KR20180074788A - 암의 치료에 유용한 디하이드로이미다조피라지논 유도체 - Google Patents
암의 치료에 유용한 디하이드로이미다조피라지논 유도체 Download PDFInfo
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- KR20180074788A KR20180074788A KR1020187016091A KR20187016091A KR20180074788A KR 20180074788 A KR20180074788 A KR 20180074788A KR 1020187016091 A KR1020187016091 A KR 1020187016091A KR 20187016091 A KR20187016091 A KR 20187016091A KR 20180074788 A KR20180074788 A KR 20180074788A
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- South Korea
- Prior art keywords
- methyl
- compound
- formula
- pharmaceutically acceptable
- pyrazine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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| WO2017068412A1 (en) | 2015-10-21 | 2017-04-27 | Otsuka Pharmaceutical Co., Ltd. | Benzolactam compounds as protein kinase inhibitors |
| SG11201803066VA (en) * | 2015-11-09 | 2018-05-30 | Astrazeneca Ab | Dihydroimidazopyrazinone derivatives useful in the treatment of cancer |
| GB201706327D0 (en) | 2017-04-20 | 2017-06-07 | Otsuka Pharma Co Ltd | A pharmaceutical compound |
| EP3845538B1 (en) * | 2018-10-10 | 2023-11-08 | Shenzhen TargetRx, Inc. | Dihydroimidazopyrazinone compound, composition including same, and use thereof |
| KR20210145773A (ko) | 2019-03-28 | 2021-12-02 | 지앙수 헨그루이 메디슨 컴퍼니 리미티드 | 티에노헤테로고리형 유도체, 이의 제조 방법 및 이의 의약적 용도 |
| EP3978498A1 (en) | 2019-05-24 | 2022-04-06 | Jiangsu Hengrui Medicine Co., Ltd. | Substituted fused bicyclic derivative, preparation method therefor, and application thereof in medicines |
| AU2020288273B2 (en) * | 2019-06-06 | 2025-11-13 | Hutchison Medipharma Limited | Tricyclic compounds and their use |
| EP4069687B1 (en) * | 2019-12-05 | 2024-01-31 | Astrazeneca AB | Process and intermediates for the production of formula (i) |
| WO2021110169A1 (zh) * | 2019-12-06 | 2021-06-10 | 南京明德新药研发有限公司 | 作为erk抑制剂的噻唑并内酰胺类化合物及其应用 |
| TW202221001A (zh) | 2020-09-29 | 2022-06-01 | 大陸商江蘇恒瑞醫藥股份有限公司 | 吡咯並雜環類衍生物的晶型及其製備方法 |
| WO2022262797A1 (en) * | 2021-06-18 | 2022-12-22 | Shanghai Antengene Corporation Limited | Combination of an erk inhibitor and a kras inhibitor and uses thereof |
| WO2022268065A1 (en) * | 2021-06-22 | 2022-12-29 | Fochon Biosciences, Ltd. | Compounds as erk inhibitors |
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| US20250304593A1 (en) | 2022-05-12 | 2025-10-02 | Skyhawk Therapeutics, Inc. | Compositions useful for modulating splicing |
| WO2024006971A2 (en) * | 2022-07-01 | 2024-01-04 | The Scripps Research Institute | Antimalarial compounds |
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| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
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| EP2655376B1 (en) * | 2010-12-22 | 2017-08-23 | Janssen Pharmaceutica NV | 5,6-DIHYDRO-IMIDAZO[1,2-a]PYRAZIN-8-YLAMINE DERIVATIVES USEFUL AS INHIBITORS OF BETA-SECRETASE (BACE) |
| CN106905324B (zh) * | 2011-10-10 | 2018-09-25 | H.隆德贝克有限公司 | 具有咪唑并吡嗪酮骨架的pde9抑制剂 |
| JP2013166727A (ja) * | 2012-02-16 | 2013-08-29 | Dainippon Sumitomo Pharma Co Ltd | ジヒドロイミダゾピラジノン誘導体 |
| PT2820009T (pt) | 2012-03-01 | 2018-04-12 | Array Biopharma Inc | Inibidores de serina/treonina quinases |
| US9532987B2 (en) | 2013-09-05 | 2017-01-03 | Genentech, Inc. | Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases |
| EA031243B1 (ru) | 2013-12-06 | 2018-12-28 | Дженентек, Инк. | Ингибиторы серин/треонинкиназ |
| CN105980387B (zh) | 2013-12-30 | 2019-04-19 | 阵列生物制药公司 | 丝氨酸/苏氨酸激酶抑制剂 |
| CA2934679C (en) | 2013-12-30 | 2023-02-28 | Genentech, Inc. | Serine/threonine kinase inhibitors |
| CN112645927A (zh) | 2014-04-09 | 2021-04-13 | 基因泰克公司 | 用于制备药物的方法 |
| US10412619B2 (en) * | 2014-11-14 | 2019-09-10 | Qualcomm Incorporated | Buffer status report for eDCS |
| WO2016162325A1 (en) * | 2015-04-07 | 2016-10-13 | Astrazeneca Ab | Substituted 3,4-dihydropyrrolo[1,2-a]pyrazin-1 (2h)-one derivatives as kinase inhibitors |
| WO2016192063A1 (en) | 2015-06-03 | 2016-12-08 | Changzhou Jiekai Pharmatech Co. Ltd | Heterocyclic compounds as erk inhibitors |
| CN106536522B (zh) | 2015-06-03 | 2020-08-28 | 捷思英达医药技术（上海）有限公司 | 用于治疗银屑病的杂环化合物 |
| SG11201803066VA (en) * | 2015-11-09 | 2018-05-30 | Astrazeneca Ab | Dihydroimidazopyrazinone derivatives useful in the treatment of cancer |
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