JP6877423B2 - がんの処置において有用なジヒドロイミダゾピラジノン誘導体 - Google Patents

がんの処置において有用なジヒドロイミダゾピラジノン誘導体 Download PDF

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JP6877423B2
JP6877423B2 JP2018522784A JP2018522784A JP6877423B2 JP 6877423 B2 JP6877423 B2 JP 6877423B2 JP 2018522784 A JP2018522784 A JP 2018522784A JP 2018522784 A JP2018522784 A JP 2018522784A JP 6877423 B2 JP6877423 B2 JP 6877423B2
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methyl
compound
formula
pharmaceutically acceptable
pyrazine
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JP2019503337A (ja
JP2019503337A5 (enExample
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リチャード・アンドリュー・ウォード
クリフォード・デイビッド・ジョーンズ
スティーブン・スワロウ
マーク・アンドリュー・グレアム
アンドリュー・ホーンビー・ドブソン
ジェイムズ・フランシス・マッケイブ
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AstraZeneca AB
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2018522784A 2015-11-09 2016-11-08 がんの処置において有用なジヒドロイミダゾピラジノン誘導体 Active JP6877423B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562252726P 2015-11-09 2015-11-09
US62/252,726 2015-11-09
US201662401351P 2016-09-29 2016-09-29
US62/401,351 2016-09-29
PCT/EP2016/076932 WO2017080979A1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer

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JP2019503337A JP2019503337A (ja) 2019-02-07
JP2019503337A5 JP2019503337A5 (enExample) 2020-04-16
JP6877423B2 true JP6877423B2 (ja) 2021-05-26

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US (2) US9902731B2 (enExample)
EP (1) EP3374359B1 (enExample)
JP (1) JP6877423B2 (enExample)
KR (1) KR20180074788A (enExample)
CN (1) CN108349983B (enExample)
AU (1) AU2016351813B2 (enExample)
BR (1) BR112018008397B1 (enExample)
CA (1) CA3003549A1 (enExample)
CL (1) CL2018001226A1 (enExample)
CO (1) CO2018004857A2 (enExample)
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CY (1) CY1123627T1 (enExample)
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HR (1) HRP20200342T1 (enExample)
IL (1) IL258953A (enExample)
LT (1) LT3374359T (enExample)
ME (1) ME03770B (enExample)
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PE (1) PE20181288A1 (enExample)
PH (1) PH12018500987A1 (enExample)
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SG (1) SG11201803066VA (enExample)
SI (1) SI3374359T1 (enExample)
SM (1) SMT202000152T1 (enExample)
SV (1) SV2018005687A (enExample)
TN (1) TN2018000119A1 (enExample)
TW (1) TWI730012B (enExample)
WO (1) WO2017080979A1 (enExample)
ZA (1) ZA201803742B (enExample)

