KR20190007517A - 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 - Google Patents
치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 Download PDFInfo
- Publication number
- KR20190007517A KR20190007517A KR1020197000258A KR20197000258A KR20190007517A KR 20190007517 A KR20190007517 A KR 20190007517A KR 1020197000258 A KR1020197000258 A KR 1020197000258A KR 20197000258 A KR20197000258 A KR 20197000258A KR 20190007517 A KR20190007517 A KR 20190007517A
- Authority
- KR
- South Korea
- Prior art keywords
- substituent group
- group
- substituted
- compound
- alkyl
- Prior art date
Links
- 0 *c1c(*)c(Cc2ccccc2NC2)c2c(*)c1* Chemical compound *c1c(*)c(Cc2ccccc2NC2)c2c(*)c1* 0.000 description 1
- ZTNVYCIKQPQLIP-VOTSOKGWSA-N CC(C)/C(/C)=N/C Chemical compound CC(C)/C(/C)=N/C ZTNVYCIKQPQLIP-VOTSOKGWSA-N 0.000 description 1
- GATYZYSJMIZJSS-UHFFFAOYSA-N COC(c(c(CSc1ccccc1)c1)ccc1F)=O Chemical compound COC(c(c(CSc1ccccc1)c1)ccc1F)=O GATYZYSJMIZJSS-UHFFFAOYSA-N 0.000 description 1
- GHXSJDJRQWTFFT-UHFFFAOYSA-N COC(c(c(C[Br]=C)c1)ccc1F)=O Chemical compound COC(c(c(C[Br]=C)c1)ccc1F)=O GHXSJDJRQWTFFT-UHFFFAOYSA-N 0.000 description 1
- QHSXWHBYKZRILY-UHFFFAOYSA-N O=C1c(cccc2)c2SCc2cc(F)ccc12 Chemical compound O=C1c(cccc2)c2SCc2cc(F)ccc12 QHSXWHBYKZRILY-UHFFFAOYSA-N 0.000 description 1
- KJFGARCEIKWDDX-UHFFFAOYSA-N OC(c(c(CSc1ccccc1)c1)ccc1F)=O Chemical compound OC(c(c(CSc1ccccc1)c1)ccc1F)=O KJFGARCEIKWDDX-UHFFFAOYSA-N 0.000 description 1
- VJWTVMYNFPBIRE-UHFFFAOYSA-N OC1c(cccc2)c2SCc2c1ccc(F)c2 Chemical compound OC1c(cccc2)c2SCc2c1ccc(F)c2 VJWTVMYNFPBIRE-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
- A61K9/1623—Sugars or sugar alcohols, e.g. lactose; Derivatives thereof; Homeopathic globules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/20—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/22—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
- C07D513/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Pulmonology (AREA)
- Dermatology (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Otolaryngology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JPJP-P-2016-157732 | 2016-08-10 | ||
JP2016157732 | 2016-08-10 | ||
PCT/JP2017/028923 WO2018030463A1 (ja) | 2016-08-10 | 2017-08-09 | 置換された多環性ピリドン誘導体およびそのプロドラッグを含有する医薬組成物 |
Related Child Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020197000494A Division KR20190018469A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
KR1020197000492A Division KR20190014086A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20190007517A true KR20190007517A (ko) | 2019-01-22 |
Family
ID=61020748
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020197000258A KR20190007517A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
KR1020197000492A KR20190014086A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
KR1020197000494A KR20190018469A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
Family Applications After (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020197000492A KR20190014086A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
KR1020197000494A KR20190018469A (ko) | 2016-08-10 | 2017-08-09 | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 |
Country Status (21)
Country | Link |
---|---|
US (3) | US10759814B2 (de) |
EP (1) | EP3498281A4 (de) |
JP (2) | JP6249434B1 (de) |
KR (3) | KR20190007517A (de) |
CN (1) | CN110494141A (de) |
AR (1) | AR109315A1 (de) |
