KR20180048804A - 바리티닙 및 항암제를 포함하는 병용 요법 - Google Patents
바리티닙 및 항암제를 포함하는 병용 요법 Download PDFInfo
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- KR20180048804A KR20180048804A KR1020187008555A KR20187008555A KR20180048804A KR 20180048804 A KR20180048804 A KR 20180048804A KR 1020187008555 A KR1020187008555 A KR 1020187008555A KR 20187008555 A KR20187008555 A KR 20187008555A KR 20180048804 A KR20180048804 A KR 20180048804A
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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| PCT/EP2016/070888 WO2017037298A1 (en) | 2015-09-04 | 2016-09-05 | A combination therapy comprising varlitinib and an anticancer agent |
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| US20180353510A1 (en) | 2015-09-04 | 2018-12-13 | Aslan Pharmaceuticals Pte Ltd | Treatment of Biliary Duct Cancer |
| EP3445366A1 (de) * | 2016-04-21 | 2019-02-27 | Aslan Pharmaceuticals PTE Limited | Verfahren zur behandlung von leberkrebs |
| WO2018160138A1 (en) | 2017-03-02 | 2018-09-07 | Aslan Pharmaceuticals Pte Ltd | Dhodh inhibitor for treating haematological cancer |
| US11311548B2 (en) | 2017-03-02 | 2022-04-26 | Aslan Pharmaceuticals Pte. Ltd. | Cancer therapy |
| WO2019012030A1 (en) | 2017-07-13 | 2019-01-17 | INSERM (Institut National de la Santé et de la Recherche Médicale) | DHODH INHIBITOR AND CHK1 INHIBITOR FOR THE TREATMENT OF CANCER |
| WO2019083456A1 (en) * | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER FOR NORMALIZING ANGIOGENESIS IN A CANCER MASS |
| WO2019083457A1 (en) * | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS MUTATION OF THE BETA-CATENIN PATHWAY |
| WO2019083458A1 (en) * | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR THE TREATMENT OF CANCER TO REDUCE HYPOXIA |
| WO2019083455A1 (en) * | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS PRESENTING HER1, HER2 AND / OR HER3-ACTIVATED HERC-RECEPTOR CANCER CELLS |
| CN110914346B (zh) | 2018-04-13 | 2022-03-25 | 株式会社Lg化学 | 通过后处理交联来改善隔板的物理特性的方法和由此制备的隔板 |
| JP2022504201A (ja) * | 2018-10-09 | 2022-01-13 | アスラン ファーマシューティカルズ ピーティーイー リミテッド | バリチニブのマロン酸塩 |
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| GB201913123D0 (en) | 2019-09-11 | 2019-10-23 | Seald As | Compositions and methods for treatment of cholangiocarcinoma |
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| JP2010516771A (ja) | 2007-01-30 | 2010-05-20 | シェーリング コーポレイション | テモゾロミドおよび多標的キナーゼ阻害剤を使用する薬学的組成物および方法 |
| GB0706633D0 (en) * | 2007-04-04 | 2007-05-16 | Cyclacel Ltd | Combination |
| WO2010127417A2 (en) | 2009-05-05 | 2010-11-11 | Katholieke Universiteit Leuven | Hepatocellular carcinoma |
| EP2444088A1 (de) * | 2010-10-22 | 2012-04-25 | Almirall, S.A. | Aminoderivate zur Behandlung proliferativer Hauterkrankungen |
| JP2015508156A (ja) | 2012-01-25 | 2015-03-16 | ディーエヌエートリックス インコーポレイテッド | バイオマーカーならびに腫瘍溶解性ウイルスと免疫調節法とを用いる併用療法 |
| KR20170039774A (ko) | 2012-07-30 | 2017-04-11 | 알렉스 와 힌 영 | 종양 세포, 암세포파괴 바이러스 벡터 및 면역 체크포인트 조절인자를 갖는 암 백신 시스템 |
| US10139415B2 (en) | 2013-02-27 | 2018-11-27 | Daiichi Sankyo Company, Limited | Method for predicting responsiveness to compound inhibiting MAPK signal transduction pathway |
| CN104415335A (zh) | 2013-09-02 | 2015-03-18 | 北京中康万达医药科技有限公司 | 体内个体化系统免疫治疗方法和装置 |
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| TWI660739B (zh) | 2013-10-25 | 2019-06-01 | 製藥公司 | 使用布魯頓氏酪胺酸激酶抑制劑之治療及免疫療法 |
| RU2016142476A (ru) | 2014-03-31 | 2018-05-07 | Дженентек, Инк. | Комбинированная терапия, включающая антиангиогенезные агенты и агонисты, связывающие ох40 |
| SG11201703326SA (en) | 2014-10-24 | 2017-05-30 | Aladar Szalay | Combination immunotherapy approach for treatment of cancer |
| US20180353510A1 (en) | 2015-09-04 | 2018-12-13 | Aslan Pharmaceuticals Pte Ltd | Treatment of Biliary Duct Cancer |
| US20190117655A1 (en) | 2015-09-04 | 2019-04-25 | Aslan Pharmaceuticals Pte Ltd | Treatment of Biliary Duct Cancer |
| EP3445366A1 (de) | 2016-04-21 | 2019-02-27 | Aslan Pharmaceuticals PTE Limited | Verfahren zur behandlung von leberkrebs |
| EP3475284B1 (de) | 2016-06-24 | 2022-11-02 | Mersana Therapeutics, Inc. | Pyrrolobenzodiazepine und konjugate davon |
| GB201611580D0 (en) | 2016-07-01 | 2016-08-17 | Aslan Pharmaceuticals Pte Ltd | Method |
| WO2019083457A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS MUTATION OF THE BETA-CATENIN PATHWAY |
| WO2019083455A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER IN A PATIENT IDENTIFIED AS PRESENTING HER1, HER2 AND / OR HER3-ACTIVATED HERC-RECEPTOR CANCER CELLS |
| WO2019083456A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR USE IN THE TREATMENT OF CANCER FOR NORMALIZING ANGIOGENESIS IN A CANCER MASS |
| WO2019083458A1 (en) | 2017-10-25 | 2019-05-02 | Aslan Pharmaceuticals Pte Ltd | VARLITINIB FOR THE TREATMENT OF CANCER TO REDUCE HYPOXIA |
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| US20180243302A1 (en) | 2018-08-30 |
| WO2017037292A1 (en) | 2017-03-09 |
| EP3344251B1 (de) | 2021-04-28 |
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| US20180353510A1 (en) | 2018-12-13 |
| JP7332293B2 (ja) | 2023-08-23 |
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| US10682353B2 (en) | 2020-06-16 |
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| WO2017037299A1 (en) | 2017-03-09 |
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| US10849899B2 (en) | 2020-12-01 |
| KR20180043356A (ko) | 2018-04-27 |
| US20200009144A1 (en) | 2020-01-09 |
| WO2017037298A1 (en) | 2017-03-09 |
| JP2018535923A (ja) | 2018-12-06 |
| EP3344252B1 (de) | 2020-02-26 |
| CN108135900A (zh) | 2018-06-08 |
| CN108135901A (zh) | 2018-06-08 |
| EP3344253B1 (de) | 2020-02-26 |
| WO2017037300A1 (en) | 2017-03-09 |
| CN108025010A (zh) | 2018-05-11 |
| JP2018526382A (ja) | 2018-09-13 |
| EP3344252A1 (de) | 2018-07-11 |
| EP3344253A1 (de) | 2018-07-11 |
| CN113750238A (zh) | 2021-12-07 |
| US10357494B2 (en) | 2019-07-23 |
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