KR20170131449A - Hcv의 거대고리 단백질 가수분해효소 저해제 제조를 위한 방법 및 중간물질 - Google Patents

Hcv의 거대고리 단백질 가수분해효소 저해제 제조를 위한 방법 및 중간물질 Download PDF

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KR20170131449A
KR20170131449A KR1020177026974A KR20177026974A KR20170131449A KR 20170131449 A KR20170131449 A KR 20170131449A KR 1020177026974 A KR1020177026974 A KR 1020177026974A KR 20177026974 A KR20177026974 A KR 20177026974A KR 20170131449 A KR20170131449 A KR 20170131449A
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South Korea
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compound
formula
compounds
xviia
mol
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KR1020177026974A
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도미니크 파울 미쉘 드프레
도미니크 존 오메로드
안드라스 호바쓰
토마스 쇼 무디
머드 브로사트
올리비에 리앙
니콜라스 브리아몬트
세바스티앙 프랑수와 엠마뉴엘 르메르
세바스티앙 니콜라스 제이 허먼트
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얀센 파마슈티칼즈, 인코포레이티드
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Publication of KR20170131449A publication Critical patent/KR20170131449A/ko

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/82—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a ring other than a six-membered aromatic ring
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    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22—Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/40—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
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    • C07C67/00—Preparation of carboxylic acid esters
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07—ORGANIC CHEMISTRY
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    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/001—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by metabolizing one of the enantiomers
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    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/24—Preparation of oxygen-containing organic compounds containing a carbonyl group
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    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
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    • C07B2200/07—Optical isomers
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    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/60—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • C07C233/61—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by doubly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/74—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C69/757—Esters of carboxylic acids having an esterified carboxyl group bound to a carbon atom of a ring other than a six-membered aromatic ring having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety

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  • Chemical & Material Sciences (AREA)
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  • Wood Science & Technology (AREA)
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  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Plural Heterocyclic Compounds (AREA)
KR1020177026974A 2015-03-27 2016-03-25 Hcv의 거대고리 단백질 가수분해효소 저해제 제조를 위한 방법 및 중간물질 KR20170131449A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP15161431 2015-03-27
EP15161431.0 2015-03-27
PCT/IB2016/051720 WO2016157058A1 (en) 2015-03-27 2016-03-25 Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv

Publications (1)

Publication Number Publication Date
KR20170131449A true KR20170131449A (ko) 2017-11-29

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ID=52737010

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177026974A KR20170131449A (ko) 2015-03-27 2016-03-25 Hcv의 거대고리 단백질 가수분해효소 저해제 제조를 위한 방법 및 중간물질

Country Status (15)

Country Link
US (1) US20180093943A1 (zh)
EP (1) EP3274324A1 (zh)
JP (1) JP2018517661A (zh)
KR (1) KR20170131449A (zh)
CN (1) CN107429270A (zh)
AU (1) AU2016241924A1 (zh)
BR (1) BR112017019898A2 (zh)
CA (1) CA2976175A1 (zh)
EA (1) EA201792114A1 (zh)
HK (1) HK1247246A1 (zh)
IL (1) IL253899A0 (zh)
MA (1) MA41812A (zh)
MX (1) MX2017012348A (zh)
SG (1) SG11201707594SA (zh)
WO (1) WO2016157058A1 (zh)

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
JO2768B1 (en) * 2005-07-29 2014-03-15 تيبوتيك فارماسيوتيكالز ليمتد Large cyclic inhibitors of hepatitis C virus
EP2121674B1 (en) 2007-02-01 2010-05-12 Tibotec Pharmaceuticals Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
US8048862B2 (en) 2008-04-15 2011-11-01 Intermune, Inc. Macrocyclic inhibitors of hepatitis C virus replication
ES2429013T3 (es) 2008-12-23 2013-11-12 Janssen Pharmaceuticals, Inc. Procedimientos e intermedios para la preparación de un inhibidor macrocíclico de la proteasa de VHC
EP3239129A1 (en) 2010-03-16 2017-11-01 Janssen Pharmaceuticals, Inc. Processes and intermediates for preparing a macrocyclic protease inhibitor of hcv
JP2014527061A (ja) * 2011-08-24 2014-10-09 グラクソスミスクライン エルエルシー Ｃ型肝炎の組合せ治療
KR20140063726A (ko) 2011-09-22 2014-05-27 얀센 파마슈티칼즈, 인코포레이티드 Hcv의 거대고리 단백질 분해효소 억제제의 제조 방법 및 중간물질
BR112014009849A2 (pt) 2011-10-28 2016-07-05 Janssen Pharmaceuticals Inc processo melhorado para preparação de intermediário do inibidor de protease macrocíclico tmc 435

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Publication number Publication date
CN107429270A (zh) 2017-12-01
HK1247246A1 (zh) 2018-09-21
BR112017019898A2 (pt) 2018-06-12
EA201792114A1 (ru) 2018-01-31
JP2018517661A (ja) 2018-07-05
EP3274324A1 (en) 2018-01-31
AU2016241924A1 (en) 2017-08-24
WO2016157058A1 (en) 2016-10-06
SG11201707594SA (en) 2017-10-30
CA2976175A1 (en) 2016-10-06
US20180093943A1 (en) 2018-04-05
MX2017012348A (es) 2017-12-14
MA41812A (fr) 2018-01-30
IL253899A0 (en) 2017-10-31

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