KR20170095306A - 유방암 치료제에 대한 반응을 예측하는 방법 및 유방암의 치료 방법 - Google Patents
유방암 치료제에 대한 반응을 예측하는 방법 및 유방암의 치료 방법 Download PDFInfo
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- KR20170095306A KR20170095306A KR1020177019159A KR20177019159A KR20170095306A KR 20170095306 A KR20170095306 A KR 20170095306A KR 1020177019159 A KR1020177019159 A KR 1020177019159A KR 20177019159 A KR20177019159 A KR 20177019159A KR 20170095306 A KR20170095306 A KR 20170095306A
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Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101923250B1 (ko) | 2011-07-29 | 2018-11-28 | 메디베이션 프로스테이트 테라퓨틱스 엘엘씨 | 유방암의 치료 |
| US20140243211A1 (en) | 2013-02-28 | 2014-08-28 | Indiana University Research & Technology Corporation | Blood biomarkers for suicidality |
| SG11201704425TA (en) | 2014-12-12 | 2017-06-29 | Medivation Prostate Therapeutics Inc | Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer |
| WO2016201299A1 (en) | 2015-06-12 | 2016-12-15 | Indiana University Research & Technology Corporation | Predicting suicidality using a combined genomic and clinical risk assessment |
| KR101966493B1 (ko) * | 2016-06-27 | 2019-04-05 | 국립암센터 | 삼중음성유방암 예후 예측용 바이오마커 |
| KR101896558B1 (ko) * | 2016-11-21 | 2018-09-07 | 주식회사 젠큐릭스 | 유방암 환자의 예후 예측 방법 |
| JPWO2018198927A1 (ja) * | 2017-04-26 | 2019-11-07 | 日本電信電話株式会社 | Ｎ×ｎ光スイッチ |
| CA3105451A1 (en) | 2017-05-12 | 2018-11-15 | Indiana University Research And Technology Corporation | Precision medicine for treating and preventing suicidality |
| RU2648523C1 (ru) * | 2017-05-22 | 2018-03-26 | Федеральное государственное бюджетное научное учреждение "Томский национальный исследовательский медицинский центр" Российской академии наук ("Томский НИМЦ") | Способ прогнозирования исхода заболевания у больных люминальным в и трижды негативным раком молочной железы у пациенток, не получавших в неоадъювантном режиме химио- или гормонотерапию |
| CA3105389C (en) * | 2018-05-14 | 2025-05-20 | Hinova Pharmaceuticals Inc. | A formulation of hc-1119 as well as the production method and the use thereof |
| WO2020001473A1 (zh) * | 2018-06-28 | 2020-01-02 | 复旦大学 | 小核仁核糖核酸snord33作为生物标记物用于制备检测试剂盒中的用途 |
| CN109735625A (zh) * | 2019-03-18 | 2019-05-10 | 马榕 | 乳头溢液在检测肿瘤相关基因中的应用 |
| CN114334000B (zh) * | 2021-12-28 | 2025-07-25 | 上海中医药大学 | 基于转录组图谱的组合药物生成方法、系统及存储介质 |
| US20260043086A1 (en) * | 2022-08-06 | 2026-02-12 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Predictive biomarker in avastin in colon cancer |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| US5800992A (en) | 1989-06-07 | 1998-09-01 | Fodor; Stephen P.A. | Method of detecting nucleic acids |
| US6040138A (en) | 1995-09-15 | 2000-03-21 | Affymetrix, Inc. | Expression monitoring by hybridization to high density oligonucleotide arrays |
| EP0880598A4 (en) | 1996-01-23 | 2005-02-23 | Affymetrix Inc | RAPID EVALUATION OF NUCLEIC ACID ABUNDANCE DIFFERENCE, WITH A HIGH-DENSITY OLIGONUCLEOTIDE SYSTEM |
| EP1027456B1 (en) | 1997-10-31 | 2005-03-16 | Affymetrix, Inc. (a Delaware Corporation) | Expression profiles in adult and fetal organs |
| US6020135A (en) | 1998-03-27 | 2000-02-01 | Affymetrix, Inc. | P53-regulated genes |
| US6937713B1 (en) | 1999-12-30 | 2005-08-30 | At&T Corp. | IP call forward profile |
| US7504222B2 (en) | 2001-10-31 | 2009-03-17 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of breast cancer |
| US20070192880A1 (en) | 2003-10-03 | 2007-08-16 | University Of Rochester | Horming response element binding transregulators |
| US20070059720A9 (en) | 2004-12-06 | 2007-03-15 | Suzanne Fuqua | RNA expression profile predicting response to tamoxifen in breast cancer patients |
| US7709517B2 (en) | 2005-05-13 | 2010-05-04 | The Regents Of The University Of California | Diarylhydantoin compounds |
| JP4644737B2 (ja) | 2005-05-13 | 2011-03-02 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | ジアリールヒダントイン化合物 |
| CA2630974A1 (en) | 2005-11-23 | 2007-05-31 | University Of Utah Research Foundation | Methods and compositions involving intrinsic genes |
