KR20170109329A

KR20170109329A - Atopic treatment composition for manufacturing hydrogen water of high density for Atopic improvement and method

Info

Publication number: KR20170109329A
Application number: KR1020160033304A
Authority: KR
Inventors: 임동표; 김두환; 정갑택
Original assignee: 주식회사 엠비지
Priority date: 2016-03-21
Filing date: 2016-03-21
Publication date: 2017-09-29
Also published as: KR101785090B1

Abstract

The present invention relates to a composition for treating atopic diseases using high concentration of hydrogen peroxide useful for improving atopy, and more particularly to a composition for treating atopic diseases, which is excellent in the removal of active oxygen, a mineral which releases a large amount of far infrared rays and anions, The present invention relates to a composition for treating atopic dermatitis using high concentration of hydrogen peroxide, which is useful for atopic amelioration and suppression of symptoms of atopic eczema without using side effects by using propolis called antibiotics, and a method for producing the composition.

Description

[0001] The present invention relates to a composition for treating atopic diseases using high concentration of hydrogen peroxide,

The present invention relates to a composition for treating atopic diseases using high concentration of hydrogen peroxide useful for improving atopy, and more particularly to a composition for treating atopic diseases, which is excellent in the removal of active oxygen, a mineral which releases a large amount of far infrared rays and anions, The present invention relates to a composition for treating atopic dermatitis using high concentration of hydrogen peroxide, which is useful for atopic amelioration which suppresses and alleviates the symptoms of atopic eczema without using side effects by using propolis called antibiotics.

In recent years, patients with atopic skin disease have increased in size, particularly those with dry atopic skin, those with weak skin or poor resistance, and patients with atopic skin disease are rapidly increasing in symptom severity.

Atopic skin disease is a skin disease caused by various pollutants and bacteria such as Staphylococcus aureus, which is susceptible to dry skin or dry skin.

However, various pollutants, bacteria, volatile organic compounds in the air, and ozone, which cause skin hypersensitivity reactions, have a synergistic action to aggravate symptoms of atopic skin diseases.

Atopy refers to an immediate physiological reaction that occurs when an individual having an atopic subject is exposed to a specific antigen. As a result of excessive production of immunoglobulin E and deterioration of cell-mediated immune function, the skin, respiratory mucosa, Every part of the body is accompanied by symptoms such as allergic dermatitis, allergic rhinitis, asthma, allergic conjunctivitis, and atopic hives.

Although atopic dermatitis may show individual differences, it usually involves severe itching, skin dryness, rashes, dirt, scabs, scaly skin, etc., which can cause emotional anxiety, stress, tension, frustration, And other allergic diseases such as urticaria, metal allergies, asthma and allergic rhinitis, etc., are becoming serious social problems that threaten the public health today.

Typical drugs known to be effective for atopic dermatitis so far include steroids, antihistamines, antibiotics, non-steroids, sedatives and nerve stabilizers.

Double steroids are excellent for anti-inflammatory and immunosuppressive effects. On the other hand, when used for a long time, the skin elasticity disappears and becomes thinner, and the vaginal opening becomes unstable. In severe cases, systemic symptoms due to hormones, adrenal function decrease, And when the medicine is stopped, the symptoms deteriorate explosively.

Antihistamines are only temporary measures to alleviate the itch symptoms by inhibiting histamine from being liberated from mast cells, and side effects such as insomnia, anxiety and loss of appetite are seen when used for a long time.

In addition, antibiotics are intended to prevent secondary bacterial infections caused by scratching, rather than as a fundamental therapeutic drug for atopic dermatitis. The use of antibiotics increases resistance and gastrointestinal function, Aplastic anemia due to bone marrow function, and the like.

In addition, other non-steroids are only a moisturizing agent for relieving symptoms of atopic dermatitis, and sedatives and nervous stabilizers are merely an adjuvant for symptom relief rather than a fundamental therapeutic goal.

Moreover, these existing atopic treatments have different effects depending on the constitution of the individual, and in particular, the addition and use of an artificial chemical composition during the composition and the manufacturing process are premised on, and apart from the pharmacological components, they act as serious allergens It is very difficult to trust its safety because the possibilities are so great.

Korean Patent Laid-Open No. 10-2001-0089716 discloses that a therapeutic agent for skin dryness comprises spirooxathiolan quinuclidine derivative or an acid addition salt thereof as an active ingredient, but for the synthesis of the corresponding derivative, 3-hydroxy-3-mercaptomethylquinuclidine And a chemical treatment such as reaction with a carbonyl compound and isolation.

In contrast, in the case of the present invention, it is possible to suppress and alleviate symptoms of atopic eczema by using alkali water which is excellent in the removal of active oxygen, minerals releasing a large amount of far infrared rays and anions, and propolis called medicinal plants and natural antibiotics By providing an atopic eczemirant composition using a natural material, it can be effectively used without side effects.

Generally, hydrogenated water refers to water in which hydrogen is dissolved at a high dissolved amount. This hydrogenated water has an antioxidative action of removing active oxygen to prevent aging and to prevent the aging of diabetes, hypertension, arteriosclerosis, cancer, dementia And it is effective for skin beauty, diet, fatigue recovery, strengthening of immunity, atopic dermatitis and so on.

Hydrogen water is obtained by dissolving hydrogen gas in raw water. As a dissolving method of hydrogen gas, it is generally used that a hydrogen gas is brought into contact with raw water by using a gas dissolving film filled with a hollow fiber membrane in the cylinder.

As the hydrogen gas supply method, there are a method using hydrogen gas used for semiconductor manufacturing, a method using hydrogen gas bomb, and a method using hydrogen gas generated by electrolysis of water. However, due to the cleanliness of hydrogen gas and the simplicity of facilities, A method using hydrogen gas generated by the hydrogen gas is widely used.

