BR112018008397B1 - Composto, sal farmacêuticamente aceitável e formas cristalinas - Google Patents

Composto, sal farmacêuticamente aceitável e formas cristalinas Download PDF

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Publication number
BR112018008397B1
BR112018008397B1 BR112018008397-6A BR112018008397A BR112018008397B1 BR 112018008397 B1 BR112018008397 B1 BR 112018008397B1 BR 112018008397 A BR112018008397 A BR 112018008397A BR 112018008397 B1 BR112018008397 B1 BR 112018008397B1
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BR
Brazil
Prior art keywords
methyl
compound
formula
pyrazin
dihydroimidazo
Prior art date
Application number
BR112018008397-6A
Other languages
English (en)
Portuguese (pt)
Other versions
BR112018008397A2 (pt
Inventor
Richard Andrew Ward
Clifford David Jones
Steven Swallow
Mark Andrew Graham
Andrew Hornby Dobson
James Francis Mccabe
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BR112018008397A2 publication Critical patent/BR112018008397A2/pt
Publication of BR112018008397B1 publication Critical patent/BR112018008397B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112018008397-6A 2015-11-09 2016-11-08 Composto, sal farmacêuticamente aceitável e formas cristalinas BR112018008397B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562252726P 2015-11-09 2015-11-09
US62/252,726 2015-11-09
US201662401351P 2016-09-29 2016-09-29
US62/401,351 2016-09-29
PCT/EP2016/076932 WO2017080979A1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer

Publications (2)

Publication Number Publication Date
BR112018008397A2 BR112018008397A2 (pt) 2018-10-23
BR112018008397B1 true BR112018008397B1 (pt) 2023-12-12

Family

ID=57241113

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112018008397-6A BR112018008397B1 (pt) 2015-11-09 2016-11-08 Composto, sal farmacêuticamente aceitável e formas cristalinas

Country Status (35)

Country Link
US (2) US9902731B2 (enExample)
EP (1) EP3374359B1 (enExample)
JP (1) JP6877423B2 (enExample)
KR (1) KR20180074788A (enExample)
CN (1) CN108349983B (enExample)
AU (1) AU2016351813B2 (enExample)
BR (1) BR112018008397B1 (enExample)
CA (1) CA3003549A1 (enExample)
CL (1) CL2018001226A1 (enExample)
CO (1) CO2018004857A2 (enExample)
CR (1) CR20180316A (enExample)
CY (1) CY1123627T1 (enExample)
DK (1) DK3374359T3 (enExample)
EA (1) EA038028B1 (enExample)
ES (1) ES2780650T3 (enExample)
HR (1) HRP20200342T1 (enExample)
IL (1) IL258953A (enExample)
LT (1) LT3374359T (enExample)
ME (1) ME03770B (enExample)
MX (1) MX376639B (enExample)
MY (1) MY197626A (enExample)
NI (1) NI201800058A (enExample)
PE (1) PE20181288A1 (enExample)
PH (1) PH12018500987A1 (enExample)
PL (1) PL3374359T3 (enExample)
PT (1) PT3374359T (enExample)
RS (1) RS60155B1 (enExample)
SG (1) SG11201803066VA (enExample)
SI (1) SI3374359T1 (enExample)
SM (1) SMT202000152T1 (enExample)
SV (1) SV2018005687A (enExample)
TN (1) TN2018000119A1 (enExample)
TW (1) TWI730012B (enExample)
WO (1) WO2017080979A1 (enExample)
ZA (1) ZA201803742B (enExample)

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WO2017068412A1 (en) 2015-10-21 2017-04-27 Otsuka Pharmaceutical Co., Ltd. Benzolactam compounds as protein kinase inhibitors
SMT202000152T1 (it) * 2015-11-09 2020-05-08 Astrazeneca Ab Derivati di diidroimidazopirazinone utili nel trattamento di cancro
GB201706327D0 (en) 2017-04-20 2017-06-07 Otsuka Pharma Co Ltd A pharmaceutical compound
JP7352981B2 (ja) * 2018-10-10 2023-09-29 深▲チェン▼市塔吉瑞生物医薬有限公司 ジヒドロイミダゾピラジノン化合物、該化合物を含む組成物およびその使用
KR20210145773A (ko) 2019-03-28 2021-12-02 지앙수 헨그루이 메디슨 컴퍼니 리미티드 티에노헤테로고리형 유도체, 이의 제조 방법 및 이의 의약적 용도
EP3978498A1 (en) 2019-05-24 2022-04-06 Jiangsu Hengrui Medicine Co., Ltd. Substituted fused bicyclic derivative, preparation method therefor, and application thereof in medicines
PH12021553058A1 (en) 2019-06-06 2022-07-25 Hutchison Medipharma Ltd Tricyclic compounds and their use
TW202134242A (zh) 2019-12-05 2021-09-16 瑞典商阿斯特捷利康公司 用於生產式(i)之方法及中間體
EP4071155A4 (en) * 2019-12-06 2024-01-17 D3 Bio (Wuxi) Co., Ltd. Thiazololactam compound as erk inhibitor and use thereof
US20230331731A1 (en) 2020-09-29 2023-10-19 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Crystal form of pyrrolo heterocyclic derivative and preparation method therefor
AR126166A1 (es) * 2021-06-18 2023-09-27 Antengene Discovery Ltd Combinación de un inhibidor de erk y un inhibidor de kras y usos de estos
WO2022268065A1 (en) * 2021-06-22 2022-12-29 Fochon Biosciences, Ltd. Compounds as erk inhibitors
EP4378478A4 (en) 2021-07-27 2025-11-12 Toray Industries MEDICINE FOR THE TREATMENT AND/OR PREVENTION OF CANCER
EP4426702A1 (en) 2021-11-04 2024-09-11 Skyhawk Therapeutics, Inc. Condensed-pyrazine amine derivatives for treating sca3
EP4514807B1 (en) 2022-04-27 2025-12-17 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
US20260027118A1 (en) 2022-05-12 2026-01-29 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2024006971A2 (en) * 2022-07-01 2024-01-04 The Scripps Research Institute Antimalarial compounds

