SG11202110909XA - Continuous production of recombinant proteins - Google Patents

Continuous production of recombinant proteins

Info

Publication number
SG11202110909XA
SG11202110909XA SG11202110909XA SG11202110909XA SG11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA
Authority
SG
Singapore
Prior art keywords
continuous production
recombinant proteins
recombinant
proteins
continuous
Prior art date
Application number
SG11202110909XA
Inventor
Michael Coolbaugh
Tarl Vetter
Chad Varner
Kevin Brower
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of SG11202110909XA publication Critical patent/SG11202110909XA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2688—Biological processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2697—Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/08—Fully permeating type; Dead-end filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
SG11202110909XA 2019-04-03 2020-04-01 Continuous production of recombinant proteins SG11202110909XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962828755P 2019-04-03 2019-04-03
PCT/US2020/026107 WO2020205928A1 (en) 2019-04-03 2020-04-01 Continuous production of recombinant proteins

Publications (1)

Publication Number Publication Date
SG11202110909XA true SG11202110909XA (en) 2021-10-28

Family

ID=70482780

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202110909XA SG11202110909XA (en) 2019-04-03 2020-04-01 Continuous production of recombinant proteins

Country Status (12)

Country Link
US (1) US11912741B2 (en)
EP (1) EP3947705A1 (en)
JP (1) JP2022519950A (en)
KR (1) KR20210149117A (en)
CN (1) CN113825840A (en)
AU (1) AU2020253381A1 (en)
CA (1) CA3135611A1 (en)
IL (1) IL286745A (en)
MX (1) MX2021012078A (en)
SG (1) SG11202110909XA (en)
TW (1) TW202102519A (en)
WO (1) WO2020205928A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021197249A1 (en) * 2020-03-30 2021-10-07 上海复宏汉霖生物技术股份有限公司 System and method for continuous purification of target molecules
WO2022251261A1 (en) * 2021-05-25 2022-12-01 Boehringer Ingelheim International Gmbh A method and system for integrated and continuous viral filtration, concentration and buffer exchange
WO2022248623A1 (en) * 2021-05-26 2022-12-01 Simabs Nv Integrated continuous bioprocess production platform
WO2023052357A1 (en) * 2021-09-28 2023-04-06 Merck Patent Gmbh Integrated solution for process intensification using inline constantly pressurized tank: "icpt"
WO2023167584A1 (en) * 2022-03-01 2023-09-07 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability
EP4252882A1 (en) * 2022-03-31 2023-10-04 Sartorius Stedim Biotech GmbH Separation system for separating and purifying a target component
US20240101945A1 (en) * 2022-09-28 2024-03-28 Genzyme Corporation Systems and devices for producing biological products and methods of using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2467746C (en) 2001-11-20 2012-10-02 Burcon Nutrascience (Mb) Corp. Continuous process for production of oil seed protein isolate
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
US20130260419A1 (en) * 2010-12-06 2013-10-03 Thomas C. Ransohoff Continuous processing methods for biological products
RU2662929C2 (en) * 2013-03-08 2018-07-31 Джензим Корпорейшн Integrated continuous manufacturing of therapeutic protein drug substances
JP6463734B2 (en) 2013-05-06 2019-02-06 サノフイＳａｎｏｆｉ Continuous multi-step method for purifying antibodies
US8946395B1 (en) * 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
JP2017515501A (en) * 2014-05-02 2017-06-15 ノヴォ ノルディスク アー／エス Integrated continuous biomanufacturing method
AU2015259228B2 (en) * 2014-05-13 2020-04-23 Amgen Inc. Process control systems and methods for use with filters and filtration processes
US9335000B2 (en) * 2014-05-30 2016-05-10 Finesse Solutions, Inc. Aseptic connectors for bio-processing containers
US20170183376A1 (en) * 2014-06-24 2017-06-29 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
RU2021119421A (en) * 2016-08-16 2021-07-13 Джензим Корпорейшн METHODS FOR PROCESSING FLUID MEDIUM CONTAINING RECOMBINANT THERAPEUTIC PROTEIN AND THEIR APPLICATION
US20220348977A1 (en) * 2017-03-09 2022-11-03 Alexion Pharmaceuticals, Inc. Glycoprotein manufacturing process

Also Published As

Publication number Publication date
US11912741B2 (en) 2024-02-27
IL286745A (en) 2021-10-31
JP2022519950A (en) 2022-03-25
KR20210149117A (en) 2021-12-08
US20200317728A1 (en) 2020-10-08
WO2020205928A1 (en) 2020-10-08
CN113825840A (en) 2021-12-21
EP3947705A1 (en) 2022-02-09
MX2021012078A (en) 2022-01-04
TW202102519A (en) 2021-01-16
AU2020253381A1 (en) 2021-12-02
CA3135611A1 (en) 2020-10-08

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