KR102451704B1 - Method for manufacturing composition for inhibiting atopic dermatitis using hydrogen water and natural material mixture - Google Patents

Abstract

The present invention relates to a composition for inhibiting atopic dermatitis, and more particularly, to a method for manufacturing a composition for inhibiting atopic dermatitis which can help suppress atopic dermatitis without allergies or side effects, and can be used in various industries such as food, beverages, cosmetics, pharmaceuticals, and pet products through a composition containing a mixture of natural ingredients including high-concentration hydrogen water and sturgeon water-soluble oil with excellent active oxygen removal efficiency.

Description

Method for manufacturing composition for inhibiting atopic dermatitis using hydrogen water and natural material mixture

The present invention relates to a composition for inhibiting atopic dermatitis, and more particularly, through a composition containing a natural ingredient mixture including high-concentration hydrogen water and sturgeon water-soluble oil having excellent active oxygen removal effect, atopic dermatitis without allergy or side effects It relates to a method for producing a composition for inhibiting atopic dermatitis, which can help suppress dermatitis and can be used in various industrial fields such as food, beverages, cosmetics, pharmaceuticals, and pet products.

Sturgeon ( Acipenser sinensis ) is a fish species originating from 450 to 350 million years ago (Devonian), belonging to the family Acipenseridae, and is a wild fish that is widely distributed in the northern mid-latitudes of the northern hemisphere. Currently, 26 species of sturgeon are known, and interest in many countries is increasing due to their economic and ecological values.

Siberian sturgeon, which was first transplanted and bred in Korea in March 1997 at Kanakov Farm in Russia, and produced as a seedling in 2003, has excellent environmental adaptability, grows faster than other breeds cultivated in Korea, and has good meat quality. Because of this, it is gaining popularity as a target fish for aquaculture. The maximum body length is 3 m, and the weight grows to 200-300 kg, and some species grow to a maximum body length of 8 m or more, and some have a maximum lifespan of more than 100 years. At about 6-7 years of age, it grows to more than 1 m and produces caviar.

Sturgeon has a chewy texture and is used for sashimi, smoked, barbecue, steak and skewered dishes, steamed heads and soup dishes, shark fins, one of China's three major delicacies, and cartilage used as special dishes, tonics and industrial ingredients. have. In addition, sturgeon contains a large amount of active ingredients such as protein, essential amino acids, unsaturated fatty acids, vitamins, EPA, and DHA, and has brain development, nutritional suppression, fatigue recovery, blood circulation improvement, dementia prevention, osteoporosis, arthritis, antioxidant action, etc. As the excellent efficacy of .

Recently, as the aquaculture technology of sturgeon begins to develop, the general public has more opportunities to encounter sturgeon. became

However, in the raw materials for sturgeon marketed to date, sufficient research on the actual content of sturgeon, the content of active ingredients, processing method, extraction efficiency, etc. is not made. In particular, in Korea, there is no processing technology for sturgeon and products using it, so sturgeon is not yet objectively and publicly recognized by consumers as a functional material and product.

On the other hand, atopic dermatitis (Atopic dermatitis) is a representative skin disease appearing in people with atopic allergy, often, a chronic skin disease called fetal fever, dry skin and itching are the main symptoms. Atopic dermatitis is on the rise worldwide, mainly begins in infancy and childhood, and has a chronic and frequent relapse.

The cause of atopic dermatitis is not clearly identified, but environmental factors, genetic predisposition, immunochemical reactions, and abnormal skin barrier are considered to be the main causes.

As a method of suppressing such atopic dermatitis, steroids, antihistamines, or antibiotics are mostly used pharmaceutically, but the cause is administered as it is, so it cannot be a fundamental solution, and side effects or drug dependence may occur. There are disadvantages. In recent years, many diets and herbal remedies have been developed, but their effects are not satisfactory, so there is a limit to their practical application.

Republic of Korea Patent Publication No. 10-2009-0111066 Republic of Korea Patent Publication No. 10-2009-0017182

The present invention is to solve the above problems, and is a natural ingredient comprising high-concentration hydrogen water with excellent active oxygen removal efficacy and water-soluble sturgeon oil rich in nutrients such as essential amino acids and excellent in antioxidant and blood circulation improvement effects. An object of the present invention is to provide a method for preparing a composition for inhibiting atopic dermatitis, which can help suppress atopic dermatitis without allergy or side effects through a composition containing the mixture.

