWOI-HOYKHHGWSA-N Fc1cccc(F)c1-c1cc(-c2c(C[C@H]3[C@H]4CNC3)c(cccc3)c3cc2)c4cc1 Chemical compound Fc1cccc(F)c1-c1cc(-c2c(C[C@H]3[C@H]4CNC3)c(cccc3)c3cc2)c4cc1 KVLGRJMEOCZWOI-HOYKHHGWSA-N 0.000 description 1
- UNNNSSSZULOEPR-UHFFFAOYSA-N O=C(N(CC1)CC1c1ccccc1)Cl Chemical compound O=C(N(CC1)CC1c1ccccc1)Cl UNNNSSSZULOEPR-UHFFFAOYSA-N 0.000 description 1
- FAQWEVBLCRDLDT-ZHACJKMWSA-N O=S(/C=C/c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)(c(cc1Br)ccc1F)=O Chemical compound O=S(/C=C/c1ccc(C(C(F)(F)F)(C(F)(F)F)OCc(c(F)ccc2)c2F)cc1)(c(cc1Br)ccc1F)=O FAQWEVBLCRDLDT-ZHACJKMWSA-N 0.000 description 1
- CUXMXWCMIDZEOK-UHFFFAOYSA-N OC(C(F)(F)F)(C(F)(F)F)c1ccc(CS(c(cc2Br)ccc2F)(=O)=O)cc1 Chemical compound OC(C(F)(F)F)(C(F)(F)F)c1ccc(CS(c(cc2Br)ccc2F)(=O)=O)cc1 CUXMXWCMIDZEOK-UHFFFAOYSA-N 0.000 description 1
- TVLDDSRTNBHFOV-NPGWBMRXSA-N OC(C(F)(F)F)(C(F)(F)F)c1ccc([C@H]2[C@H](Cc3c(cccc4)c4ccc3)C(C3=CC=CC3)NC2)cc1 Chemical compound OC(C(F)(F)F)(C(F)(F)F)c1ccc([C@H]2[C@H](Cc3c(cccc4)c4ccc3)C(C3=CC=CC3)NC2)cc1 TVLDDSRTNBHFOV-NPGWBMRXSA-N 0.000 description 1
- UFZXWMPAZINOKM-ZCYQVOJMSA-N OC[C@](CN(C1)C(NCc2ccccc2)=O)([C@@H]1c1ccc(C(C(F)(F)F)(C(F)(F)F)O)cc1)c(cc1)ccc1F Chemical compound OC[C@](CN(C1)C(NCc2ccccc2)=O)([C@@H]1c1ccc(C(C(F)(F)F)(C(F)(F)F)O)cc1)c(cc1)ccc1F UFZXWMPAZINOKM-ZCYQVOJMSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4155—1,2-Diazoles non condensed and containing further heterocyclic rings
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
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- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K31/4965—Non-condensed pyrazines
- A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
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- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/08—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
- C07D407/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- C—CHEMISTRY; METALLURGY
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/08—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing alicyclic rings
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662420182P | 2016-11-10 | 2016-11-10 | |
| US62/420,182 | 2016-11-10 | ||
| US201662433425P | 2016-12-13 | 2016-12-13 | |
| US62/433,425 | 2016-12-13 | ||
| PCT/US2017/060507 WO2018089406A1 (en) | 2016-11-10 | 2017-11-08 | Ror gamma modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20190076041A true KR20190076041A (ko) | 2019-07-01 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197016350A Withdrawn KR20190076041A (ko) | 2016-11-10 | 2017-11-08 | Ror 감마 조정제 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US11078186B2 (enExample) |
| EP (1) | EP3538522A1 (enExample) |
| JP (1) | JP2019534301A (enExample) |
| KR (1) | KR20190076041A (enExample) |
| CN (1) | CN110167930A (enExample) |
| MA (1) | MA46760A (enExample) |
| WO (1) | WO2018089406A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP7014795B2 (ja) * | 2016-12-13 | 2022-02-01 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | Rorガンマのモデュレーターとしての化合物 |
| US11034669B2 (en) | 2018-11-30 | 2021-06-15 | Nuvation Bio Inc. | Pyrrole and pyrazole compounds and methods of use thereof |
| CN109761863B (zh) * | 2019-01-19 | 2020-10-02 | 湘潭大学 | (e)-(2-(苯基磺酰基)乙烯基)苯及其衍生物及合成方法 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US2852526A (en) * | 1955-05-03 | 1958-09-16 | Schering Corp | Substituted pyrrolidines |
| JPS5821622B2 (ja) * | 1973-02-28 | 1983-05-02 | ウェルファイド株式会社 | ピロリジンメタノ−ル ノ セイゾウホウ |
| JP3637974B2 (ja) * | 1993-03-25 | 2005-04-13 | エーザイ株式会社 | ピロリジン誘導体 |
| US5665754A (en) * | 1993-09-20 | 1997-09-09 | Glaxo Wellcome Inc. | Substituted pyrrolidines |
| CN105209457A (zh) * | 2013-03-15 | 2015-12-30 | 艾伯维德国有限责任两合公司 | 吡咯烷衍生物,含有其的药物组合物及其在治疗中的用途 |
| ES2669208T3 (es) * | 2014-01-06 | 2018-05-24 | Bristol-Myers Squibb Company | Derivados de pirrolidinilsulfona y su uso como moduladores de ROR gamma |
-
2017
- 2017-11-08 CN CN201780082798.0A patent/CN110167930A/zh active Pending
- 2017-11-08 MA MA046760A patent/MA46760A/fr unknown
- 2017-11-08 WO PCT/US2017/060507 patent/WO2018089406A1/en not_active Ceased
- 2017-11-08 KR KR1020197016350A patent/KR20190076041A/ko not_active Withdrawn
- 2017-11-08 US US16/348,195 patent/US11078186B2/en active Active
- 2017-11-08 JP JP2019524149A patent/JP2019534301A/ja not_active Withdrawn
- 2017-11-08 EP EP17808660.9A patent/EP3538522A1/en not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| EP3538522A1 (en) | 2019-09-18 |
| MA46760A (fr) | 2021-06-02 |
| CN110167930A (zh) | 2019-08-23 |
| US20200024257A1 (en) | 2020-01-23 |
| JP2019534301A (ja) | 2019-11-28 |
| US11078186B2 (en) | 2021-08-03 |
| WO2018089406A1 (en) | 2018-05-17 |
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