AU (2) | AU2017310774B2 (de) |
BR (1) | BR112019001911A2 (de) |
CA (1) | CA3033180C (de) |
CL (2) | CL2019000325A1 (de) |
CR (1) | CR20190123A (de) |
IL (1) | IL264709B2 (de) |
MA (1) | MA45939A (de) |
MX (2) | MX2019001640A (de) |
PE (1) | PE20190662A1 (de) |
RU (1) | RU2727962C1 (de) |
SG (2) | SG10201912212XA (de) |
TW (2) | TWI663172B (de) |
UA (1) | UA125218C2 (de) |
WO (1) | WO2018030463A1 (de) |
ZA (2) | ZA201900935B (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
MY189144A (en) * | 2015-04-28 | 2022-01-28 | Shionogi & Co | Substituted polycyclic pyridone derivatives and prodrugs thereof |
CR20180356A (es) * | 2015-12-15 | 2018-08-22 | Shionogi & Co | Un medicamento caracterizado por combinar un inhibidor de la endonucleasa cap-dependiente del virus de la influenza y un fármaco anti-influenza |
WO2017153919A1 (en) | 2016-03-08 | 2017-09-14 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
US11261198B2 (en) | 2016-06-20 | 2022-03-01 | Shionogi & Co., Ltd. | Process for preparing substituted polycyclic pyridone derivative and crystal thereof |
AU2017310774B2 (en) * | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
AU2018331172B2 (en) * | 2017-09-18 | 2022-12-01 | Sunshine Lake Pharma Co., Ltd. | Influenza virus replication inhibitor and use thereof |
EP3693373A4 (de) * | 2017-10-06 | 2021-11-03 | Shionogi & Co., Ltd. | Verfahren zur stereoselektiven herstellung von substituierten polycyclischen pyridonderivaten |
CA3088926A1 (en) * | 2018-01-17 | 2019-07-25 | Jiangxi Caishi Pharmaceutical Technology Co., Ltd. | Pyridone derivative, composition and use as antiviral drug thereof |
CN110041327B (zh) * | 2018-01-17 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
CN111303147B (zh) * | 2018-12-12 | 2024-07-02 | 江西彩石医药科技有限公司 | 吡啶酮衍生物、其组合物及作为抗流感病毒药物的应用 |
EP3759113A1 (de) | 2018-02-28 | 2021-01-06 | Novartis AG | 10-(diphenyl)methyl)-4-hydroxy-8,9,9a,10-tetrahydro-7h-pyrrolo [1',2':4,5] pyrazino[1,2-b] pyridazin-3,5-dionderivate und verwandte verbindungen als inhibitoren der orthomyxovirus-replikation zur behandlung von influenza |
CN108440564B (zh) * | 2018-04-11 | 2019-08-06 | 安帝康(无锡)生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
MX2020011130A (es) * | 2018-04-24 | 2022-09-09 | Shionogi & Co | Forma de dosificacion solida que tiene excelente estabilidad. |
BR112020021059B1 (pt) | 2018-04-24 | 2022-08-30 | Shionogi & Co., Ltd | Forma de dosagem sólida |
CN109956956B (zh) * | 2018-05-15 | 2020-07-07 | 广东东阳光药业有限公司 | 一种并环吡啶酮化合物的制备方法 |
CN108558907B (zh) * | 2018-06-01 | 2019-08-09 | 海化生命(厦门)科技有限公司 | 一种关键中间体2的制备方法 |
WO2020020267A1 (zh) * | 2018-07-27 | 2020-01-30 | 深圳市塔吉瑞生物医药有限公司 | 一种取代的多环性吡啶酮化合物及其前药 |
CN110872247A (zh) * | 2018-08-29 | 2020-03-10 | 上海复星星泰医药科技有限公司 | Xofluza含硫杂环化合物、其中间体及制备方法 |
WO2020058745A1 (en) * | 2018-09-18 | 2020-03-26 | Shionogi & Co., Ltd. | Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof |
CN111377944A (zh) * | 2018-12-25 | 2020-07-07 | 广东东阳光药业有限公司 | Baloxavir marboxil晶型及其制备方法 |
WO2020181025A1 (en) | 2019-03-05 | 2020-09-10 | Assia Chemical Industries Ltd | Solid state forms of baloxavir marboxil |
SG11202109050WA (en) | 2019-03-12 | 2021-09-29 | Shionogi & Co | Treating influenza using substituted polycyclic pyridone derivatives and prodrugs thereof in a subject having influenza and a complication risk factor |