These and other objects and advantages of the present invention will become apparent from the following description of preferred embodiments.

The purpose is to prepare a natural juice by mincing each of pumpkin leaves, red beans and onions; Soaking buckwheat seeds in purified water at 26° C. for 24 hours to germinate buckwheat, followed by drying to prepare buckwheat malt; and preparing a natural fresh juice mixture in which the natural juice, the buckwheat malt and hydrogen water are mixed in a weight ratio of 1.5: 1: 0.8; a first step comprising;

preparing sturgeon oil according to a method for obtaining raw materials of sturgeon; performing a first aging of the sturgeon oil to prepare an aged sturgeon oil; For the aged sturgeon oil, a pre-treatment step of foaming by forming a change in the physical properties of the oil using a high-pressure processor and a fine nozzle; Second aging of the pre-treated sturgeon oil aged product; A step of mixing the aged sturgeon oil with the second aging is performed and water, input to a distillation extractor, and second extraction; After performing the second extraction, the remaining aged sturgeon oil is mixed with water again, added to a distillation extractor, and a third extraction is performed to prepare a primary water-soluble oil; Preparing a primary additive composition containing edible snails and a secondary additive composition containing Puer's tea and chrysanthemum, respectively; and preparing a secondary water-soluble oil by distilling and extracting a mixture of the primary water-soluble oil, the primary additive composition, and the secondary additive composition; and

Preparing a mixture composition by mixing 120 to 150 parts by weight of the water-soluble sturgeon oil obtained in the second step and 25 to 35 parts by weight of the purslane herbal water with respect to 100 parts by weight of the natural raw juice mixture obtained in the first step; It can be achieved by a method for preparing a composition for inhibiting atopic dermatitis, including a third step.

The hydrogen water is characterized in that the hydrogen content is 1,400 to 1,700 ppb, and is weakly alkaline hydrogen water having a pH of 7.3 to 9.3.

The method for preparing the hydrogen water includes the steps of treating raw water with an anion exchange resin to obtain alkaline ionized water from which anions are removed; and mixing hydrogen generated by electrolyzing the obtained alkaline ionized water to obtain hydrogen water.

In the third step, the mixed composition is processed into a gel or jelly formulation, and the processing method includes 20 to 30 parts by weight of hydrogen water, 1 to 10 parts by weight of a gelling agent, and sugar and sodium citrate in the mixed composition further mixing 1 to 10 parts by weight of other additives and stirring at 300 to 400 rpm; and completely dissolving the gelling agent while raising the temperature to 85 to 90° C. during the stirring step to prepare a jelly form.

The method for obtaining the raw material of the sturgeon includes: a culture step of culturing sturgeon fry for at least 3 years using a natural antibiotic; A pre-processing step of pre-treating the farmed sturgeon to a whole state; A cold storage step of rapidly cooling the pretreated sturgeon, wherein the rapid cooling is to reach a temperature of -80 to -20°C within 5 to 20 minutes; and thawing and washing the cooled sturgeon, then putting the whole sturgeon into a pneumatic extractor and performing a first extraction to obtain sturgeon oil.

According to the present invention, it is possible to prepare a composition for inhibiting atopic dermatitis containing a natural ingredient mixture comprising high concentration hydrogen water and water-soluble sturgeon oil.

The high-concentration hydrogen water combines with active oxygen, which is a harmful oxygen generated inside the human body, and discharges it to the outside of the body. can perform

The water-soluble sturgeon oil excludes artificial chemicals such as surfactants and forms a water-soluble oil formulation only by a physical separation method using a natural nanotechnology method, thereby ensuring human safety and environmental friendliness. In addition, the sturgeon water-soluble oil composition contains sturgeon oil obtained from whole sturgeon, contains a high content of active ingredients in sturgeon, and can secure human safety and improved quality due to non-antibiotics. .

According to the present invention, through a composition mixed with water-soluble sturgeon oil and natural ingredient mixture, which is rich in nutrients such as essential amino acids and has excellent antioxidant and blood circulation improvement effects, it can help suppress atopic dermatitis without allergies or side effects. There may be provided a method for producing a composition for inhibiting atopic dermatitis.

Such a composition for inhibiting atopic dermatitis can be utilized in various industrial fields, such as, for example, food, drinking water, cosmetics, pharmaceuticals, pet-related products, and vegetable raw material compositions.

