CA3009509A1 - Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages - Google Patents

Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages Download PDF

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CA3009509A1
CA3009509A1 CA3009509A CA3009509A CA3009509A1 CA 3009509 A1 CA3009509 A1 CA 3009509A1 CA 3009509 A CA3009509 A CA 3009509A CA 3009509 A CA3009509 A CA 3009509A CA 3009509 A1 CA3009509 A1 CA 3009509A1
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days
population
cells
neural crest
enteric
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French (fr)
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Lorenz Studer
Faranak FATTAHI
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Memorial Sloan Kettering Cancer Center
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Memorial Sloan Kettering Cancer Center
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0618—Cells of the nervous system
    • C12N5/0619—Neurons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/30—Nerves; Brain; Eyes; Corneal cells; Cerebrospinal fluid; Neuronal stem cells; Neuronal precursor cells; Glial cells; Oligodendrocytes; Schwann cells; Astroglia; Astrocytes; Choroid plexus; Spinal cord tissue
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
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CA3009509A 2015-12-23 2016-12-22 Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages Pending CA3009509A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562387468P 2015-12-23 2015-12-23
US62/387,468 2015-12-23
PCT/US2016/068430 WO2017112901A1 (en) 2015-12-23 2016-12-22 Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages

Publications (1)

Publication Number Publication Date
CA3009509A1 true CA3009509A1 (en) 2017-06-29

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CA3009509A Pending CA3009509A1 (en) 2015-12-23 2016-12-22 Cell-based treatment and drug discovery in hirschsprung's disease enabled by pluripotent stem cell-derived human enteric neural crest lineages

Country Status (9)

Country Link
US (1) US12371662B2 (https=)
EP (1) EP3414322A4 (https=)
JP (2) JP7549442B2 (https=)
KR (1) KR20180093063A (https=)
CN (1) CN108699528A (https=)
AU (2) AU2016377701B2 (https=)
CA (1) CA3009509A1 (https=)
IL (1) IL260214B2 (https=)
WO (1) WO2017112901A1 (https=)

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SG10201801654RA (en) 2014-05-28 2018-04-27 Childrens Hospital Med Ct Methods and systems for converting precursor cells into gastric tissues through directed differentiation
AU2015331848B2 (en) 2014-10-17 2022-03-03 Children's Hospital Medical Center, D/B/A Cincinnati Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
KR20180105236A (ko) * 2016-02-05 2018-09-27 메모리얼 슬로안-케터링 캔서 센터 줄기 세포-유래 외배엽 계통 전구체의 분화 방법
CN109415685B (zh) 2016-05-05 2023-07-04 儿童医院医疗中心 用于体外制造胃底组织的方法和与其相关的组合物
EP4553082A3 (en) 2016-11-04 2025-08-20 Children's Hospital Medical Center Liver organoid compositions and methods of making and using same
EP3548507A4 (en) 2016-12-05 2020-07-15 Children's Hospital Medical Center COLON ORGANOIDS AND PROCESSES FOR THE PREPARATION AND USE THEREOF
JP7248586B2 (ja) 2017-04-14 2023-03-29 チルドレンズ ホスピタル メディカル センター 複数ドナー幹細胞組成物およびそれを作製する方法
JP7094567B2 (ja) * 2017-04-27 2022-07-04 国立大学法人京都大学 神経堤細胞および交感神経細胞の製造方法
EP3694603B1 (en) 2017-10-10 2026-04-08 Children's Hospital Medical Center Esophageal tissue and/or organoid compositions and methods of making same
EP3727394A4 (en) 2017-12-21 2021-09-08 Children's Hospital Medical Center DIGITALIZED HUMAN ORGANOIDS AND METHOD OF USING THEREOF
CN108559726A (zh) * 2017-12-28 2018-09-21 上海安集协康生物技术股份有限公司 一种对脑损伤类疾病有治疗作用的细胞亚群及其制备方法
AU2019258575A1 (en) 2018-04-27 2020-10-29 Shionogi & Co., Ltd. Tetrahydropyranooxazine derivatives having selective BACE1 inhibitory activity
EP4678727A3 (en) 2018-07-26 2026-03-11 Children's Hospital Medical Center Hepato-biliary-pancreatic tissues and methods of making same
WO2020040166A1 (ja) * 2018-08-22 2020-02-27 国立大学法人京都大学 腸管神経前駆細胞の製造方法
CA3112026A1 (en) 2018-09-12 2020-03-19 Children's Hospital Medical Center Organoid compositions for the production of hematopoietic stem cells and derivatives thereof
AU2019401518B2 (en) * 2018-12-21 2026-02-26 The Regents Of The University Of California Method of producing enteric neurons and uses thereof
US12600943B2 (en) 2019-02-01 2026-04-14 The University Of Hong Kong Innervated organoid compositions and methods of making same
AU2020263484B2 (en) * 2019-04-24 2026-04-16 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Nociceptor differentiation from human pluripotent stem cells
AU2020283048A1 (en) 2019-05-31 2021-12-23 Children's Hospital Medical Center Shaped organoid compositions and methods of making same
US12497597B2 (en) 2019-05-31 2025-12-16 Children's Hospital Medical Center Methods of generating and expanding hematopoietic stem cells
CN110747276B (zh) * 2019-11-22 2020-06-30 山东大学齐鲁医院 Bace2作为胶质瘤预后/诊断/治疗标志物的应用
CA3162011A1 (en) * 2019-12-19 2021-06-24 Rodolphe SORET Use of glial cell line-derived neurotrophic factor (gdnf) for the treatment of enteric neuropathies
US20230126711A1 (en) * 2020-03-25 2023-04-27 The Regents Of The University Of California Enteric nitrergic neurons and methods of using the same
WO2022046771A1 (en) * 2020-08-24 2022-03-03 The Johns Hopkins University Juvenile protective factors to arrest and reverse aging in the enteric nervous system
WO2022199682A1 (zh) * 2021-03-26 2022-09-29 广州市妇女儿童医疗中心 先天性巨结肠的诊断或早期诊断标志物及其应用
US20240252545A1 (en) * 2021-05-07 2024-08-01 Children's Hospital Los Angeles Methods for Making Stem Cell-Derived Enteric Neural Crest Cells and Their Use in Enteric Neuropathy Treatment
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Publication number Publication date
WO2017112901A1 (en) 2017-06-29
IL260214B1 (en) 2024-04-01
KR20180093063A (ko) 2018-08-20
JP2022095796A (ja) 2022-06-28
AU2016377701B2 (en) 2023-04-06
AU2023204373A1 (en) 2023-08-03
AU2016377701A1 (en) 2018-07-12
IL260214B2 (en) 2024-08-01
US12371662B2 (en) 2025-07-29
CN108699528A (zh) 2018-10-23
JP2019503679A (ja) 2019-02-14
EP3414322A1 (en) 2018-12-19
IL260214A (en) 2018-07-31
JP7549442B2 (ja) 2024-09-11
US20180291339A1 (en) 2018-10-11
EP3414322A4 (en) 2020-03-04

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