SG11202110909XA - Continuous production of recombinant proteins - Google Patents
Continuous production of recombinant proteinsInfo
- Publication number
- SG11202110909XA SG11202110909XA SG11202110909XA SG11202110909XA SG11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA SG 11202110909X A SG11202110909X A SG 11202110909XA
- Authority
- SG
- Singapore
- Prior art keywords
- continuous production
- recombinant proteins
- recombinant
- proteins
- continuous
- Prior art date
Links
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 title 1
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 title 1
- 238000010924 continuous production Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
- C12P21/005—Glycopeptides, glycoproteins
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
- B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
- B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
- B01D61/145—Ultrafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/58—Multistep processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
- C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
- C12M37/02—Filters
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2688—Biological processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2311/00—Details relating to membrane separation process operations and control
- B01D2311/26—Further operations combined with membrane separation processes
- B01D2311/2697—Chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/08—Fully permeating type; Dead-end filtration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D2315/00—Details relating to the membrane module operation
- B01D2315/16—Diafiltration
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
- B01D61/14—Ultrafiltration; Microfiltration
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
- C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
- C12M47/10—Separation or concentration of fermentation products
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Analytical Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Water Supply & Treatment (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Sustainable Development (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201962828755P | 2019-04-03 | 2019-04-03 | |
PCT/US2020/026107 WO2020205928A1 (en) | 2019-04-03 | 2020-04-01 | Continuous production of recombinant proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11202110909XA true SG11202110909XA (en) | 2021-10-28 |
Family
ID=70482780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11202110909XA SG11202110909XA (en) | 2019-04-03 | 2020-04-01 | Continuous production of recombinant proteins |
Country Status (13)
Country | Link |
---|---|
US (2) | US11912741B2 (en) |
EP (1) | EP3947705A1 (en) |
JP (1) | JP2022519950A (en) |
KR (1) | KR20210149117A (en) |
CN (1) | CN113825840A (en) |
AU (1) | AU2020253381A1 (en) |
BR (1) | BR112021019217A2 (en) |
CA (1) | CA3135611A1 (en) |
IL (1) | IL286745A (en) |
MX (1) | MX2021012078A (en) |
SG (1) | SG11202110909XA (en) |
TW (1) | TW202102519A (en) |
WO (1) | WO2020205928A1 (en) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2021197249A1 (en) * | 2020-03-30 | 2021-10-07 | 上海复宏汉霖生物技术股份有限公司 | System and method for continuous purification of target molecules |
AU2022280018A1 (en) * | 2021-05-25 | 2023-10-12 | Boehringer Ingelheim International Gmbh | A method and system for integrated and continuous viral filtration, concentration and buffer exchange |
WO2022248623A1 (en) * | 2021-05-26 | 2022-12-01 | Simabs Nv | Integrated continuous bioprocess production platform |
CA3233651A1 (en) * | 2021-09-28 | 2023-04-06 | Merck Patent Gmbh | Integrated solution for process intensification using inline constantly pressurized tank: "icpt" |
WO2023167584A1 (en) * | 2022-03-01 | 2023-09-07 | Biosanapharma B.V. | Continuous manufacturing of a biological substance with process traceability |
EP4252882A1 (en) * | 2022-03-31 | 2023-10-04 | Sartorius Stedim Biotech GmbH | Separation system for separating and purifying a target component |
US20240101945A1 (en) * | 2022-09-28 | 2024-03-28 | Genzyme Corporation | Systems and devices for producing biological products and methods of using the same |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20070015910A1 (en) | 2001-11-20 | 2007-01-18 | Barker Larry D | Continuous process for production of oil seed protein isolate |
US8945895B2 (en) * | 2009-07-31 | 2015-02-03 | Baxter International Inc. | Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof |
EP2649016B1 (en) | 2010-12-06 | 2020-06-10 | Pall Corporation | Continuous processing methods for biological products |
SG10201709131UA (en) * | 2013-03-08 | 2017-12-28 | Genzyme Corp | Continuous purification of therapeutic proteins |
BR112015027812B1 (en) * | 2013-05-06 | 2021-03-30 | Sanofi | METHOD FOR PURIFYING A PROTEIN FROM A SOLUTION |
US8946395B1 (en) * | 2013-10-18 | 2015-02-03 | Abbvie Inc. | Purification of proteins using hydrophobic interaction chromatography |
JP2017515501A (en) * | 2014-05-02 | 2017-06-15 | ノヴォ ノルディスク アー/エス | Integrated continuous biomanufacturing method |
IL285529B2 (en) * | 2014-05-13 | 2023-03-01 | Amgen Inc | Process control systems and methods for use with filters and filtration processes |
SG10201806210SA (en) * | 2014-05-30 | 2018-08-30 | Finesse Solutions Inc | Aseptic connectors for bio-processing containers |
WO2015198320A1 (en) * | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
MX2019001859A (en) | 2016-08-16 | 2019-08-29 | Genzyme Corp | Methods of processing a fluid including a recombinant therapeutic protein and use thereof. |
EP3592372A4 (en) * | 2017-03-09 | 2021-01-13 | Alexion Pharmaceuticals, Inc. | Glycoprotein manufacturing process |
-
2020
- 2020-04-01 SG SG11202110909XA patent/SG11202110909XA/en unknown
- 2020-04-01 CN CN202080036857.2A patent/CN113825840A/en active Pending
- 2020-04-01 JP JP2021559051A patent/JP2022519950A/en active Pending
- 2020-04-01 BR BR112021019217A patent/BR112021019217A2/en unknown
- 2020-04-01 WO PCT/US2020/026107 patent/WO2020205928A1/en unknown
- 2020-04-01 TW TW109111192A patent/TW202102519A/en unknown
- 2020-04-01 AU AU2020253381A patent/AU2020253381A1/en active Pending
- 2020-04-01 EP EP20723603.5A patent/EP3947705A1/en active Pending
- 2020-04-01 KR KR1020217035567A patent/KR20210149117A/en active Search and Examination
- 2020-04-01 CA CA3135611A patent/CA3135611A1/en active Pending
- 2020-04-01 US US16/837,126 patent/US11912741B2/en active Active
- 2020-04-01 MX MX2021012078A patent/MX2021012078A/en unknown
-
2021
- 2021-09-27 IL IL286745A patent/IL286745A/en unknown
-
2024
- 2024-01-18 US US18/416,145 patent/US20240150395A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
AU2020253381A1 (en) | 2021-12-02 |
CA3135611A1 (en) | 2020-10-08 |
TW202102519A (en) | 2021-01-16 |
KR20210149117A (en) | 2021-12-08 |
US20200317728A1 (en) | 2020-10-08 |
CN113825840A (en) | 2021-12-21 |
WO2020205928A1 (en) | 2020-10-08 |
JP2022519950A (en) | 2022-03-25 |
EP3947705A1 (en) | 2022-02-09 |
US11912741B2 (en) | 2024-02-27 |
BR112021019217A2 (en) | 2021-11-30 |
US20240150395A1 (en) | 2024-05-09 |
MX2021012078A (en) | 2022-01-04 |
IL286745A (en) | 2021-10-31 |
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