| LT2656842T (lt) | 2006-03-27 | 2016-09-26 | The Regents Of The University Of California | Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui |
| KR101456722B1 (ko) | 2006-03-29 | 2014-10-31 | 더 리전트 오브 더 유니버시티 오브 캘리포니아 | 디아릴티오히단토인 화합물 |
| TWI469971B (zh) | 2007-10-26 | 2015-01-21 | Univ California | 二芳基乙內醯脲類化合物 |
| CN103169973A (zh) * | 2007-11-12 | 2013-06-26 | 彼帕科学公司 | 使用4-碘-3-硝基苯甲酰胺化合物与抗肿瘤剂组合治疗乳腺癌 |
| US8450290B2 (en) | 2007-11-26 | 2013-05-28 | Enzon Pharmaceuticals, Inc. | Methods for treating androgen receptor dependent disorders including cancers |
| WO2009114534A1 (en) | 2008-03-14 | 2009-09-17 | The Regents Of The University Of California | Multi-gene classifiers and prognostic indicators for cancers |
| DK2297359T3 (en) | 2008-05-30 | 2014-02-24 | Univ Utah Res Found | Gene expression profiles to predict the outcome of breast cancer |
| NZ594741A (en) | 2009-02-24 | 2014-03-28 | Medivation Prostate Therapeutics Inc | Specific diarylhydantoin and diarylthiohydantoin compounds |
| EP2416657A4 (en) | 2009-04-09 | 2012-09-05 | Medivation Prostate Therapeutics Inc | COMPOUNDS COMPRISING SUBSTITUTED DI-ARYLHYDANTOIDS AND DI-ARYLTHIOHYDANTOINES AND METHODS OF USE THEREOF |
| EP2425015B1 (en) | 2009-04-29 | 2018-01-10 | Ralph Wirtz | A method to assess prognosis and to predict therapeutic success in cancer by determining hormone receptor expression levels |
| WO2011022316A1 (en) | 2009-08-20 | 2011-02-24 | The Regents Of The University Of Colorado, A Body Corporate | Mirnas dysregulated in triple-negative breast cancer |
| JP2013504064A (ja) | 2009-09-03 | 2013-02-04 | ザ スクリプス リサーチ インスティチュート | 循環腫瘍細胞を分類する方法 |
| WO2011044327A1 (en) | 2009-10-07 | 2011-04-14 | Medivation Prostate Therapeutics, Inc. | Substituted phenylcarbamoyl alkylamino arene compounds and n,n'-bis-arylurea compounds |
| US8781912B2 (en) | 2011-03-15 | 2014-07-15 | Opera Solutions, Llc | Computer-based method and computer program product for setting floor prices for items sold at auction |
| AU2012229123B2 (en) * | 2011-03-15 | 2017-02-02 | British Columbia Cancer Agency Branch | Methods of treating breast cancer with anthracycline therapy |
| KR101923250B1 (ko) | 2011-07-29 | 2018-11-28 | 메디베이션 프로스테이트 테라퓨틱스 엘엘씨 | 유방암의 치료 |
| AU2012345789B2 (en) | 2011-11-30 | 2018-02-15 | British Columbia Cancer Agency Branch | Methods of treating breast cancer with taxane therapy |
| US10175240B2 (en) | 2012-08-23 | 2019-01-08 | The Regents Of The University Of Colorado, A Body Corporate | Method for determining breast cancer treatment |
| US9175291B2 (en) * | 2012-10-11 | 2015-11-03 | Isis Pharmaceuticals Inc. | Modulation of androgen receptor expression |
| US20140154681A1 (en) | 2012-11-12 | 2014-06-05 | Nanostring Technologies, Inc. | Methods to Predict Breast Cancer Outcome |
| US10679730B2 (en) * | 2013-05-28 | 2020-06-09 | The University Of Chicago | Prognostic and predictive breast cancer signature |
| SG11201704425TA (en) | 2014-12-12 | 2017-06-29 | Medivation Prostate Therapeutics Inc | Method for predicting response to breast cancer therapeutic agents and method of treatment of breast cancer |
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| US20220056541A1 (en) | 2022-02-24 |
| EP3230471A1 (en) | 2017-10-18 |
| JP2018504892A (ja) | 2018-02-22 |
| WO2016094408A1 (en) | 2016-06-16 |
| US20160168646A1 (en) | 2016-06-16 |
| CA2970469A1 (en) | 2016-06-16 |
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| US20190169697A1 (en) | 2019-06-06 |
| IL252587A0 (en) | 2017-07-31 |
| SG11201704425TA (en) | 2017-06-29 |
| ES2748005T3 (es) | 2020-03-12 |
| US11186876B2 (en) | 2021-11-30 |
| ZA201703904B (en) | 2019-12-18 |
| EP3604556A1 (en) | 2020-02-05 |
| BR112017012142A2 (pt) | 2018-01-02 |
| AU2015360767A1 (en) | 2017-06-08 |
| RU2017120330A3 (https=) | 2019-07-24 |
| CN107109488A (zh) | 2017-08-29 |
| EP3230471B1 (en) | 2019-08-28 |
| US10196693B2 (en) | 2019-02-05 |
| RU2017120330A (ru) | 2019-01-14 |
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