KR20180005225A - 생물제약적 및 생물학적 거대분자 생성물 생산용 모듈형 플랜트를 조절하고 제어하기 위한 공정 제어 시스템 - Google Patents

생물제약적 및 생물학적 거대분자 생성물 생산용 모듈형 플랜트를 조절하고 제어하기 위한 공정 제어 시스템 Download PDF

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KR20180005225A
KR20180005225A KR1020177035436A KR20177035436A KR20180005225A KR 20180005225 A KR20180005225 A KR 20180005225A KR 1020177035436 A KR1020177035436 A KR 1020177035436A KR 20177035436 A KR20177035436 A KR 20177035436A KR 20180005225 A KR20180005225 A KR 20180005225A
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Korean (ko)
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페터 슈반
마틴 로베단
옌스 베른스하우젠
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바이엘 악티엔게젤샤프트
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/44—Multiple separable units; Modules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/58—Reaction vessels connected in series or in parallel
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/10—Perfusion
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/44—Means for regulation, monitoring, measurement or control, e.g. flow regulation of volume or liquid level
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/48—Automatic or computerized control
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05D—SYSTEMS FOR CONTROLLING OR REGULATING NON-ELECTRIC VARIABLES
    • G05D7/00—Control of flow
    • G05D7/06—Control of flow characterised by the use of electric means
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B11/00—Automatic controllers
    • G05B11/01—Automatic controllers electric
    • G05B11/36—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential
    • G05B11/42—Automatic controllers electric with provision for obtaining particular characteristics, e.g. proportional, integral, differential for obtaining a characteristic which is both proportional and time-dependent, e.g. P. I., P. I. D.
    • G—PHYSICS
    • G05—CONTROLLING; REGULATING
    • G05B—CONTROL OR REGULATING SYSTEMS IN GENERAL; FUNCTIONAL ELEMENTS OF SUCH SYSTEMS; MONITORING OR TESTING ARRANGEMENTS FOR SUCH SYSTEMS OR ELEMENTS
    • G05B13/00—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion
    • G05B13/02—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric
    • G05B13/0265—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion
    • G05B13/0275—Adaptive control systems, i.e. systems automatically adjusting themselves to have a performance which is optimum according to some preassigned criterion electric the criterion being a learning criterion using fuzzy logic only

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Sustainable Development (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Computer Hardware Design (AREA)
  • General Physics & Mathematics (AREA)
  • Automation & Control Theory (AREA)
  • Artificial Intelligence (AREA)
  • Software Systems (AREA)
  • Mathematical Physics (AREA)
  • Fuzzy Systems (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Evolutionary Computation (AREA)
  • Medical Informatics (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Feedback Control In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Testing And Monitoring For Control Systems (AREA)
  • Peptides Or Proteins (AREA)
  • Flow Control (AREA)
KR1020177035436A 2015-05-13 2016-05-10 생물제약적 및 생물학적 거대분자 생성물 생산용 모듈형 플랜트를 조절하고 제어하기 위한 공정 제어 시스템 Ceased KR20180005225A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15167538.6A EP3093335A1 (de) 2015-05-13 2015-05-13 Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten
EP15167538.6 2015-05-13
PCT/EP2016/060369 WO2016180798A1 (de) 2015-05-13 2016-05-10 Prozessleitsystem zur regelung und steuerung einer modular aufgebauten anlage zur produktion von biopharmazeutischen und biologischen makromolekularen produkten

Publications (1)

Publication Number Publication Date
KR20180005225A true KR20180005225A (ko) 2018-01-15

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ID=53177195

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KR1020177035436A Ceased KR20180005225A (ko) 2015-05-13 2016-05-10 생물제약적 및 생물학적 거대분자 생성물 생산용 모듈형 플랜트를 조절하고 제어하기 위한 공정 제어 시스템

Country Status (21)

Country Link
US (2) US20180127461A1 (https=)
EP (2) EP3093335A1 (https=)
JP (1) JP6833721B2 (https=)
KR (1) KR20180005225A (https=)
CN (1) CN107849506B (https=)
AR (1) AR104554A1 (https=)
AU (1) AU2016259746B2 (https=)
BR (1) BR112017024373B1 (https=)
CA (1) CA2985678A1 (https=)
DK (1) DK3294856T3 (https=)
ES (1) ES2760468T3 (https=)
IL (1) IL255556B (https=)
MX (1) MX380681B (https=)
PL (1) PL3294856T3 (https=)
PT (1) PT3294856T (https=)
RU (1) RU2724495C2 (https=)
SA (1) SA517390330B1 (https=)
SG (1) SG11201709329YA (https=)
TW (1) TWI689303B (https=)
WO (1) WO2016180798A1 (https=)
ZA (1) ZA201708418B (https=)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3431173A1 (en) 2017-07-19 2019-01-23 Bayer Pharma Aktiengesellschaft Continuous manufacture of guidance molecule drug conjugates
CN112639850A (zh) * 2018-09-05 2021-04-09 联邦科学和工业研究组织 用于多参数制造过程的监视器
EP3699697A1 (en) 2019-02-25 2020-08-26 Bayer Aktiengesellschaft Automated simultaneous process control
JP7604486B2 (ja) * 2020-05-29 2024-12-23 株式会社ダイセル 異常変調原因特定装置、異常変調原因特定方法及び異常変調原因特定プログラム
EP4544020A1 (de) 2022-06-24 2025-04-30 Bilfinger Life Science GmbH Modulare vorrichtung und verfahren zur kontinuierlichen herstellung von biotechnologischen produkten
DE102022208467A1 (de) 2022-06-24 2024-01-04 Bilfinger Life Science Gmbh Modulare Vorrichtung und Verfahren zur kontinuierlichen Herstellung von biotechnologischen Produkten
EP4711439A1 (en) 2024-09-16 2026-03-18 Sartorius Stedim Biotech GmbH Flow system with recirculation loop