EP3714889A1 (de) | 2019-03-29 | 2020-09-30 | F. Hoffmann-La Roche AG | Verbindung und verfahren zur verhinderung der übertragung des influenzavirus |
WO2020205835A1 (en) * | 2019-04-01 | 2020-10-08 | Nikang Therapeutics, Inc. | Fused polycyclic pyridone compounds as influenza virus replication inhibitors |
CN111825699B (zh) * | 2019-04-15 | 2023-02-21 | 上海复星星泰医药科技有限公司 | 含硫杂环化合物及其制备方法 |
RU2720305C1 (ru) * | 2019-05-07 | 2020-04-28 | Андрей Александрович Иващенко | Замещенный 3,4,12,12а-тетрагидро-1Н-[1,4]оксазино[3,4-c]пиридо[2,1-f] [1,2,4]триазин-6,8-дион, фармацевтическая композиция, способы их получения и применения |
CN111909174B (zh) * | 2019-05-08 | 2022-01-21 | 江西彩石医药科技有限公司 | 吡啶酮衍生物的晶型及制备方法和应用 |
CN110105372B (zh) * | 2019-06-05 | 2022-05-10 | 南京焕然生物科技有限公司 | 一种r-7-(苄氧基)-四氢-1h-恶嗪并吡啶并-三嗪-6,8-二酮的制备方法 |
CN114907378A (zh) * | 2019-07-11 | 2022-08-16 | 南京征祥医药有限公司 | 可用于治疗流感病毒感染的化合物 |
CA3146423A1 (en) * | 2019-08-13 | 2021-02-18 | Stefan De Buck | Improved dosage of baloxavir marboxil for pediatric patients |
CN112552315B (zh) * | 2019-09-26 | 2023-05-23 | 北京澳合药物研究院有限公司 | 一种巴洛沙韦玛波酯及其衍生物的纯化方法 |
WO2021057834A1 (zh) * | 2019-09-27 | 2021-04-01 | 广东东阳光药业有限公司 | 一种酯化合物的晶型及其制备方法 |
CN112707862B (zh) * | 2019-10-24 | 2022-09-27 | 广东东阳光药业有限公司 | 一种并环吡啶酮化合物的制备方法 |
CN115175913B (zh) * | 2019-11-13 | 2023-11-28 | 南京知和医药科技有限公司 | 取代的双三环化合物及其药物组合物和用途 |
WO2021129602A1 (zh) * | 2019-12-23 | 2021-07-01 | 石家庄迪斯凯威医药科技有限公司 | 取代的多环化合物及其药物组合物和用途 |
WO2021129799A1 (zh) * | 2019-12-27 | 2021-07-01 | 广东东阳光药业有限公司 | 流感病毒复制抑制剂及其用途 |
CN112898346B (zh) * | 2020-01-23 | 2023-11-10 | 南京知和医药科技有限公司 | 水溶性多环化合物及其药物组合物和用途 |
CN112876510A (zh) * | 2020-02-10 | 2021-06-01 | 石家庄迪斯凯威医药科技有限公司 | 一种磷酸酯类多环化合物及其药物组合物和用途 |
CN111647005A (zh) * | 2020-06-15 | 2020-09-11 | 安徽皓元药业有限公司 | 巴洛沙韦新晶型及其制备方法 |
CN111875619B (zh) * | 2020-07-30 | 2021-06-25 | 深圳市新阳唯康科技有限公司 | 巴洛沙韦酯的晶型及其制备方法 |
CN111961064A (zh) * | 2020-08-25 | 2020-11-20 | 石家庄龙泽制药股份有限公司 | 巴洛沙韦酯的新晶型及其制备方法和应用 |
CN112409379B (zh) * | 2020-09-28 | 2023-07-28 | 长沙晶易医药科技股份有限公司 | 氘代的二氢二苯并硫杂卓化合物以及包含该化合物的药物组合物 |
CN112400801B (zh) * | 2020-12-07 | 2022-07-22 | 天津医科大学第二医院 | 一种喉癌前病变动物模型及其构建方法和应用 |
TW202308646A (zh) * | 2021-05-10 | 2023-03-01 | 大陸商南京征祥醫藥有限公司 | 治療流感化合物的晶型及應用 |
CN117343079A (zh) * | 2022-07-05 | 2024-01-05 | 山东如至生物医药科技有限公司 | 一种新型抗流感病毒化合物及其药物组合物和用途 |
CN116284048B (zh) * | 2023-05-18 | 2023-08-15 | 长沙晶易医药科技股份有限公司 | 一种化合物及其制备方法、药物组合物和用途 |
Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
WO2005016927A1 (ja) | 2003-08-13 | 2005-02-24 | Japan Tobacco Inc. | 含窒素縮合環化合物及びそのhivインテグラーゼ阻害剤としての利用 |
WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
WO2007049675A1 (ja) | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
WO2010147068A1 (ja) | 2009-06-15 | 2010-12-23 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体 |
WO2012039414A1 (ja) | 2010-09-24 | 2012-03-29 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
US20130090300A1 (en) | 2011-07-22 | 2013-04-11 | Joseph D. Bauman | Inhibitors of influenza endonuclease activity and tools for their discovery |
WO2013057251A2 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ag | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2013174930A2 (en) | 2012-05-23 | 2013-11-28 | Savira Pharmaceuticals Gmbh | 7-oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014023691A1 (en) | 2012-08-06 | 2014-02-13 | Savira Pharmaceuticals Gmbh | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014043252A2 (en) | 2012-09-11 | 2014-03-20 | Rutgers, The State University Of New Jersey | Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones |
WO2014074926A1 (en) | 2012-11-09 | 2014-05-15 | Rutgers, The State University Of New Jersey | Therapeutic hydroxyquinolones |
WO2014108407A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Pyridone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014108406A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014108408A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Naphthyridinone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2015038655A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
Family Cites Families (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1830312A (en) * | 1919-05-08 | 1931-11-03 | Westinghouse Lamp Co | Electric lamp |
DE759917T1 (de) * | 1995-02-27 | 1998-10-22 | Gilead Sciences Inc | Neue selektive inhibitoren viraler oder bakterieller neuraminidasen |
US8066108B2 (en) | 2007-09-27 | 2011-11-29 | Air Cruisers Company | Vessel escape slides and associated equipment |
TWI518084B (zh) | 2009-03-26 | 2016-01-21 | 鹽野義製藥股份有限公司 | 哌喃酮與吡啶酮衍生物之製造方法 |
JP5766690B2 (ja) | 2010-04-12 | 2015-08-19 | 塩野義製薬株式会社 | インテグラーゼ阻害活性を有するピリドン誘導体 |
US20130102601A1 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ltd | Pyrimidin-4-one derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2013174931A1 (en) | 2012-05-23 | 2013-11-28 | Savira Pharmaceuticals Gmbh | 7-oxo-4,7 -dihydro- pyrazolo [1, 5 -a] pyrimidine derivatives which are useful in the treatment, amelioration or prevention of a viral disease |
HUE043349T2 (hu) | 2013-09-12 | 2019-08-28 | Janssen Biopharma Inc | Piridazinon vegyületek és ezek alkalmazása |
CA2953862A1 (en) | 2014-07-07 | 2016-01-14 | F. Hoffmann-La Roche Ag | Dihydropyridopyrazine-1,8-diones and their use in the treatment, amelioration or prevention of viral diseases |
CN107001355A (zh) | 2014-07-07 | 2017-08-01 | 萨维拉制药有限公司 | 吡啶并吡嗪化合物和它们在治疗、改善或预防流感中的用途 |
JPWO2016084922A1 (ja) * | 2014-11-28 | 2017-09-07 | 塩野義製薬株式会社 | 1,2,4−トリアジン誘導体およびその医薬組成物 |
MY189144A (en) | 2015-04-28 | 2022-01-28 | Shionogi & Co | Substituted polycyclic pyridone derivatives and prodrugs thereof |
PE20180194A1 (es) * | 2015-04-28 | 2018-01-26 | Shionogi & Co | Derivados de piridona policiclica sustituida y profarmaco de los mismos |
US20170081331A1 (en) | 2015-09-18 | 2017-03-23 | F. Hoffmann-La Roche Ag | Pyrazolopyrazines and their use in the treatment, amelioration or prevention of a viral disease |
US9988390B2 (en) | 2015-10-30 | 2018-06-05 | F. Hoffmann-La Roche Ag | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
CR20180356A (es) * | 2015-12-15 | 2018-08-22 | Shionogi & Co | Un medicamento caracterizado por combinar un inhibidor de la endonucleasa cap-dependiente del virus de la influenza y un fármaco anti-influenza |
WO2017109088A1 (en) | 2015-12-23 | 2017-06-29 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
JP6806413B2 (ja) | 2016-02-03 | 2021-01-06 | 塩野義製薬株式会社 | 多環性ピリドン誘導体およびそのプロドラッグ |
WO2017153919A1 (en) | 2016-03-08 | 2017-09-14 | Novartis Ag | Tricyclic compounds useful to treat orthomyxovirus infections |
WO2017156194A1 (en) | 2016-03-08 | 2017-09-14 | The Regents Of The University Of California | Compositions and methods for inhibiting influenza rna polymerase pa endonuclease |
PL416447A1 (pl) | 2016-03-10 | 2017-09-11 | Międzynarodowy Instytut Biologii Molekularnej i Komórkowej w Warszawie | Inhibitory nukleazy (kompleksu polimerazy) wirusa grypy |
