KR20180062495A - Antimicrobial composition for wet tissue containing bellflower extract and manufacturing method thereof - Google Patents
Antimicrobial composition for wet tissue containing bellflower extract and manufacturing method thereof Download PDFInfo
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Abstract
Description
본 발명은 천연물질 추출물을 포함하는 물티슈 조성물에 관한 것으로, 자세하게는 도라지 추출물을 첨가함으로 피부에 안전한 물티슈의 제조할 수 있는 항균 물티슈 조성물 및 이의 제조방법에 관한 것이다.The present invention relates to a wet tissue composition comprising a natural substance extract, and more particularly, to an antibacterial wet tissue composition capable of producing a skin-safe wet tissue by adding a bellflower extract and a method for producing the same.
근래에 신종플루, 메르스 등의 감염성 질병으로 인한 개인위생 중요성이 강조되고 있는 기운데, 사람의 피부 및 손에 의한 세균 및 바이러스의 감염에 의해 대부분의 질병이 발병됨에 따라 물티슈 시장이 폭발적으로 성장하고 있으며, 특히 환절기마다 찾아오는 감기, 독감, 황사로 인해 항균 물티슈에 대한 요구가 증가하고 있다.In recent years, the importance of personal hygiene due to infectious diseases such as swine flu and mers is emphasized. Most diseases are caused by bacterial and viral infections caused by human skin and hands, resulting in explosive growth of the wet tissue market. And the demand for anti-bacterial wet tissue is increasing due to cold, flu, and dust, which come in every season.
일반적으로 피부에 상주하는 상재성 세균으로는 표피포도상구균(Staphylococcus epidermis)과 황색포도상구균(Staphylococcus aureus) 등이 있다. 표피포도상구균은 구균과에서 가장 잘 알려진 종류로 인간과 다른 항온동물의 피부와 점질피막에 보편적으로 존재하며, 일반적으로는 병원성이 없으나 저항력이 약해진 사람에게 나타나는 감염위험이 있다. 황색포도상구균은 상처감염·종기·피부감염의 중요한 병원균이며 식중독의 가장 일반적인 원인 가운데 하나로서, 건강한 사람의 30 ~ 50%에서도 발견되며 화농성 상청, 침 등에도 존재할 수 있기 때문에 개인위생에 소홀히 한경우 오염될 수 있다.Typically, resident bacteria that reside in the skin include Staphylococcus epidermis and Staphylococcus aureus. Staphylococcus epidermidis is the most well-known strain of Streptococcus pneumoniae. It is commonly found in the skin and mucous membranes of humans and other warm-blooded animals, and is generally not pathogenic, but is at risk of infection in people with reduced resistance. Staphylococcus aureus is an important pathogen of wound infections, boils, skin infections and is one of the most common causes of food poisoning. It is found in 30% to 50% of healthy people and can also exist in the suppurative supernumerary and acupuncture points. .
물티슈는 통상 이러한 감염 가능성이 있는 오염물을 닦아 내는 세정용도로 사용되지만 사람의 피부와 직접 맞닿는 사용방식과 함께 하루에도 몇 번씩 사용되는 반복성으로 인해 피부에 대한 안전성이 중요하게 여겨지고 있으며 특히, 연약한 피부와 환경적인 측면을 고려한 천연성분의 친환경적인 물티슈 조성물 개발이 필요한 실정이다.Wet tissues are usually used for cleaning wipes that may contaminate these infectious items. However, safety of the skin is important due to the repetition that is repeated several times a day, in addition to the use of direct contact with human skin. Especially, It is necessary to develop an environmentally friendly wipes composition which is environmentally friendly.