However, the effects of the present invention are not limited to the above-mentioned effects, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

Hereinafter, the present invention will be described in detail with reference to embodiments and drawings of the present invention. It will be apparent to those of ordinary skill in the art that these examples are only presented as examples to explain the present invention in more detail, and that the scope of the present invention is not limited by these examples. .

Further, unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, and in case of conflict, this specification, including definitions description will take precedence.

In order to clearly explain the invention proposed in the drawings, parts irrelevant to the description are omitted, and similar reference numerals are attached to similar parts throughout the specification. And, when a part "includes" a certain component, this means that other components may be further included, rather than excluding other components, unless otherwise stated. In addition, the "unit" described in the specification means one unit or block that performs a specific function.

In each step, the identification code (first, second, etc.) is used for convenience of description, and the identification code does not describe the order of each step, and each step does not clearly describe a specific order in context. It may be performed differently from the order specified above. That is, each step may be performed in the same order as specified, may be performed substantially simultaneously, or may be performed in the reverse order.

Hereinafter, embodiments and examples of the present application will be described in detail with reference to the accompanying drawings. However, it may not be limited to these embodiments and examples and drawings of the present application.

One aspect of the present application, for preparing a natural raw juice mixture, a first step; a second step of preparing sturgeon water-soluble oil; And with respect to 100 parts by weight of the natural raw juice mixture obtained in the first step, 120 to 150 parts by weight of the water-soluble sturgeon oil obtained in the second step and 25 to 35 parts by weight of the purslane herbal water to prepare a mixed composition, a third It provides a method for preparing a composition for inhibiting atopic dermatitis, including the step.

Step 1: Preparation of natural raw juice mixture

First, pumpkin leaves, red beans and onions can be prepared as natural ingredients with excellent atopic dermatitis suppression effect.

Pumpkin leaves are rich in moisture and vitamin C to moisturize the skin, have excellent antioxidant effects that remove oxidative substances and free radicals that are harmful to the human body, and contain a large amount of beta-carotene to strengthen all mucous membranes of the body, including the skin. It is effective in preventing atopic dermatitis.

의 온도에서 수분이 제거될 때까지 건조시킨 다음에, 다지거나 빻아서 호박잎 생즙을 제조할 수 있다. As an example, the pumpkin leaf may be used with a leaf circumference of 15 to 20 cm. The pumpkin leaves are collected from June to October before frost and about 10 to 14

Fresh pumpkin leaf juice can be prepared by drying at a temperature of

Red beans are rich in saponins and have an excellent diuretic effect. In particular, they help to remove contaminants from the skin and pores to remove atopic dermatitis and blemishes. In addition, niacin in the red bean helps the skin to synthesize proteins and creates a strong skin barrier.

As an example, after the red beans are collected, they are dried in a cool place at a temperature of 15° C. or less, and minced or ground to prepare fresh red bean juice.

Onions are rich in polyphenols, which are excellent in inhibiting the generation of free radicals, preventing skin aging and preventing wrinkles, and are rich in antibacterial ingredients to alleviate skin troubles.

As an example, the onion is peeled and cut to an appropriate size, and then immersed in ice water for 1 hour to remove the pungent taste. Then, the onion is removed and dried at a temperature of 10° C. or less for 24 to 48 hours to remove moisture. The drying is repeated 2-3 times. Thereafter, the onion can be put in a device and minced or ground to prepare fresh onion juice.

The raw pumpkin leaf juice, red bean juice and onion juice are preferably mixed in a weight ratio of 1: 1: 0.3 to 0.4.

Next, buckwheat malt can be prepared.

Buckwheat is not only high in protein but also contains lysine, an essential amino acid, significantly higher than other grains, and rich in zinc (Zn), magnesium (Mg), manganese (Mn) and copper (Cu). In particular, various phenolic substances, including rutin and que rcetin, which are flavonoid-based substances contained in buckwheat, act as natural antioxidants and are excellent for reducing inflammation and reducing body heat. have an effect

When the buckwheat is germinated and used to prepare buckwheat malt, it is possible to further increase the antioxidant effect of buckwheat. As an example, the buckwheat malt may be prepared by immersing buckwheat seeds in purified water at 26° C. for 24 hours to germinate buckwheat, and then drying.

Next, hydrogen water, specifically, high concentration hydrogen water can be prepared. The hydrogen water may be alkaline hydrogen water, specifically, weak alkaline hydrogen water. The hydrogen water contains a large amount of hydrogen, and as the alkalinity increases, the antioxidant effect may increase. The hydrogen water combines with active oxygen, which is a harmful oxygen generated inside the human body, and discharges it to the outside of the human body. do.

