SI2459715T1 - Postopek za čiščenje rekombinantnega ADAMTS13 in drugih proteinov ter sestavkov le-teh - Google Patents

Postopek za čiščenje rekombinantnega ADAMTS13 in drugih proteinov ter sestavkov le-teh

Info

Publication number
SI2459715T1
SI2459715T1 SI201031958T SI201031958T SI2459715T1 SI 2459715 T1 SI2459715 T1 SI 2459715T1 SI 201031958 T SI201031958 T SI 201031958T SI 201031958 T SI201031958 T SI 201031958T SI 2459715 T1 SI2459715 T1 SI 2459715T1
Authority
SI
Slovenia
Prior art keywords
proteins
compositions
purifying recombinant
recombinant adamts13
adamts13
Prior art date
Application number
SI201031958T
Other languages
English (en)
Inventor
Meinhard Hasslacher
Artur Mitterer
Christian Fiedler
Christa Mayer
Original Assignee
Baxalta GmbH
Baxalta Incorporated
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Baxalta GmbH, Baxalta Incorporated filed Critical Baxalta GmbH
Publication of SI2459715T1 publication Critical patent/SI2459715T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6489—Metalloendopeptidases (3.4.24)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/12—Purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N11/00—Carrier-bound or immobilised enzymes; Carrier-bound or immobilised microbial cells; Preparation thereof
    • C12N11/14—Enzymes or microbial cells immobilised on or in an inorganic carrier
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C12N7/06—Inactivation or attenuation by chemical treatment
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24087—ADAMTS13 endopeptidase (3.4.24.87)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Sustainable Development (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
SI201031958T 2009-07-31 2010-08-02 Postopek za čiščenje rekombinantnega ADAMTS13 in drugih proteinov ter sestavkov le-teh SI2459715T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US23030809P 2009-07-31 2009-07-31
EP10737917.4A EP2459715B1 (en) 2009-07-31 2010-08-02 Method for purifying recombinant adamts13 and other proteins and compositions thereof
PCT/EP2010/061192 WO2011012726A2 (en) 2009-07-31 2010-08-02 Method for purifying recombinant adamts13 and other proteins and compositions thereof

Publications (1)

Publication Number Publication Date
SI2459715T1 true SI2459715T1 (sl) 2020-01-31

Family

ID=42588355

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201031958T SI2459715T1 (sl) 2009-07-31 2010-08-02 Postopek za čiščenje rekombinantnega ADAMTS13 in drugih proteinov ter sestavkov le-teh

Country Status (23)

Country Link
US (3) US8945895B2 (sl)
EP (3) EP4299735A3 (sl)
JP (6) JP5907869B2 (sl)
KR (7) KR101769634B1 (sl)
CN (3) CN107267490A (sl)
AU (1) AU2010277491B2 (sl)
BR (1) BR112012002140A2 (sl)
CA (2) CA2769362A1 (sl)
CO (1) CO6612194A2 (sl)
DK (1) DK2459715T3 (sl)
EA (3) EA034292B1 (sl)
ES (1) ES2763207T3 (sl)
HR (1) HRP20192303T1 (sl)
HU (1) HUE046909T2 (sl)
IN (1) IN2012DN00907A (sl)
LT (1) LT2459715T (sl)
MX (2) MX2012001263A (sl)
NZ (2) NZ620988A (sl)
PL (1) PL2459715T3 (sl)
PT (1) PT2459715T (sl)
SG (2) SG178175A1 (sl)
SI (1) SI2459715T1 (sl)
WO (1) WO2011012726A2 (sl)

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Also Published As

Publication number Publication date
MX2012001263A (es) 2012-05-22
HRP20192303T1 (hr) 2020-10-02
JP5907869B2 (ja) 2016-04-26
EP2459715A2 (en) 2012-06-06
US20110081700A1 (en) 2011-04-07
US8945895B2 (en) 2015-02-03
CO6612194A2 (es) 2013-02-01
AU2010277491A1 (en) 2012-02-16
EA201270214A1 (ru) 2012-08-30
NZ597756A (en) 2014-03-28
JP2015147815A (ja) 2015-08-20
ES2763207T3 (es) 2020-05-27
CN107267490A (zh) 2017-10-20
EP3211077A1 (en) 2017-08-30
PL2459715T3 (pl) 2020-04-30
EA023783B1 (ru) 2016-07-29
CN107988192A (zh) 2018-05-04
KR20200146042A (ko) 2020-12-31
EA201500952A1 (ru) 2016-05-31
EP4299735A2 (en) 2024-01-03
JP2018203781A (ja) 2018-12-27
PT2459715T (pt) 2020-01-09
EP2459715B1 (en) 2019-10-02
AU2010277491A2 (en) 2012-06-21
AU2010277491B2 (en) 2015-12-17
JP6216930B2 (ja) 2017-10-25
KR20190122272A (ko) 2019-10-29
SG193855A1 (en) 2013-10-30
BR112012002140A2 (pt) 2015-09-15
JP2016222724A (ja) 2016-12-28
KR20170096061A (ko) 2017-08-23
KR20230170815A (ko) 2023-12-19
CA2769362A1 (en) 2011-02-03
US20230242897A1 (en) 2023-08-03
LT2459715T (lt) 2020-01-10
KR20220066435A (ko) 2022-05-24
JP2021004265A (ja) 2021-01-14
KR101769634B1 (ko) 2017-08-18
EA201992487A1 (ru) 2020-05-31
US20150104849A1 (en) 2015-04-16
MX348178B (es) 2017-05-29
WO2011012726A3 (en) 2011-03-31
HUE046909T2 (hu) 2020-04-28
EA034292B1 (ru) 2020-01-24
WO2011012726A2 (en) 2011-02-03
KR20120053013A (ko) 2012-05-24
JP2022171925A (ja) 2022-11-11
US11661593B2 (en) 2023-05-30
NZ620988A (en) 2015-07-31
KR101883610B1 (ko) 2018-07-30
CA2916508A1 (en) 2011-02-03
DK2459715T3 (da) 2020-01-06
EP4299735A3 (en) 2024-04-24
CN102482660A (zh) 2012-05-30
SG178175A1 (en) 2012-03-29
KR20180087463A (ko) 2018-08-01
IN2012DN00907A (sl) 2015-04-03
JP2013500711A (ja) 2013-01-10

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