WO2017158147A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2017158151A1 (en) | 2016-03-18 | 2017-09-21 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
US11261198B2 (en) | 2016-06-20 | 2022-03-01 | Shionogi & Co., Ltd. | Process for preparing substituted polycyclic pyridone derivative and crystal thereof |
WO2017223231A1 (en) | 2016-06-21 | 2017-12-28 | Alios Biopharma, Inc. | (s)-8-(benzhydryl )-6-isopropyl-3,5-dioxo- 5, 6,7,8,-tetrahydro-3h-pyrazino-[1,2-b]pyridazin-yl-isobutyrate antiviral agent for use in treating influenza |
AU2017310774B2 (en) * | 2016-08-10 | 2023-01-19 | Shionogi & Co., Ltd. | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof |
JOP20170169A1 (ar) | 2016-08-29 | 2019-01-30 | Novartis Ag | مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو |
CN108440564B (zh) | 2018-04-11 | 2019-08-06 | 安帝康(无锡)生物科技有限公司 | 被取代的多环氨基甲酰基吡啶酮衍生物及其前药 |
-
2017
- 2017-08-09 AU AU2017310774A patent/AU2017310774B2/en active Active
- 2017-08-09 RU RU2019104987A patent/RU2727962C1/ru active
- 2017-08-09 WO PCT/JP2017/028923 patent/WO2018030463A1/ja unknown
- 2017-08-09 KR KR1020197000258A patent/KR20190007517A/ko active Search and Examination
- 2017-08-09 EP EP17839530.7A patent/EP3498281A4/de active Pending
- 2017-08-09 BR BR112019001911-1A patent/BR112019001911A2/pt active Search and Examination
- 2017-08-09 MX MX2019001640A patent/MX2019001640A/es unknown
- 2017-08-09 CN CN201780063164.0A patent/CN110494141A/zh active Pending
- 2017-08-09 AR ARP170102235A patent/AR109315A1/es unknown
- 2017-08-09 SG SG10201912212XA patent/SG10201912212XA/en unknown
- 2017-08-09 KR KR1020197000492A patent/KR20190014086A/ko active Search and Examination
- 2017-08-09 UA UAA201901914A patent/UA125218C2/uk unknown
- 2017-08-09 PE PE2019000351A patent/PE20190662A1/es unknown
- 2017-08-09 MA MA045939A patent/MA45939A/fr unknown
- 2017-08-09 US US16/323,580 patent/US10759814B2/en active Active
- 2017-08-09 KR KR1020197000494A patent/KR20190018469A/ko not_active Application Discontinuation
- 2017-08-09 JP JP2017545688A patent/JP6249434B1/ja active Active
- 2017-08-09 CR CR20190123A patent/CR20190123A/es unknown
- 2017-08-09 CA CA3033180A patent/CA3033180C/en active Active
- 2017-08-09 SG SG11201900869QA patent/SG11201900869QA/en unknown
- 2017-08-10 TW TW106127161A patent/TWI663172B/zh active
- 2017-08-10 TW TW108115903A patent/TWI711621B/zh active
- 2017-10-24 JP JP2017204957A patent/JP6267397B1/ja active Active
-
2019
- 2019-02-07 CL CL2019000325A patent/CL2019000325A1/es unknown
- 2019-02-07 IL IL264709A patent/IL264709B2/en unknown
- 2019-02-08 MX MX2021010629A patent/MX2021010629A/es unknown
- 2019-02-13 ZA ZA2019/00935A patent/ZA201900935B/en unknown
- 2019-12-18 ZA ZA2019/08427A patent/ZA201908427B/en unknown
-
2020
- 2020-07-24 US US16/937,877 patent/US11306106B2/en active Active
- 2020-08-04 CL CL2020002032A patent/CL2020002032A1/es unknown
-
2022
- 2022-03-08 US US17/689,194 patent/US20220281890A1/en not_active Abandoned
-
2023
- 2023-04-17 AU AU2023202350A patent/AU2023202350A1/en active Pending
Patent Citations (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB2280435A (en) | 1993-07-29 | 1995-02-01 | Merck & Co Inc | Anti-viral agent |
US5475109A (en) | 1994-10-17 | 1995-12-12 | Merck & Co., Inc. | Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease |
WO2005016927A1 (ja) | 2003-08-13 | 2005-02-24 | Japan Tobacco Inc. | 含窒素縮合環化合物及びそのhivインテグラーゼ阻害剤としての利用 |
WO2006066414A1 (en) | 2004-12-23 | 2006-06-29 | Virochem Pharma Inc. | Hydroxydihydropyridopy razine-1,8-diones and methods for inhibiting hiv integrase |
WO2007049675A1 (ja) | 2005-10-27 | 2007-05-03 | Shionogi & Co., Ltd. | Hivインテグラーゼ阻害活性を有する多環性カルバモイルピリドン誘導体 |
WO2010147068A1 (ja) | 2009-06-15 | 2010-12-23 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体 |
WO2012039414A1 (ja) | 2010-09-24 | 2012-03-29 | 塩野義製薬株式会社 | 置換された多環性カルバモイルピリドン誘導体のプロドラッグ |
US20130090300A1 (en) | 2011-07-22 | 2013-04-11 | Joseph D. Bauman | Inhibitors of influenza endonuclease activity and tools for their discovery |
WO2013057251A2 (en) | 2011-10-21 | 2013-04-25 | F. Hoffmann-La Roche Ag | Heteroaryl hydroxamic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2013174930A2 (en) | 2012-05-23 | 2013-11-28 | Savira Pharmaceuticals Gmbh | 7-oxo-thiazolopyridine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014023691A1 (en) | 2012-08-06 | 2014-02-13 | Savira Pharmaceuticals Gmbh | Dihydroxypyrimidine carbonic acid derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014043252A2 (en) | 2012-09-11 | 2014-03-20 | Rutgers, The State University Of New Jersey | Therapeutic hydroxypyridinones, hydroxypyrimidinones and hydroxypyridazinones |
WO2014074926A1 (en) | 2012-11-09 | 2014-05-15 | Rutgers, The State University Of New Jersey | Therapeutic hydroxyquinolones |
WO2014108407A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Pyridone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014108406A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Pyrimidone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2014108408A1 (en) | 2013-01-08 | 2014-07-17 | Savira Pharmaceuticals Gmbh | Naphthyridinone derivatives and their use in the treatment, amelioration or prevention of a viral disease |
WO2015038655A1 (en) | 2013-09-12 | 2015-03-19 | Alios Biopharma, Inc. | Aza-pyridone compounds and uses thereof |
Non-Patent Citations (4)
Title |
---|
Antimicrobial Agents And Chemotherapy, Dec. 1994, p.2827-2837 |
Antimicrobial Agents And Chemotherapy, May 1996, p.1304-1307 |
Tetrahedron Lett 1995, 36(12), 2005 |
Tetrahedron Lett 1995, 36(12), 2009 |
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
KR20190007517A (ko) | 치환된 다환성 피리돈 유도체 및 그의 프로드러그를 함유하는 의약 조성물 | |
KR101981912B1 (ko) | 치환된 다환성 피리돈 유도체 및 그의 프로드러그 | |
KR102084109B1 (ko) | 캡 의존적 엔도뉴클레아제 저해제 및 항인플루엔자 약을 조합하는 것을 특징으로 하는 인플루엔자 치료용 의약 | |
JP6806413B2 (ja) | 多環性ピリドン誘導体およびそのプロドラッグ | |
KR20190049916A (ko) | 치환된 다환성 피리돈 유도체 및 그의 프로드러그 | |
JP2019059697A (ja) | 置換された多環性ピリダジン誘導体およびそのプロドラッグ | |
NZ791086A (en) | Substituted polycyclic pyridone derivative and pharmaceutical composition containing prodrug thereof | |
WO2023033018A1 (ja) | Hiv複製阻害作用を有する縮合複素環誘導体 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
A201 | Request for examination | ||
A302 | Request for accelerated examination | ||
AMND | Amendment | ||
E902 | Notification of reason for refusal | ||
AMND | Amendment | ||
E601 | Decision to refuse application | ||
X091 | Application refused [patent] | ||
AMND | Amendment | ||
J201 | Request for trial against refusal decision | ||
J301 | Trial decision |
Free format text: TRIAL NUMBER: 2019101002647; TRIAL DECISION FOR APPEAL AGAINST DECISION TO DECLINE REFUSAL REQUESTED 20190806 Effective date: 20200204 |
|
J121 | Written withdrawal of request for trial |