또한, 종래의 물티슈 업계에서는 CPC(염화세틸피리디늄), MIC(메칠이소치아졸리논) 등 항균 기능을 낼 수 있는 화학방부제들을 사용하여 왔으나 피부화상이나 발진, 세포막 손상 등의 부작용 문제와 함께 이들 합성 원료들의 안전성이 문제로 지적됨에 따라 피부에 무해한 천연물질 조성물에 대한 연구가 진행되고 있다.Further, in the conventional wet tissue industry, chemical preservatives such as CPC (cetylpyridinium chloride) and MIC (methylisothiazolinone) have been used. However, they have problems such as skin burns, rashes, As the safety of synthetic raw materials has been pointed out as a problem, studies on natural material compositions harmless to the skin are under way.
본 발명에서 주목하는 주요 성분인 도라지는 초롱꽃과의 여러해살이풀로서, 여름에 흰색과 보라색으로 꽃이 피며 뿌리는 식용하는 식물로서, 주요 성분은 사포닌이며, 한방에서는 치열(治熱), 폐열, 편도염, 설사에 사용하고 특히 항균, 항바이러스, 항염증, 항산화, 해독, 진통, 진정, 면역증강, 모세혈관 강화작용 등의 유용성이 알려지고 있으며, 일반 및 유행성 세균의 감염을 방지하여 사람 사이에서의 전염을 막을 수 있는 1차적인 용도로도 활용가능 가능하다.The main ingredient of the present invention, bellflower, is a perennial herbaceous plant, which blooms in summer and flowers in white and purple, and its root is edible. Its main ingredient is saponin. In herbals, It is used for tonsillitis and diarrhea. Especially, antibacterial, antiviral, anti-inflammatory, antioxidant, detoxification, analgesic, sedation, immune enhancement and capillary strengthening are known. It is also possible to use it as a primary use to prevent the spread of the disease.
본 발명은 상기와 같은 도라지의 효능을 고려하여 창출된 것으로, 본 발명의 목적은 인체에 무해한 천연 성분의 도라지가 가지고 있는 우수한 항균성, 살균성을 물티슈에 접목할 수 있는 도라지 추출물을 함유한 항균 물티슈 조성물 및 이의 제조방법을 제공하는 것이다.The object of the present invention is to provide an antimicrobial wet tissue composition containing a bellflower extract which is capable of binding an antimicrobial and bactericidal property of a natural bellflower harmless to the human body to a wet tissue, And a method for producing the same.
상기와 같은 목적을 위해 본 발명 물티슈 조성물 및 이의 제조방법은, 분쇄된 건조 도라지에 대하여, 상기 도라지의 중량 대비 5 내지 30배의 에탄올에 투입 후, 3 내지 28시간 동안 정치하여 추출물을 얻는 단계; 상기 추출물을 여과 및 감압 농축하는 단계; 로 이루어지는 것을 특징으로 한다.For the same purpose, the wet tissue composition of the present invention and the method of manufacturing the same are prepared by adding 5 to 30 times the weight of the bellflower to the pulverized dried bellflower and allowing it to stand for 3 to 28 hours to obtain an extract; Filtering and concentrating the extract; .
이때 상기 도라지의 중량대비 글리세린 3 내지 10 중량%와, 알코올 1 ~ 2 중량%를 첨가하여 혼합물을 얻는 단계; 를 더 포함할 수 있다.Adding 3 to 10% by weight of glycerin and 1 to 2% by weight of alcohol to the weight of the bellflower to obtain a mixture; As shown in FIG.
또는 정제수 60~90 중량%, 상기 감압 농축된 추출물 0.5~5.0중량%, 에칠헥실글리세린 0.5~2중량%, 데실렌글라이콜 0.5~2중량%, 소듐시트레이트 0.1~1중량%, 디프로필렌글라이콜 0.5~2중량%, 락틱애씨드 0.01~0.05중량%, 녹차추출물0.1~3.0중량%, 벤조산나트륨 0.1~0.2중량%, 소듐하이알루로네이트 0.01~0.1중량% 혼합하는 단계; 를 더 포함할 수 있다.Or an aqueous solution containing 60 to 90% by weight of purified water, 0.5 to 5.0% by weight of the concentrated extract under reduced pressure, 0.5 to 2% by weight of ethylhexyl glycerin, 0.5 to 2% by weight of decyleneglycol, 0.1 to 1% Mixing 0.5 to 2 wt% of glycols, 0.01 to 0.05 wt% of lactic acid, 0.1 to 3.0 wt% of green tea extract, 0.1 to 0.2 wt% of sodium benzoate, and 0.01 to 0.1 wt% of sodium hyaluronate; As shown in FIG.
