EA038028B1 - Производные дигидроимидазопиразинона, применимые в лечении рака - Google Patents

Производные дигидроимидазопиразинона, применимые в лечении рака Download PDF

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EA038028B1
EA038028B1 EA201891063A EA201891063A EA038028B1 EA 038028 B1 EA038028 B1 EA 038028B1 EA 201891063 A EA201891063 A EA 201891063A EA 201891063 A EA201891063 A EA 201891063A EA 038028 B1 EA038028 B1 EA 038028B1
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Prior art keywords
methyl
compound
dihydroimidazo
amino
formula
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EA201891063A
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English (en)
Russian (ru)
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EA201891063A1 (ru
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Ричард Эндрью Уорд
Клиффорд Дэвид Джонс
Стивен Суоллоу
Марк Эндрю Грэм
Эндрю Хорнби Добсон
Джеймс Фрэнсис Маккэйб
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Астразенека Аб
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Publication of EA201891063A1 publication Critical patent/EA201891063A1/ru
Publication of EA038028B1 publication Critical patent/EA038028B1/ru

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • A61K31/4161,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
EA201891063A 2015-11-09 2016-11-08 Производные дигидроимидазопиразинона, применимые в лечении рака EA038028B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562252726P 2015-11-09 2015-11-09
US201662401351P 2016-09-29 2016-09-29
PCT/EP2016/076932 WO2017080979A1 (en) 2015-11-09 2016-11-08 Dihydroimidazopyrazinone derivatives useful in the treatment of cancer

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EA201891063A1 EA201891063A1 (ru) 2018-12-28
EA038028B1 true EA038028B1 (ru) 2021-06-24

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EP (1) EP3374359B1 (enExample)
JP (1) JP6877423B2 (enExample)
KR (1) KR20180074788A (enExample)
CN (1) CN108349983B (enExample)
AU (1) AU2016351813B2 (enExample)
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CA (1) CA3003549A1 (enExample)
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BR112021017957A2 (pt) 2019-03-28 2021-11-23 Jiangsu Hengrui Medicine Co Derivado tienoeterocíclico, método de preparação do mesmo e uso médico do mesmo
WO2020238776A1 (zh) 2019-05-24 2020-12-03 江苏恒瑞医药股份有限公司 取代的稠合双环类衍生物、其制备方法及其在医药上的应用
BR112021024546A2 (pt) 2019-06-06 2022-02-08 Hutchison Medipharma Ltd Compostos tricíclicos e uso dos mesmos
EP4069687B1 (en) * 2019-12-05 2024-01-31 Astrazeneca AB Process and intermediates for the production of formula (i)
AU2020398022B2 (en) * 2019-12-06 2023-04-27 D3 Bio (Wuxi) Co., Ltd. Thiazololactam compound as ERK inhibitor and use thereof
CN116437915B (zh) 2020-09-29 2025-03-18 江苏恒瑞医药股份有限公司 一种吡咯并杂环类衍生物的晶型及其制备方法
WO2022262797A1 (en) * 2021-06-18 2022-12-22 Shanghai Antengene Corporation Limited Combination of an erk inhibitor and a kras inhibitor and uses thereof
WO2022268065A1 (en) * 2021-06-22 2022-12-29 Fochon Biosciences, Ltd. Compounds as erk inhibitors
MX2024000965A (es) 2021-07-27 2024-02-09 Toray Industries Medicamento para el tratamiento y/o prevencion de cancer.
US20250129090A1 (en) 2021-11-04 2025-04-24 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
WO2023212237A1 (en) 2022-04-27 2023-11-02 Skyhawk Therapeutics, Inc. Compositions useful for modulating splicing
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DK3374359T3 (da) 2020-03-30
RS60155B1 (sr) 2020-05-29
SI3374359T1 (sl) 2020-04-30
CR20180316A (es) 2018-10-05
CN108349983B (zh) 2021-02-26
ME03770B (me) 2021-04-20
HK1256283A1 (en) 2019-09-20
AU2016351813A1 (en) 2018-06-21
BR112018008397A2 (pt) 2018-10-23
EP3374359A1 (en) 2018-09-19
MY197626A (en) 2023-06-29
SV2018005687A (es) 2018-07-20
HRP20200342T1 (hr) 2020-06-12
EA201891063A1 (ru) 2018-12-28
NI201800058A (es) 2018-10-18
ZA201803742B (en) 2020-08-26
US10202391B2 (en) 2019-02-12
BR112018008397B1 (pt) 2023-12-12
US20180237443A1 (en) 2018-08-23
WO2017080979A1 (en) 2017-05-18
TW201728586A (zh) 2017-08-16
LT3374359T (lt) 2020-03-25
TN2018000119A1 (en) 2019-10-04
KR20180074788A (ko) 2018-07-03
JP2019503337A (ja) 2019-02-07
CO2018004857A2 (es) 2018-07-19
TWI730012B (zh) 2021-06-11
SMT202000152T1 (it) 2020-05-08
AU2016351813B2 (en) 2019-05-30
EP3374359B1 (en) 2020-01-08
JP6877423B2 (ja) 2021-05-26
CY1123627T1 (el) 2022-03-24
CA3003549A1 (en) 2017-05-18
SG11201803066VA (en) 2018-05-30
ES2780650T3 (es) 2020-08-26
PH12018500987A1 (en) 2019-01-28
PE20181288A1 (es) 2018-08-07
US9902731B2 (en) 2018-02-27
MX376639B (es) 2025-03-07
PT3374359T (pt) 2020-03-27
MX2018005725A (es) 2018-08-14
CN108349983A (zh) 2018-07-31
PL3374359T3 (pl) 2020-06-29
CL2018001226A1 (es) 2018-10-05
US20170204100A1 (en) 2017-07-20
IL258953A (en) 2018-06-28

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