The method for producing hydrogen water may be obtained by electrolyzing raw water including tap water and groundwater to generate hydrogen. As a method for producing the hydrogen water, it may be prepared using a production apparatus commonly used in the art.

For example, alkaline ionized water can be obtained by treating the raw water with an anion exchange resin to remove anions such as Cl ^-1 , SO ₄ ^-2 , PO ₄ ^-3 , CO ₃ ^-2 , HCO ₃ ^-1 . Then, by electrolyzing the obtained alkaline ionized water, hydrogen generated from the cathode can be mixed to prepare hydrogen water.

As an example, the prepared hydrogen water may be weak alkaline hydrogen water having a hydrogen content of 1,400 to 1,700 ppb and a pH of 7.3 to 9.3.

Next, a natural fresh juice mixture in which the natural juice, the buckwheat malt, and the hydrogen water are mixed in a weight ratio of 1.5: 1: 0.8 can be prepared. The natural fresh juice mixture may be mixed more uniformly by performing agitation by a conventional method.

Step 2: Preparation of sturgeon water-soluble oil composition

<Sturgeon Oil>

First, sturgeon oil obtained according to the method for obtaining raw materials of sturgeon can be obtained.

The method for obtaining the raw material of the sturgeon includes: a culture step (S1) of culturing sturgeon fry for at least 3 years using a natural antibiotic; A pre-processing step (S2) of shipping the cultured sturgeon and pre-processing it in a whole state; However, the rapid cooling of the pre-treated sturgeon, the rapid cooling is to reach a temperature of -80 to -20 ℃ between 5 minutes to 20 minutes, a cold storage step (S3); and thawing and washing the cooled sturgeon, and then putting the whole sturgeon into a pneumatic extractor and performing a first extraction to obtain sturgeon oil (S4).

More specifically, in the step S1, sturgeon, specifically, sturgeon fry (稚魚) are cultured. Breeds of the sturgeon include beluga sturgeon (Huso huso), Kaluga sturgeon (Huso dauricus), Siberian sturgeon (Acipenser baerii), Russian sturgeon (Acipenser gueldenstaedti), sturgeon sturgeon (Acipenser ruthenus), white Sturgeon (Acipenser transmontanus), Amur sturgeon (Acipenser schrenckii), Chinese sturgeon (Acipenser sinensis), spatula sturgeon (Polyodon spathula) and hybrids thereof may be selected from the group consisting of. The sturgeon according to an embodiment of the present invention may be, for example, a hybrid of a Siberian sturgeon and a beluga sturgeon, but is not limited thereto.

The environment of the aquaculture may be a freshwater aquaculture farm, the freshwater source may be river water, groundwater, mountain spring water, and tap water, and the freshwater source may be a water source that has undergone purification treatment such as dechlorination treatment with activated carbon.

The aquaculture may be carried out until the sturgeon fry are adult sturgeons weighing at least 1 kg, for example, it may last for more than 3 years, for example 3 to 5 years.

The mod is oriented towards an antibiotic-free environment. That is, in the sturgeon culture of the present invention, as in the prior art, chemical components such as various antibiotics and growth promoters administered for weight gain and meat quality improvement of the sturgeon are not used, and natural antibiotics made of natural materials can be used. can

For example, sea salt may be used as the natural antibiotic. Specifically, by allowing the sturgeon to consume sea salt during the culture, it is possible to effectively remove impurities including harmful bacteria inside the sturgeon. The intake of the sea salt is preferably performed within the range of 1 to 3 times a month.

In the steps S2 and S3, the cultured sturgeon may be pre-treated and then stored chilled. The pre-treatment is to be carried out in the form of whole (whole or not sliced or cut) without cutting the sturgeon for each part.

The cultured sturgeon is shipped and pre-treatment is performed, but first, 10 to 12 days before a preset shipment date, for example, 10 days before, the sturgeon may fast so that it does not consume any food. By allowing the sturgeon to fast, impurities in the intestines are emptied cleanly, so that the yield of the active ingredients of the whole sturgeon can be further increased.

After the fasting, the sturgeon is shipped and cleaned, and then the sturgeon's head is struck with a rubber hammer once or twice to stun it. The stunned sturgeon can then be rapidly cooled immediately for storage. The condition of the rapid cooling may be such that it reaches a temperature of -80 to -20°C in a short time, for example, between 5 and 20 minutes.