On the other hand, in the present invention, it is used as a solvent of an atopic eczema relieving composition capable of alleviating the symptom of atopic eczema by making alkaline hydrogen sulfide which is excellent for removing active oxygen by using ground water or tap water.

Recently, one of the most important causes of adult diseases such as hypertension, diabetes and heart disease is the acidification of the constitution due to excessive intake of acidic foods such as meat and fish. In order to improve the acidic constitution to weak alkaline constitution, And the user is required to be able to adjust the pH concentration of alkaline water in a simple, quick and easy manner suitable for taste, constitution, and the like.

As an apparatus for producing the above-mentioned hydrogenated water, conventionally known techniques are disclosed in Korean Patent Laid-open Publication No. 10-2011-39647, an electrolytic water water producing apparatus, Korean Patent Registration No. 10-1076631, No. 10-0995713 discloses an electrode assembly for electrolysis, an oxygen-hydrogen generator having the same, a device for producing hydrogen-containing water having the same, and a device for producing dissolved water of Korean Patent No. 10-1250470. The problem is that the hydrogen content in the hydrogenated water is too low.

Republic of Korea Patent Publication No. 10-2015-0134576, and the arc image composition and a manufacturing method for the atopic symptoms are delivered hydronium ions because of the reduced water by electrolysis of water does not separate the cathode chamber and an anode chamber (H ₃ O ⁺⁾ and There is a problem that the concentration of hydrogen in water is very low due to coexistence of hydroxide ions (OH < ^- & gt ^; ).

In general, oxygen is inhaled into the body by human breathing, which is used in the oxidation process. Some of the oxygen is produced in various metabolic processes, which attack the living body tissue and damage the cells. And other diseases such as diabetes, stroke, myocardial infarction, hepatitis, nephritis, atopy, Parkinson's disease, ultraviolet radiation and radiation, and aging. It is known that about 90% of diseases of the lung are related to active oxygen.

Although it is known that it is good to take a lot of foods such as SOD (active oxygen scavenger) and vitamin C to remove the active oxygen which is the source of all kinds of diseases, the strongest antioxidant power of active oxygen is hydrogen, Hydrogen is in the spotlight.

In order to eliminate such active oxygen, antioxidants such as ascorbic acid (vitamin C) may be ingested. When such ascorbic acid reduces active oxygen, ascorbic acid generates new ascorbic acid oxidized by active oxygen This is known to damage genes.

Thus, in general, antioxidants have the potential to cause some side effects as a result of a series of reduction and oxidation chain reactions.

On the other hand, active hydrogens can be said to be safe because they combine with active oxygen to reduce and remove active oxygen, resulting in only water.

Therefore, it is more effective to take antioxidants in a natural way. Therefore, a water-containing water producing apparatus (Korean Patent Registration No. 10-1076631) has been provided to dissolve hydrogen in water.

It is said that 2% of the oxygen used to inhale oxygen every day is the active oxygen that is harmful to the human body and is the source of all diseases.

In order to remove this active oxygen, it is consumed as food or product containing vitamin C. However, it is known that hydrogen is several hundred times higher in antioxidant power than vitamin C.

These hydrogen have been reported to be effective in the human body, such as diabetes, cancer, obesity, dementia, hyperlipemia, rheumatism, and aging as well as atopic dermatitis (Treatment of atopy dermatitis with hydrogen containing water; shoto-kai medical corporation , MD Yoshikazu Irie).

However, there are many techniques applied to compositions for treating atopic diseases using alkaline ionized water. However, studies using weakly alkaline hydrogenated water and strong alkaline hydrogenated water are insufficient and techniques applied to atopic treatment compositions have not been disclosed yet.

Far infrared ray is a wave of 6 ~ 15 microns in the wavelength range of 0.76 ~ 1.00 microns in the wavelength range, penetrates deeply into the human body to a depth of 30 ~ 50mm, resonates and resonates to generate self heat, And expels the waste matter and harmful heavy metals in the cell tissue through the sweat glands to the outside of the skin. Accordingly, by facilitating metabolism in the human body, natural healing power of the human body can be improved, and atopic eczema generated in the skin can be suppressed or alleviated.

Among the natural minerals in Korea, the minerals that are known to emit far-infrared rays are ilite, pozzolan, sericite, loess, silica, diatomaceous earth, alumina and kaolin etc. They are mainly used in ceramics, glass, building bricks, water purification agents, refractories, .

The biomedical effects of far-infrared rays revealed through various researches at home and abroad have shown that the biomedical effect of the far-infrared rays is to promote the growth of the living body, to activate the blood circulation, to maintain the balance of the autonomic nervous system (to help maintain heart homeostasis, Efficacy to relieve pain, such as discharge, shoulder pain, and backache, EEG stabilization effect, and sleeping effect.

Ilrite used as a material of the present invention is a fine clay mineral having an average particle size of 1,136.8 nm mainly composed of SiO ₂ , Al ₂ O ₃ , K ₂ O, FeO, and Fe ₂ O ₃ and adsorbs heavy metals and toxic gases It has deodorizing effect and has antibacterial effect against viruses, bacteria and fungi. It is known that it emits far infrared rays at room temperature, generates anion, and emits oxygen in water.

Illight has antimicrobial properties, so it can prevent the deterioration of the product without adding a chemical preservative.

In addition to reducing the amount of chemical substances that are the main cause of skin irritation, it also prevents the growth of various bacteria and fungi on the skin, which can fundamentally reduce skin troubles.

In addition, since it exhibits excellent adsorption properties, various contaminants such as excess sebum and cosmetic residue in pores such as excess sebum, especially heavy metals, can be effectively removed to maintain a clean skin.

