KR20180093063A - 다능성 줄기 세포-유래 인간 장 신경관 계통에 의해 구현되는 히르슈슈프룽병에서의 세포-기반 치료 및 약물 발견 - Google Patents

다능성 줄기 세포-유래 인간 장 신경관 계통에 의해 구현되는 히르슈슈프룽병에서의 세포-기반 치료 및 약물 발견 Download PDF

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KR20180093063A
KR20180093063A KR1020187020591A KR20187020591A KR20180093063A KR 20180093063 A KR20180093063 A KR 20180093063A KR 1020187020591 A KR1020187020591 A KR 1020187020591A KR 20187020591 A KR20187020591 A KR 20187020591A KR 20180093063 A KR20180093063 A KR 20180093063A
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로렌즈 스튜더
파라나크 파타히
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메모리얼 슬로안-케터링 캔서 센터
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KR1020187020591A 2015-12-23 2016-12-22 다능성 줄기 세포-유래 인간 장 신경관 계통에 의해 구현되는 히르슈슈프룽병에서의 세포-기반 치료 및 약물 발견 Ceased KR20180093063A (ko)

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US201562387468P 2015-12-23 2015-12-23
US62/387,468 2015-12-23
PCT/US2016/068430 WO2017112901A1 (en) 2015-12-23 2016-12-22 Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages

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US (1) US12371662B2 (https=)
EP (1) EP3414322A4 (https=)
JP (2) JP7549442B2 (https=)
KR (1) KR20180093063A (https=)
CN (1) CN108699528A (https=)
AU (2) AU2016377701B2 (https=)
CA (1) CA3009509A1 (https=)
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AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
KR20180105236A (ko) * 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
JP7094567B2 (ja) * 2017-04-27 2022-07-04 国立大学法人京都大学 神経堤細胞および交感神経細胞の製造方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CN108559726A (zh) * 2017-12-28 2018-09-21 上海安集协康生物技术股份有限公司 一种对脑损伤类疾病有治疗作用的细胞亚群及其制备方法
AU2019258575A1 (en) 2018-04-27 2020-10-29 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
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WO2020040166A1 (ja) * 2018-08-22 2020-02-27 国立大学法人京都大学 腸管神経前駆細胞の製造方法
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
AU2019401518B2 (en) * 2018-12-21 2026-02-26 The Regents Of The University Of California Method of producing enteric neurons and uses thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020263484B2 (en) * 2019-04-24 2026-04-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nociceptor differentiation from human pluripotent stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN110747276B (zh) * 2019-11-22 2020-06-30 山东大学齐鲁医院 Bace2作为胶质瘤预后/诊断/治疗标志物的应用
CA3162011A1 (en) * 2019-12-19 2021-06-24 Rodolphe SORET Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
US20230126711A1 (en) * 2020-03-25 2023-04-27 The Regents Of The University Of California Enteric nitrergic neurons and methods of using the same
WO2022046771A1 (en) * 2020-08-24 2022-03-03 The Johns Hopkins University Juvenile protective factors to arrest and reverse aging in the enteric nervous system
WO2022199682A1 (zh) * 2021-03-26 2022-09-29 广州市妇女儿童医疗中心 先天性巨结肠的诊断或早期诊断标志物及其应用
US20240252545A1 (en) * 2021-05-07 2024-08-01 Children's Hospital Los Angeles Methods for Making Stem Cell-Derived Enteric Neural Crest Cells and Their Use in Enteric Neuropathy Treatment
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WO2017112901A1 (en) 2017-06-29
IL260214B1 (en) 2024-04-01
JP2022095796A (ja) 2022-06-28
AU2016377701B2 (en) 2023-04-06
AU2023204373A1 (en) 2023-08-03
AU2016377701A1 (en) 2018-07-12
CA3009509A1 (en) 2017-06-29
IL260214B2 (en) 2024-08-01
US12371662B2 (en) 2025-07-29
CN108699528A (zh) 2018-10-23
JP2019503679A (ja) 2019-02-14
EP3414322A1 (en) 2018-12-19
IL260214A (en) 2018-07-31
JP7549442B2 (ja) 2024-09-11
US20180291339A1 (en) 2018-10-11
EP3414322A4 (en) 2020-03-04

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