KR20150127249A - 암 치료를 위한 암 줄기세포 경로 키나아제의 저해제로서 3-(아릴 또는 헤테로아릴)메틸렌인돌린-2-온 유도체 - Google Patents
암 치료를 위한 암 줄기세포 경로 키나아제의 저해제로서 3-(아릴 또는 헤테로아릴)메틸렌인돌린-2-온 유도체 Download PDFInfo
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- KR20150127249A KR20150127249A KR1020157028817A KR20157028817A KR20150127249A KR 20150127249 A KR20150127249 A KR 20150127249A KR 1020157028817 A KR1020157028817 A KR 1020157028817A KR 20157028817 A KR20157028817 A KR 20157028817A KR 20150127249 A KR20150127249 A KR 20150127249A
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- substituted
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- 0 **(C(C1)=O)c2c1cccc2 Chemical compound **(C(C1)=O)c2c1cccc2 0.000 description 14
- JFOOEDDZLOHEJR-UHFFFAOYSA-N C/[O]=C(/C1)\Nc(cc2)c1cc2Br Chemical compound C/[O]=C(/C1)\Nc(cc2)c1cc2Br JFOOEDDZLOHEJR-UHFFFAOYSA-N 0.000 description 1
- SCGQNJHAAYUQOO-UHFFFAOYSA-N CC(C)(C)OC(N(CC1)CCC1C(N)=S)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1C(N)=S)=O SCGQNJHAAYUQOO-UHFFFAOYSA-N 0.000 description 1
- VLQVNXNVTZYXCK-STZFKDTASA-N CC(C)(C)OC(N(CC1)CCC1c1nc(-c(cc2/C3=C/c4c(C)cc(C)[nH]4)ccc2NC3=O)c[s]1)=O Chemical compound CC(C)(C)OC(N(CC1)CCC1c1nc(-c(cc2/C3=C/c4c(C)cc(C)[nH]4)ccc2NC3=O)c[s]1)=O VLQVNXNVTZYXCK-STZFKDTASA-N 0.000 description 1
- CYZVCAZFYPJMHI-UHFFFAOYSA-N CC(CCC(C)C1(C)C2)CCC2(C)[N+]1(C)[O-] Chemical compound CC(CCC(C)C1(C)C2)CCC2(C)[N+]1(C)[O-] CYZVCAZFYPJMHI-UHFFFAOYSA-N 0.000 description 1
- BXFPTCYBFJOZHJ-UHFFFAOYSA-N CC1(C)OB(c(cc2)cc(C3)c2NC3=O)OC1(C)C Chemical compound CC1(C)OB(c(cc2)cc(C3)c2NC3=O)OC1(C)C BXFPTCYBFJOZHJ-UHFFFAOYSA-N 0.000 description 1
- SRKPFIRKHZTHCI-UQQQWYQISA-N CCN(CC)CCNC(c1c(C)[nH]c(/C=C(/c2cc(-c3c[s]c(C(CC4)CN4C(OC(C)(C)C)=O)n3)ccc2N2)\C2=O)c1C)=O Chemical compound CCN(CC)CCNC(c1c(C)[nH]c(/C=C(/c2cc(-c3c[s]c(C(CC4)CN4C(OC(C)(C)C)=O)n3)ccc2N2)\C2=O)c1C)=O SRKPFIRKHZTHCI-UQQQWYQISA-N 0.000 description 1
- ISDRBJIUTNDFDB-WQRHYEAKSA-N Cc1c(/C=C(/c2cc(-c3c[s]c(C4CCNCC4)n3)ccc2N2)\C2=O)[nH]c(C)c1 Chemical compound Cc1c(/C=C(/c2cc(-c3c[s]c(C4CCNCC4)n3)ccc2N2)\C2=O)[nH]c(C)c1 ISDRBJIUTNDFDB-WQRHYEAKSA-N 0.000 description 1
- RDFZYUOHJBXMJA-UHFFFAOYSA-N Cc1c(C=O)[nH]c(C)c1 Chemical compound Cc1c(C=O)[nH]c(C)c1 RDFZYUOHJBXMJA-UHFFFAOYSA-N 0.000 description 1
- VPGLFNOKHAIGEC-UHFFFAOYSA-N O=C(CC1)CCN1c1ccccc1 Chemical compound O=C(CC1)CCN1c1ccccc1 VPGLFNOKHAIGEC-UHFFFAOYSA-N 0.000 description 1
- WXJWBEAGVWVEDM-UHFFFAOYSA-N O=C(CCl)c(cc1C2)ccc1NC2=O Chemical compound O=C(CCl)c(cc1C2)ccc1NC2=O WXJWBEAGVWVEDM-UHFFFAOYSA-N 0.000 description 1
- HNZPMRASSGXBGQ-UHFFFAOYSA-N O=C(Cc1c2)Nc1ccc2-[n]1nnc(-c2ccccc2)c1 Chemical compound O=C(Cc1c2)Nc1ccc2-[n]1nnc(-c2ccccc2)c1 HNZPMRASSGXBGQ-UHFFFAOYSA-N 0.000 description 1
- GWNKNCWLVUABNX-UHFFFAOYSA-N O=C(Cc1c2)Nc1ccc2-c1c[s]c(C2CCNCC2)n1 Chemical compound O=C(Cc1c2)Nc1ccc2-c1c[s]c(C2CCNCC2)n1 GWNKNCWLVUABNX-UHFFFAOYSA-N 0.000 description 1
- FULWHAYNKAPLBJ-UHFFFAOYSA-N O=C1Nc2ccc(C(CC3)CCN3c3ccccc3)cc2C1 Chemical compound O=C1Nc2ccc(C(CC3)CCN3c3ccccc3)cc2C1 FULWHAYNKAPLBJ-UHFFFAOYSA-N 0.000 description 1
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361780248P | 2013-03-13 | 2013-03-13 | |
| US201361780263P | 2013-03-13 | 2013-03-13 | |
| US61/780,248 | 2013-03-13 | ||
| US61/780,263 | 2013-03-13 | ||