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US10457669B2 (en) 2015-10-21 2019-10-29 Otsuka Pharmaceutical Co., Ltd. Benzolactam compounds as protein kinase inhibitors
ME03770B (me) * 2015-11-09 2021-04-20 Astrazeneca Ab Derivati dihidroimidazopirazinona korisni za upotrebu u tretmanu raka
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
CN110577543B (zh) * 2018-10-10 2022-07-08 深圳市塔吉瑞生物医药有限公司 一种二氢咪唑并吡嗪酮化合物及包含该化合物的组合物及其用途
WO2020192750A1 (zh) 2019-03-28 2020-10-01 江苏恒瑞医药股份有限公司 噻吩并杂环类衍生物、其制备方法及其在医药上的应用
CN113825757B (zh) 2019-05-24 2023-10-20 江苏恒瑞医药股份有限公司 取代的稠合双环类衍生物、其制备方法及其在医药上的应用
UA130454C2 (uk) 2019-06-06 2026-02-25 Хатчісон Медіфарма Лімітед Трициклічні сполуки та їх застосування
CA3157504A1 (en) * 2019-12-05 2021-06-10 Astrazeneca Ab Process and intermediates for the production of formula (i)
CN114829365B (zh) * 2019-12-06 2023-04-25 南京明德新药研发有限公司 作为erk抑制剂的噻唑并内酰胺类化合物及其应用
KR20230079120A (ko) 2020-09-29 2023-06-05 지앙수 헨그루이 파마슈티컬스 컴퍼니 리미티드 피롤로 헤테로고리계 유도체의 결정형 및 이의 제조 방법
CN117529321A (zh) * 2021-06-18 2024-02-06 上海德琪医药科技有限公司 Erk抑制剂和kras抑制剂的组合及其用途
WO2022268065A1 (en) * 2021-06-22 2022-12-29 Fochon Biosciences, Ltd. Compounds as erk inhibitors
MX2024000965A (es) 2021-07-27 2024-02-09 Toray Industries Medicamento para el tratamiento y/o prevencion de cancer.
WO2023081860A1 (en) 2021-11-04 2023-05-11 Skyhawk Therapeutics, Inc. Triazine amino derivatives for treating sca3
US20250340570A1 (en) 2022-04-27 2025-11-06 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
EP4522622A1 (en) 2022-05-12 2025-03-19 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024006971A2 (en) * 2022-07-01 2024-01-04 The Scripps Research Institute Antimalarial compounds

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CN107849046B (zh) 2015-06-03 2020-06-12 常州捷凯医药科技有限公司 作为erk抑制剂的杂环化合物
ME03770B (me) * 2015-11-09 2021-04-20 Astrazeneca Ab Derivati dihidroimidazopirazinona korisni za upotrebu u tretmanu raka

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Publication number Publication date
MY197626A (en) 2023-06-29
ME03770B (me) 2021-04-20
AU2016351813A1 (en) 2018-06-21
US20180237443A1 (en) 2018-08-23
MX376639B (es) 2025-03-07
KR20180074788A (ko) 2018-07-03
AU2016351813B2 (en) 2019-05-30
EA201891063A1 (ru) 2018-12-28
CY1123627T1 (el) 2022-03-24
PT3374359T (pt) 2020-03-27
NI201800058A (es) 2018-10-18
PH12018500987A1 (en) 2019-01-28
CA3003549A1 (en) 2017-05-18
US20170204100A1 (en) 2017-07-20
US10202391B2 (en) 2019-02-12
JP2019503337A (ja) 2019-02-07
CN108349983B (zh) 2021-02-26
LT3374359T (lt) 2020-03-25
PE20181288A1 (es) 2018-08-07
SG11201803066VA (en) 2018-05-30
SV2018005687A (es) 2018-07-20
TWI730012B (zh) 2021-06-11
SMT202000152T1 (it) 2020-05-08
TN2018000119A1 (en) 2019-10-04
RS60155B1 (sr) 2020-05-29
CR20180316A (es) 2018-10-05
ZA201803742B (en) 2020-08-26
EA038028B1 (ru) 2021-06-24
EP3374359B1 (en) 2020-01-08
CN108349983A (zh) 2018-07-31
DK3374359T3 (da) 2020-03-30
TW201728586A (zh) 2017-08-16
PL3374359T3 (pl) 2020-06-29
ES2780650T3 (es) 2020-08-26
SI3374359T1 (sl) 2020-04-30
HRP20200342T1 (hr) 2020-06-12
US9902731B2 (en) 2018-02-27
CO2018004857A2 (es) 2018-07-19
EP3374359A1 (en) 2018-09-19
HK1256283A1 (en) 2019-09-20
BR112018008397B1 (pt) 2023-12-12
WO2017080979A1 (en) 2017-05-18
CL2018001226A1 (es) 2018-10-05
BR112018008397A2 (pt) 2018-10-23
IL258953A (en) 2018-06-28
MX2018005725A (es) 2018-08-14

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