Family Cites Families (16)

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WO1994011838A1 (en) * 1992-11-06 1994-05-26 Abbott Laboratories Process control system for biological fluid testing
JP2004198123A (ja) * 2002-12-16 2004-07-15 Shimadzu Corp 分取液体クロマトグラフ質量分析装置
JP3823092B2 (ja) * 2003-03-11 2006-09-20 株式会社日立ハイテクノロジーズ 分離分析装置
JP2006018711A (ja) * 2004-07-05 2006-01-19 Earekkusu:Kk 液体除染剤供給システム
WO2006039588A2 (en) 2004-09-30 2006-04-13 Bayer Healthcare Llc Devices and methods for integrated continuous manufacturing of biological molecules
CN101321856A (zh) * 2005-05-09 2008-12-10 萨克松尼亚生物科技有限责任公司 用于细胞培养模块的供应系统
CN101400418B (zh) * 2006-03-17 2012-11-14 沃特世科技公司 保持流体完整性和预先形成梯度的适于液相色谱的溶剂输送系统
JP4831480B2 (ja) * 2006-06-21 2011-12-07 三浦工業株式会社 膜濾過システム
WO2012072822A1 (en) * 2010-12-03 2012-06-07 Mindseeds Laboratories Srl Microanalysis of cellular function
KR102027596B1 (ko) * 2010-12-06 2019-10-01 타폰 바이오시스템즈, 인코포레이티드 생물학적 산물을 위한 연속 처리 방법
CN103243026B (zh) * 2012-02-14 2014-09-03 常州医凌生命科技有限公司 多功能全自动细胞及溶液处理仪
EP2682168A1 (en) * 2012-07-02 2014-01-08 Millipore Corporation Purification of biological molecules
WO2014112527A1 (ja) * 2013-01-18 2014-07-24 株式会社島津製作所 サンプル濃縮装置
SG10201709131UA (en) 2013-03-08 2017-12-28 Genzyme Corp Continuous purification of therapeutic proteins
DE102013212540A1 (de) * 2013-06-27 2014-12-31 Agilent Technologies Inc. Konditionieren eines nachfolgenden Probenpakets in einer Probentrennstufe während Prozessierens eines vorangehenden Probenpakets in einer Probenweiterverarbeitungsstufe
CN107406816B (zh) * 2014-07-31 2021-10-12 马里兰大学巴尔的摩分校 用于从人类血液制造蛋白质的微量生物处理系统和方法

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Publication number Publication date
SA517390330B1 (ar) 2021-09-22
EP3294856A1 (de) 2018-03-21
JP2018524668A (ja) 2018-08-30
SG11201709329YA (en) 2017-12-28
IL255556A (en) 2018-01-31
RU2017143437A (ru) 2019-06-13
ZA201708418B (en) 2022-08-31
TWI689303B (zh) 2020-04-01
MX2017014527A (es) 2018-03-12
AU2016259746A1 (en) 2017-12-07
CA2985678A1 (en) 2016-11-17
AR104554A1 (es) 2017-07-26
MX380681B (es) 2025-03-12
US20180127461A1 (en) 2018-05-10
BR112017024373A2 (pt) 2018-07-31
PL3294856T3 (pl) 2020-04-30
HK1252939A1 (zh) 2019-06-06
US20210221842A1 (en) 2021-07-22
RU2724495C2 (ru) 2020-06-23
EP3294856B1 (de) 2019-09-18
RU2017143437A3 (https=) 2019-08-29
EP3093335A1 (de) 2016-11-16
WO2016180798A1 (de) 2016-11-17
CN107849506A (zh) 2018-03-27
BR112017024373B1 (pt) 2022-08-09
JP6833721B2 (ja) 2021-02-24
AU2016259746A8 (en) 2018-04-05
TW201717886A (zh) 2017-06-01
DK3294856T3 (da) 2019-12-09
AU2016259746B2 (en) 2020-12-24
ES2760468T3 (es) 2020-05-14
IL255556B (en) 2022-04-01
PT3294856T (pt) 2019-12-16
CN107849506B (zh) 2020-11-03

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