KR20170048426A - 시각 장애를 치료하기 위한 조성물 및 방법 - Google Patents

시각 장애를 치료하기 위한 조성물 및 방법 Download PDF

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Publication number
KR20170048426A
KR20170048426A KR1020177007882A KR20177007882A KR20170048426A KR 20170048426 A KR20170048426 A KR 20170048426A KR 1020177007882 A KR1020177007882 A KR 1020177007882A KR 20177007882 A KR20177007882 A KR 20177007882A KR 20170048426 A KR20170048426 A KR 20170048426A
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KR
South Korea
Prior art keywords
lanosterol
ophthalmic
crystalline
lens
composition
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
KR1020177007882A
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English (en)
Korean (ko)
Inventor
캉 장
루이 호우
후이민 카이
Original Assignee
광저우 캉루이 바이오로지컬 파마슈티컬 테크놀로지 씨오., 엘티디.
더 리젠츠 오브 더 유니버시티 오브 캘리포니아
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Application filed by 광저우 캉루이 바이오로지컬 파마슈티컬 테크놀로지 씨오., 엘티디., 더 리젠츠 오브 더 유니버시티 오브 캘리포니아 filed Critical 광저우 캉루이 바이오로지컬 파마슈티컬 테크놀로지 씨오., 엘티디.
Publication of KR20170048426A publication Critical patent/KR20170048426A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/40—Cyclodextrins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/10—Ophthalmic agents for accommodation disorders, e.g. myopia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/12—Ophthalmic agents for cataracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • Y10S514/912—

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
KR1020177007882A 2014-08-22 2015-08-24 시각 장애를 치료하기 위한 조성물 및 방법 Withdrawn KR20170048426A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462040721P 2014-08-22 2014-08-22
US62/040,721 2014-08-22
US201562194120P 2015-07-17 2015-07-17
US62/194,120 2015-07-17
PCT/US2015/046453 WO2016029199A1 (en) 2014-08-22 2015-08-24 Compositions and methods to treat vision disorders

Publications (1)

Publication Number Publication Date
KR20170048426A true KR20170048426A (ko) 2017-05-08

Family

ID=55351326

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177007882A Withdrawn KR20170048426A (ko) 2014-08-22 2015-08-24 시각 장애를 치료하기 위한 조성물 및 방법

Country Status (13)