Ilyite penetrates deeply into the skin by transmitting negative ions and heat to maintain smooth and resilient skin. It produces anion exchange with the generation of anion and far-infrared ray radiation to release skin wastes, maintain healthy skin, and maintain moist skin with proper moisturizing effect.

In addition, Illight has been listed on the International Cosmetic Ingredient Dictionary (ICID), and has become available as a raw material for cosmetics.

In the case of the present invention, it is intended to provide a cosmetic composition for improving atopic sensation, which contains an intact ichthyol extract obtained by condensing water vapor generated by heating in a heating furnace with heating in a heating furnace or by condensing water vapor passed through a sunlight.

On the other hand, pozzolan is made of volcanic rocks and is known as a kind of pyrophyllite. It is known as an orphan material created during the Cretaceous period and its major origin is the minerals found in the village of Pozori, near Bari Island, Italy. It is the site of the Colosseum Stadium, It was used instead.

These buildings have been preserved in their original form for many years without cracks and corrosion to this day, as the pozzolans have been used by scholars.

Pozzolan emits 90 ~ 97% of far infrared rays, which are beneficial for human health, at a wavelength of 5 ~ 20 ㎛ and is useful for restoring fatigue, promoting blood circulation, activating circulation system of the human body, skin health of microvascular vessels, restoring fatigue such as muscles and limbs, Elimination of headache due to air purification, sterilization, heavy metal neutralization, water purification, air purification, and odor removal.

In particular, the pozzolans from Italy and Korea emit a very high number of anions from natural minerals because of the large release effect of germanium or far-infrared rays, providing effects of oxygen supply, sterilization and deodorization from plant to human body and natural environment .

A coating agent containing natural pozzolan as an active ingredient can be easily prepared in any form according to a conventional production method.

For example, when preparing a cream type coating agent, the natural pozzolana of the present invention is contained in a cream base of a general water type (O / W) or water type (W / O), and a flavor, a chelating agent, a colorant, an antioxidant, Etc. may be used as needed, and synthetic or natural materials such as proteins, minerals, and vitamins may be used in combination for the purpose of improving physical properties.

On the other hand, the sericite contained in the atopic eczema relieving agent composition using natural materials is a kind of clay minerals, the color of which is silver-white, and the silk gloss is strongly exhibited.

Mineralogically, it belongs to the mica group. Its chemical composition and crystal structure are similar to muscovite, the far-infrared emissivity is about 93%, the anion generation is about 700 / cc and the safest anion, It has a function to adsorb various harmful substances.

In addition, sericite is a far-infrared ray emitter, which is a mineral that emits far-infrared rays as shown in the report of the Ministry of Science and Technology, "Research on raw materials and rocks used as far-infrared radiations" or "Study on the value-added improvement of nonmetal minerals" Have.

The ginseng extract is effective in improving the side effects of saponin by removing excess cholesterol and triglyceride in the blood and helping to improve the blood flow. Therefore, the vitamin B complex (B ₁ , B ₂ , B ₁₂ , C ), Nicotinic acid, pantothenic acid, folic acid, biotin, and the like.

Korean Patent Laid-Open No. 10-2003-78093 discloses a composition for treating skin diseases containing processed ginseng or an extract thereof as an active ingredient.

Such a skin disease relieving composition containing ginseng extract has an effect of alleviating symptoms of various skin diseases due to inherent characteristics of ginseng.

The green tea leaves contain a large amount of catechin, and are excellent in various adult disease prevention, anti-cancer and sterilization functions, and are rich in vitamin C, vitamin E, beta carotene, plant fiber, minerals and chlorophyll.

Aloe is a plant belonging to the genus Aloe, which has germicidal power against bacteria and fungi and contains aloe tine which neutralizes toxins, aloe vera effective for ulcers, and anti-cancer alumitin.

Other ingredients include steroids, amino acids, saponins, wound healing hormones, and minerals.

If you cut off the leaves of aloe, a yellowish substance flows out, which is particularly effective for constipation. In the private sector, aloe leaf juice is used for gastrointestinal diseases and is also used for trauma and burns. It also neutralizes dry and oily skin, and has a moisturizing effect on the skin, making it a cosmetic ingredient.

In the present invention, a functional composition for alleviating atopic skin diseases is constituted by including aloe juice, which is an extract of liquid component extracted by pulverizing aloe leaves to form an aloe crushed product and filtering the aloe crushed product.

In addition to covering the body of the body and protecting the whole body, skin is a tissue that is responsible for crust, respiration, excretion, secretion, body temperature control, immune response, and other important functions.

The most ideal skin pH of humans is 4.7 ~ 5.75, which is mildly acidic. If the acidity of the skin is close to acid, it is called oily skin and if it is close to alkaline, it is dry skin.

The skin is weakly acidic by the secretions of low fatty acids, ascorbic acid, lactic acid, amino acids and the like secreted from sebaceous glands and glands (sweat glands).

The thin acid film on the surface of the skin is a natural protective film that protects the skin from external physical and chemical damage. In general, bacteria such as bacteria are alkaline, so they do not survive in a weakly acidic environment of the skin.

The pH of the skin is closely related to the skin condition, the protective film, and the keratin condition. When the pH range of the skin is out of the normal range, the balance is broken and skin disease occurs.

If the acidity of the skin gets closer to alkaline, it will be easily damaged by external stimuli, and the trouble will become more easily.

It is easily infiltrated by various bacteria and becomes less sensitive to skin immunity.

In addition, the balance of the skin water balance is broken. The sebum is secreted vigorously and secreted sebum may block the pores to cause troubles, or dry acne may occur which is caused by the lack of moisture and the horny pores blocking the pores.

It is known that the pH of acne skin is increased to 7.5 and that of atopic skin to pH 8.0.

On the other hand, if the skin pH is in a normal range with a weak acidity, the weakly acidic membrane forms a skin barrier to protect the skin from external harmful substances.

