JP6877423B2 - がんの処置において有用なジヒドロイミダゾピラジノン誘導体 - Google Patents

がんの処置において有用なジヒドロイミダゾピラジノン誘導体 Download PDF

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JP6877423B2
JP6877423B2 JP2018522784A JP2018522784A JP6877423B2 JP 6877423 B2 JP6877423 B2 JP 6877423B2 JP 2018522784 A JP2018522784 A JP 2018522784A JP 2018522784 A JP2018522784 A JP 2018522784A JP 6877423 B2 JP6877423 B2 JP 6877423B2
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methyl
compound
formula
pharmaceutically acceptable
pyrazine
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JP2019503337A (ja
JP2019503337A5 (enExample
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リチャード・アンドリュー・ウォード
クリフォード・デイビッド・ジョーンズ
スティーブン・スワロウ
マーク・アンドリュー・グレアム
アンドリュー・ホーンビー・ドブソン
ジェイムズ・フランシス・マッケイブ
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AstraZeneca AB
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018522784A 2015-11-09 2016-11-08 がんの処置において有用なジヒドロイミダゾピラジノン誘導体 Active JP6877423B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562252726P 2015-11-09 2015-11-09
US62/252,726 2015-11-09
US201662401351P 2016-09-29 2016-09-29
US62/401,351 2016-09-29
PCT/EP2016/076932 WO2017080979A1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer

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JP2019503337A JP2019503337A (ja) 2019-02-07
JP2019503337A5 JP2019503337A5 (enExample) 2020-04-16
JP6877423B2 true JP6877423B2 (ja) 2021-05-26

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US (2) US9902731B2 (enExample)
EP (1) EP3374359B1 (enExample)
JP (1) JP6877423B2 (enExample)
KR (1) KR20180074788A (enExample)
CN (1) CN108349983B (enExample)
AU (1) AU2016351813B2 (enExample)
BR (1) BR112018008397B1 (enExample)
CA (1) CA3003549A1 (enExample)
CL (1) CL2018001226A1 (enExample)
CO (1) CO2018004857A2 (enExample)
CR (1) CR20180316A (enExample)
CY (1) CY1123627T1 (enExample)
DK (1) DK3374359T3 (enExample)
EA (1) EA038028B1 (enExample)
ES (1) ES2780650T3 (enExample)
HR (1) HRP20200342T1 (enExample)
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ME (1) ME03770B (enExample)
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US10457669B2 (en) 2015-10-21 2019-10-29 Otsuka Pharmaceutical Co., Ltd. Benzolactam compounds as protein kinase inhibitors
WO2017080979A1 (en) * 2015-11-09 2017-05-18 Astrazeneca Ab Dihydroimidazopyrazinone derivatives useful in the treatment of cancer
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
EP3845538B1 (en) * 2018-10-10 2023-11-08 Shenzhen TargetRx, Inc. Dihydroimidazopyrazinone compound, composition including same, and use thereof
JP2022527744A (ja) 2019-03-28 2022-06-06 ジエンス ヘンルイ メデイシンカンパニー リミテッド チエノ複素環式誘導体、この誘導体のための調製方法及び医療に関するこの誘導体の使用
JP2022534224A (ja) 2019-05-24 2022-07-28 江蘇恒瑞医薬股▲ふん▼有限公司 置換縮合二環式誘導体、その調製方法、および医薬におけるその適用
CN117486890A (zh) * 2019-06-06 2024-02-02 和记黄埔医药(上海)有限公司 三环类化合物及其用途
AU2020397222B2 (en) * 2019-12-05 2023-07-06 Astrazeneca Ab Process and intermediates for the production of formula (i)
CA3160903A1 (en) * 2019-12-06 2021-06-10 Medshine Discovery Inc. Thiazololactam compound as erk inhibitor and use thereof
JP2023543080A (ja) 2020-09-29 2023-10-12 江▲蘇▼恒瑞医▲薬▼股▲フン▼有限公司 ピロロ複素環系誘導体の結晶及びその製造方法
AR126166A1 (es) * 2021-06-18 2023-09-27 Antengene Discovery Ltd Combinación de un inhibidor de erk y un inhibidor de kras y usos de estos
WO2022268065A1 (en) * 2021-06-22 2022-12-29 Fochon Biosciences, Ltd. Compounds as erk inhibitors
AU2022320304A1 (en) 2021-07-27 2024-02-29 Toray Industries, Inc. Medicament for treatment and/or prevention of cancer
WO2023081859A1 (en) 2021-11-04 2023-05-11 Skyhawk Therapeutics, Inc. Triazine amino derivatives for treating sca3
US20250340572A1 (en) 2022-04-27 2025-11-06 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
EP4522623A1 (en) 2022-05-12 2025-03-19 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024006971A2 (en) * 2022-07-01 2024-01-04 The Scripps Research Institute Antimalarial compounds

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JP2013166727A (ja) * 2012-02-16 2013-08-29 Dainippon Sumitomo Pharma Co Ltd ジヒドロイミダゾピラジノン誘導体
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JP2019503337A (ja) 2019-02-07
PT3374359T (pt) 2020-03-27
US20180237443A1 (en) 2018-08-23
AU2016351813A1 (en) 2018-06-21
TWI730012B (zh) 2021-06-11
US9902731B2 (en) 2018-02-27
TW201728586A (zh) 2017-08-16
EA201891063A1 (ru) 2018-12-28
KR20180074788A (ko) 2018-07-03
EP3374359A1 (en) 2018-09-19
TN2018000119A1 (en) 2019-10-04
IL258953A (en) 2018-06-28
SMT202000152T1 (it) 2020-05-08
MY197626A (en) 2023-06-29
EP3374359B1 (en) 2020-01-08
DK3374359T3 (da) 2020-03-30
BR112018008397A2 (pt) 2018-10-23
HK1256283A1 (en) 2019-09-20
AU2016351813B2 (en) 2019-05-30
US10202391B2 (en) 2019-02-12
CO2018004857A2 (es) 2018-07-19
ZA201803742B (en) 2020-08-26
PE20181288A1 (es) 2018-08-07
SV2018005687A (es) 2018-07-20
BR112018008397B1 (pt) 2023-12-12
CR20180316A (es) 2018-10-05
NI201800058A (es) 2018-10-18
CA3003549A1 (en) 2017-05-18
LT3374359T (lt) 2020-03-25
US20170204100A1 (en) 2017-07-20
SI3374359T1 (sl) 2020-04-30
EA038028B1 (ru) 2021-06-24
RS60155B1 (sr) 2020-05-29
WO2017080979A1 (en) 2017-05-18
MX376639B (es) 2025-03-07
CN108349983B (zh) 2021-02-26
ME03770B (me) 2021-04-20
CY1123627T1 (el) 2022-03-24
HRP20200342T1 (hr) 2020-06-12
PH12018500987A1 (en) 2019-01-28
PL3374359T3 (pl) 2020-06-29
ES2780650T3 (es) 2020-08-26
SG11201803066VA (en) 2018-05-30
CL2018001226A1 (es) 2018-10-05
MX2018005725A (es) 2018-08-14
CN108349983A (zh) 2018-07-31

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