KR20180132861A - Bet 단백질 분해제 - Google Patents

Bet 단백질 분해제 Download PDF

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Publication number
KR20180132861A
KR20180132861A KR1020187032621A KR20187032621A KR20180132861A KR 20180132861 A KR20180132861 A KR 20180132861A KR 1020187032621 A KR1020187032621 A KR 1020187032621A KR 20187032621 A KR20187032621 A KR 20187032621A KR 20180132861 A KR20180132861 A KR 20180132861A
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KR
South Korea
Prior art keywords
pharmaceutically acceptable
compound
solvate
acceptable salt
group
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
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KR1020187032621A
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English (en)
Korean (ko)
Inventor
샤오멍 왕
빙 주오
푸밍 쑤
지엔타오 후
롱촨 바이
차오-이에 양
Original Assignee
더 리젠츠 오브 더 유니버시티 오브 미시간
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Publication date
Application filed by 더 리젠츠 오브 더 유니버시티 오브 미시간 filed Critical 더 리젠츠 오브 더 유니버시티 오브 미시간
Publication of KR20180132861A publication Critical patent/KR20180132861A/ko
Abandoned legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0808—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
KR1020187032621A 2016-04-12 2017-04-06 Bet 단백질 분해제 Abandoned KR20180132861A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662321499P 2016-04-12 2016-04-12
US62/321,499 2016-04-12
US201662393888P 2016-09-13 2016-09-13
US62/393,888 2016-09-13
PCT/US2017/026278 WO2017180417A1 (en) 2016-04-12 2017-04-06 Bet protein degraders

Publications (1)

Publication Number Publication Date
KR20180132861A true KR20180132861A (ko) 2018-12-12

Family

ID=58548921

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020187032621A Abandoned KR20180132861A (ko) 2016-04-12 2017-04-06 Bet 단백질 분해제

Country Status (15)

Country Link
US (1) US10633386B2 (cg-RX-API-DMAC10.html)
EP (1) EP3442976B1 (cg-RX-API-DMAC10.html)
JP (1) JP7072519B2 (cg-RX-API-DMAC10.html)
KR (1) KR20180132861A (cg-RX-API-DMAC10.html)
CN (1) CN109311890B (cg-RX-API-DMAC10.html)
AU (1) AU2017250076B2 (cg-RX-API-DMAC10.html)
BR (1) BR112018070859A2 (cg-RX-API-DMAC10.html)
CA (1) CA3020541A1 (cg-RX-API-DMAC10.html)
IL (1) IL262139B (cg-RX-API-DMAC10.html)
MX (1) MX384905B (cg-RX-API-DMAC10.html)
RU (1) RU2752677C2 (cg-RX-API-DMAC10.html)
SG (1) SG11201808729WA (cg-RX-API-DMAC10.html)
UA (1) UA123168C2 (cg-RX-API-DMAC10.html)
WO (1) WO2017180417A1 (cg-RX-API-DMAC10.html)
ZA (1) ZA201806969B (cg-RX-API-DMAC10.html)

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RU2018139537A (ru) 2020-05-14
RU2018139537A3 (cg-RX-API-DMAC10.html) 2020-08-11
JP2019511528A (ja) 2019-04-25
RU2752677C2 (ru) 2021-07-29
IL262139A (en) 2018-11-29
AU2017250076A1 (en) 2018-11-08
UA123168C2 (uk) 2021-02-24
MX2018012379A (es) 2019-07-04
EP3442976A1 (en) 2019-02-20
US20190169195A1 (en) 2019-06-06
CN109311890A (zh) 2019-02-05
US10633386B2 (en) 2020-04-28
AU2017250076B2 (en) 2021-07-22
SG11201808729WA (en) 2018-11-29
CA3020541A1 (en) 2017-10-19
ZA201806969B (en) 2019-12-18
IL262139B (en) 2021-05-31
EP3442976B1 (en) 2022-07-20
JP7072519B2 (ja) 2022-05-20
WO2017180417A1 (en) 2017-10-19
BR112018070859A2 (pt) 2019-02-05
CN109311890B (zh) 2021-08-31
MX384905B (es) 2025-03-14

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