By rapidly cooling the sturgeon immediately after it is rapidly stunned in the above manner, it is possible to obtain high-quality active ingredients in the form of whole sturgeon while minimizing the pain of the sturgeon.

In the step S4, sturgeon raw material, that is, sturgeon oil is obtained.

After thawing the cooled and stored sturgeon for 2 to 6 hours, the whole fish body is washed evenly with water or saline to remove various impurities such as residual blood or residual intestines.

The first extraction may be performed on the sturgeon in the form of whole fish. The first extraction method may be performed using a pneumatic extractor, specifically, a pneumatic hot water extractor. The whole sturgeon may be put into the pneumatic extractor together with water as a solvent. In this case, the solvent may further include calamansi stock solution, bellflower stock solution, and beet stock solution.

As an example, an extraction raw material obtained by mixing 50% by weight of the whole sturgeon, 41% by weight of water, 5% by weight of calamansi undiluted solution, 2% by weight of bellflower undiluted solution and 2% by weight of beet undiluted solution is added to the pneumatic extractor to make 1 extraction can be performed.

The pneumatic extractor is 100 to 104 ° C., for example, at 102 ° C., 2.3 to 2.7 atmospheres, for example, may be carried out under the conditions of 2.5 atmospheres, and the extraction time is 98 to 102 hours, for example, 100 hours. it is preferable

After the first extraction, specific gravity separation in which upper, middle, and lower layers are separated may be performed using the difference in specific gravity. As a specific method for the specific gravity separation, first, without removing steam (steam) in a state in which the pneumatic extractor is operating, the obtained primary extract is placed directly in the stirrer tank. In this case, the primary extract contained in the agitator tank may be a liquid sturgeon extract, and the liquid sturgeon extract may account for about 80% by weight based on the total weight of the extraction raw material.

Thereafter, the remaining extraction raw materials may be compressed once or twice or more with a compressor provided in the pneumatic extractor to obtain a secondary extract. In this case, the secondary extract may be sturgeon oil, and the sturgeon oil may account for about 5% by weight based on the total weight of the extraction raw material.

Then, the remaining raw material of the extraction, that is, sturgeon solid content can be obtained. The sturgeon solid content may include sturgeon meat, cartilage, bone marrow, or a combination thereof. The sturgeon solid content may account for about 15% by weight based on the total weight of the extraction raw material.

The method for obtaining the raw material of sturgeon described in step S4 is to perform specific gravity separation at the same time as extraction, and in a simpler process, all of the sturgeon liquid extract, sturgeon oil and sturgeon solids obtained from whole sturgeon make it possible to obtain

<Sturgeon water-soluble oil composition>

Second, the first aging of the sturgeon oil may be performed to prepare an aged sturgeon oil. Sterilization may be performed before performing the first aging. The method of sterilization may be performed according to a known technique generally used in the art.

The first aging is carried out in a shaded place by putting the sturgeon oil in a container for aging, and may be natural aging performed under conditions similar to natural conditions. Specifically, the aging is preferably carried out for 25 days to 35 days, for example 30 days, for example, in the temperature range of 17 to 21 ℃, for example, 17 ℃, there is no sunlight, air It can be carried out under the prevailing conditions.

When the first aging is performed in the above-described condition range, impurities in the sturgeon oil may sink or float and be removed later, thereby increasing the purity of the sturgeon oil and further increasing the content of the active ingredient. After the aging, filtration may be performed separately.

Third, the sturgeon oil aged product may be pre-treated. The pre-treatment may be an operation of making the oil state immediately before water-soluble (solubilization) in order to obtain a formulation of a water-soluble oil later.

A specific method of performing the pretreatment is to cause a change in the physical properties of the sturgeon oil, for example, passing the sturgeon oil through a high-pressure injector and a fine nozzle provided in the high-pressure injector several to several tens to hundreds of times while passing the sturgeon It may be to foam the shark oil. In this case, the efficiency of the foaming operation may be increased while injecting air using a separate injection pump.

This pre-treatment process may be repeated a number of times until the oil becomes a cream-like formulation. At this time, the time when the oil becomes a formulation such as fresh cream may be in a state immediately before water-solubilization (solubilization) to obtain a water-soluble oil.