Generally, it is known that bacteria do not survive well below pH 6.0, so it is difficult for bacteria to grow in weakly acidic skin.

Accordingly, there is an increasing demand for a cosmetic composition for controlling skin pH balance.

Generally, in order to adjust the pH, a chemical substance called a pH adjusting agent or a buffering agent is added. Examples of the controlling agent used in cosmetics include sodium phosphate, citric acid, stearic acid, disodium citrate, disodium phosphate, sodium citrate, triethanolamine, And phosphoric acid caries.

However, long-term use of these ingredients may cause irritation to the skin, especially when triethanolamine accumulates in the body for a long time and is known to have a detrimental effect on eye-related diseases.

Accordingly, in the present invention, the present invention provides Korean Patent Application No. 10-2016-0031831 filed in 2016, which is an apparatus for producing high-concentration hydrogen water useful for improvement of atopy and an acidic water Can be used as a pH regulator by using an acidic water obtained from an anode through electrolysis to remove the pH value of the skin.

Korean Patent Laid-Open Publication No. 10-2002-46329 discloses a composition for external use for improving atopic dermatitis, which contains a natural nonionic surfactant, a higher alcohol, a moisturizing component, an anti-inflammatory component and an itch inhibiting component.

Korean Patent Laid-Open No. 10-2004-46776 discloses a composition for improving atopic dermatitis including sodium silicate, castor oil, calcium chloride, magnesium sulfate, and purified water.

Korean Patent Publication No. 10-431076 discloses a cosmetic having antibacterial, moisturizing, anti-inflammatory, and free radical scavenging effects of atopic skin, which includes white wool, barley, echinacea, and fermented soybean extract have.

Korean Patent Laid-Open Publication No. 10-2006-118809 discloses a functional composition for alleviating atopic dermatitis, which comprises various herbal medicines such as Killer, Gobon, Kwakyang, Gakyung, and the like.

The functional composition for alleviating atopic dermatitis containing such herbal medicines has the effect of alleviating atopic dermatitis to some extent by soothing the skin's hypersensitivity symptoms by the herbal medicines.

Further, in the study on the composition for treating atopic diseases, there has not been disclosed a technique of applying a water-soluble propolis.

Korean Patent Publication No. 10-2001-0089716 Korean Patent Publication No. 10-2015-0134576

SUMMARY OF THE INVENTION Accordingly, the present invention has been made keeping in mind the above problems occurring in the prior art,

It is an object of the present invention to provide an atopic eczematizing emollient composition using alkaline hydrogen peroxide, thereby reducing pain and irritation of the skin due to atopic symptoms, thereby eliminating inconvenience of a patient during treatment and shortening a treatment period There is a purpose.

More particularly, the present invention relates to a method for preparing an alkaline water or a strong alkaline water by using an anion exchange resin as raw water such as groundwater or tap water, It is intended to provide an atopic eczulatory emollient composition using a natural material which suppresses and alleviates symptoms of eczema eczema using mineral water and a medicinal plant which emit a large amount of far infrared rays and anions therefrom.

In the conventional method for producing hydrogen water by electrolysis of water, the most problematic is that the pH of the water of the final product is not constant because the pH of the water is not constant due to the influence of the pH of the raw water. It is intended to solve.

When the raw water is electrolyzed, scales caused by mineral substances such as calcium contained in tap water, ground water or natural water are prevented from occurring on the electrode and the inner surface of the main body, and residual chlorine and hypochlorite ions To suppress the generation of odor and to inhibit the production of total trihalomethanes.

In order to achieve the object of the present invention,

A method for preparing an atopic treatment composition using high-concentration hydrogen peroxide, which is useful for improving atopy according to an embodiment of the present invention,

(S100) of producing alkaline deionized (-) ionized water by using a weakly basic anion exchange resin and a strongly basic anion exchange resin,

A step S200 of electrolyzing the alkali deionized water to prepare weak alkaline hydrogen water (pH 7.2 to 9.5), strong alkaline hydrogen water (pH 9.5 to 13.0) and acidic ionized water (pH 1.0 to 6.0) ,

A step (S300) of producing a natural ore water powder selected from the group consisting of diatomite, zeolite, zeolite, pozzolan, sericite,

(S400) mixing the natural ore water powder with the weakly alkaline hydrogen water to prepare a natural ore water mixture,

Mixing the ginseng, green tea leaves and aloe leaf extract (S500)

(S600) mixing the medicinal plant mixture with weakly alkaline hydrogen water to prepare a medicinal plant mixture,

(S700) mixing 20 to 50 parts by weight of the natural ore water mixture, 20 to 50 parts by weight of the medicinal plant mixture and 0.1 to 5 parts by weight of the natural antibiotic propolis based on 100 parts by weight of alkaline hydrogen water,

Stirring the mixture for 100 to 150 minutes, recovering and re-introducing the alkaline hydrogen fluoride to form a gel composition (S800)

(S900) after quenching the gel composition to room temperature, and then aging the quenched gel at room temperature for 120 hours to obtain an atopic eczulatory emollient composition.

The present invention relates to a composition for treating atopic diseases using high concentration of hydrogen peroxide, which is useful for improving atopy,

It is added to the ointment and ointment for treatment of atopy. It uses alkali water which is excellent for the removal of active oxygen, minerals that emit a large amount of far infrared rays and anions, and medicinal plants mainly used in oriental medicine. At the same time, , The volatile organic compounds which are the promoter of atopic eczema are anionized and the ozone molecules are decomposed to provide the effect of totally suppressing and alleviating the symptoms of atopic eczema.

In addition, it is possible to manufacture alkaline water, while preventing scales caused by minerals such as calcium contained in raw water such as tap water, ground water or natural water from occurring on the surface of the electrode and the inside of the body, thereby improving production efficiency, Can be obtained.

