KR20180033606A - 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물 - Google Patents

베타-ENaC-관련 질환을 치료하기 위한 유기 조성물 Download PDF

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KR20180033606A
KR20180033606A KR1020187008466A KR20187008466A KR20180033606A KR 20180033606 A KR20180033606 A KR 20180033606A KR 1020187008466 A KR1020187008466 A KR 1020187008466A KR 20187008466 A KR20187008466 A KR 20187008466A KR 20180033606 A KR20180033606 A KR 20180033606A
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antisense strand
sequence
seq
nos
enac
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Korean (ko)
Inventor
안토닌 디 포거롤레스
존 엘. 디너
엠마 히크만
그레고리 힌클
스투아트 밀스테인
앤-마리 풀리치노
앤드류 스프라그
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애로우헤드 파마슈티컬스 인코포레이티드
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Priority to KR1020227000366A priority Critical patent/KR20220008383A/ko
Publication of KR20180033606A publication Critical patent/KR20180033606A/ko
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088Compounds having three or more nucleosides or nucleotides
    • A61K31/713Double-stranded nucleic acids or oligonucleotides
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    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/14Type of nucleic acid interfering nucleic acids [NA]
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KR1020187008466A 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물 Ceased KR20180033606A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020227000366A KR20220008383A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US32737910P 2010-04-23 2010-04-23
US61/327,379 2010-04-23
US33339810P 2010-05-11 2010-05-11
US61/333,398 2010-05-11
PCT/EP2011/056299 WO2011131707A1 (en) 2010-04-23 2011-04-20 ORGANIC COMPOSITIONS TO TREAT BETA-ENaC-RELATED DISEASES

Related Parent Applications (1)

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KR1020127030568A Division KR20130051954A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물

Related Child Applications (2)

Application Number Title Priority Date Filing Date
KR1020227000366A Division KR20220008383A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020197031212A Division KR20190122893A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물

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KR20180033606A true KR20180033606A (ko) 2018-04-03

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Application Number Title Priority Date Filing Date
KR1020187008466A Ceased KR20180033606A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020197031212A Ceased KR20190122893A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020127030568A Ceased KR20130051954A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020227000366A Ceased KR20220008383A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물

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KR1020197031212A Ceased KR20190122893A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020127030568A Ceased KR20130051954A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물
KR1020227000366A Ceased KR20220008383A (ko) 2010-04-23 2011-04-20 베타-ENaC-관련 질환을 치료하기 위한 유기 조성물

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US (10) US8344127B2 (https=)
EP (3) EP3431604A1 (https=)
JP (6) JP5857378B2 (https=)
KR (4) KR20180033606A (https=)
CN (2) CN102985544A (https=)
AR (1) AR081082A1 (https=)
AU (1) AU2011244335B2 (https=)
BR (1) BR112012027080A2 (https=)
CA (2) CA3098080A1 (https=)
DK (1) DK2561077T3 (https=)
EA (1) EA034363B1 (https=)
ES (1) ES2574204T3 (https=)
MX (2) MX350595B (https=)
TW (1) TWI434692B (https=)
WO (1) WO2011131707A1 (https=)

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EP2852668B1 (en) * 2012-07-12 2016-04-27 ProQR Therapeutics II B.V. Oligonucleotides for making a change in the sequence of a target rna molecule present in a living cell
EP3110381B1 (en) 2014-02-28 2020-07-15 Attends Healthcare Products, Inc. Absorbent article with multi-layer folded absorbent core
WO2018027550A1 (en) * 2016-08-09 2018-02-15 Shanghai Yao Yuan Biotechnology Co., Ltd. Methods and compositions for appetite control and weight management
BR112019012060A2 (pt) 2016-12-14 2020-03-10 Attends Healthcare Products Inc. Laminados absorventes, núcleos absorventes e artigos descartáveis utilizando os laminados absorventes e métodos relacionados
ES3019585T3 (en) 2018-05-28 2025-05-20 Attends Healthcare Products Inc Dryness layer laminate for absorbent articles
CN109364248B (zh) * 2018-10-16 2021-05-18 哈尔滨医科大学 ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用
TW202130809A (zh) * 2019-10-29 2021-08-16 美商愛羅海德製藥公司 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法
US20230136960A1 (en) * 2020-03-19 2023-05-04 Nature's Toolbox, Inc. Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same
CN114149492A (zh) * 2020-08-21 2022-03-08 中国人民解放军军事科学院军事医学研究院 一种用于预防甲型流感病毒感染的HA-mRNA疫苗

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