KR20160129453A - Cosmetic composition for skin winkle improvement containing Fermented extract of horse placenta and horse oil - Google Patents

Abstract

The present invention aims at providing a cosmetic composition for improving skin wrinkles containing a horse placenta fermented product, a horse oil and a herbal medicine component, Wherein the active ingredient is 0.01 to 15% by weight based on the total weight of the cosmetic composition.
The cosmetic composition for improving skin wrinkles containing the matal half-fermented product and the hemp oil of the present invention has no unique odor and toxicity due to the use of the fermented product of the mata-van, and thus has no side effects on the skin, And exhibits an effect of improving wrinkles, exhibiting a short period of time, and exhibiting a long lasting effect because of its excellent cell activity through cell proliferation, the effect of enhancing collagen synthesis, and enhancing immunity.

Description

[0001] The present invention relates to a cosmetic composition for skin wrinkle improvement containing fermented extract of horse placenta and horse oil,

The present invention relates to a cosmetic composition for improving skin wrinkles containing a fermented mackerel and a hemp, and more particularly, to a cosmetic composition for improving skin wrinkles which is safe to skin and has excellent formulation stability, To a cosmetic composition.

In general, skin wrinkles are known to be produced by various factors such as moisture content of skin, collagen content, immunity to external environment, and especially, 70% Of the collagen fibers is reduced by aging, or the collagen fibers are deformed by the external environment, so that a lot of wrinkles are generated and deepened on the skin.

Conventionally, in order to improve the wrinkles of the skin, the composition has been provided as a cosmetic composition for suppressing transdermal water evaporation, a collagen for providing skin elasticity, and the like. In recent years, herbal medicines have been used for moisturizing, anti- Has been reported to be superior in terms of the effect of improving skin wrinkles, and the use of herbal medicines has become prominent in the field of cosmetics, and thus many studies have been conducted on cosmetic compositions using herbal medicine extracts.

In addition, the effect of horse placenta extract on pigmentation inhibition, as well as whitening action (Mallick Set el., Pigment Cell Res. Feb 18 (1), 25-33, 2005) And it is used for ingredients such as cosmetics and foods.

As a prior art related to the cosmetic composition using the herbal medicine component, for example, Korean Patent Publication No. 10-1135264 discloses a cosmetic composition containing the herbal medicine, , A wrinkle-improving or moisturizing effect, and Korean Patent Publication No. 10-1251040 discloses a cosmetic composition which is composed of 100 parts by weight of herbal medicine material containing marjoram, citrus peel, 1 to 70% by weight of the herbal medicine extract and the whitish tree extract, and the cosmetic base as the remaining amount, wherein the remaining amount of the snail mucilage filtrate is 1 to 5% by weight A whitening cosmetic composition using the extract of Wortmannia crassifolia is disclosed have.

For example, Korean Patent Registration No. 10-0987302 discloses a cosmetic composition using a horse placenta, which comprises i) at least 30 to 40 parts by weight of a mackerel papain, a protease, a peptidase, Adding 0.2 to 0.6 parts by weight of a protease selected from the mixture thereof and 65 to 100 parts by weight of water to a first proteolytic reaction at 60 to 70 캜; ii) 0.05 to 0.2 parts by weight of the protease is further added to the reaction product of i) to perform a second proteolytic reaction at 60 to 70 ° C; and iii) the reaction product of ii) has a moisture content of 1 to 3 1.0 to 1.5 parts by weight of activated charcoal in weight% and then removing the odor and color under a high purity nitrogen or vacuum pressure of 0.1 to 0.5 atm. Discloses a composition for improving wrinkles, which is disclosed in Korean Patent Laid-Open Publication No. 10-2010-0104144, and discloses a composition for skin whitening comprising an nanoliposome containing an extract of Maehu and Mataiban as an active ingredient However, in the case of Matthew Semi-extract, it is easily discolored due to its unique odor and instability, and it solves the disadvantage that the skin is stimulated by toxicity when used at a high concentration I can not.

The present invention relates to a cosmetic preparation for improving skin wrinkles, which is safe for skin and has excellent formulation stability, by combining a hemp oil and a herbal composition in combination with the elimination of odor elimination and toxicity specific to a mate- rial semi-fermented product Respectively.