That is, it is possible to suppress the generation of odor and to suppress the production of total trihalomethane by removing residual chlorine and hypochlorous acid ions generated during electrolysis of water.

It is possible to easily produce weak alkaline hydrogen water having a pH of 7.2 to 9.5 and strong alkaline hydrogen water having a redox potential higher than that of a pH of 9.5 to 13.0 and acidic ionized water having a pH of 1 to 6, It can be used as an atopic treatment composition, food for drinking, beverage, medical, agricultural and industrial use (disinfection, disinfection, pH adjusting agent).

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process diagram showing a method for manufacturing an atopic treatment composition using high-concentration hydrogen peroxide, which is useful for improving atopy according to an embodiment of the present invention.
2 to 6 are comparative photographs of patients' skin before and after the composition for treating atopic symptoms according to an embodiment of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION Hereinafter, the present invention will be described in detail with reference to embodiments of a composition for treating atopic diseases using high-concentration hydrogen peroxide useful for improving atopy and methods for preparing the same.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process diagram showing a method for manufacturing an atopic treatment composition using high-concentration hydrogen peroxide, which is useful for improving atopy according to an embodiment of the present invention.

As shown in Fig. 1, the method for producing an atopic treatment composition of the present invention comprises:

Mixing the ginseng, green tea leaves and aloe leaf extract (S500)

Specifically, the raw water is made alkaline deionized water (S100) by using a weakly basic anion exchange resin and a strong basic anion exchange resin, and the alkaline deionized water is electrolyzed to produce weak alkaline water (pH 7 (PH9.5 ~ 13.0) and acidic ionized water (pH 1.0 ~ 6.0) are prepared (S200).

The step of producing the alkaline hydrogen water is disclosed in detail in Korean Patent Application No. 10-2016-0031831 filed in 2016 by the present invention through a device and a method for producing high-concentration hydrogen water useful for improvement of atopy.

Therefore, a detailed description will be omitted.

Thereafter, a natural ore water powder selected from the group consisting of ilite, pozzolan, sericite, or a mixture thereof is prepared (S300), and the natural ore water powder is mixed with weakly alkaline hydrofluoric acid to prepare a natural ore water mixture (S400) do.

Then, ginseng, green tea leaves and aloe leaf extract are mixed (S500), and the medicinal plant mixture is mixed with weakly alkaline hydrogen water to prepare a medicinal plant mixture (S600).

Thereafter, 20 to 50 parts by weight of the natural ore water mixture, 20 to 50 parts by weight of the medicinal plant mixture, and 0.1 to 5 parts by weight of the natural antibiotic propolis are mixed to form a mixture (S700) based on 100 parts by weight of alkaline hydrogen water, The mixture is stirred for 100 to 150 minutes, and the alkaline hydrous water to be evaporated is recovered and re-introduced to form a gel composition (S800).

Thereafter, the gel composition is quenched to room temperature, and the quenched gel is aged at room temperature for 120 hours to obtain an atopic eczulatory emollient composition (S900).

On the other hand, the present invention relates to a pharmaceutical composition comprising 20 to 50 parts by weight of a natural ore selected from the group consisting of ilite, pozzolan, sericite or a mixture thereof, based on 100 parts by weight of an alkali hydrogen water, 20 to 50 parts by weight of a herbal medicine 20 To 50 parts by weight.

Preferably, 10 to 20 parts by weight of ginseng, 5 to 15 parts by weight of green tea leaves, and 2 to 4 parts by weight of aloe leaf extract are prepared.

The atopic eczema emollient composition using a natural material is composed of a mixture containing 0.05 to 5 parts by weight of propolis.

The atopic eczema relieving composition using a natural material according to an embodiment of the present invention includes 20 to 50 parts by weight of a natural ore selected from the group consisting of illyite, pozzolan, sericite, and mixtures thereof based on 100 parts by weight of alkaline hydrogen water.

The natural ore water may be processed into powder, for example, and used in the present invention.

At this time, the larger the surface area per unit weight of the natural ore water powder, the smaller the size of the powder, the more the contact area with air increases, thereby improving the anionization function and the moisturizing function of ozone.

In the present invention, fine inorganic powder, pozzolan powder, and sericite powder of 8,000 to 12,000 mesh, preferably 10,000 mesh, formed by pulverizing allyl, pozzolan and sericite at an ultra-high speed of about 7,000 rpm in a pulverizer are preferably used .

Thus, the atopic eczemonic emollient composition comprising a natural ore water powder selected from the group consisting of anilite powder, pozzolan powder, sericite powder, or mixture powder thereof which is finely pulverized to 8,000 to 12,000 mesh and emits anion and far-infrared rays, And is in intimate contact with the molecule to anionize the ozone molecule.

When the average particle size of the natural ore water powder is less than 8,000 mesh, the contact area with the air is decreased to decrease the anionization function of the ozone. If the average particle size of the natural ore water powder exceeds 12,000 mesh, It is not improved and only the manufacturing cost and the manufacturing time are increased.

If the amount of the natural ore water contained in the atopic eczemic emollient composition of the present invention is less than 20 parts by weight, the anionization function and the moisturizing function of the ozone of the composition are deteriorated. If the content of natural ore water exceeds 50 parts by weight, And the feel of the prepared composition is deteriorated.

In addition, the atopic eczulatory relieving composition of the present invention further includes an alkaline hydrogen water for improving anion release, ginseng, green tea leaf, and aloe leaf extract to enhance anion emission, as well as natural ore water such as ilite, pozzolan, It has excellent permeability to the human body and is excellent in moisturizing the skin of the human body, so that the satisfaction of the user of the composition can be improved.

In an atopic eczema relieving composition using a natural material according to an embodiment of the present invention, 10 to 20 parts by weight of ginseng may be included based on 100 parts by weight of alkaline hydrogen water.

