KR20150098681A - 바이러스 유사 입자 정제 - Google Patents

바이러스 유사 입자 정제 Download PDF

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Publication number
KR20150098681A
KR20150098681A KR1020157020558A KR20157020558A KR20150098681A KR 20150098681 A KR20150098681 A KR 20150098681A KR 1020157020558 A KR1020157020558 A KR 1020157020558A KR 20157020558 A KR20157020558 A KR 20157020558A KR 20150098681 A KR20150098681 A KR 20150098681A
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KR
South Korea
Prior art keywords
vlps
chromatographic
chromatography
norovirus
vlp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
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KR1020157020558A
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English (en)
Korean (ko)
Inventor
토마스 에스 베드빅
브라이언 스테드먼
찰스 리차드슨
토마스 알 포버트
찰스 알 페트리
Original Assignee
다케다 백신즈 인코포레이티드
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Publication of KR20150098681A publication Critical patent/KR20150098681A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/02—Recovery or purification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16023—Virus like particles [VLP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/16011—Caliciviridae
    • C12N2770/16051—Methods of production or purification of viral material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Epidemiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Mycology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020157020558A 2007-03-14 2008-03-14 바이러스 유사 입자 정제 Ceased KR20150098681A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US90682107P 2007-03-14 2007-03-14
US60/906,821 2007-03-14
PCT/US2008/057072 WO2008113011A2 (en) 2007-03-14 2008-03-14 Virus like particle purification

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020097021421A Division KR101576219B1 (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020167036031A Division KR20170001720A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Publications (1)

Publication Number Publication Date
KR20150098681A true KR20150098681A (ko) 2015-08-28

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ID=39760420

Family Applications (3)

Application Number Title Priority Date Filing Date
KR1020157020558A Ceased KR20150098681A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020167036031A Ceased KR20170001720A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020097021421A Active KR101576219B1 (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Family Applications After (2)

Application Number Title Priority Date Filing Date
KR1020167036031A Ceased KR20170001720A (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제
KR1020097021421A Active KR101576219B1 (ko) 2007-03-14 2008-03-14 바이러스 유사 입자 정제

Country Status (12)

Country Link
US (4) US8481693B2 (cg-RX-API-DMAC7.html)
EP (1) EP2134360B1 (cg-RX-API-DMAC7.html)
JP (4) JP5284290B2 (cg-RX-API-DMAC7.html)
KR (3) KR20150098681A (cg-RX-API-DMAC7.html)
AU (1) AU2008224877B2 (cg-RX-API-DMAC7.html)
CA (1) CA2683977C (cg-RX-API-DMAC7.html)
DK (1) DK2134360T3 (cg-RX-API-DMAC7.html)
ES (1) ES2559421T3 (cg-RX-API-DMAC7.html)
HU (1) HUE028605T2 (cg-RX-API-DMAC7.html)
PL (1) PL2134360T3 (cg-RX-API-DMAC7.html)
SG (2) SG179488A1 (cg-RX-API-DMAC7.html)
WO (1) WO2008113011A2 (cg-RX-API-DMAC7.html)

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Publication number Publication date
WO2008113011A2 (en) 2008-09-18
US20190282686A1 (en) 2019-09-19
JP2019068846A (ja) 2019-05-09
KR20100015562A (ko) 2010-02-12
EP2134360B1 (en) 2015-11-18
KR20170001720A (ko) 2017-01-04
JP5284290B2 (ja) 2013-09-11
JP2017086090A (ja) 2017-05-25
US20130344107A1 (en) 2013-12-26
CA2683977C (en) 2017-04-25
WO2008113011A3 (en) 2008-12-24
DK2134360T3 (en) 2016-02-22
HUE028605T2 (en) 2016-12-28
KR101576219B1 (ko) 2015-12-10
US10792353B2 (en) 2020-10-06
AU2008224877B2 (en) 2013-07-11
AU2008224877A1 (en) 2008-09-18
US8481693B2 (en) 2013-07-09
CA2683977A1 (en) 2008-09-18
ES2559421T3 (es) 2016-02-12
US10172930B2 (en) 2019-01-08
PL2134360T3 (pl) 2016-05-31
HK1138795A1 (zh) 2010-09-03
US9359410B2 (en) 2016-06-07
JP2013176392A (ja) 2013-09-09
EP2134360A4 (en) 2011-08-24
SG10201701988TA (en) 2017-04-27
EP2134360A2 (en) 2009-12-23
US20160317645A1 (en) 2016-11-03
US20100150961A1 (en) 2010-06-17
SG179488A1 (en) 2012-04-27
JP2010530734A (ja) 2010-09-16

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