IL286745A - Continuous production of recombinant proteins - Google Patents

Continuous production of recombinant proteins

Info

Publication number
IL286745A
IL286745A IL286745A IL28674521A IL286745A IL 286745 A IL286745 A IL 286745A IL 286745 A IL286745 A IL 286745A IL 28674521 A IL28674521 A IL 28674521A IL 286745 A IL286745 A IL 286745A
Authority
IL
Israel
Prior art keywords
continuous production
recombinant proteins
recombinant
proteins
continuous
Prior art date
Application number
IL286745A
Other languages
Hebrew (he)
Original Assignee
Genzyme Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genzyme Corp filed Critical Genzyme Corp
Publication of IL286745A publication Critical patent/IL286745A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1807—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using counter-currents, e.g. fluidised beds
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/18—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns
    • B01D15/1864—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to flow patterns using two or more columns
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/145—Ultrafiltration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/58—Multistep processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14—Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M37/00—Means for sterilizing, maintaining sterile conditions or avoiding chemical or biological contamination
    • C12M37/02—Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2688—Biological processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2311/00—Details relating to membrane separation process operations and control
    • B01D2311/26—Further operations combined with membrane separation processes
    • B01D2311/2697—Chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/08—Fully permeating type; Dead-end filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/16—Diafiltration
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00—Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10—Separation or concentration of fermentation products
IL286745A 2019-04-03 2021-09-27 Continuous production of recombinant proteins IL286745A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201962828755P 2019-04-03 2019-04-03
PCT/US2020/026107 WO2020205928A1 (en) 2019-04-03 2020-04-01 Continuous production of recombinant proteins

Publications (1)

Publication Number Publication Date
IL286745A true IL286745A (en) 2021-10-31

Family

ID=70482780

Family Applications (1)

Application Number Title Priority Date Filing Date
IL286745A IL286745A (en) 2019-04-03 2021-09-27 Continuous production of recombinant proteins

Country Status (12)

Country Link
US (1) US11912741B2 (en)
EP (1) EP3947705A1 (en)
JP (1) JP2022519950A (en)
KR (1) KR20210149117A (en)
CN (1) CN113825840A (en)
AU (1) AU2020253381A1 (en)
CA (1) CA3135611A1 (en)
IL (1) IL286745A (en)
MX (1) MX2021012078A (en)
SG (1) SG11202110909XA (en)
TW (1) TW202102519A (en)
WO (1) WO2020205928A1 (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021197249A1 (en) * 2020-03-30 2021-10-07 上海复宏汉霖生物技术股份有限公司 System and method for continuous purification of target molecules
KR20240013153A (en) * 2021-05-25 2024-01-30 베링거 인겔하임 인터내셔날 게엠베하 Method and system for integrated continuous virus filtration, concentration and buffer exchange
EP4347778A1 (en) * 2021-05-26 2024-04-10 Simabs NV Integrated continuous bioprocess production platform
WO2023052357A1 (en) * 2021-09-28 2023-04-06 Merck Patent Gmbh Integrated solution for process intensification using inline constantly pressurized tank: "icpt"
WO2023167584A1 (en) * 2022-03-01 2023-09-07 Biosanapharma B.V. Continuous manufacturing of a biological substance with process traceability
EP4252882A1 (en) * 2022-03-31 2023-10-04 Sartorius Stedim Biotech GmbH Separation system for separating and purifying a target component
US20240101945A1 (en) * 2022-09-28 2024-03-28 Genzyme Corporation Systems and devices for producing biological products and methods of using the same

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100933766B1 (en) 2001-11-20 2009-12-24 버콘 뉴트라사이언스 (엠비) 코포레이션 Process for the Continuous Production of Oil Seed Protein Isolates
US8945895B2 (en) * 2009-07-31 2015-02-03 Baxter International Inc. Methods of purifying recombinant ADAMTS13 and other proteins and compositions thereof
WO2012078677A2 (en) 2010-12-06 2012-06-14 Tarpon Biosystems, Inc. Continuous processing methods for biological products
CN105377874A (en) * 2013-03-08 2016-03-02 建新公司 Continuous purification of therapeutic proteins
HUE038741T2 (en) * 2013-05-06 2018-11-28 Sanofi Sa Continuous multistep process for purifying antibodies
US8946395B1 (en) * 2013-10-18 2015-02-03 Abbvie Inc. Purification of proteins using hydrophobic interaction chromatography
EP3137484A1 (en) * 2014-05-02 2017-03-08 Novo Nordisk A/S Integrated continuous biomanufacturing process
MX2016014855A (en) * 2014-05-13 2017-08-07 Amgen Inc Process control systems and methods for use with filters and filtration processes.
US9335000B2 (en) * 2014-05-30 2016-05-10 Finesse Solutions, Inc. Aseptic connectors for bio-processing containers
WO2015198320A1 (en) * 2014-06-24 2015-12-30 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
AU2017313042A1 (en) 2016-08-16 2019-04-04 Genzyme Corporation Methods of processing a fluid including a recombinant therapeutic protein and use thereof
WO2018164995A1 (en) * 2017-03-09 2018-09-13 Alexion Pharmaceuticals, Inc . Glycoprotein manufacturing process

Also Published As

Publication number Publication date
CA3135611A1 (en) 2020-10-08
CN113825840A (en) 2021-12-21
SG11202110909XA (en) 2021-10-28
EP3947705A1 (en) 2022-02-09
US20200317728A1 (en) 2020-10-08
AU2020253381A1 (en) 2021-12-02
TW202102519A (en) 2021-01-16
MX2021012078A (en) 2022-01-04
JP2022519950A (en) 2022-03-25
WO2020205928A1 (en) 2020-10-08
KR20210149117A (en) 2021-12-08
US11912741B2 (en) 2024-02-27

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