The ginseng extract is effective in improving side effects by removing extra cholesterol and triglyceride in blood by supporting saponin in the blood stream. Therefore, the ginseng extract provides sufficient nutrition and oxygen to the skin cells and alleviates symptoms of various skin diseases.

The atopic eczema relieving composition using a natural material according to an embodiment of the present invention may contain 5-15 parts by weight of green tea leaves based on 100 parts by weight of alkaline hydrogen water.

The green tea leaves contain a large amount of catechin and are excellent in various adult disease prevention, anticancer, and antiseptic functions, and are rich in vitamin C, vitamin E, beta carotene, plant fiber, minerals and chlorophyll.

Such green tea leaves may be used in the present invention in the form of extract or powder.

When the green tea leaves are used in the form of an extract, green tea leaves are washed with acidic water, and the washed green tea leaves are ground to prepare green tea leaf pulverized material. The green tea leaf pulverized material is pressed to extract liquid components And filtered to obtain a green tea leaf extract which is a liquid component.

When the green tea leaves are used in the form of powders, the green tea leaves are washed, naturally dried until the water disappears on the surface of the green tea leaves, and the dried green tea leaves are dried at 8,000 It is preferable to use fine green tea leaf powder of ~ 12,000 mesh.

When the amount of the green tea leaf powder contained in the atopic eczulatory emollient composition of the present invention is less than 5 parts by weight, various kinds of adult diseases preventive function, anticancer function and sterilizing function of the composition are deteriorated. When the content of green tea leaf powder is more than 15 parts by weight, The composition does not gel properly.

If the amount of the aloe juice contained is less than 2 parts by weight based on 100 parts by weight of alkali hydrogen water in the atopic eczema relieving composition using a natural material according to an embodiment of the present invention, Function and sterilizing function are lowered and the content of the aloe juice is 4 parts by weight, the functional composition for alleviating atopic skin diseases is provided with sufficient pollutant neutralizing function and sterilizing function.

If the amount of the propolis contained is less than 0.05 part by weight based on 100 parts by weight of alkali hydrogen water in the atopic eczema relieving composition using the natural material according to an embodiment of the present invention, the sterilizing function of the functional composition for alleviating atopic skin disease If the content of propolis is more than 5 parts by weight, the sterilizing function of the functional composition for atopic skin disease mitigation is reduced.

Hereinafter, the present invention will be described in detail with reference to the preferred embodiments.

It should be noted, however, that the present invention is not limited to the following examples.

Example 1 Hydrophobic production process

May be the tongtap the SV 40 to DIAION SA21A resin column of a strongly basic anion exchange resins, cations such as Ca ⁺² ion as shown in Table 1 is not removed, the sound, such as ^{_{^{Cl -1, PO 4 -3 (-}}} ) ion was only possible to obtain the removal of pH 9.5 ~ 13.0 water, cations such as weakly basic anion exchange resin DIAION WA20 tongtap to the resin column with SV 30 Ca ⁺² ion is not removed, Cl ^-1, PO ₄ ^-3, such as a negative (-) ions only and the pH to obtain the removal of water of 7.2 ~ 9.3.

Raw water SA20A processed water WA20 processed number Remarks pH 7.7 9.5 to 13.0 7.2 to 9.5 Redox potential + 3.40 mV -480mV -300mV Ca < ² > (ppm) 18.04 18.04 18.04

Cation

Mg ^{+ 2} (ppm) 4.6 4.6 4.6 Mn ^{+ 2} (ppm) 0.01 0.01 0.01 Zn ^{+ 2} (ppm) 0.01 0.01 0.01 Fe ⁺³ (ppm) 0.02 0.02 0.02 Al ⁺³ (ppm) 0.06 0.06 0.06 Cl- ¹ (ppm) 10.3 0 0 Anion SO ₄ ^-2 (ppm) 9.3 0 0 PO ₄ ^-3 (ppm) 0.007 0 0

In order to make the deionized water having a pH of 7.2 to 9.5 obtained in Example 1 to be acidic and hydrogenated, Korean Patent Application No. 10-2016-0031831 filed by the present invention, which is an electrolysis disclosed in a device for producing high- Is sent to the electrolyzer (310) of the process (300).

The electrolytic cell is divided into an anode chamber electrode and the cathode chamber electrode by the diaphragm can pass only ions with electrical properties, when a voltage is applied to the as anion removing of pH 7.2 ~ 9.5 the number of electrolysis cathode compartment hydrogen and OH ^- And an alkaline aqueous solution is generated. At the same time, oxygen and H are generated in the anode chamber to generate acidic water.

The alkaline water produced in the cathode chamber is converted into a high concentration of hydrogen peroxide through the activated carbon porous material adsorbent 410, which is an adsorption condensing facility, to obtain alkaline hydrogen water having a pH of 7.2 to 9.5 including the 1,600 ppb hydrogen dissolved amount, And is stored in the hydrogenated water storage tank 510.

At this time, the acidic water generated in the anode chamber is sent to a separate acidic water (pH 1-6) storage tank 530, which is used as a sterilizing water for washing the composition materials and a pH adjuster for the final product of the composition.

Similarly, the deionized water having a pH of 9.3 to 13.0 is sent to the electrolytic bath of the electrolysis step (300) to produce acidic water and hydrogenated water.

When the voltage is applied to the electrolytic cell, the deionized water of pH 9.5 ~ 13.0 is electrolyzed, and hydrogen and OH ^- are generated in the cathode chamber, and alkaline water is produced. At the same time, oxygen and H ⁺ are generated in the anode chamber and acidic water is generated.

The alkaline water produced in the cathode chamber is converted into a high concentration of hydrogen peroxide through the activated carbon porous material adsorption unit, which is an adsorption condensing facility, so that alkaline hydrogen water having a pH of 9.5 to 13.0 including the hydrogen dissolved amount of 1,800 ppb is obtained, (520).

