EA201201457A1 - Органические композиции для лечения заболеваний, связанных с бета-субъединицей эпителиальных натриевых каналов - Google Patents

Органические композиции для лечения заболеваний, связанных с бета-субъединицей эпителиальных натриевых каналов

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Publication number
EA201201457A1
EA201201457A1 EA201201457A EA201201457A EA201201457A1 EA 201201457 A1 EA201201457 A1 EA 201201457A1 EA 201201457 A EA201201457 A EA 201201457A EA 201201457 A EA201201457 A EA 201201457A EA 201201457 A1 EA201201457 A1 EA 201201457A1
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EA
Eurasian Patent Office
Prior art keywords
treatment
diseases associated
epitelial
unit
sodium channels
Prior art date
Application number
EA201201457A
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English (en)
Other versions
EA034363B1 (ru
Inventor
Антонен Де-Фужероль
Джон Л. Динер
Эмма Хикман
Грегори Хинкле
Стюарт Милстейн
Анн-Мари Пюлишино
Эндрью Спраге
Original Assignee
Новартис Аг
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Application filed by Новартис Аг filed Critical Новартис Аг
Publication of EA201201457A1 publication Critical patent/EA201201457A1/ru
Publication of EA034363B1 publication Critical patent/EA034363B1/ru

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Abstract

В заявке описывают агенты РНКи, применимые в способах лечения заболеваний, связанных с β-ENaC, например муковисцидоза, псевдогипоальдостеронизма типа 1 (ПГА1), синдрома Лиддла, гипертонии, алкалоза, гипокалиемии и гипертонии, связанной с ожирением, используя терапевтически эффективное количество агента РНКи к β-ENaC.
EA201201457A 2010-04-23 2011-04-20 Фармацевтическая композиция для ингибирования экспрессии гена beta-enac и ее применение EA034363B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US32737910P 2010-04-23 2010-04-23
US33339810P 2010-05-11 2010-05-11
PCT/EP2011/056299 WO2011131707A1 (en) 2010-04-23 2011-04-20 ORGANIC COMPOSITIONS TO TREAT BETA-ENaC-RELATED DISEASES

Publications (2)

Publication Number Publication Date
EA201201457A1 true EA201201457A1 (ru) 2013-04-30
EA034363B1 EA034363B1 (ru) 2020-01-30

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EA201201457A EA034363B1 (ru) 2010-04-23 2011-04-20 Фармацевтическая композиция для ингибирования экспрессии гена beta-enac и ее применение

Country Status (15)

Country Link
US (10) US8344127B2 (ru)
EP (3) EP3431604A1 (ru)
JP (6) JP5857378B2 (ru)
KR (4) KR20180033606A (ru)
CN (2) CN102985544A (ru)
AR (1) AR081082A1 (ru)
AU (1) AU2011244335B2 (ru)
BR (1) BR112012027080A2 (ru)
CA (2) CA3098080A1 (ru)
DK (1) DK2561077T3 (ru)
EA (1) EA034363B1 (ru)
ES (1) ES2574204T3 (ru)
MX (1) MX350595B (ru)
TW (1) TWI434692B (ru)
WO (1) WO2011131707A1 (ru)

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CN109475552B (zh) * 2016-08-09 2022-04-05 上海药苑生物科技有限公司 用于食欲控制和体重管理的方法和组合物
MX2020012801A (es) 2018-05-28 2021-03-25 Attends Healthcare Products Inc Laminado con capa de sequedad para articulos absorbentes.
CN109364248B (zh) * 2018-10-16 2021-05-18 哈尔滨医科大学 ENaC及其抑制剂在预防、缓解和/或治疗动脉粥样硬化中的应用
TW202130809A (zh) * 2019-10-29 2021-08-16 美商愛羅海德製藥公司 用於抑制β-ENaC表現之RNAi藥劑、其組合物及使用方法
US20230136960A1 (en) * 2020-03-19 2023-05-04 Nature's Toolbox, Inc. Novel MRNA-Based COVID-19 Multi-Valent Vaccine and Methods of Scaled Production of the Same
CN114149492A (zh) * 2020-08-21 2022-03-08 中国人民解放军军事科学院军事医学研究院 一种用于预防甲型流感病毒感染的HA-mRNA疫苗

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