Country Link
US (1) US10471076B2 (OSRAM)
EP (1) EP3182977B1 (OSRAM)
JP (1) JP6706020B2 (OSRAM)
KR (1) KR20170048426A (OSRAM)
CN (2) CN111529481B (OSRAM)
AU (1) AU2015305199A1 (OSRAM)
BR (1) BR112017003529A2 (OSRAM)
CA (1) CA2958868A1 (OSRAM)
EA (1) EA035798B1 (OSRAM)
HK (1) HK1243325A1 (OSRAM)
MX (1) MX2017002374A (OSRAM)
SG (1) SG11201701377YA (OSRAM)
WO (1) WO2016029199A1 (OSRAM)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3182977B1 (en) 2014-08-22 2021-05-05 The Regents Of The University Of California Lanosterol for use in treating vision disorders
AU2016298951B2 (en) * 2015-07-27 2019-07-04 Catacore, Inc Compositions for the treatment of cataracts
CN109364020B (zh) * 2015-09-02 2021-12-28 盛世泰科生物医药技术(苏州)有限公司 一种用于预防和治疗白内障的眼用制剂及其制备方法
CN107397745A (zh) * 2016-08-24 2017-11-28 上海毕傲图生物科技有限公司 唑类化合物眼用制剂
CN106344587A (zh) * 2016-08-24 2017-01-25 上海毕傲图生物科技有限公司 羊毛甾醇类化合物眼用制剂
DK3536698T3 (da) * 2017-01-25 2021-09-27 Guangzhou Ocusun Ophthalmic Biotechnology Co Ltd Lanosterol-prodrugforbindelse og anvendelse deraf
GB2581656A (en) * 2017-11-17 2020-08-26 Piraee Mahmood Combinations of lanosterol or 25-hydroxycholesterol including derivatives thereof useful in the treatment of lens disorders
CN109985052A (zh) * 2017-12-29 2019-07-09 上海蓝木化工有限公司 三萜类化合物的新用途
JP7532259B2 (ja) * 2018-04-05 2024-08-13 プレックス ファーマスーティカルズ，インク 眼疾患治療薬剤
KR102788262B1 (ko) * 2018-07-25 2025-03-27 광저우 오쿠순 옵탈믹 바이오테크놀로지 캄파니 리미티드 라노 스테롤 전구 약물 화합물의 결정 형태 및 이의 용도
WO2020177714A1 (zh) * 2019-03-04 2020-09-10 中山大学中山眼科中心 一种羊毛甾醇前药化合物的组合物及其制备方法和应用
MX2021009520A (es) 2021-08-06 2023-02-07 Foodvica S A De C V Composicion oftalmica para el tratamiento de trastornos visuales.
CN115737654B (zh) 2021-09-03 2025-11-21 成都瑞沐生物医药科技有限公司 一种滴眼给药预防和/或治疗白内障的眼用制剂
CN116570706A (zh) * 2022-02-09 2023-08-11 上海瑞吉康生物医药有限公司 使用多肽治疗白内障的方法
TW202404608A (zh) * 2022-04-15 2024-02-01 大陸商廣州潤爾眼科生物科技有限公司 甾體化合物在製備預防和／或治療老花眼的藥物的用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9216106B2 (en) * 2003-04-09 2015-12-22 Directcontact Llc Device and method for the delivery of drugs for the treatment of posterior segment disease
WO2005084208A2 (en) * 2004-02-27 2005-09-15 New York University A novel class of sterol ligands and their uses in regulation of cholesterol and gene expression
US7517870B2 (en) * 2004-12-03 2009-04-14 Fondazione Telethon Use of compounds that interfere with the hedgehog signaling pathway for the manufacture of a medicament for preventing, inhibiting, and/or reversing ocular diseases related with ocular neovascularization
US20100068251A1 (en) * 2006-10-10 2010-03-18 Jina Pharmaceuticals, Inc. Aqueous Systems For The Preparation Of Lipid Based Pharmaceutical Compounds; Compositions, Methods, And Uses Thereof
US9114070B2 (en) * 2008-02-29 2015-08-25 Nagoya Industrial Science Research Institute Liposome for delivery to posterior segment of eye and pharmaceutical composition for disease in posterior segment of eye
KR101496507B1 (ko) * 2008-08-05 2015-03-03 아마조니아 피토메디카멘토스 엘티디에이 라노스타-8,24-디엔-3-올의 제약학적 용도
CN110101708A (zh) * 2012-07-17 2019-08-09 密执安大学评议会 治疗白内障的非手术方法
CN104602670A (zh) * 2012-08-31 2015-05-06 博士伦公司 含有ω-3 脂肪酸的眼用组合物
EP3182977B1 (en) 2014-08-22 2021-05-05 The Regents Of The University Of California Lanosterol for use in treating vision disorders

Also Published As

Publication number Publication date
CA2958868A1 (en) 2016-02-25
MX2017002374A (es) 2017-09-15
CN111529481A (zh) 2020-08-14
CN107206009A (zh) 2017-09-26
EP3182977A4 (en) 2018-04-11
EA035798B1 (ru) 2020-08-12
US10471076B2 (en) 2019-11-12
EP3182977B1 (en) 2021-05-05
JP6706020B2 (ja) 2020-06-03
SG11201701377YA (en) 2017-03-30
CN107206009B (zh) 2020-03-27
CN111529481B (zh) 2023-09-15
EP3182977A1 (en) 2017-06-28
WO2016029199A1 (en) 2016-02-25
BR112017003529A2 (pt) 2019-08-20
AU2015305199A1 (en) 2017-04-13
US20170065617A1 (en) 2017-03-09
EA201790397A1 (ru) 2017-08-31
JP2017525769A (ja) 2017-09-07
HK1243325A1 (zh) 2018-07-13

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Patent event date: 20170322

Patent event code: PA01051R01D

Comment text: International Patent Application

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PN2301 Change of applicant

Patent event date: 20190429

Comment text: Notification of Change of Applicant

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