This pre-treatment process does not use artificial chemical components such as surfactants used in the prior art, but causes physical property changes in the components only with a physical nano method to form water solubility (solubilization) to obtain a formulation of water-soluble oil in the future make it possible That is, in one embodiment of the present invention, as a method for producing a water-soluble sturgeon oil using a natural nanotechnology method, drinking water, food, cosmetics, pharmaceuticals, pet-related fields, and vegetable raw material composition, in which harmlessness to the human body and environmental friendliness should be given priority in particular It can be used in a wide range of fields such as

The pre-treated sturgeon oil aged product may be stored in a container at room temperature, for example, 1 to 35° C., specifically, 18 to 23° C. after the second aging. The second aging is natural aging like the first aging, and specific conditions are the same as those of the first aging, but the aging period is preferably about 10 days.

Fourth, the first water-soluble oil may be prepared by performing the second extraction and the third extraction together with the pre-treated sturgeon oil aged product and water. In this case, the method of the second extraction and the third extraction may be distillation extraction.

Specifically, in the second extraction, the pretreated aged sturgeon oil and water are mixed in a distillation extractor in a 1:1 weight ratio, and then distillation extraction may be performed. Then, after the second extraction, all the water vapor evaporates and the remaining water is added to the remaining aged sturgeon oil in a weight ratio of 1:1.2 to 1.5, and then a third extraction of distillation extraction can be performed. The third extraction is repeated at least 30 times, thereby obtaining a primary water-soluble oil.

The primary water-soluble oil may be a formulation in the process of preparing the final water-soluble oil. The primary water-soluble oil may be added to a stirrer and stirred once or twice.

Fifth, an additive composition can be prepared. The additive composition may be a primary additive composition comprising edible snails, respectively, and a secondary additive composition comprising Pu-erh tea and chrysanthemum.

The primary additive composition may further include one or more selected from the group of primary natural ingredients consisting of baekbong ogolgae, white wood ear mushroom, beets, kelp root, and bellflower. As an example, the first additive composition may include a primary natural component that is a mixture of edible snails, baekbong ogolgae, white woody mushrooms, beets, kelp roots and bellflower. In this case, the natural ingredient may be used that is cut into an average size of about 4 to 7 cm by cleaning the raw material state.

The primary natural ingredient and water are mixed in a weight ratio of 1:1, then put into a pneumatic extractor, and the primary natural ingredient extract extracted at a temperature of 100° C. or higher for 100 hours, that is, a primary additive composition can be prepared.

The secondary additive composition is a group of secondary natural ingredients consisting of lotus seed, sea bamboo shoot, centella asiatica, wormwood, wormwood, mint, eugeunpi, hagocho, guccippong, wasong, chaga mushroom, samchae, calamansi and mulberry leaf It may further include one or more selected from. In one example, the secondary additive composition contains Pu'er tea, chrysanthemum, lotus seed, sea bamboo shoot, centella asiatica, wormwood, wormwood, mint, eugeunpi, hagocho, gucci bbong, wasong, chaga mushroom, samchae, calamansi and mulberry leaf. A mixture of secondary natural ingredients may be included. In this case, the natural ingredient may be used that is cut into an average size of about 4 to 7 cm by cleaning the raw material state.

The secondary natural ingredient and water are mixed in a weight ratio of 1:1, then put into a pneumatic extractor, and a secondary natural ingredient extract extracted at a temperature of 100° C. or higher for 100 hours, that is, a secondary additive composition can be prepared.

Then, the first natural component extract and the second natural component extract are each aged at room temperature, 1 to 35°C, for example, 19 to 23°C, for 10 days, then put together in a stirrer and stirred, Distillation extraction may be performed. For example, 50 parts by weight of the second natural component extract and 50 parts by weight of water are mixed with respect to 100 parts by weight of the first natural component extract, and then, it can be added to a distillation extractor for distillation extraction.

When the distillation extraction is completed, it is possible to obtain a mixed additive composition obtained from the mixed extraction of the first natural component extract and the second natural component extract.

Sixth, the primary water-soluble oil and the mixed additive composition may be distilled and extracted to prepare a secondary water-soluble oil. The primary water-soluble oil and the mixed additive composition may be mixed in a weight ratio of 1:1, and the distillation extraction may be performed once or twice to three times.

The secondary water-soluble oil may be "sturgeon water-soluble oil composition" in the present invention. That is, the water-soluble sturgeon oil composition may include a mixed additive composition obtained by distilling a mixture of sturgeon oil and an additive that is a natural component.

