KR20150089005A - H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원 - Google Patents

H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원 Download PDF

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KR20150089005A
KR20150089005A KR1020157012693A KR20157012693A KR20150089005A KR 20150089005 A KR20150089005 A KR 20150089005A KR 1020157012693 A KR1020157012693 A KR 1020157012693A KR 20157012693 A KR20157012693 A KR 20157012693A KR 20150089005 A KR20150089005 A KR 20150089005A
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influenza
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테드 엠. 로스
도날드 엠. 카터 제이알.
코레이 제이. 크레바르
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유니버시티 오브 피츠버그 - 오브 더 커먼웰쓰 시스템 오브 하이어 에듀케이션
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KR1020157012693A 2012-11-27 2013-11-27 H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원 Withdrawn KR20150089005A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261730186P 2012-11-27 2012-11-27
US61/730,186 2012-11-27
PCT/US2013/072279 WO2014085616A1 (en) 2012-11-27 2013-11-27 Computationally optimized broadly reactive antigens for h1n1 influenza

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KR20150089005A true KR20150089005A (ko) 2015-08-04

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KR1020157012693A Withdrawn KR20150089005A (ko) 2012-11-27 2013-11-27 H1n1에 대한 계산적으로 최적화되고 넓은 반응성의 항원

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US (3) US9309290B2 (cg-RX-API-DMAC7.html)
EP (1) EP2925773B1 (cg-RX-API-DMAC7.html)
JP (2) JP2016505538A (cg-RX-API-DMAC7.html)
KR (1) KR20150089005A (cg-RX-API-DMAC7.html)
CN (1) CN104797594A (cg-RX-API-DMAC7.html)
AU (2) AU2013352179B2 (cg-RX-API-DMAC7.html)
CA (1) CA2891682A1 (cg-RX-API-DMAC7.html)
HK (1) HK1212708A1 (cg-RX-API-DMAC7.html)
IN (1) IN2015DN03070A (cg-RX-API-DMAC7.html)
MX (1) MX2015005056A (cg-RX-API-DMAC7.html)
RU (1) RU2015124805A (cg-RX-API-DMAC7.html)
SG (1) SG11201503989PA (cg-RX-API-DMAC7.html)
WO (1) WO2014085616A1 (cg-RX-API-DMAC7.html)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3431100B1 (en) * 2010-09-14 2021-09-08 University of Pittsburgh- Of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for influenza
CN103732749B (zh) * 2011-06-20 2017-03-29 高等教育联邦系统-匹兹堡大学 计算优化的宽反应性的h1n1流感抗原
MY166953A (en) 2012-03-30 2018-07-25 Univ Pittsburgh Commonwealth Sys Higher Education Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses
CN107530417A (zh) * 2014-12-19 2018-01-02 俄勒冈健康与科学大学 H1n1流感的计算优化的广泛反应性抗原的协同共同给药
CA2986701A1 (en) * 2015-06-09 2016-12-15 Sanofi Pasteur, Inc. Methods of optimizing nucleotide sequences encoding engineered influenza proteins
CN109563138B (zh) 2016-06-03 2022-09-23 圣诺菲·帕斯图尔公司 经改造的流感血凝素多肽的修饰