| PCT/US2014/026498 WO2014160401A1 (en) | 2013-03-13 | 2014-03-13 | 3-(aryl or heteroaryl) methyleneindolin-2-one derivatives as inhibitors of cancer stem cell pathway kinases for the treatment of cancer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20150127249A true KR20150127249A (ko) | 2015-11-16 |
Family
ID=50639949
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157028817A Ceased KR20150127249A (ko) | 2013-03-13 | 2014-03-13 | 암 치료를 위한 암 줄기세포 경로 키나아제의 저해제로서 3-(아릴 또는 헤테로아릴)메틸렌인돌린-2-온 유도체 |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20160031888A1 (enExample) |
| EP (1) | EP2970206A1 (enExample) |
| JP (2) | JP6378308B2 (enExample) |
| KR (1) | KR20150127249A (enExample) |
| CN (1) | CN105408320B (enExample) |
| AU (2) | AU2014243869A1 (enExample) |
| BR (1) | BR112015022431A2 (enExample) |
| CA (1) | CA2904152A1 (enExample) |
| HK (1) | HK1220184A1 (enExample) |
| IL (1) | IL240960A0 (enExample) |
| MX (1) | MX2015011456A (enExample) |
| RU (2) | RU2015143526A (enExample) |
| SG (2) | SG10201806965XA (enExample) |
| WO (1) | WO2014160401A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104876928B (zh) * | 2015-05-07 | 2016-09-14 | 浙江司太立制药股份有限公司 | 7-氮杂吲哚啉-2-酮类化合物及其制备方法 |
| JPWO2017026119A1 (ja) * | 2015-08-10 | 2018-05-24 | 大日本住友製薬株式会社 | 5−(チアゾール−4−イル)インドリン−2−オン誘導体の精製方法 |
| KR102109869B1 (ko) * | 2015-11-12 | 2020-05-13 | 영남대학교 산학협력단 | 7-아자인돌린-2-온 유도체 또는 이의 약제학적 허용가능한 염을 유효성분으로 함유하는 약학 조성물 |
| CN105461705B (zh) * | 2015-11-30 | 2018-04-10 | 中国医科大学 | 二苯并氮杂卓二酮类抗肿瘤化合物及其制备方法 |
| WO2018005444A2 (en) | 2016-06-28 | 2018-01-04 | Boston Biomedical, Inc. | Methods for treating cancer |
| CN107698593A (zh) * | 2016-08-09 | 2018-02-16 | 南京天印健华医药科技有限公司 | 作为fgfr抑制剂的杂环化合物 |
| CN106432228A (zh) * | 2016-09-06 | 2017-02-22 | 浙江司太立制药股份有限公司 | 含有4‑肟基‑1‑哌啶基片段的7‑氮杂吲哚啉‑2‑酮类化合物及其制备方法 |
| CN106397436A (zh) * | 2016-09-06 | 2017-02-15 | 浙江司太立制药股份有限公司 | 5‑溴‑7‑氮杂吲哚啉‑2‑酮类化合物及其制备方法 |
| WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
| TWI779059B (zh) | 2017-06-30 | 2022-10-01 | 財團法人工業技術研究院 | 化合物用於製備治療自體免疫神經疾病及/或神經退化性疾病之藥物的用途 |
| CN110357878B (zh) * | 2018-03-26 | 2022-04-12 | 武汉誉祥医药科技有限公司 | 1,3-二氢-2H-吡咯并[3,2-b]吡啶-2-酮衍生物及其医药用途 |
| CN119954787A (zh) | 2018-04-18 | 2025-05-09 | 星座制药公司 | 甲基修饰酶的调节剂、其组合物和用途 |
| US11919912B2 (en) | 2018-05-21 | 2024-03-05 | Constellation Pharmaceuticals, Inc. | Modulators of methyl modifying enzymes, compositions and uses thereof |
| BR112021005086A2 (pt) | 2018-09-18 | 2021-06-08 | 1Globe Biomedical Co., Ltd. | tratamento para doença hepática gordurosa não alcoólica |
| US12390460B2 (en) * | 2018-09-18 | 2025-08-19 | 1Globe Biomedical Co., Ltd. | Treatment for obesity |
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| US20190241569A1 (en) | 2019-08-08 |
| EP2970206A1 (en) | 2016-01-20 |
| US20160031888A1 (en) | 2016-02-04 |
| CN105408320A (zh) | 2016-03-16 |
| MX2015011456A (es) | 2016-05-31 |
| SG10201806965XA (en) | 2018-09-27 |
| WO2014160401A1 (en) | 2014-10-02 |
| IL240960A0 (en) | 2015-11-30 |
| SG11201507346PA (en) | 2015-10-29 |
| RU2015143526A (ru) | 2017-04-19 |
| RU2019104092A (ru) | 2019-03-20 |
| CA2904152A1 (en) | 2014-10-02 |
| BR112015022431A2 (pt) | 2017-05-09 |
| AU2014243869A1 (en) | 2015-09-24 |
| CN105408320B (zh) | 2019-08-13 |
| JP2016513656A (ja) | 2016-05-16 |
| JP6378308B2 (ja) | 2018-08-22 |
| JP2018168187A (ja) | 2018-11-01 |
| HK1220184A1 (zh) | 2017-04-28 |
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