The sturgeon water-soluble oil (composition) is an oil formulation that can be easily solubilized in water without artificial chemicals such as surfactants, and can be widely used in drinking water or food fields, where harmlessness to the human body and environmental friendliness must be given priority. .

Step 3: Preparation of a composition for inhibiting atopic dermatitis

With respect to 100 parts by weight of the natural raw juice mixture obtained in the first step, 120 to 150 parts by weight, for example, 130 parts by weight, of the water-soluble sturgeon oil (composition) obtained in the second step can be mixed to prepare a mixture composition.

The mixture composition, based on 100 parts by weight of the natural raw juice mixture, 25 to 35 parts by weight of purslane herb, for example, may further include 30 parts by weight.

Purslane herb is rich in antioxidants and powerful antibacterial ingredients, so it is very helpful in suppressing atopic dermatitis due to its excellent effect of excreting toxins from the skin and relieving inflammation.

As the purslane herbal water, water prepared by drying purslane herbs and immersing them in hot water at 24 to 30° C. for 24 hours may be used, and the dried purslane herbs are mixed with sugar in a weight ratio of 1:1 and then aged. can also be used.

The natural raw juice mixture, the water-soluble sturgeon oil composition, and the purslane herbal water may be stirred in a conventional manner so as to be more uniformly mixed.

The stirring is sufficiently performed for 30 minutes to 90 minutes at a speed of 150 to 200 rpm, at this time, it may be mixed more uniformly by including a natural emulsifier such as lecithin.

The composition, for example, can be utilized in various industrial fields such as food, drinking water, cosmetics, pharmaceuticals, pet-related products, and vegetable raw material composition.

For example, the composition may be prepared in the form of a food composition, that is, various health supplements provided by a method conventional in the art. For example, the food composition may be liquid such as a suspension, emulsion, or beverage; Alternatively, solids such as sticks, gels, pills, tableting, jellies, chips, and the like; It can be manufactured in various forms in the form of

For example, the food composition may be prepared as a beverage composition, and the shape thereof may be, for example, a liquid stick type, a liquid pouch type, etc., but is not limited thereto.

When the food composition is prepared as a beverage composition, it may further include, for example, acacia honey, pear juice, bellflower juice, apple juice, or a natural sweetener component of a combination thereof in addition to the above-described components. As an example, based on 100 parts by weight of the natural fresh juice mixture, 15 to 20 parts by weight of a natural sweetener obtained by mixing pear juice and acacia honey in a weight ratio of 1:1 may be further included.

By further including these natural sweeteners, it is possible to prepare a novel health functional food that can simultaneously secure the antioxidant function of sturgeon nutrients and natural juice by eliminating the objection to ingestion of sturgeon and improving the sensuality. have.

As another example, the food composition may be prepared in a gel or jelly formulation. Specifically, as a method for processing the mixed composition into the gel or jelly formulation, for example, 20 to 30 parts by weight of the hydrogen water prepared in the first step in the mixed composition, pectin, gelatin and agar, etc. 1 to 10 parts by weight of a conventional gelling agent and 1 to 10 parts by weight of other conventional additives including sugar and sodium citrate are further mixed, and then the mixture may be specifically stirred at 300 to 400 rpm. While the temperature is raised to 85 to 90 °C during the stirring step, the gelling agent can be completely dissolved to prepare a jelly form.

However, the manufacturing method is not limited thereto, and may include methods and components commonly used in the art without limitation.

For example, the composition may be included in a cosmetic composition and manufactured as a skin product. Examples of application of skin products include basic cosmetics (lotions, serums, essences, lotions, creams, etc.) for preparing and protecting the skin, color cosmetics (makeup base, foundation, powder, eye shadow, lip gloss, lipstick, lip balm, etc.) , Make-up for nails (manicure, nutrition, enhancer, top coat, etc.), cleansing cosmetics (foam cleansing, cleansing oil, cleansing lotion, cleansing cream, cleansing gel, pack, mask, soap, cleansing tissue, etc.), sun It may include both care cosmetics and body cosmetics (body lotion, shower gel, body cream, body oil, etc.).

As an example, the composition may be contained as a functional ingredient in an emulsion-type cosmetic composition such as an essence or serum. The emulsion-type cosmetic may include, without limitation, ingredients and other additives commonly used in addition to the functional ingredients, and the manufacturing method may follow conventional techniques.

