KR20150125653A - 아이소프렌의 생물학적 생성을 위한 조성물 및 방법 - Google Patents

아이소프렌의 생물학적 생성을 위한 조성물 및 방법 Download PDF

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KR20150125653A
KR20150125653A KR1020157023131A KR20157023131A KR20150125653A KR 20150125653 A KR20150125653 A KR 20150125653A KR 1020157023131 A KR1020157023131 A KR 1020157023131A KR 20157023131 A KR20157023131 A KR 20157023131A KR 20150125653 A KR20150125653 A KR 20150125653A
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isoprene
leu
ala
glu
methanotrophic bacteria
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Korean (ko)
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에펜디 레너드
제레미 민샬
존 네스
토마스 조셉 퍼셀
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칼리스타, 인코포레이티드
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    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
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    • C12Y103/99—Oxidoreductases acting on the CH-CH group of donors (1.3) with other acceptors (1.3.99)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01029—Geranylgeranyl diphosphate synthase (2.5.1.29)
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    • C12Y205/01—Transferases transferring alkyl or aryl groups, other than methyl groups (2.5) transferring alkyl or aryl groups, other than methyl groups (2.5.1)
    • C12Y205/01032—15-Cis-phytoene synthase (2.5.1.32)
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    • C12Y402/00—Carbon-oxygen lyases (4.2)
    • C12Y402/03—Carbon-oxygen lyases (4.2) acting on phosphates (4.2.3)
    • C12Y402/03027—Isoprene synthase (4.2.3.27)
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    • C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
    • C12Y101/01267—1-Deoxy-D-xylulose-5-phosphate reductoisomerase (1.1.1.267)
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    • C12Y117/01—Oxidoreductases acting on CH or CH2 groups (1.17) with NAD+ or NADP+ as acceptor (1.17.1)
    • C12Y117/01002—4-Hydroxy-3-methylbut-2-enyl diphosphate reductase (1.17.1.2)
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    • C12Y117/07—Oxidoreductases acting on CH or CH2 groups (1.17) with an iron-sulfur protein as acceptor (1.17.7)
    • C12Y117/07001—(E)-4-Hydroxy-3-methylbut-2-enyl-diphosphate synthase (1.17.7.1)
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KR1020157023131A 2013-03-07 2014-03-06 아이소프렌의 생물학적 생성을 위한 조성물 및 방법 Withdrawn KR20150125653A (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361774342P 2013-03-07 2013-03-07
US61/774,342 2013-03-07
US201461928333P 2014-01-16 2014-01-16
US61/928,333 2014-01-16
PCT/US2014/021258 WO2014138419A1 (en) 2013-03-07 2014-03-06 Compositions and methods for biological production of isoprene

Publications (1)

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KR20150125653A true KR20150125653A (ko) 2015-11-09

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KR1020157023131A Withdrawn KR20150125653A (ko) 2013-03-07 2014-03-06 아이소프렌의 생물학적 생성을 위한 조성물 및 방법

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Country Link
US (1) US20160017374A1 (https=)
EP (1) EP2964748A4 (https=)
JP (1) JP2016508737A (https=)
KR (1) KR20150125653A (https=)
CN (1) CN105008514A (https=)
AU (1) AU2014225631A1 (https=)
BR (1) BR112015021003A2 (https=)
CA (1) CA2901588A1 (https=)
RU (1) RU2015131480A (https=)
WO (1) WO2014138419A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025155137A1 (ko) * 2024-01-18 2025-07-24 한국생명공학연구원 메탄으로부터 이소프렌 생산능을 갖는 형질전환체

