KR20180087463A - 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물 - Google Patents

재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물 Download PDF

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KR20180087463A
KR20180087463A KR1020187021317A KR20187021317A KR20180087463A KR 20180087463 A KR20180087463 A KR 20180087463A KR 1020187021317 A KR1020187021317 A KR 1020187021317A KR 20187021317 A KR20187021317 A KR 20187021317A KR 20180087463 A KR20180087463 A KR 20180087463A
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adamts13
protein
chromatography
sample
buffer
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마인하르트 하슬라허
아르투르 미테러
크리스티안 피에들러
크리스타 마이어
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박스알타 인코퍼레이티드
박스앨타 게엠베하
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    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/12—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by hydrolysis, i.e. solvolysis in general
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
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    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
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    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)

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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020187021317A 2009-07-31 2010-08-02 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물 Ceased KR20180087463A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23030809P 2009-07-31 2009-07-31
US61/230,308 2009-07-31
PCT/EP2010/061192 WO2011012726A2 (en) 2009-07-31 2010-08-02 Method for purifying recombinant adamts13 and other proteins and compositions thereof

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KR1020177022447A Division KR101883610B1 (ko) 2009-07-31 2010-08-02 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물

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KR1020197031048A Division KR20190122272A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물

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KR1020187021317A Ceased KR20180087463A (ko) 2009-07-31 2010-08-02 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020227016072A Ceased KR20220066435A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020197031048A Ceased KR20190122272A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020127004995A Active KR101769634B1 (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020177022447A Active KR101883610B1 (ko) 2009-07-31 2010-08-02 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020237042089A Ceased KR20230170815A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020207036716A Ceased KR20200146042A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물

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KR1020227016072A Ceased KR20220066435A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020197031048A Ceased KR20190122272A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020127004995A Active KR101769634B1 (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020177022447A Active KR101883610B1 (ko) 2009-07-31 2010-08-02 재조합 adamts13 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020237042089A Ceased KR20230170815A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물
KR1020207036716A Ceased KR20200146042A (ko) 2009-07-31 2010-08-02 재조합 ａｄａｍｔｓ１３ 및 기타 단백질을 정제하는 방법, 그리고 이들의 조성물

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EP (3) EP4299735B1 (enExample)
JP (6) JP5907869B2 (enExample)
KR (7) KR20180087463A (enExample)
CN (3) CN107988192A (enExample)
AU (1) AU2010277491B2 (enExample)
CA (2) CA2916508A1 (enExample)
CO (1) CO6612194A2 (enExample)
DK (1) DK2459715T3 (enExample)
EA (3) EA034292B1 (enExample)
ES (3) ES3000382T3 (enExample)
HR (1) HRP20192303T1 (enExample)
HU (1) HUE046909T2 (enExample)
IN (1) IN2012DN00907A (enExample)
LT (1) LT2459715T (enExample)
MX (2) MX2012001263A (enExample)
NZ (2) NZ597756A (enExample)
PL (2) PL3211077T3 (enExample)
PT (1) PT2459715T (enExample)
SG (2) SG178175A1 (enExample)
SI (1) SI2459715T1 (enExample)
WO (1) WO2011012726A2 (enExample)

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