KR20150013838A - 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물 - Google Patents

당뇨병 치료를 위한 글루코키나아제 활성화제 조성물 Download PDF

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Publication number
KR20150013838A
KR20150013838A KR1020147035545A KR20147035545A KR20150013838A KR 20150013838 A KR20150013838 A KR 20150013838A KR 1020147035545 A KR1020147035545 A KR 1020147035545A KR 20147035545 A KR20147035545 A KR 20147035545A KR 20150013838 A KR20150013838 A KR 20150013838A
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South Korea
Prior art keywords
acceptable salt
pharmaceutically acceptable
rti
diabetes
glucokinase activator
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Ceased
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KR1020147035545A
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English (en)
Korean (ko)
Inventor
로페트 마리아 카르멘 바르칼스
텅 퐁
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트랜스테크 파르마 엘엘씨
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Priority to KR1020217006420A priority Critical patent/KR102371364B1/ko
Publication of KR20150013838A publication Critical patent/KR20150013838A/ko
Ceased legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Emergency Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020147035545A 2012-05-17 2013-05-15 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물 Ceased KR20150013838A (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217006420A KR102371364B1 (ko) 2012-05-17 2013-05-15 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261648110P 2012-05-17 2012-05-17
US61/648,110 2012-05-17
PCT/US2013/041076 WO2013173417A2 (en) 2012-05-17 2013-05-15 Glucokinase activator compositions for the treatment of diabetes

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020217006420A Division KR102371364B1 (ko) 2012-05-17 2013-05-15 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물

Publications (1)

Publication Number Publication Date
KR20150013838A true KR20150013838A (ko) 2015-02-05

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KR1020147035545A Ceased KR20150013838A (ko) 2012-05-17 2013-05-15 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물
KR1020217006420A Active KR102371364B1 (ko) 2012-05-17 2013-05-15 당뇨병 치료를 위한 글루코키나아제 활성화제 조성물

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Country Status (16)

Country Link
US (3) US10004782B2 (cg-RX-API-DMAC7.html)
EP (1) EP2849776B1 (cg-RX-API-DMAC7.html)
JP (1) JP6234443B2 (cg-RX-API-DMAC7.html)
KR (2) KR20150013838A (cg-RX-API-DMAC7.html)
CN (2) CN118453592A (cg-RX-API-DMAC7.html)
AU (2) AU2013262895A1 (cg-RX-API-DMAC7.html)
BR (1) BR112014028622A2 (cg-RX-API-DMAC7.html)
CA (1) CA2872021C (cg-RX-API-DMAC7.html)
EA (1) EA201492109A1 (cg-RX-API-DMAC7.html)
ES (1) ES2878001T3 (cg-RX-API-DMAC7.html)
HK (1) HK1202458A1 (cg-RX-API-DMAC7.html)
IL (1) IL235484A0 (cg-RX-API-DMAC7.html)
IN (1) IN2014DN09554A (cg-RX-API-DMAC7.html)
MX (1) MX360304B (cg-RX-API-DMAC7.html)
SG (2) SG10201609644UA (cg-RX-API-DMAC7.html)
WO (1) WO2013173417A2 (cg-RX-API-DMAC7.html)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3574912A1 (en) 2018-05-30 2019-12-04 Lee, Sam-Goo Composition for treating diabetic disease
KR20210016416A (ko) * 2018-05-31 2021-02-15 후아 메디슨 (상하이) 엘티디. 글루코키나제 활성화제 및 dpp-iv 억제제를 포함하는 약제학적 병용물, 조성물 및 병용 제제, 및 이의 제조 방법 및 용도

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AU2020426356A1 (en) * 2020-01-31 2022-08-25 Hua Medicine (Shanghai) Ltd. Treating treatment-resistant diabetes with glucokinase activator
US11872221B2 (en) 2020-01-31 2024-01-16 Hua Medicine (Shanghai) Ltd. Treating untreated or treatment-resistant diabetes with glucokinase activator
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
WO2021243646A1 (en) * 2020-06-04 2021-12-09 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with hepatic impairment
CA3185831A1 (en) * 2020-06-04 2021-12-09 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
US11857536B2 (en) 2020-06-04 2024-01-02 Hua Medicine (Shanghai) Ltd. Glucokinase activator for treating diabetes with renal impairment
US12479808B2 (en) 2020-06-08 2025-11-25 Vtv Therapeutics Llc Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof
CA3181665A1 (en) * 2020-06-08 2021-12-16 Jing TENG Crystalline forms of {2-[3-cyclohexyl-3-(trans-4-propoxy- cyclohexyl)-ureido]-thiazol-5-ylsulfanyl} -acetic acid and and uses thereof
CN115350268B (zh) * 2022-08-24 2025-02-11 深圳青澜生物技术有限公司 一种用于治疗糖尿病的制剂、微针及其制备工艺

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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3574912A1 (en) 2018-05-30 2019-12-04 Lee, Sam-Goo Composition for treating diabetic disease
KR20190136285A (ko) 2018-05-30 2019-12-10 이삼구 당뇨질환의 치료용 조성물
KR20210016416A (ko) * 2018-05-31 2021-02-15 후아 메디슨 (상하이) 엘티디. 글루코키나제 활성화제 및 dpp-iv 억제제를 포함하는 약제학적 병용물, 조성물 및 병용 제제, 및 이의 제조 방법 및 용도
KR20210016420A (ko) * 2018-05-31 2021-02-15 후아 메디슨 (상하이) 엘티디. 글루코키나제 활성화제 및 sglt-2 억제제를 포함하는 약제학적 병용물, 조성물, 및 병용 제제, 및 이의 제조방법 및 용도

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JP2015517525A (ja) 2015-06-22
AU2013262895A1 (en) 2014-11-13
BR112014028622A2 (pt) 2017-06-27
US10980861B2 (en) 2021-04-20
US10588943B2 (en) 2020-03-17
KR102371364B1 (ko) 2022-03-07
JP6234443B2 (ja) 2017-11-22
HK1202458A1 (en) 2015-10-02
EP2849776A2 (en) 2015-03-25
MX360304B (es) 2018-10-29
IL235484A0 (en) 2014-12-31
EA201492109A1 (ru) 2015-07-30
US20140066372A1 (en) 2014-03-06
ES2878001T3 (es) 2021-11-18
US20180311314A1 (en) 2018-11-01
CN104349790A (zh) 2015-02-11
US20200138909A1 (en) 2020-05-07
WO2013173417A2 (en) 2013-11-21
CA2872021C (en) 2022-08-16
SG11201406987UA (en) 2014-12-30
KR20210027547A (ko) 2021-03-10
CA2872021A1 (en) 2013-11-21
AU2017203835B2 (en) 2018-11-22
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