The present invention aims at providing a cosmetic composition for improving skin wrinkles containing Horse placenta fermented product and horse oil, more specifically, a horse placenta fermentation with reduced specific odor and toxicity It is intended to provide a cosmetic composition for wrinkle improvement which is long-lasting and highly safe while exhibiting a wrinkle-reducing effect of skin in a short time by combining water, hemp oil and herbal ingredients.

As a solution to achieve the object of the present invention, a cosmetic composition for improving skin wrinkles containing a fermented mateial body and a fermented milk comprises 1 to 50 parts by weight of a fermented mate- rial, 1 to 50 parts by weight of maize, 1 to 10 1 to 10 parts by weight of citron extract, 1 to 10 parts by weight of an extract of Prunus persica, and 1 to 10 parts by weight of an extract of Prunus mume extract is contained in an amount of 0.01 to 15% by weight based on the total weight of the cosmetic composition.

The horse placenta is composed of nucleic acid components such as essential amino acids, RNA and DNA, antioxidant enzymes such as SOD (Super Oxide Dismutase), Hyaluronic acid, antioxidant, immunocompetent factor (cytocine), placental peptide, Growth factors such as insulin-like growth factor, epidermal growth factor (EGFS) and unique senescent cell activating factor (SCAFS), and cytokines such as fatigue recovery, Immune enhancement, etc.

The horse placenta fermented product according to the present invention is prepared by inoculating a matte bacterium with at least one microorganism selected from microorganisms of lactic acid bacteria and fermenting the mixture at a fermentation temperature of 38 ° C for 10 days and then stabilizing the fermentation product by the microorganism After the fermentation process is finished, the fermentation product is obtained by filtration.

The above-mentioned mathematical semi-fermented product exhibits a spoilage accompanied by a bad odor when the condition is set incorrectly during the fermentation process. In the case of the preferable normal fermentation, the pH is stably maintained at about 3 to 4 without accompanied by odor .

Lactic acid bacteria which can be used in the present invention include Lactobacillus sp., Specifically Lactobacillus plantarum, Lactobacillus delbrueckii, Lactobacillus bulgaricus, Lactobacillus casei, Lactobacillus brevis, Lactobacillus acidophilus, Pediococcus pentosaceus, Pediococcus cerevisiae, Lactobacillus spp., Lactobacillus spp., Lactobacillus spp., Lactobacillus spp. One from Lactococcus lactis, Leuconostoc citreum, Leuconostoc mesenteroides, Bifidobacterium bifidum, and Lactobacillus helveticus. One is from Lactococcus lactis, Leuconostoc citreum, Leuconostoc mesenteroides, Bifidobacterium bifidum and Lactobacillus helveticus. Or more.

The antimicrobial activity of the mate- rial fermented product according to the present invention varies according to the kind of the microorganism to be used. However, in the present invention, Lactobacillus (Lactobacillus sp. plantarum, Lactobacillus delbrueckii, Lactobacillus acidophilus, and Lactobacillus helveticus are preferred. Among them, Lactobacillus helveticus is preferred, and Lactobacillus spp. It is more preferable to use it.

The Mayu according to the present invention can be used in Chinese classical medical records such as' Appreciation of hair, '' Healing of hands and feet ',' And has been widely used as a treatment for burns and atopic dermatitis in Asian countries such as Japan since ancient times.

Although Mayu is an animal oil, many unsaturated fatty acids in vegetable are much more than saturated fatty acid. Palmitoleic acid, which is one of the constituents of unsaturated fatty acids, is an important substance in atopy. It is the main ingredient of sebum which constitutes human skin. It is recognized as an important substance in relation to the effect. It is known as a functional substance which protects the skin by strong antibacterial and anti-inflammatory action, exhibits the effects of moisturizing, protecting skin, promoting cell regeneration and ultraviolet ray blocking and promoting insulin secretion function have.

Particularly, in Mayu, palmitoleic acid contains 2 to 3 times as much as other animal oils, and Mayu is very similar to human. Even if such similarities are caused by the Mayu oil, there is no skin troubles. Mayu has a melting point (melting point) It is 30 ~ 40 ℃ similar to human body temperature, which is higher than oil, but it can penetrate into human skin quickly and deeply. Its ingredients are very similar to human sebum and absorbed well. Natural cosmetics It is widely used as a skin cosmetic ingredient because it contains a large amount of vitamin E.