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100877019B1 (ko) 2000-06-23 2009-01-07 와이어쓰 홀딩스 코포레이션 야생형 및 키메릭 인플루엔자 바이러스성입자(브이엘피)의 조립
US20050181459A1 (en) 2002-06-11 2005-08-18 Matthew Baker Method for mapping and eliminating T cell epitopes
US8592197B2 (en) 2003-07-11 2013-11-26 Novavax, Inc. Functional influenza virus-like particles (VLPs)
WO2006104615A2 (en) 2005-02-24 2006-10-05 University Of Massachusetts Influenza nucleic acids, polypeptides, and uses thereof
CN101227920A (zh) 2005-07-19 2008-07-23 陶氏环球技术公司 重组流感疫苗
WO2007072214A2 (en) 2005-12-19 2007-06-28 Novartis Vaccines And Diagnostics Srl Methods of clustering gene and protein sequences
US20080045472A1 (en) 2006-03-31 2008-02-21 Council Of Scientific And Industrial Research Bharat Biotech Targets for human micro rnas in avian influenza virus (h5n1) genome
HRP20130163T1 (hr) 2006-09-07 2013-03-31 Crucell Holland B.V. Ljudske molekule za vezanje koje mogu neutralizirati virus influence h5n1 i njihova uporaba
WO2009022236A2 (en) 2007-08-16 2009-02-19 Tripep Ab Immunogen platform
WO2009073330A2 (en) * 2007-11-12 2009-06-11 The Trustees Of The University Of Pennsylvania Novel vaccines against multiple subtypes of influenza virus
KR101956910B1 (ko) * 2008-01-21 2019-03-12 메디카고 인코포레이티드 헤마글루티닌을 발현하는 트랜스제닉 식물에서 생산된 재조합 인플루엔자 바이러스-유사 입자(VLPs)
US7981428B2 (en) 2008-01-23 2011-07-19 Academia Sinica Flu vaccines and methods of use thereof
US20120034253A1 (en) 2008-09-25 2012-02-09 Fraunhofer Usa, Inc. Influenza Vaccines, Antigens, Compositions, and Methods
US20110177122A1 (en) 2008-09-26 2011-07-21 The United States Of America, As Represented By The Secretary, Dept. Of Health & Human Services Dna prime/activated vaccine boost immunization to influenza virus
CN103585643A (zh) 2009-04-03 2014-02-19 梅里亚有限公司 运载新城疫病毒的禽疫苗
JP5871796B2 (ja) * 2009-06-24 2016-03-01 メディカゴ インコーポレイテッド ヘマグルチニンを含むキメラインフルエンザウイルス様粒子
US8298820B2 (en) 2010-01-26 2012-10-30 The Trustees Of The University Of Pennsylvania Influenza nucleic acid molecules and vaccines made therefrom
US20110184160A1 (en) * 2010-01-26 2011-07-28 Weiner David B Nucleic acid molecule encoding consensus influenza a hemagglutinin h1
CN102373184A (zh) * 2010-08-09 2012-03-14 中山大学 禽流感和传染性支气管炎混合病毒样颗粒、制备方法和应用
EP3431100B1 (en) * 2010-09-14 2021-09-08 University of Pittsburgh- Of the Commonwealth System of Higher Education Computationally optimized broadly reactive antigens for influenza
CN103732749B (zh) * 2011-06-20 2017-03-29 高等教育联邦系统-匹兹堡大学 计算优化的宽反应性的h1n1流感抗原
RU2653756C2 (ru) 2012-02-07 2018-05-14 Юниверсити Оф Питтсбург - Оф Зе Коммонвэлс Систем Оф Хайе Эдьюкейшн Оптимизированные с помощью компьютера антигены с широким спектром реактивности для вирусов гриппа h3n2
JP6175452B2 (ja) 2012-02-13 2017-08-02 ユニバーシティ オブ ピッツバーグ − オブ ザ コモンウェルス システム オブ ハイヤー エデュケイション ヒトおよびトリh5n1インフルエンザのための、計算で最適化した反応性の広い抗原
MY166953A (en) * 2012-03-30 2018-07-25 Univ Pittsburgh Commonwealth Sys Higher Education Computationally optimized broadly reactive antigens for h5n1 and h1n1 influenza viruses

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SG11201503989PA (en) 2015-06-29
US20160166677A1 (en) 2016-06-16
JP2018183149A (ja) 2018-11-22
US10017544B2 (en) 2018-07-10
US20170114102A1 (en) 2017-04-27
US9566328B2 (en) 2017-02-14
AU2013352179B2 (en) 2017-12-21
RU2015124805A (ru) 2017-01-13
JP2016505538A (ja) 2016-02-25
EP2925773B1 (en) 2018-12-26
EP2925773A1 (en) 2015-10-07
AU2013352179A1 (en) 2015-05-14
EP2925773A4 (en) 2016-06-08
CN104797594A (zh) 2015-07-22
US20140147459A1 (en) 2014-05-29
WO2014085616A1 (en) 2014-06-05
CA2891682A1 (en) 2014-06-05
US9309290B2 (en) 2016-04-12
HK1212708A1 (zh) 2016-06-17
IN2015DN03070A (cg-RX-API-DMAC7.html) 2015-10-02
AU2018201876A1 (en) 2018-04-12
MX2015005056A (es) 2015-07-23
AU2013352179A8 (en) 2015-05-28

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