According to an embodiment of the present invention, it is possible to prepare a composition for inhibiting atopic dermatitis containing a natural ingredient mixture including high concentration hydrogen water and water-soluble sturgeon oil.

The high-concentration hydrogen water combines with active oxygen, which is a harmful oxygen generated inside the human body, and discharges it to the outside of the body. can perform

The sturgeon water-soluble oil composition contains sturgeon oil obtained from whole sturgeon, contains a high content of active ingredients in sturgeon, and can secure human safety and improved quality due to non-antibiotics. In addition, human safety and environmental friendliness can be secured by excluding artificial chemicals such as surfactants by using a physical natural nanotechnology method and forming a water-soluble oil formulation only by a physical separation method.

Furthermore, the mixed composition according to an embodiment of the present invention provides abundant nutrients such as low molecular weight collagen, protein, essential amino acids, and vitamins essential for maintaining skin health from the water-soluble sturgeon oil composition to the natural raw juice. By allowing it to exert synergy with various antioxidant functions by

In this specification, only a few examples among the various embodiments performed by the present inventors will be described, but the technical spirit of the present invention is not limited or limited thereto, and it is of course that it may be modified and variously implemented by those skilled in the art.

Claims (5)

Chop each pumpkin leaf, red bean and onion to prepare a natural juice;
Soaking buckwheat seeds in purified water at 26° C. for 24 hours to germinate buckwheat, followed by drying to prepare buckwheat malt; and
Preparing a natural fresh juice mixture by mixing the natural juice, the buckwheat malt and hydrogen water in a weight ratio of 1.5: 1: 0.8; a first step, including;
preparing sturgeon oil according to a method for obtaining raw materials of sturgeon;
performing a first aging of the sturgeon oil to prepare an aged sturgeon oil;
For the aged sturgeon oil, a pre-treatment step of foaming by forming a change in the physical properties of the oil using a high-pressure processor and a nozzle;
Second aging of the pre-treated sturgeon oil aged product;
A step of mixing the aged sturgeon oil with the second aging is performed and water, input to a distillation extractor, and second extraction;
After performing the second extraction, the remaining aged sturgeon oil is mixed with water again, added to a distillation extractor, and a third extraction is performed to prepare a primary water-soluble oil;
Preparing a primary additive composition containing edible snails and a secondary additive composition containing Puer's tea and chrysanthemum, respectively; and
A second step of preparing a water-soluble sturgeon oil comprising; distilling and extracting a mixture of the first water-soluble oil, the first additive composition, and the second additive composition to prepare a secondary water-soluble oil; and
Preparing a mixture composition by mixing 120 to 150 parts by weight of the water-soluble sturgeon oil obtained in the second step and 25 to 35 parts by weight of the purslane herbal water with respect to 100 parts by weight of the natural raw juice mixture obtained in the first step; A third step of doing; characterized in that it includes
The method of obtaining the raw material of the sturgeon,
aquaculture stage, in which sturgeon fry are cultured using natural antibiotics for at least 3 years;
A pre-processing step of pre-treating the farmed sturgeon to a whole state;
A cold storage step of rapidly cooling the pretreated sturgeon, wherein the rapid cooling is to reach a temperature of -80 to -20°C within 5 to 20 minutes; and
After thawing and washing the chilled sturgeon, the whole sturgeon is put into a pneumatic extractor and the first extraction is performed to obtain sturgeon oil; Way. According to claim 1,
The hydrogen water, a hydrogen content of 1,400 to 1,700 ppb, characterized in that weak alkaline hydrogen water having a pH of 7.3 to 9.3, a method for inhibiting atopic dermatitis composition. According to claim 1,
The method for producing the hydrogen water,
treating raw water with an anion exchange resin to obtain alkaline ionized water from which anions are removed; and
A method for producing a composition for inhibiting atopic dermatitis, comprising: obtaining hydrogen water by mixing hydrogen generated by electrolyzing the obtained alkaline ionized water. According to claim 1,
In the third step, the mixed composition is processed into a gel or jelly formulation, and the processing method includes 20 to 30 parts by weight of hydrogen water, 1 to 10 parts by weight of a gelling agent, and sugar and sodium citrate in the mixed composition further mixing 1 to 10 parts by weight of other additives and stirring at 300 to 400 rpm; and
The method for producing a composition for inhibiting atopic dermatitis, comprising the step of completely dissolving the gelling agent while raising the temperature to 85 to 90 ℃ during the stirring step to prepare a jelly form. delete