In addition, the present invention is a plant widely known as a medicinal plant such as Hwangchujang, Yuzawa, Morinaceae, and Oriental herbaceous plant. The extract of Hwachulchil is extracted with hot water at 80 ℃ for 3 ~ 5 hours, , And citron, quince, juniper, and necropolis are extracted by the same method.

It is preferable that the extracts of each of the above-mentioned Huangchu tree, citron, quince and fragrant wood have a solid content ratio of 0.1 to 2.0% by weight based on the weight ratio of the extract. When the solid content is more than 2.0% by weight, There is difficulty in industrialization.

The cosmetic composition for improving skin wrinkles containing the matal half-fermented product and the hemp oil of the present invention has no unique odor and toxicity due to the use of the fermented product of the mata-van, and thus has no side effects on the skin, And exhibits an effect of improving wrinkles, exhibiting a short period of time, and exhibiting a long lasting effect because of its excellent cell activity through cell proliferation, the effect of enhancing collagen synthesis, and enhancing immunity.

Fig. 1 is a chart showing the result of visual evaluation of the wrinkle-improving effect of the half-fermented product of the matthews half body.
FIG. 2 is a graph showing the results of a questionnaire survey on the effect of improving the wrinkles of a product after 8 weeks of using the product in a human body application test of the wrinkle-reducing effect of the maturity-grade fermented product.

EXAMPLES Hereinafter, the present invention will be described in detail with reference to Examples and Test Examples. However, the present invention is not limited by the following examples.

≪ Example 1 >

One). Manufacture of fermented mate

The matthews were stored frozen immediately after harvesting and thawed during the fermentation process. 200 g of sugar and 300 g of oligosaccharide were added to 2 kg of the matte semi-pulverized product having a size of about 10 mm, and the mixture was inoculated with 3% (w / v) of Lactobacillus helveticus, For 10 days. After that, the fermentation product was aged at room temperature for about 3 months to stabilize the fermentation product by the microorganism. At this time, the fermented product of the mattheca spp. Was found to have a solid content of 1.0 to 1.5 wt% and a pH of 3.0 to 4.0.

2). Production of herbal medicine ingredient extract

1 Kg of well dried yellowtail was extracted with hot water at 80 ° C for 4 hours, cooled to room temperature, and filtered to obtain an extract.

The extract had a solids content of 0.1 to 2.0% by weight based on the weight of the extract, and a pH of 5.0 to 7.0. Citron, quince and juniper were also extracted by the same method to obtain respective extracts.

3). Preparation of a mixture of the matthews fermented product, horse oil and herbal medicine component extract of the present invention

Fermented material according to the present invention, 2 parts by weight of fermented mate- rial, 2 parts by weight of maize, 16 parts by weight of extract, 1% by weight of Houttuynia cylindrica extract, 1% by weight of citron extract, 1% A mixture of hemp and herbal ingredients extracts was prepared.

Example 2 Cosmetic formulation

<Formulation Example> The following <Formulation Example> was prepared using the active ingredient in which the extract of Maternal and Semi-fermented product according to the present invention prepared in Example 1 was mixed, And the present invention is not limited to the formulation examples.

&Lt; Formulation Example 1 > INCI Name Formulation (g) Remarks Propanediol 7.00 Dipotassium glycyrrhizate 0.10 Allantoin 0.10 PEG-60 hydrogenated castor oil 0.20 Dipropyleneglycol 5.00 Glycerin 4.00 Sodium carbomer 0.15 Phenoxyethanol 0.30 A mixture of fermented mate, fermented bean curd and herbal extracts 0.20 Hexanediol 2.00 Water to 100.00

&Lt; Formulation Example 2 > INCI Name Formulation (g) Remarks Butandiol 10.00 Dipotassium glycyrrhizate 0.10 Allantoin 0.10 PEG-40 Hydrogenated Castor Oil 0.10 Adenosine 0.04 Acrylates / C10-30 alkyl acrylate crosspolymer 0.15 Xanthan gum 0.05 Phenoxyethanol 0.30 Methylparaben 0.20 PEG-40 hydrogenated castor oil, PPG-26-Buteth-26, butylene glycol, glycerine, Copper Tripeptide-1, Phenoxyethanol, Methylparaben, Butylparaben, Ethylparaben, Isobutylparaben, Propylparaben,

