KR20180035906A - Lag-3 및 pd-1에 특이적인 신규 융합 폴리펩타이드 - Google Patents
Lag-3 및 pd-1에 특이적인 신규 융합 폴리펩타이드 Download PDFInfo
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- KR20180035906A KR20180035906A KR1020187006631A KR20187006631A KR20180035906A KR 20180035906 A KR20180035906 A KR 20180035906A KR 1020187006631 A KR1020187006631 A KR 1020187006631A KR 20187006631 A KR20187006631 A KR 20187006631A KR 20180035906 A KR20180035906 A KR 20180035906A
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/62—DNA sequences coding for fusion proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/03—Peptides having up to 20 amino acids in an undefined or only partially defined sequence; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
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- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
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- Animal Behavior & Ethology (AREA)
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- Public Health (AREA)
- Veterinary Medicine (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
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| EP16150707 | 2016-01-11 | ||
| EP16150707.4 | 2016-01-11 | ||
| PCT/EP2016/068860 WO2017025498A1 (en) | 2015-08-07 | 2016-08-08 | Novel fusion polypeptide specific for lag-3 and pd-1 |
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| KR20180035906A true KR20180035906A (ko) | 2018-04-06 |
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| SG11201811184UA (en) | 2016-06-20 | 2019-01-30 | F Star Beta Ltd | Lag -3 binding members |
| GB201612520D0 (en) | 2016-07-19 | 2016-08-31 | F-Star Beta Ltd | Binding molecules |
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| ES3024433T3 (en) | 2017-12-19 | 2025-06-04 | F Star Therapeutics Ltd | Fc binding fragments comprising a pd-l1 antigen-binding site |
| EP3746480A1 (en) * | 2018-01-31 | 2020-12-09 | F. Hoffmann-La Roche AG | Bispecific antibodies comprising an antigen-binding site binding to lag3 |
| FR3078536A1 (fr) * | 2018-03-05 | 2019-09-06 | Peptinov Sas | Composition vaccinale anti-pd-1 |
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| KR102876940B1 (ko) | 2018-03-30 | 2025-10-24 | 난징 레전드 바이오테크 씨오., 엘티디. | Lag-3에 대한 단일-도메인 항체 및 이의 용도 |
| GB201811403D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | Antibody molecules |
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| IL280002B2 (en) | 2018-07-12 | 2025-05-01 | F Star Beta Ltd | Antibody molecules that bind CD137 and OX40 |
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| GB201811410D0 (en) | 2018-07-12 | 2018-08-29 | F Star Beta Ltd | OX40 Binding molecules |
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| EP4178611A1 (en) | 2020-07-07 | 2023-05-17 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
| AU2021331476A1 (en) | 2020-08-28 | 2023-05-04 | Bristol-Myers Squibb Company | Lag-3 antagonist therapy for hepatocellular carcinoma |
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| WO2022120179A1 (en) | 2020-12-03 | 2022-06-09 | Bristol-Myers Squibb Company | Multi-tumor gene signatures and uses thereof |
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- 2016-08-08 HK HK18113535.5A patent/HK1254450A1/zh unknown
- 2016-08-08 RU RU2018107991A patent/RU2018107991A/ru not_active Application Discontinuation
- 2016-08-08 BR BR112018000366A patent/BR112018000366A2/pt not_active Application Discontinuation
- 2016-08-08 MX MX2018001567A patent/MX2018001567A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20190010231A1 (en) | 2019-01-10 |
| RU2018107991A3 (enExample) | 2020-02-17 |
| CN107922470A (zh) | 2018-04-17 |
| CA2994631A1 (en) | 2017-02-16 |
| AU2016306597A1 (en) | 2018-02-22 |
| BR112018000366A2 (pt) | 2018-09-11 |
| EP3331901A1 (en) | 2018-06-13 |
| HK1254450A1 (zh) | 2019-07-19 |
| RU2018107991A (ru) | 2019-09-09 |
| JP2018526989A (ja) | 2018-09-20 |
| WO2017025498A1 (en) | 2017-02-16 |
| EA201890456A1 (ru) | 2018-07-31 |
| MX2018001567A (es) | 2018-11-09 |
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