KR20160135739A - 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 - Google Patents

폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 Download PDF

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Publication number
KR20160135739A
KR20160135739A KR1020167027152A KR20167027152A KR20160135739A KR 20160135739 A KR20160135739 A KR 20160135739A KR 1020167027152 A KR1020167027152 A KR 1020167027152A KR 20167027152 A KR20167027152 A KR 20167027152A KR 20160135739 A KR20160135739 A KR 20160135739A
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KR
South Korea
Prior art keywords
group
nitrogen
rti
heterocycle
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020167027152A
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English (en)
Korean (ko)
Inventor
파멜라 브라운
마이클 도슨
모나 시모노빅
스티븐 보악스
에스더 두페르치
스티븐 제임스 스탠웨이
앙투아네트 윌슨
스티븐 프레드릭 모스
Original Assignee
뉴 파마 라이센스 홀딩스 리미티드
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Publication date
Priority claimed from GB201404301A external-priority patent/GB201404301D0/en
Priority claimed from GB201421019A external-priority patent/GB201421019D0/en
Application filed by 뉴 파마 라이센스 홀딩스 리미티드 filed Critical 뉴 파마 라이센스 홀딩스 리미티드
Priority to KR1020237036093A priority Critical patent/KR20230152779A/ko
Publication of KR20160135739A publication Critical patent/KR20160135739A/ko
Ceased legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • C07K7/62—Polymyxins; Related peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020167027152A 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도 Ceased KR20160135739A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020237036093A KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GB201404301A GB201404301D0 (en) 2014-03-11 2014-03-11 Compounds and combinations
GB1404301.2 2014-03-11
GB201421019A GB201421019D0 (en) 2014-11-26 2014-11-26 Compounds
GB1421019.9 2014-11-26
PCT/EP2015/055046 WO2015135976A1 (en) 2014-03-11 2015-03-11 Polymyxin derivatives and their use in combination therapy together with different antibiotics

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020237036093A Division KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Publications (1)

Publication Number Publication Date
KR20160135739A true KR20160135739A (ko) 2016-11-28

Family

ID=52823596

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020167027152A Ceased KR20160135739A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도
KR1020237036093A Pending KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020237036093A Pending KR20230152779A (ko) 2014-03-11 2015-03-11 폴리믹신 유도체 및 상이한 항생제와의 조합 요법에 있어서의 이들의 용도

Country Status (21)