At this time, the acidic ionized water (pH 1 to 6) generated in the anode chamber is sent to the separate acidic water storage tank 530.

These acidic waters are mainly used as washing sanitizer disinfectant and pH regulator.

Natural ore water Step of preparing the mixture

Using a nano-pulverizer (ATOMIZER, FUJI PAUDAL, Japan), pulverized at a super-high speed of 7,000 rpm to obtain 10,000 mesh of anilite, pozzolan and sericite powders.

A natural ore water mixture was obtained by mixing 200 g of diatomite powder, 200 g of pozzolan powder and 200 g of sericite powder in 1,000 g of alkaline hydrogen water having a pH of 7.2 to 9.5.

The step of preparing the medicinal plant mixture

The ginseng was washed with acidic water obtained from the positive (+) electrode in the electrolysis and naturally dried until the water disappears on the surface. The dried ginseng was nano-milled at a high speed of 7,000 rpm in a nano mill to prepare a 10,000 mesh ginseng powder &Lt; / RTI >

Green tea leaves are washed with acidic water and dried naturally until the water disappears

The green tea leaves of 10,000 mesh were formed by nano milling the dried green tea leaves at a high speed of 7,000 rpm in a nano mill.

The aloe leaves were washed with acidic water and pulverized, and the resulting pulverized product was filtered to obtain a liquid component extract, aloe juice.

Step of preparing water-soluble propolis powder

The propolis collected from the honeycomb was immersed in two volumes of ethanol for 6 weeks and then filtered through a filter to obtain propolis (EEP) extracted with ethanol.

The mixture of EEP and water in the reaction tank was mixed at a ratio of 1: 1 and reacted for 24 hours to separate into REEP (Residue of Ethanol Extracted Propo1is) separated into the upper layer and WEP (Water Extracted Propolis) separated into the lower layer.

The upper layer was removed and the lower layer of water-soluble propolis was obtained and powdered to prepare a water-soluble propolis powder.

After mixing 1 g of propolis in a reactor capable of recovering liquid alkaline water of 1,000 g, ginseng powder of 300 g, green tea leaf powder of 150 g, and aloe juice of 40 g in a liquid phase evaporator, acidic water Was used as a pH regulator to obtain a mixture having a pH of 4.7 to 5.75.

The mixture of the natural ore and the medicinal plant was agitated at 85 rpm at 500 rpm for 120 minutes to obtain a gel composition. The alkaline hydrogen peroxide solution was recovered and gelled while re-introduced to obtain a gel composition.

The gel composition was placed in a quencher and forcedly quenched at room temperature. The gel was aged at room temperature for 120 hours to obtain an atopic eczemirant emollient composition.

The composition for alleviating atopic symptoms prepared in Example 1 was applied to the hands of a person without skin disease for 5 days at a size of 5 × 5 cm 2 and covered with gauze for 1 hour to sufficiently absorb the composition.

Since no specificity was found in the skin after 15 days, it was confirmed that the composition for relieving atopic symptoms did not cause toxicity and side effects on human skin.

Furthermore, it was confirmed that the dry feeling on the skin applied with the composition for alleviating the burns and atopic symptoms was reduced, and it was confirmed that the composition had moisture resistance against moisture.

In order to confirm the therapeutic effect of the above-mentioned emollient composition, a composition for relieving atopic symptoms was applied to a skin area having atopic symptoms to perform a therapeutic experiment.

The application method was to apply thinly to the lesion, then repeated several times, and massage it so as to exert an anion effect.

&Lt; Comparative Example 1 &

Atopic eczema emollient composition was prepared under the same conditions as in Example 1 except that the natural light mineral water mixed powder of the diol, pozzolan, and sericite of Example 1 was not added.

&Lt; Comparative Example 2 &

The atopic eczemirant composition was prepared under the same conditions as in Example 1 except that the medicinal plant mixtures of Example 1 were not added.

&Lt; Comparative Example 3 &

An atopic eczulatory emollient composition was prepared under the same conditions as in Example 1 except that 1,000 g of alkaline ionized water was added instead of 1,000 g of the alkaline aqueous solution of Example 1 to obtain an atopic eczemirant composition.

&Lt; Comparative Example 4 &

The atopic eczulatory emollient composition was prepared under the same conditions as in Example 1 except that 1,000 g of tap water was added instead of 1,000 g of the alkaline aqueous solution of Example 1 to obtain an atopic eczulatory emollient composition.

&Lt; Comparative Example 5 &

The atopic eczematric emollient composition was prepared under the same conditions as in Example 1 except that 1 ml of the propolis of Example 1 was not added to obtain the atopic eczemirant composition.

Far-infrared and anion emission

The infrared emissivity and anion emission test of Example 1 and Comparative Examples 1 to 5 were carried out.

The anion emission test was conducted in accordance with KICM-FIR-1042, an anion emission test method commonly used in the Korea Testing and Research Institute of Korea. The far infrared ray emission amount was measured according to KCIM-FIR-1005 The results are shown in Table 2.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Far infrared ray
Emissivity (%) 92.3 82.6 88.7 82.8 80.6 90.5 Anion
(Dogs / cc) 11,000 8.000 10,000 7.000 6.800 10,200

As a result of the measurement of far infrared ray and anion emission amount, the atopic eczulatory emollient composition of the present invention had far infrared ray emissivity exceeding 90% or more and an anion index of 6.000 or more at a wavelength of 5 to 20 탆.

Efficacy test for atopic dermatitis

It was tested for 1 month for 10 individuals per each composition of Example 1 and Comparative Examples 1 to 5 for 40 patients suffering from itching and atopic dermatitis.

