KR20170117113A - 면역 관문 저해제와 조합한 플리나불린의 용도 - Google Patents

면역 관문 저해제와 조합한 플리나불린의 용도 Download PDF

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Publication number
KR20170117113A
KR20170117113A KR1020177025140A KR20177025140A KR20170117113A KR 20170117113 A KR20170117113 A KR 20170117113A KR 1020177025140 A KR1020177025140 A KR 1020177025140A KR 20177025140 A KR20177025140 A KR 20177025140A KR 20170117113 A KR20170117113 A KR 20170117113A
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Prior art keywords
inhibitor
cancer
immune
antibody
ctla
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Ceased
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KR1020177025140A
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English (en)
Korean (ko)
Inventor
란 황
글로리아 치-이에 리
Original Assignee
비욘드스프링 파마수티컬스, 인코포레이티드.
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Priority to KR1020247022015A priority Critical patent/KR20240110996A/ko
Publication of KR20170117113A publication Critical patent/KR20170117113A/ko
Ceased legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507Comprising a combination of two or more separate antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Endocrinology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020177025140A 2015-02-12 2016-02-11 면역 관문 저해제와 조합한 플리나불린의 용도 Ceased KR20170117113A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020247022015A KR20240110996A (ko) 2015-02-12 2016-02-11 면역 관문 저해제와 조합한 플리나불린의 용도

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201562115468P 2015-02-12 2015-02-12
US62/115,468 2015-02-12
US201562255259P 2015-11-13 2015-11-13
US62/255,259 2015-11-13
PCT/US2016/017602 WO2016130839A1 (en) 2015-02-12 2016-02-11 Use of plinabulin in combination with immune checkpoint inhibitors

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020247022015A Division KR20240110996A (ko) 2015-02-12 2016-02-11 면역 관문 저해제와 조합한 플리나불린의 용도

Publications (1)

Publication Number Publication Date
KR20170117113A true KR20170117113A (ko) 2017-10-20

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KR1020177025140A Ceased KR20170117113A (ko) 2015-02-12 2016-02-11 면역 관문 저해제와 조합한 플리나불린의 용도
KR1020247022015A Pending KR20240110996A (ko) 2015-02-12 2016-02-11 면역 관문 저해제와 조합한 플리나불린의 용도

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US (1) US20180028531A1 (enExample)
EP (1) EP3256130A4 (enExample)
JP (4) JP7243021B2 (enExample)
KR (2) KR20170117113A (enExample)
CN (2) CN107427510A (enExample)
AU (3) AU2016219204B2 (enExample)
CA (1) CA2975729A1 (enExample)
CL (1) CL2017002050A1 (enExample)
HK (1) HK1247816A1 (enExample)
IL (2) IL286282B2 (enExample)
MX (2) MX394865B (enExample)
MY (1) MY193968A (enExample)
NZ (1) NZ734256A (enExample)
RU (1) RU2723021C2 (enExample)
SG (1) SG11201706281YA (enExample)
WO (1) WO2016130839A1 (enExample)

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RU2017127966A3 (enExample) 2019-06-20
CL2017002050A1 (es) 2018-04-13
IL286282B2 (en) 2023-10-01
HK1247816A1 (zh) 2018-10-05
CN117100753A (zh) 2023-11-24
AU2016219204A1 (en) 2017-08-24
NZ750444A (en) 2021-03-26
MX2017010338A (es) 2017-12-20
CA2975729A1 (en) 2016-08-18
BR112017016902A2 (pt) 2018-03-27
AU2016219204B2 (en) 2021-01-21
EP3256130A4 (en) 2018-08-01
AU2021202416B2 (en) 2024-02-15
JP2022190005A (ja) 2022-12-22
IL286282B1 (en) 2023-06-01
RU2017127966A (ru) 2019-03-12
SG11201706281YA (en) 2017-09-28
WO2016130839A1 (en) 2016-08-18
MX394865B (es) 2025-03-24
NZ734256A (en) 2019-02-22
AU2021202416A1 (en) 2021-05-20
RU2723021C2 (ru) 2020-06-08
JP2024174070A (ja) 2024-12-13
MY193968A (en) 2022-11-03
JP7157181B2 (ja) 2022-10-19
CN107427510A (zh) 2017-12-01
MX2022007472A (es) 2022-06-29
IL253784A0 (en) 2017-09-28
JP7564172B2 (ja) 2024-10-08
KR20240110996A (ko) 2024-07-16
IL253784B (en) 2021-09-30
JP7243021B2 (ja) 2023-03-22
JP2018508572A (ja) 2018-03-29
AU2024200672A1 (en) 2024-02-22
US20180028531A1 (en) 2018-02-01
JP2021050247A (ja) 2021-04-01
EP3256130A1 (en) 2017-12-20
IL286282A (en) 2021-10-31

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