또한, 상기 여과는 1 내지 10㎛ 구멍 사이즈를 갖는 여과지를 이용하고, 상기 감압 농축은 최초 부피의 10 내지 30%의 부피가 되도록 할 수 있다.The filtration may be performed using a filter paper having a pore size of 1 to 10 mu m, and the reduced pressure concentration may be 10 to 30% of the initial volume.
상기와 같은 목적을 위해 도라지 추출물을 함유한 항균 물티슈 조성물은 앞서 설명한 방법을 통해 제조되는 것을 특징으로 한다.For the same purpose, the antibacterial wet tissue composition containing the bellflower extract is produced through the above-described method.
본 발명은 천연물질인 도라지 추출물을 물티슈 조성물로 사용함에 항균 및 항염 활성과 함께 피부에 사용시 자극을 최대한 완화할 수 있으며, 개인의 위생관리를 철저히 할 수 있도록 돕게 됨에 따라 국민건강에 이바지할 수 있다.The present invention uses antibacterial and anti-inflammatory activity as a wet tissue composition, which is a natural substance, as a wet tissue composition. It can alleviate the stimulation when used on the skin as much as possible and contributes to public health by helping to thoroughly manage personal hygiene .
도 1은 본 발명의 바람직한 실시예에 따른 제조과정을 나타낸 순서도,
도 2는 본 발명에 따른 추출물에 대한 각종 균류의 성장억제율 측정실험결과를 나타낸 사진이다.1 is a flowchart showing a manufacturing process according to a preferred embodiment of the present invention,
FIG. 2 is a photograph showing the results of experiments for measuring growth inhibition rates of various fungi on the extract according to the present invention. FIG.
이하, 첨부된 도면을 참조하며 본 발명 도라지 추출물을 함유한 항균 물티슈 조성물 및 이의 제조방법을 구체적으로 설명한다.BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, an antimicrobial wet tissue composition containing the present invention will be described in detail with reference to the accompanying drawings.
도 1은 본 발명의 바람직한 실시예에 따른 제조과정을 나타낸 순서도이다.1 is a flowchart illustrating a manufacturing process according to a preferred embodiment of the present invention.
본 발명의 주요원료는 도라지로서, 첫 번째 단계(S 110)에서는 분쇄된 건조 도라지에 대하여, 상기 도라지의 중량 대비 5 내지 30배의 에탄올에 투입 후, 3 내지 28시간 동안 정치하여 추출물을 얻게 되며, 두 번째 단계(S 120)로는 상기 추출물을 여과 및 감압 농축하게 된다.The main raw material of the present invention is a bellflower, and in the first step (S 110), the pulverized dried bellflower is put into ethanol of 5 to 30 times the weight of the bellflower, and then allowed to stand for 3 to 28 hours to obtain an extract , And in the second step (S 120), the extract is filtered and concentrated under reduced pressure.
이때 상기 여과는 1 내지 10㎛ 구멍 사이즈를 갖는 여과지를 이용하고, 상기 감압 농축은 최초 부피의 10 내지 30%의 부피가 되도록 하는 것이 바람직하다.At this time, it is preferable that the filtration is performed using a filter paper having a pore size of 1 to 10 mu m, and the reduced pressure concentration is preferably 10 to 30% of the initial volume.
이와 같이 감압 농축된 추출물을 물티슈 원단에 바로 흡습시켜 사용도 가능하며 이때 원활한 효과를 위해 상기 물티슈 원단의 흡습율은 70 ~ 80%인 것이 바람직하다.In this case, it is preferable that the moisture-absorbing ratio of the wet tissue is 70 to 80% for smooth effect.