Country Link
US (3) US20170073373A1 (cg-RX-API-DMAC7.html)
EP (1) EP3116897B1 (cg-RX-API-DMAC7.html)
JP (1) JP6785659B2 (cg-RX-API-DMAC7.html)
KR (2) KR20160135739A (cg-RX-API-DMAC7.html)
CN (1) CN106232617B (cg-RX-API-DMAC7.html)
AU (1) AU2015228898B2 (cg-RX-API-DMAC7.html)
CA (1) CA2940455C (cg-RX-API-DMAC7.html)
CY (1) CY1125175T1 (cg-RX-API-DMAC7.html)
DK (1) DK3116897T3 (cg-RX-API-DMAC7.html)
ES (1) ES2910072T3 (cg-RX-API-DMAC7.html)
HR (1) HRP20220387T1 (cg-RX-API-DMAC7.html)
IL (1) IL247243B (cg-RX-API-DMAC7.html)
LT (1) LT3116897T (cg-RX-API-DMAC7.html)
MX (1) MX359104B (cg-RX-API-DMAC7.html)
PL (1) PL3116897T3 (cg-RX-API-DMAC7.html)
PT (1) PT3116897T (cg-RX-API-DMAC7.html)
RS (1) RS63138B1 (cg-RX-API-DMAC7.html)
RU (1) RU2740190C2 (cg-RX-API-DMAC7.html)
SI (1) SI3116897T1 (cg-RX-API-DMAC7.html)
TW (1) TWI709575B (cg-RX-API-DMAC7.html)
WO (1) WO2015135976A1 (cg-RX-API-DMAC7.html)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2855916A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
EP3126376B1 (en) 2014-04-01 2024-08-21 Monash University Polymyxin derivatives as antimicrobial compounds
CN107108699A (zh) 2014-11-26 2017-08-29 新药物许可控股有限公司 化合物
EP3233889B1 (en) 2014-12-16 2022-07-06 Shanghai MicuRx Pharmaceutical Co., Ltd. Antimicrobial polymyxins for treatment of bacterial infections
CN105030744B (zh) * 2015-07-09 2019-04-19 广州英赛特生物技术有限公司 取代苯胍衍生物作为多粘菌素类抗生素增效剂的应用
CN108350034B (zh) * 2015-09-29 2022-03-11 莫纳什大学 抗微生物的多黏菌素衍生的化合物
JP6744622B2 (ja) * 2016-06-16 2020-08-19 学校法人上智学院 ピペリジン化合物の製造方法
JP2021501783A (ja) * 2017-11-02 2021-01-21 ザ ユニバーシティー オブ クイーンズランド ペプチド抗生物質
LT3810633T (lt) 2018-06-25 2024-01-10 Spero Therapeutics, Inc. Junginiai
CN111690040A (zh) * 2019-03-12 2020-09-22 上海来益生物药物研究开发中心有限责任公司 多粘菌素衍生物、其制备方法和应用
CN115298198A (zh) 2020-01-21 2022-11-04 上海盟科药业股份有限公司 用于肾相关癌症靶向治疗的新型化合物和组合物
TW202233649A (zh) 2020-11-06 2022-09-01 美商斯佩羅治療學股份有限公司 化合物
CN120699105B (zh) * 2025-08-19 2025-11-21 中国药科大学 一种氘代抗菌肽及其组合物和应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060004185A1 (en) * 2004-07-01 2006-01-05 Leese Richard A Peptide antibiotics and peptide intermediates for their prepartion
SI2057185T1 (sl) * 2006-08-11 2016-10-28 Northern Antibiotics Oy Derivati polimiksina in njihove uporabe
WO2010075416A1 (en) * 2008-12-23 2010-07-01 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
CN101851270A (zh) * 2009-04-03 2010-10-06 梁浩 一种多粘菌素衍生物及其制备方法
US8415307B1 (en) * 2010-06-23 2013-04-09 Biosource Pharm, Inc. Antibiotic compositions for the treatment of gram negative infections
WO2012168820A1 (en) * 2011-06-08 2012-12-13 Pfizer Inc. Polymyxin derivatives useful as antibacterial agents
CA2855916A1 (en) * 2011-11-18 2013-05-23 Novacta Biosystems Limited Polymyxin derivatives
PT2999711T (pt) * 2013-05-22 2022-07-29 Spero Therapeutics Inc Derivados de polimixina e a sua utilização em terapia de combinação em conjunto com antibióticos diferentes

Also Published As

Publication number Publication date
TWI709575B (zh) 2020-11-11
CY1125175T1 (el) 2024-12-13
HRP20220387T1 (hr) 2022-05-27
TW201617362A (zh) 2016-05-16
EP3116897A1 (en) 2017-01-18
WO2015135976A1 (en) 2015-09-17
MX359104B (es) 2018-09-14
MX2016011682A (es) 2017-04-27
US20210221848A1 (en) 2021-07-22
DK3116897T3 (da) 2022-03-28
RS63138B1 (sr) 2022-05-31
EP3116897B1 (en) 2022-03-02
JP2017510570A (ja) 2017-04-13
PT3116897T (pt) 2022-04-07
CN106232617B (zh) 2022-06-24
CA2940455C (en) 2023-03-21
SI3116897T1 (sl) 2022-06-30
RU2016139978A (ru) 2018-04-13
ES2910072T3 (es) 2022-05-11
RU2016139978A3 (cg-RX-API-DMAC7.html) 2018-10-17
AU2015228898A1 (en) 2016-10-20
IL247243B (en) 2020-04-30
CN106232617A (zh) 2016-12-14
US20230322858A1 (en) 2023-10-12
CA2940455A1 (en) 2015-09-17
KR20230152779A (ko) 2023-11-03
US20170073373A1 (en) 2017-03-16
IL247243A0 (en) 2016-09-29
LT3116897T (lt) 2022-05-10
PL3116897T3 (pl) 2022-05-30
RU2740190C2 (ru) 2021-01-12
AU2015228898B2 (en) 2018-11-15
JP6785659B2 (ja) 2020-11-18

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