For the symptoms such as side effects, tingling, and aggravation of symptoms during the experimental period, the test was stopped immediately and the overall evaluation was evaluated for improvement of the itching status within 1 month and evaluated as shown in Table 3 below.

Table 3 below shows the effect of atopic dermatitis relief by visual determination.

score Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 High improvement 10 8 3 4 2 One One Intermediate line 7.5 2 4 4 6 4 4 Low improvement 5 0 3 2 2 5 4 No improvement 2.5 0 0 0 0 One Sum 95 75 80 75 65.0 62.5 Average 9.5 7.5 8.0 7.5 6.5 6.3

In Table 3, when the area of the area of occurrence of atopic dermatitis visible to the naked eye is almost eliminated, improvement is achieved with high improvement. When 3/4 (75% ), It was judged as improvement without improvement when there was little difference between areas before and after the experiment.

As can be seen from Table 3 above, the composition comprising alkaline hydrogen water, natural ore water mixture, medicinal plant mixture, and propolis may be any one of alkaline hydrogen water, natural ore water mixture, medicinal plant mixture, Showed a superior mitigation effect of atopic dermatitis as compared with the added composition.

As shown in Tables 2 and 3, the atopic eczema relieving composition using the natural material of the present invention is excellent in moisturizing property, and releases a large amount of anion and far-infrared rays to affect ozone molecules, which are promoters of atopic eczema, It was found that the effect of suppressing and alleviating atopic eczema symptoms by switching to anion ozone which is insignificant.

2 to 6 are comparative photographs of patients' skin before and after the composition for relieving atopic symptoms according to an embodiment of the present invention.

In the case of FIG. 2, it was confirmed that the atopic treatment composition of the present invention was provided to the lesion and improved after 2 months, and it was confirmed that the treatment was significantly improved after 3 months I could.

In the case of FIG. 3, it was confirmed that the atopic treatment composition of the present invention was provided to the affected part and improved after 2 months, Months after the start of the study.

In FIG. 4, it can be seen that the atopic treatment composition of the present invention was provided to the affected part and improved after 2 months, And it was confirmed that it was significantly improved.

In the case of FIG. 5, it was confirmed that the atopic treatment composition of the present invention was provided to the affected part and improved after 2 months, And it was confirmed that it was significantly improved.

In the case of FIG. 6, it was confirmed that the atopic treatment composition of the present invention was provided to the affected part and improved after 1 month, And it was confirmed that it was significantly improved.

As shown in FIG. 2 to FIG. 6, patients with severe atopic symptoms such as ankle, foot, shin, thigh, and whole body were significantly affected. However, when the atopic treatment composition according to the present invention was provided for at least one month It was confirmed that it was improved.

It will be appreciated by those skilled in the art that the present invention may be embodied in other specific forms without departing from the spirit or essential characteristics thereof. It is to be understood, therefore, that the embodiments described above are to be considered in all respects as illustrative and not restrictive.

The scope of the present invention is defined by the appended claims rather than the detailed description and all changes or modifications derived from the meaning and scope of the claims and their equivalents are to be construed as being included within the scope of the present invention do.

none

Claims

A method for manufacturing an atopic treatment composition,
(S100) of producing alkaline deionized (-) ionized water by using a weakly basic anion exchange resin and a strongly basic anion exchange resin,
A step S200 of electrolyzing the alkali deionized water to prepare weak alkaline hydrogen water (pH 7.2 to 9.5), strong alkaline hydrogen water (pH 9.5 to 13.0) and acidic ionized water (pH 1.0 to 6.0) ,
A step (S300) of producing a natural ore water powder selected from the group consisting of diatomite, zeolite, zeolite, pozzolan, sericite,
(S400) mixing the natural ore water powder with the weakly alkaline hydrogen water to prepare a natural ore water mixture,
Mixing the ginseng, green tea leaves and aloe leaf extract (S500)
(S600) mixing the medicinal plant mixture with weakly alkaline hydrogen water to prepare a medicinal plant mixture,
(S700) mixing 20 to 50 parts by weight of the natural ore water mixture, 20 to 50 parts by weight of the medicinal plant mixture and 0.1 to 5 parts by weight of the natural antibiotic propolis based on 100 parts by weight of alkaline hydrogen water,
Stirring the mixture for 100 to 150 minutes, recovering and re-introducing the alkaline hydrogen fluoride to form a gel composition (S800)
And a step (S900) of rapidly cooling the gel composition to room temperature and then aging the rapidly quenched gel at room temperature for 120 hours to obtain an atopic eczemirant emollient composition (S900). The atopic eczema &Lt; / RTI >

The method according to claim 1,
The weakly basic anion exchange resin is used to make the weakly alkaline water (pH 7.2 to 9.5), and the strongly basic anion exchange resin is used to make the strong alkaline aqueous solution (pH 9.5 to 13.0) The method comprising the steps of:

The method according to claim 1,
(PH 1 to 6) produced in the positive (+) ear room as a pH regulator of the atopic eczemirant emollient composition when the water is electrolyzed to make alkaline hydrogen water. The high concentration water A method for preparing an atopic treatment composition using a small amount of water.

100 parts by weight of an alkali hydrogen water obtained in a cathode chamber by electrolysis of water;
20 to 50 parts by weight of natural ore water, which is a natural ore, pozzolan, sericite or a mixture thereof;
20 to 50 parts by weight of a herbal medicine which is ginseng, green tea leaves, aloe leaf extract or a mixture thereof;
And 0.1 to 5 parts by weight of propolis. The composition for treatment of atopy using high concentration of hydrogen peroxide is useful for improving atopy.

5. The method of claim 4,
The alkaline hydrogen water may be,
Wherein the composition is any one of weakly alkaline hydrogenphosphate (pH 7.2 to 9.5) or strong alkaline hydrogenphosphate (pH 9.5 to 13.0).