더불어 항균효과를 더욱 증진시키면서 피부 자극을 최소화할 수 있도록 세 번째 단계(S 131)로서 상기 도라지의 중량 100 중량% 대비 글리세린 3 내지 10 중량%와, 알코올 1 ~ 2 중량%를 첨가하여 혼합하고 이를 물티슈 원단에 흡습시킬 수 있으며, 피부 컨디셔닝을 위해 정제수 60~90 중량%, 상기 감압 농축된 추출물 0.5~5.0중량%, 에칠헥실글리세린 0.5~2중량%, 데실렌글라이콜 0.5~2중량%, 소듐시트레이트 0.1~1중량%, 디프로필렌글라이콜 0.5~2중량%, 락틱애씨드 0.01~0.05중량%, 녹차추출물0.1~3.0중량%, 벤조산나트륨 0.1~0.2중량%, 소듐하이알루로네이트 0.01~0.1중량% 혼합하는 단계(S 132)를 수행할 수도 있다.In addition, 3 to 10% by weight of glycerin and 1 to 2% by weight of alcohol are added to 100% by weight of the bellflower as a third step (S 131) so as to further enhance the antibacterial effect while minimizing skin irritation. And the skin can be absorbed in the wet tissue. For skin conditioning, 60 to 90% by weight of purified water, 0.5 to 5.0% by weight of the concentrated extract under reduced pressure, 0.5 to 2% by weight of ethylhexyl glycerin, 0.5 to 2% 0.1 to 1 wt% of sodium citrate, 0.5 to 2 wt% of dipropylene glycol, 0.01 to 0.05 wt% of lactic acid, 0.1 to 3.0 wt% of green tea extract, 0.1 to 0.2 wt% of sodium benzoate, 0.01 to 0.01 wt% of sodium hyaluronate To 0.1% by weight (S 132).
실시 예 1. 도라지 추출물의 제조Example 1. Preparation of Bellflower Extract
건조된 도라지를 세절한 후 다시 분쇄하여 분말상으로 수득하였다. 여기에 70%(v/v) 에탄올을 건조 원물 대비 20배 첨가하여 3시간 동안 추출하고, 1㎛ 구멍 사이즈의 종이 여과지를 이용하여 고분자 침전물 및 균체를 제거한 후, 추출액을 수득하였다. 상기 도라지 추출액을 감압회전농축장치를 통해 본래 부피의 15.7%의 부피가 되도록 농축하여 도라지 추출물 농축액을 얻었다. The dried bellflower was finely cut and then pulverized again to obtain a powder. Then, 70% (v / v) ethanol was added to the dried material at a ratio of 20 times, and the mixture was extracted for 3 hours. Then, the polymer precipitate and cells were removed using a paper filter paper having a size of 1 탆 pore. The bellflower extract solution was concentrated to a volume of 15.7% of the original volume through a rotary evaporator to obtain a bellflower extract concentrate.
실험 예 1. 도라지 추출물의 항균력 실험 Experimental Example 1. Antibacterial activity test of the bellflower extract
1. 항균력 실험방법1. Antimicrobial activity test method
상기 실시예 1에서 제조된 도라지 추출물을 농도별로 액상 배지에 첨가하여 각 균주를 일정량 접종하고 8시간 배양한 후, 이를 고체 배지에 평판 배양하여 형성된 집락수를 측정하였다. 실험대상 균주로는 표피포도상구균(S. epidermis), 대장균(E.coli) 및 황색포도상구균(S. aureus) 을 이용하였고, 추출물의 항균활성을 log CFU/ml의 단위로 측정하였으며 도라지 추출물이 첨가되지 않은 것(0%)을 기준으로 성장억제율을 측정하였다. 실험은 3번 시행하여 평균값으로 사용하였다.The platycodone extract prepared in Example 1 was added to the liquid medium for each concentration, and a certain amount of each strain was inoculated and cultured for 8 hours. The platelets were cultured on a solid medium to measure the number of colonies formed. The antimicrobial activity of the extracts was measured in units of log CFU / ml, and the extracts of the bellflower extracts were used to determine the antimicrobial activity of the extracts. The extracts of S. epidermis, E. coli and S. aureus were used as test strains. The growth inhibition rate was measured on the basis of no addition (0%). The experiment was carried out three times and used as the average value.