0.01 Lysine, Histidine, Arginine, Aspartic acid, Threonine, Serine, Glutamic acid, Proline, Glycine, Alanine, Valine, Methionine, Isoleucine, Leucine, Tyrosine, Phenylalanine, Cysteine

0.01 Acetyl hexapeptide-8 0.10 A mixture of fermented mate, fermented bean curd and herbal extracts 1.50 Water to 100.00

&Lt; Formulation Example 3 > INCI Name Formulation (%) Remarks Glycerin 7.00 Butylene Glycol 5.00 Sodium Hyaluronate 3.00 Tremella Fuciformis Sporocarp Extract 3.00 Cetyl Ethylhexanoate 2.00 Stearic Acid 2.00 Cetearyl Alcohol 2.00 A mixture of fermented mate, fermented bean curd and herbal extracts 10.00 Hydrolyzed Glycosaminoglycans 2.00 Glyceryl Polyacrylate 2.00 Phytosteryl / decyltetradecyl myristoyl methyl Beta-domain 1.50 Dimethicone 1.00 Cetearyl Olivate, Sorbitan Olivate 1.00 Benzyl Glycol, Butoxydiglycol, Raspberry Ketone 1.00 Polysorbate 60 0.50 Sodium Polyacryloyldimethyl Taurate, Hydrogenated Polydecene, Trideceth-10
0.40 Arginine 0.30 Carbomer 0.30 Ceramide 3 0.10 Tocopheryl Acetate 0.10 Sodium Citrate 0.10 Disodium EDTA 0.05 Hydrolyzed Hyaluronic Acid 0.01 Dipotassium Glycyrrhizate 0.01 Water to 100.00

&Lt; Formulation Example 4 > INCI Name Formulation (%) Remarks Glycerin 5.00 Pentylene glycol 3.50 Glucose, Sorbitol, Citric acid 0.10 Butylene glycol 3.00 Water, Sodium hyaluronate 7.00 Water, btylene glycol, carbomer, sodium stearate, hydrolyzed wheat protein, zinc gluconate, atelocollagen, Sodium Chondroitin Sulfate
0.50 Disodium EDTA 0.03 Petrolatum 4.00 Mineral oil, Lanolin alcohol 2.00 Ceresin 3.00 Butyrospermum parkii (Shea butter) 4.00 Lauryl PEG-9 polydimethylsiloxyethyl dimethicone 2.00 Phenyl trimethicone 4.00 Limnanthes alba (Meadowfoam) seed oil 2.00 Vitis vinifera (Grape) seed oil 1.00 Tocopheryl acetate 0.50 Silica 0.50 Arachidyl alcohol, Behenyl alcohol, Arachidyl glucoside 5.00 PEG-8 Dilaurate 1.00 A mixture of fermented mate, fermented bean curd and herbal extracts 2.00 Phenoxyethanol 0.30 Caprylhydroxamic acid, Caprylyl glycol, Glycerin 0.50 Fragrance 0.10 Water to 100.00

The cosmetic composition of the present invention can be blended with an ordinary ingredient to be incorporated in a cosmetic composition for general skin. The oil component content of the cosmetic composition according to the present invention is selected in consideration of enhancement of emulsifying ability and economical efficiency, and at least one oil selected from vegetable oil, mineral oil, silicone oil and synthetic oil can be used . In addition, 0.1 to 5% by weight of a surfactant, a higher alcohol and the like may be added to reinforce the emulsifying ability. As such surfactants, conventional surfactants such as nonionic surfactants, phospholipids and the like can be used. As the higher alcohols, alcohols having 12 to 20 carbon atoms can be used singly or in combination. In addition, in the cosmetic composition, 0.001 to 5% by weight of one or more kinds of thickening agents such as carbomer, xanthan gum, bentonite and the like may be further added in order to control the viscosity or hardness of the water phase. In addition, the composition of the present invention may further contain a pharmaceutical ingredient such as higher fatty acids and vitamins, and components used in conventional cosmetics such as an ultraviolet screening agent, an antioxidant, a preservative, a flavoring agent, a coloring agent, and a pH adjusting agent. The cosmetic composition of the present invention is a product which is absorbed through the skin, and is a product which can be used as a skin care cosmetic composition for a cosmetic composition, such as a soft longevity (skin), a convergent lotion, a nutritional lotion (lotion), a nutrition cream, a massage cream, an essence, a gel, a pack, Suspension, emulsion, spray, or serum, and may contain various conventional carriers and additives suitable for each of these formulations and known in the art. While the present invention has been described with reference to certain preferred embodiments, it is to be understood that the invention is not limited to the disclosed embodiments.