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WO2004041826A1 (en) * 2002-11-06 2004-05-21 Merck Sharp & Dohme Limited Imidazopyrazinones and imidazotriazinones derivates as gaba-a receptor anxiolytic
GB0520958D0 (en) * 2005-10-14 2005-11-23 Cyclacel Ltd Compound
CN101611007A (zh) * 2006-12-20 2009-12-23 先灵公司 新颖的jnk抑制剂
ES2648143T3 (es) * 2010-12-22 2017-12-28 Janssen Pharmaceutica Nv Derivados de 5,6-dihidro-imidazo[1,2-a]pirazin-8-ilamina útiles como inhibidores de la beta-secretasa (BACE)
MX381326B (es) * 2011-10-10 2025-03-12 H Lundbeck As Derivados de 7h-imidazo[1-5-a]pirazin-8-ona como inhibidores de la fosfodiesterasa 9(pde9); y el uso de los mismos en el tratamiento de trastornos neurodegenerativos
JP2013166727A (ja) * 2012-02-16 2013-08-29 Dainippon Sumitomo Pharma Co Ltd ジヒドロイミダゾピラジノン誘導体
PE20150666A1 (es) 2012-03-01 2015-05-06 Array Biopharma Inc Inhibidores de serina/treonina cinasa
US9532987B2 (en) 2013-09-05 2017-01-03 Genentech, Inc. Use of a combination of a MEK inhibitor and an ERK inhibitor for treatment of hyperproliferative diseases
EA031243B1 (ru) 2013-12-06 2018-12-28 Дженентек, Инк. Ингибиторы серин/треонинкиназ
MX375902B (es) * 2013-12-30 2025-03-07 Genentech Inc Inhibidores de serina/treonina cinasa.
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Also Published As

Publication number Publication date
RS60155B1 (sr) 2020-05-29
KR20180074788A (ko) 2018-07-03
TW201728586A (zh) 2017-08-16
AU2016351813B2 (en) 2019-05-30
CO2018004857A2 (es) 2018-07-19
EA201891063A1 (ru) 2018-12-28
TN2018000119A1 (en) 2019-10-04
SMT202000152T1 (it) 2020-05-08
CN108349983B (zh) 2021-02-26
EP3374359A1 (en) 2018-09-19
US20180237443A1 (en) 2018-08-23
DK3374359T3 (da) 2020-03-30
PT3374359T (pt) 2020-03-27
JP2019503337A (ja) 2019-02-07
ME03770B (me) 2021-04-20
HRP20200342T1 (hr) 2020-06-12
MY197626A (en) 2023-06-29
EP3374359B1 (en) 2020-01-08
EA038028B1 (ru) 2021-06-24
SG11201803066VA (en) 2018-05-30
LT3374359T (lt) 2020-03-25
WO2017080979A1 (en) 2017-05-18
ZA201803742B (en) 2020-08-26
IL258953A (en) 2018-06-28
CY1123627T1 (el) 2022-03-24
MX2018005725A (es) 2018-08-14
ES2780650T3 (es) 2020-08-26
US20170204100A1 (en) 2017-07-20
AU2016351813A1 (en) 2018-06-21
US9902731B2 (en) 2018-02-27
MX376639B (es) 2025-03-07
PH12018500987A1 (en) 2019-01-28
JP6877423B2 (ja) 2021-05-26
CR20180316A (es) 2018-10-05
BR112018008397A2 (pt) 2018-10-23
TWI730012B (zh) 2021-06-11
SI3374359T1 (sl) 2020-04-30
US10202391B2 (en) 2019-02-12
HK1256283A1 (en) 2019-09-20
CN108349983A (zh) 2018-07-31
CL2018001226A1 (es) 2018-10-05
CA3003549A1 (en) 2017-05-18
PE20181288A1 (es) 2018-08-07
SV2018005687A (es) 2018-07-20
PL3374359T3 (pl) 2020-06-29
NI201800058A (es) 2018-10-18

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B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
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