2. 항균력 실험결과2. Results of antibacterial activity
도 2는 본 발명에 따른 추출물에 대한 각종 균류의 성장억제율 측정실험결과를 나타낸 사진이다.FIG. 2 is a photograph showing the results of experiments for measuring growth inhibition rates of various fungi on the extract according to the present invention. FIG.
상기 [표 1]과 도 2에서 알 수 있듯이, 표피포도상구균, 대장균 및 황색포도상구균 모두에서 추출물을 2% 이상 첨가하였을 때 약 90%의 미생물 억제효과가 발생하였다. 이는 주원료로 첨가된 도라지 추출물의 항균력에 기인한 결과로 인정된다.As shown in [Table 1] and FIG. 2, about 90% of microbial inhibitory effect occurred when 2% or more of the extract was added to Staphylococcus epidermidis, E. coli and Staphylococcus aureus. This is considered to be the result of the antibacterial activity of the bellflower extract added as the main ingredient.
실험 예 2. 도라지 추출물 포함한 물티슈의 피부자극 시험Experimental Example 2. Skin irritation test of a wet tissue including a bellflower extract
제조된 천연 방부제 조성물에 양이온 음이온이 분리된 정제수 1000g, 도라지 추출물 50g, 녹차추출물 20g, 보습제인 에칠헥실글리세린, 소듐하이알루로네이트, 락틱애씨드, 보존제인 벤조산나트륨을 포함하여 중량비 100%로 구성하고 부직포 원지에 분무하여 원지 중량에 3중량 배로 흡수되도록 하여 물티슈를 제조하였다.The prepared natural preservative composition was composed of 100% by weight of purified water containing 1000 g of purified anion, 50 g of bellflower extract, 20 g of green tea extract, ethylhexyl glycerin, sodium hyaluronate, lactic acid and sodium benzoate as a preservative The nonwoven fabric was sprayed on the raw paper to be absorbed 3 times as much as the weight of the raw paper to prepare a wet tissue.
피험자 선정 기준에 부합하며, 신체가 건강하고 20 ~ 40세 사이의 건강한 성인 10명(남성 5명, 여성 5명)을 대상으로 피부 자극 실험을 실시하였으며, 시험대상자의 상박부를 70% 알코올로 세척하고 발명의 조성물을 폐쇄첩포하였다. Skin stimulation tests were performed on 10 healthy adults (5 males and 5 females) who were healthy and who were healthy and between 20 and 40 years of age. The upper part of the subjects were washed with 70% alcohol And the composition of the invention was clogged.
1. 적용부위 : Inner arm 1. Application site: Inner arm
2. 시험 방법 : 패치를 적용부위에 24시간/48시간 동안 첩포하였다가 제거한 후 20분 후 피부 자극 정도를 평가하였다.2. Test method: The patch was applied to the application site for 24 hours / 48 hours, and after 20 minutes, the skin irritation degree was evaluated.
3. 판정 기준 : 첩포 제거 후 육안 평가하여 아래의 [표 2]의 기준에 따라 점수를 부여하였다.3. Criteria of judgment: After removal of the patches, they were visually evaluated and scored according to the criteria in [Table 2] below.
상기 [표 3]과 같이 본 발명에 따른 피부 자극이 적은 조성물로 처리된 물티슈로 실험을 하였을 때 피부 안전성 측면에서 본 조성물은 피부에 자극을 주지 않는 것으로 나타났음을 알 수 있다.As shown in [Table 3], when the present invention is tested with a wet tissue treated with a composition having a low skin irritation, it can be seen that the composition does not irritate the skin in terms of skin safety.