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150100666A (ko) * 2012-12-27 2015-09-02 세키스이가가쿠 고교가부시키가이샤 재조합 세포, 및 이소프렌의 생산 방법
CN105378077A (zh) 2013-06-18 2016-03-02 凯利斯塔公司 用于使用乳酸脱氢酶转化体从c1化合物以生物方式产生乳酸的组合物和方法
CN106029870A (zh) 2014-01-16 2016-10-12 凯利斯塔公司 用于增强的氨基酸产生的微生物及相关方法
US10443060B2 (en) 2014-06-18 2019-10-15 Calysta, Inc. Nucleic acids and vectors for use with methanotrophic bacteria
JP2016059313A (ja) * 2014-09-17 2016-04-25 積水化学工業株式会社 組換え細胞、並びに、イソプレン又は環式イソプレノイドの生産方法
DE102015103608A1 (de) * 2015-03-11 2016-09-15 Basf Se Verfahren zur mikrobiellen de novo Synthese von Terpenen
CA2984797A1 (en) 2015-05-06 2016-11-10 Trelys, Inc. Compositions and methods for biological production of methionine
US10995316B2 (en) 2015-05-13 2021-05-04 Calysta, Inc. Proline auxotrophs
US20180291401A1 (en) * 2015-08-17 2018-10-11 Invista North America S.A.R.L. Methods, hosts, and reagents related thereto for production of unsaturated pentahydrocarbons, derivatives and intermediates thereof
US10533192B2 (en) 2015-12-22 2020-01-14 Nutech Ventures Production of isoprene by methane-producing archaea
KR102546640B1 (ko) 2016-01-26 2023-06-22 에스케이이노베이션 주식회사 재조합 호염성 메탄균주를 이용한 이소프렌의 제조방법
JP2018014960A (ja) * 2016-07-29 2018-02-01 横浜ゴム株式会社 発現ベクター、形質転換された藻類、形質転換された珪藻、及び、ポリヌクレオチド
EP3505618A4 (en) * 2016-10-28 2020-04-22 Sekisui Chemical Co., Ltd. RECOMBINANT CELL AND METHOD FOR PRODUCING ISOPRENE OR TERPEN
US11634733B2 (en) 2017-06-30 2023-04-25 Inv Nylon Chemicals Americas, Llc Methods, materials, synthetic hosts and reagents for the biosynthesis of hydrocarbons and derivatives thereof
US11162115B2 (en) 2017-06-30 2021-11-02 Inv Nylon Chemicals Americas, Llc Methods, synthetic hosts and reagents for the biosynthesis of hydrocarbons
US11505809B2 (en) 2017-09-28 2022-11-22 Inv Nylon Chemicals Americas Llc Organisms and biosynthetic processes for hydrocarbon synthesis
US11180707B2 (en) * 2018-08-03 2021-11-23 Faramaz Fred Faramarzi System and method for duplicating flammable gas
CN109943493B (zh) * 2019-04-17 2021-05-18 天津大学 实现通用酶催化功能多样性的突变体菌株及其构建方法
JP7754406B2 (ja) * 2021-03-26 2025-10-15 三菱ケミカル株式会社 イソプレン産生能を有する遺伝子改変微生物およびこれを用いたイソプレン製造方法
CN119736218A (zh) * 2023-09-19 2025-04-01 西安卓虹超源生物科技有限公司 一种萜类化合物的生产及菌株
WO2026010860A1 (en) 2024-07-02 2026-01-08 Bp Corporation North America Inc. Recombinant microorganisms for isoprene production
WO2026022785A2 (en) * 2024-07-26 2026-01-29 Visolis, Inc. Compositions for fuel blending made by a sustainable process, and sustainable fuel compositions therefrom

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6818424B2 (en) * 2000-09-01 2004-11-16 E. I. Du Pont De Nemours And Company Production of cyclic terpenoids
AU9635901A (en) * 2000-09-29 2002-04-08 Cargill Inc Isoprenoid production
US7947478B2 (en) * 2006-06-29 2011-05-24 The Regents Of The University Of California Short chain volatile hydrocarbon production using genetically engineered microalgae, cyanobacteria or bacteria
CN105368764B (zh) * 2007-12-13 2019-03-12 丹尼斯科美国公司 用于生产异戊二烯的组合物和方法
CA2737223A1 (en) * 2008-09-15 2010-03-18 Danisco Us Inc. Reduction of carbon dioxide emission during isoprene production by fermentation
TW201412988A (zh) * 2009-06-17 2014-04-01 Danisco Us Inc 使用ｄｘｐ及ｍｖａ途徑之改良之異戊二烯製造
DE102012012913A1 (de) * 2012-06-27 2014-01-02 Beatrice Saier Vorrichtung und Verfahren zur schaltbaren Förderung wenigstens eines Mediums
US20160002672A1 (en) * 2012-12-21 2016-01-07 Danisco Us Inc. Production of isoprene, isoprenoid, and isoprenoid precursors using an alternative lower mevalonate pathway
KR20150100666A (ko) * 2012-12-27 2015-09-02 세키스이가가쿠 고교가부시키가이샤 재조합 세포, 및 이소프렌의 생산 방법

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2025155137A1 (ko) * 2024-01-18 2025-07-24 한국생명공학연구원 메탄으로부터 이소프렌 생산능을 갖는 형질전환체

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EP2964748A1 (en) 2016-01-13
CN105008514A (zh) 2015-10-28
JP2016508737A (ja) 2016-03-24
WO2014138419A1 (en) 2014-09-12
BR112015021003A2 (pt) 2017-07-18
CA2901588A1 (en) 2014-09-12
AU2014225631A1 (en) 2015-08-13
EP2964748A4 (en) 2016-11-02
US20160017374A1 (en) 2016-01-21
RU2015131480A (ru) 2017-04-12

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