The proportion of the mixture of the mata-fermented product, the hemp oil, and the herbal medicine component extract in the formulation example is determined by considering the stability and palatability of the formulation, 0.01 to 15 wt.%. If the content is less than 0.01 wt.%, The effect / effect is insufficient. When the content is more than 15 wt.%, The stability of the formulation is deteriorated.

&Lt; Test Example 1 > Stability test of cosmetic formulation

The formulation examples prepared in Example 2 were subjected to a long-term preservation test (temperature: 25 ± 2 ° C. / relative humidity: 60 ± 5%) and an accelerated test (temperature: 40 ± 2 ° C. / relative humidity: 75 ± 5 All tests were performed for 6 months for the long-term storage test, 3 months for the accelerated test, and 10 days for the severe test. The physicochemical changes such as separation, electrophoresis and discoloration of more than 1 month were not observed and it was confirmed that the formulation had a very stable formulation.

&Lt; Test Example 2 >

As a result of measuring the inhibitory effect on the activity of MMP-1 enzyme by the fermentation product of the maturity stage, it was confirmed that the fermentation product of Mama-type inhibited the activity of the MMP-1 enzyme and the formulation cream prepared in Example 2 In the test group (A), the nutritional cream containing no active ingredient according to the present invention was used as a control group (B), and the wrinkle improvement effect test was carried out. The number of subjects participating in the wrinkle improvement effect test was 23, There were 20 subjects who had completed the test. There were 3 middle dropouts. The validity results of the human body test for the wrinkle - reducing effect were evaluated by visual inspection and instrument measurement by specialists.

<Visual Evaluation Results by Experts>

After 8 weeks of using the product, the wrinkle-improving effect was statistically significant ( p <0.05) in the test group (A) as compared to the control group (B) The group (A) was found to be effective for improving the wrinkle by about 40% as compared with the control group (B), and the results are shown in Fig. 1

<Device evaluation result>

There was statistically significant improvement in wrinkles ( p <0.05) in the test group (A) compared with the control group (B) after 8 weeks of using the product.

The results of the questionnaire survey on the effect of wrinkle improvement on the product after 8 weeks of use of the product were found to be more satisfactory for the effect of wrinkle improvement than that of the control group (B) when using the test group (A) , And the results are shown in Fig. 2.

In addition, a safety assessment was conducted, and no specific adverse skin reaction was observed during the test period.

Claims (4)

Fermented product characterized by containing 0.01 to 15% by weight of the active ingredient, which is composed of a fermented mackerel, fermented mackerel, woodchuck extract, citron extract, mosquito extract and bamboo extract, in a total weight of the cosmetic composition, A cosmetic composition for improving skin wrinkles. The method according to claim 1, wherein the active ingredient is selected from the group consisting of 1 to 50 parts by weight of fermented mackerel fermented product, 1 to 50 parts by weight of maize, 1 to 10 parts by weight of an extract of Hwangchujang, 1 to 10 parts by weight of citron extract, And 1 to 10 parts by weight of an extract of the present invention. The method according to claim 1 or 2, wherein the matte semi-fermented product is selected from the group consisting of Lactobacillus plantarum, Lactobacillus delbrueckii, Lactobacillus bulgaricus, Lactobacillus casei Lactobacillus brevis, Lactobacillus acidophilus, Pediococcus pentosaceus, Pediococcus cerevisiae, Lactococcus lactis, and the like), Lactobacillus spp., Lactobacillus spp. ), Leuconostoc citreum, Leuconostoc mesenteroides, Bifidobacterium bifidum, and Lactobacillus helveticus by fermentation with one or more strains Next, the fermented product is aged for 3 months. A cosmetic composition composition for improving skin wrinkles. The cosmetic composition according to claim 3, wherein the cosmetic composition is at least one selected from the group consisting of softening longevity (skin), convergent lotion, nutritional lotion, nutritional cream, massage cream, essence, gel, pack, powder, ointment, Hair shampoo, hair treatment, or serum, and the like.

Images