본 발명의 권리는 위에서 설명된 실시 예에 한정되지 않고 청구범위에 기재된 바에 의해 정의되며, 본 발명의 분야에서 통상의 지식을 가진 자가 청구범위에 기재된 권리범위 내에서 다양한 변형과 개작을 할 수 있다는 것은 자명하다.It is to be understood that the invention is not limited to the disclosed embodiment, but is capable of many modifications and variations within the scope of the appended claims. It is self-evident.
Claims (5)
분쇄된 건조 도라지에 대하여, 상기 도라지의 중량 대비 5 내지 30배의 에탄올에 투입 후, 3 내지 28시간 동안 정치하여 추출물을 얻는 단계(S 110);
상기 추출물을 여과 및 감압 농축하는 단계(S 120); 로 이루어지는 것을 특징으로 하는 도라지 추출물을 함유한 항균 물티슈 조성물의 제조방법.
In the wet tissue composition and its preparation method,
The pulverized dried bellflower is put into ethanol of 5 to 30 times the weight of the bellflower and allowed to stand for 3 to 28 hours to obtain an extract (S 110);
Filtering and concentrating the extract (S 120); Wherein the antifungal agent is an antifungal agent.
상기 도라지의 중량대비 글리세린 3 내지 10 중량%와, 알코올 1 ~ 2 중량%를 첨가하여 혼합물을 얻는 단계(S 131); 를 더 포함하는 것을 특징으로 하는 도라지 추출물을 함유한 항균 물티슈 조성물의 제조방법.
The method according to claim 1,
(S 131) adding 3 to 10% by weight of glycerin and 1 to 2% by weight of alcohol to the weight of the bellflower to obtain a mixture; Wherein the antimicrobial wet tissue composition further comprises a bellflower extract.
상기 조성물은 정제수 60~90 중량%, 상기 감압 농축된 추출물 0.5~5.0중량%, 에칠헥실글리세린 0.5~2중량%, 데실렌글라이콜 0.5~2중량%, 소듐시트레이트 0.1~1중량%, 디프로필렌글라이콜 0.5~2중량%, 락틱애씨드 0.01~0.05중량%, 녹차추출물0.1~3.0중량%, 벤조산나트륨 0.1~0.2중량%, 소듐하이알루로네이트 0.01~0.1중량% 혼합하는 단계(S 132); 를 더 포함하는 것을 특징으로 하는 도라지 추출물을 함유한 항균 물티슈 조성물의 제조방법.
The method according to claim 1,
Wherein the composition comprises 60 to 90% by weight of purified water, 0.5 to 5.0% by weight of the concentrated extract under reduced pressure, 0.5 to 2% by weight of ethylhexyl glycerin, 0.5 to 2% by weight of decyleneglycol, 0.1 to 1% (S) of mixing 0.5 to 2% by weight of dipropylene glycol, 0.01 to 0.05% by weight of lactic acid, 0.1 to 3.0% by weight of green tea extract, 0.1 to 0.2% by weight of sodium benzoate, and 0.01 to 0.1% by weight of sodium hyaluronate 132); Wherein the antimicrobial wet tissue composition further comprises a bellflower extract.
상기 여과는 1 내지 10㎛ 구멍 사이즈를 갖는 여과지를 이용하고, 상기 감압 농축은 최초 부피의 10 내지 30%의 부피가 되도록 하는 것을 특징으로 하는 도라지 추출물을 함유한 항균 물티슈 조성물 및 이의 제조방법.
The method according to claim 1,
Wherein the filtration is performed using a filter paper having a pore size of 1 to 10 mu m, and the reduced pressure concentration is a volume of 10 to 30% of the initial volume, and a method for producing the same.
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| KR20230077926A (en) | 2021-11-26 | 2023-06-02 | 충남대학교산학협력단 | Antimicrobial and plastic-free wet tissue containing natural extracts |
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| WO2022173169A3 (en) * | 2021-02-09 | 2022-10-06 | 농업회사법인 주식회사 한도라지 | Hand sanitizer composition having very superior skin moisturizing effect, sterilizing effect and virucidal effect by containing ionized calcium |
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