KR20170035993A - 가용성 구아닐레이트 사이클라제의 활성제로서의 헤테로사이클릭 카복실산 - Google Patents

가용성 구아닐레이트 사이클라제의 활성제로서의 헤테로사이클릭 카복실산 Download PDF

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KR20170035993A
KR20170035993A KR1020177004761A KR20177004761A KR20170035993A KR 20170035993 A KR20170035993 A KR 20170035993A KR 1020177004761 A KR1020177004761 A KR 1020177004761A KR 20177004761 A KR20177004761 A KR 20177004761A KR 20170035993 A KR20170035993 A KR 20170035993A
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mmol
mixture
reduced pressure
under reduced
solution
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Korean (ko)
Inventor
제로드 버넷 브렌너먼
존 데이비드 진
크리스토퍼 로날드 사르코
존 웨스트브룩
중화 장
마오린 유
타마라 데니스 홉킨스
마이클 디. 로우
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베링거 인겔하임 인터내셔날 게엠베하
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Application filed by 베링거 인겔하임 인터내셔날 게엠베하 filed Critical 베링거 인겔하임 인터내셔날 게엠베하
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/472Non-condensed isoquinolines, e.g. papaverine
    • A61K31/4725Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
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    • AHUMAN NECESSITIES
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    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
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    • AHUMAN NECESSITIES
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    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10Drugs for genital or sexual disorders; Contraceptives for impotence
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00Drugs for disorders of the muscular or neuromuscular system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/14Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16Anti-Parkinson drugs
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00Drugs for disorders of the senses
    • A61P27/02Ophthalmic agents
    • A61P27/06Antiglaucoma agents or miotics
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
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    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/08Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • Y10S514/866
    • Y10S514/913

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
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  • Diabetes (AREA)
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  • Pain & Pain Management (AREA)
  • Ophthalmology & Optometry (AREA)
  • Reproductive Health (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Emergency Medicine (AREA)
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  • Pulmonology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Cardiology (AREA)
KR1020177004761A 2014-07-22 2015-07-21 가용성 구아닐레이트 사이클라제의 활성제로서의 헤테로사이클릭 카복실산 Withdrawn KR20170035993A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462027376P 2014-07-22 2014-07-22
US62/027,376 2014-07-22
PCT/US2015/041245 WO2016014463A1 (en) 2014-07-22 2015-07-21 Heterocyclic carboxylic acids as activators of soluble guanylate cyclase

Publications (1)

Publication Number Publication Date
KR20170035993A true KR20170035993A (ko) 2017-03-31

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KR1020177004761A Withdrawn KR20170035993A (ko) 2014-07-22 2015-07-21 가용성 구아닐레이트 사이클라제의 활성제로서의 헤테로사이클릭 카복실산

Country Status (26)

Country Link
US (1) US9353090B2 (enrdf_load_stackoverflow)
EP (1) EP3172202B1 (enrdf_load_stackoverflow)
JP (1) JP6602840B2 (enrdf_load_stackoverflow)
KR (1) KR20170035993A (enrdf_load_stackoverflow)
CN (1) CN106459017B (enrdf_load_stackoverflow)
AP (1) AP2016009615A0 (enrdf_load_stackoverflow)
AR (1) AR101265A1 (enrdf_load_stackoverflow)
AU (1) AU2015292833B2 (enrdf_load_stackoverflow)
BR (1) BR112017000943A2 (enrdf_load_stackoverflow)
CA (1) CA2955937A1 (enrdf_load_stackoverflow)
CL (1) CL2017000071A1 (enrdf_load_stackoverflow)
CO (1) CO2017000438A2 (enrdf_load_stackoverflow)
DK (1) DK3172202T3 (enrdf_load_stackoverflow)
EA (1) EA032972B1 (enrdf_load_stackoverflow)
ES (1) ES2784477T3 (enrdf_load_stackoverflow)
HU (1) HUE049231T2 (enrdf_load_stackoverflow)
IL (1) IL249587A0 (enrdf_load_stackoverflow)
MX (1) MX378717B (enrdf_load_stackoverflow)
PE (1) PE20170249A1 (enrdf_load_stackoverflow)
PH (1) PH12017500111A1 (enrdf_load_stackoverflow)
PL (1) PL3172202T3 (enrdf_load_stackoverflow)
PT (1) PT3172202T (enrdf_load_stackoverflow)
SG (2) SG11201700507XA (enrdf_load_stackoverflow)
TW (1) TWI711615B (enrdf_load_stackoverflow)
UY (1) UY36226A (enrdf_load_stackoverflow)
WO (1) WO2016014463A1 (enrdf_load_stackoverflow)

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PE20170249A1 (es) 2017-04-05
AU2015292833B2 (en) 2019-11-28
SG10201806565SA (en) 2018-08-30
PL3172202T3 (pl) 2020-07-13
EP3172202B1 (en) 2020-01-29
SG11201700507XA (en) 2017-02-27
CO2017000438A2 (es) 2017-08-31
ES2784477T3 (es) 2020-09-28
EP3172202A1 (en) 2017-05-31
US20160024059A1 (en) 2016-01-28
US9353090B2 (en) 2016-05-31
PH12017500111A1 (en) 2017-05-29
EA201790246A1 (ru) 2017-07-31
DK3172202T3 (da) 2020-04-27
JP2017521457A (ja) 2017-08-03
IL249587A0 (en) 2017-02-28
TW201617340A (zh) 2016-05-16
BR112017000943A2 (pt) 2017-11-14
CN106459017B (zh) 2020-07-17
AR101265A1 (es) 2016-12-07
AP2016009615A0 (en) 2016-12-31
MX2017000926A (es) 2017-05-04
MX378717B (es) 2025-03-10
EA032972B1 (ru) 2019-08-30
CN106459017A (zh) 2017-02-22
CL2017000071A1 (es) 2017-06-30
TWI711615B (zh) 2020-12-01
PT3172202T (pt) 2020-05-06
CA2955937A1 (en) 2016-01-28
HUE049231T2 (hu) 2020-09-28
JP6602840B2 (ja) 2019-11-06
WO2016014463A1 (en) 2016-01-28
AU2015292833A1 (en) 2016-12-22
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